{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T19:37:49Z","timestamp":1767987469908,"version":"3.49.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T00:00:00Z","timestamp":1718236800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T00:00:00Z","timestamp":1718236800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Foundation for Science and Technology \u2013 FCT","award":["UIDB\/04750\/2020; LA\/P\/0064\/2020"],"award-info":[{"award-number":["UIDB\/04750\/2020; LA\/P\/0064\/2020"]}]},{"name":"Foundation for Science and Technology \u2013 FCT","award":["UIDB\/04750\/2020; LA\/P\/0064\/2020"],"award-info":[{"award-number":["UIDB\/04750\/2020; LA\/P\/0064\/2020"]}]},{"name":"Foundation for Science and Technology \u2013 FCT","award":["UIDB\/04750\/2020; LA\/P\/0064\/2020"],"award-info":[{"award-number":["UIDB\/04750\/2020; LA\/P\/0064\/2020"]}]},{"name":"Foundation for Science and Technology \u2013 FCT","award":["UIDB\/04750\/2020; LA\/P\/0064\/2020"],"award-info":[{"award-number":["UIDB\/04750\/2020; LA\/P\/0064\/2020"]}]},{"name":"FEDER through the Operational Program Competitiveness and Internationalization, and national funding from FCT","award":["POCI-01-0145-FEDER-032358; ref. PTDC\/SAU-EPI\/32358\/2017"],"award-info":[{"award-number":["POCI-01-0145-FEDER-032358; ref. PTDC\/SAU-EPI\/32358\/2017"]}]},{"DOI":"10.13039\/501100006752","name":"Universidade do Porto","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006752","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Breast Cancer Res Treat"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>Second primary cancers (SPCs) are estimated to affect nearly 5% of patients with breast cancer within 10 years of their diagnosis. This study aimed to estimate the contribution of SPCs to the mortality of patients with a breast first primary cancer (FPC).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A population-based cohort of 17,210 patients with a breast FPC diagnosed between 2000 and 2010 was followed for SPCs (31\/12\/2015) and vital status (30\/06\/2021). Patients diagnosed with an SPC (265 synchronous and 897 metachronous,\u2009\u2264\u20091 and\u2009&gt;\u20091 year after the FPC, respectively) were matched (1:3, by five-year age group and year of breast FPC diagnosis) to those without an SPC and alive when the corresponding SPC was diagnosed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Significantly higher hazards of death were found among patients with an SPC [hazard ratio of 1.56, 95% confidence interval (CI) 1.29\u20131.89 for synchronous SPCs; and 2.85, 95%CI 2.56\u20133.17 for metachronous SPCs] compared to patients with a breast FPC only. Estimates were higher for synchronous lung, stomach, non-Hodgkin lymphoma and breast SPCs, and metachronous liver, stomach, ovary, lung, rectum, corpus uteri, colon, breast, and non-Hodgkin lymphoma SPCs. The 15-year cumulative mortality was 59.5% for synchronous SPCs and 68.7% for metachronous SPCs, which was higher than in patients with a breast FPC only (43.6%\u00a0and 44.8%, respectively).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>In Northern Portugal, patients with an SPC following a breast FPC have a higher mortality compared with patients with a breast FPC only.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10549-024-07361-3","type":"journal-article","created":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T04:01:32Z","timestamp":1718251292000},"page":"323-330","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The contribution of second primary cancers to the mortality of patients with a first primary breast cancer"],"prefix":"10.1007","volume":"207","author":[{"given":"Elisabete","family":"Gon\u00e7alves","sequence":"first","affiliation":[]},{"given":"Filipa","family":"Fontes","sequence":"additional","affiliation":[]},{"given":"J\u00e9ssica Rocha","family":"Rodrigues","sequence":"additional","affiliation":[]},{"given":"Rita","family":"Calisto","sequence":"additional","affiliation":[]},{"given":"Maria Jos\u00e9","family":"Bento","sequence":"additional","affiliation":[]},{"given":"Nuno","family":"Lunet","sequence":"additional","affiliation":[]},{"given":"Samantha","family":"Morais","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2024,6,13]]},"reference":[{"key":"7361_CR1","unstructured":"Global Cancer Today (2020) International Agency for Research on Cancer & World Health Organization, Lyon, France"},{"key":"7361_CR2","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F (2021) Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. 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Data may be available from the authors upon reasonable request and with permission of RORENO.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Data availability"}},{"value":"The study was approved by the Ethics Committee of the Portuguese Institute of Oncology of Porto (Ref. CES IPO: 332\/020) and the analyses were performed according to RORENO guidelines ensuring the anonymity of information used.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}