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In contrast, male BC is about 100 times less common than in women, being considered a rare disease. Male BC may be a distinctive subtype of BC and available data seems to indicate that male BC has a higher dependence on genetic variants than female BC. Nevertheless, the same prognostic and predictive markers are used to determine optimal management strategies for both male and female BC. Several studies have assessed the role of genetic polymorphisms (SNPs) in DNA repair genes in female BC susceptibility. However, data on male BC is scarce. Thus, the current study aimed to assess the role of SNPs in <jats:italic>XRCC1, MUTYH<\/jats:italic> and <jats:italic>TP53<\/jats:italic> genes in a male cohort of BC, and, in addition, compare the male data with matched results previously genotyped in female BC patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p> The male BC cohort was genotyped through Real-Time PCR using TaqMan Assays for several SNPs previously analysed in Portuguese female BC patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The results obtained indicate significant differences in BC susceptibility between males and females for the <jats:italic>XRCC1<\/jats:italic> rs1799782, <jats:italic>MUTYH<\/jats:italic> rs3219489 and <jats:italic>TP53<\/jats:italic> rs1042522 and rs8064946 variants.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>In males, <jats:italic>XRCC1<\/jats:italic> and <jats:italic>TP53<\/jats:italic> variants<jats:italic>,<\/jats:italic> when in heterozygosity, seem to be related with lower susceptibility for BC, contrasting with higher susceptibility for a <jats:italic>MUTYH<\/jats:italic> variant in females. These findings may help to explain the difference in incidence of BC between the two sexes.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10549-021-06159-x","type":"journal-article","created":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T21:18:31Z","timestamp":1620076711000},"page":"295-305","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Male and female breast cancer: the two faces of the same genetic susceptibility coin"],"prefix":"10.1007","volume":"188","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9122-0732","authenticated-orcid":false,"given":"Susana Nunes","family":"Silva","sequence":"first","affiliation":[]},{"given":"Bruno Costa","family":"Gomes","sequence":"additional","affiliation":[]},{"given":"Saudade","family":"Andr\u00e9","sequence":"additional","affiliation":[]},{"given":"Ana","family":"F\u00e9lix","sequence":"additional","affiliation":[]},{"given":"Ant\u00f3nio Sebasti\u00e3o","family":"Rodrigues","sequence":"additional","affiliation":[]},{"given":"Jos\u00e9","family":"Rueff","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2021,5,3]]},"reference":[{"key":"6159_CR1","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1016\/S0140-6736(16)31891-8","volume":"389","author":"N Harbeck","year":"2017","unstructured":"Harbeck N, Gnant M (2017) Breast cancer. 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