{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T01:40:37Z","timestamp":1775266837485,"version":"3.50.1"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T00:00:00Z","timestamp":1610668800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T00:00:00Z","timestamp":1610668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cancer Causes Control"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1007\/s10552-020-01388-9","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T04:27:45Z","timestamp":1610684865000},"page":"327-336","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Body mass index as an independent prognostic factor in glioblastoma"],"prefix":"10.1007","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4279-3315","authenticated-orcid":false,"given":"Pedro","family":"Valente Aguiar","sequence":"first","affiliation":[]},{"given":"Bruno","family":"Carvalho","sequence":"additional","affiliation":[]},{"given":"Rui","family":"Vaz","sequence":"additional","affiliation":[]},{"given":"Paulo","family":"Linhares","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2021,1,15]]},"reference":[{"key":"1388_CR1","doi-asserted-by":"publisher","first-page":"143","DOI":"10.15586\/codon.glioblastoma.2017.ch8","volume-title":"Glioblastoma","author":"AF Tamimi","year":"2017","unstructured":"Tamimi AF, Juweid M (2017) Epidemiology and outcome of glioblastoma. Glioblastoma. Codon Publications, Brisbane, pp 143\u2013153"},{"issue":"1","key":"1388_CR2","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3171\/2011.2.jns10998","volume":"115","author":"N Sanai","year":"2011","unstructured":"Sanai N, Polley MY, McDermott MW, Parsa AT, Berger MS (2011) An extent of resection threshold for newly diagnosed glioblastomas. J Neurosurg 115(1):3\u20138. https:\/\/doi.org\/10.3171\/2011.2.jns10998","journal-title":"J Neurosurg"},{"key":"1388_CR3","volume-title":"Obesity and overweight fact sheet","author":"World Health Organization","year":"2018","unstructured":"World Health Organization (2018) Obesity and overweight fact sheet. World Health Organization, Geneva"},{"key":"1388_CR4","doi-asserted-by":"publisher","first-page":"88","DOI":"10.3322\/caac.21499","volume":"69","author":"H Sung","year":"2019","unstructured":"Sung H, Siegel RL, Torre LA, Pearson Stuttard J, Islami F, Fedewa SA, Goding Sauer A, Shuval K, Gapstur SM, Jacobs EJ, Giovannucci EL, Jemal A (2019) Global patterns in excess body weight and the associated cancer burden. CA 69:88\u2013112. https:\/\/doi.org\/10.3322\/caac.21499","journal-title":"CA"},{"issue":"4","key":"1388_CR5","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1093\/neuonc\/noz005","volume":"21","author":"IS Muskens","year":"2019","unstructured":"Muskens IS, Wu AH, Porcel J, Cheng I, Le Marchand L, Wiemels JL, Setiawan VW (2019) Body mass index, comorbidities, and hormonal factors in relation to meningioma in an ethnically diverse population: the Multiethnic Cohort. Neuro-Oncology 21(4):498\u2013507. https:\/\/doi.org\/10.1093\/neuonc\/noz005","journal-title":"Neuro-Oncology"},{"issue":"1","key":"1388_CR6","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1038\/bjc.2013.304","volume":"109","author":"M Wiedmann","year":"2013","unstructured":"Wiedmann M, Brunborg C, Lindemann K, Johannesen TB, Vatten L, Helseth E, Zwart J (2013) Body mass index and the risk of meningioma, glioma and schwannoma in a large prospective cohort study (The HUNT Study). Br J Cancer 109(1):289\u2013294. https:\/\/doi.org\/10.1038\/bjc.2013.304","journal-title":"Br J Cancer"},{"key":"1388_CR7","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.coph.2016.07.005","volume":"29","author":"R Kolb","year":"2016","unstructured":"Kolb R, Sutterwala FS, Zhang W (2016) Obesity and cancer: inflammation bridges the two. Curr Opin Pharmacol 29:77\u201389. https:\/\/doi.org\/10.1016\/j.coph.2016.07.005","journal-title":"Curr Opin Pharmacol"},{"issue":"12","key":"1388_CR8","doi-asserted-by":"publisher","first-page":"2922","DOI":"10.3390\/ijms20122922","volume":"20","author":"F Cirillo","year":"2019","unstructured":"Cirillo F, Catellani C, Sartori C, Lazzeroni P, Amarri S, Street ME (2019) Obesity, insulin resistance, and colorectal cancer: could miRNA dysregulation play a role? Int J Mol Sci 20(12):2922. https:\/\/doi.org\/10.3390\/ijms20122922","journal-title":"Int J Mol Sci"},{"key":"1388_CR9","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1146\/annurev-nutr-071811-150713","volume":"32","author":"N Parekh","year":"2012","unstructured":"Parekh N, Chandran U, Bandera EV (2012) Obesity in cancer survival. Annu Rev Nutr 32:311\u2013342. https:\/\/doi.org\/10.1146\/annurev-nutr-071811-150713","journal-title":"Annu Rev Nutr"},{"issue":"8","key":"1388_CR10","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1158\/1055-9965.epi-12-0485","volume":"21","author":"W Demark-Wahnefried","year":"2012","unstructured":"Demark-Wahnefried W, Platz EA, Ligibel JA, Blair CK, Courneya KS, Meyerhardt JA, Ganz PA, Rock CL, Schmitz KH, Wadden T, Philip EJ, Wolfe B, Gapstur SM, Ballard-Barbash R, McTiernan A, Minasian L, Nebeling L, Goodwin PJ (2012) The role of obesity in cancer survival and recurrence. Cancer Epidemiol Biomark Prev 21(8):1244\u20131259. https:\/\/doi.org\/10.1158\/1055-9965.epi-12-0485","journal-title":"Cancer Epidemiol Biomark Prev"},{"issue":"15","key":"1388_CR11","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.1212\/WNL.0000000000002020","volume":"85","author":"T Niedermaier","year":"2015","unstructured":"Niedermaier T, Behrens G, Schmid D, Schlecht I, Fischer B, Leitzmann MF (2015) Body mass index, physical activity, and risk of adult meningioma and glioma: a meta-analysis. Neurology 85(15):1342\u20131350. https:\/\/doi.org\/10.1212\/WNL.0000000000002020","journal-title":"Neurology"},{"issue":"2","key":"1388_CR12","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1093\/neuonc\/noz209","volume":"22","author":"CN Saunders","year":"2020","unstructured":"Saunders CN, Cornish AJ, Kinnersley B, Law PJ, Claus EB, Il\u2019yasova D, Schildkraut J, Barnholtz-Sloan JS, Olson SH, Bernstein JL, Lai RK, Chanock S, Rajaraman P, Johansen C, Jenkins RB, Melin BS, Wrensch MR, Sanson M, Bondy ML, Houlston RS (2020) Lack of association between modifiable exposures and glioma risk: a Mendelian randomization analysis. Neuro Oncol 22(2):207\u2013215. https:\/\/doi.org\/10.1093\/neuonc\/noz209","journal-title":"Neuro Oncol"},{"issue":"7","key":"1388_CR13","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1093\/neuonc\/now272","volume":"19","author":"M Wiedmann","year":"2017","unstructured":"Wiedmann M, Brunborg C, Di Ieva A, Lindemann K, Johannesen TB, Vatten L, Helseth E, Zwart JA (2017) The impact of body mass index and height on the risk for glioblastoma and other glioma subgroups: a large prospective cohort study. Neuro-Oncology 19(7):976\u2013985. https:\/\/doi.org\/10.1093\/neuonc\/now272","journal-title":"Neuro-Oncology"},{"issue":"1","key":"1388_CR14","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1007\/s11060-013-1150-2","volume":"114","author":"EM Siegel","year":"2013","unstructured":"Siegel EM, Nabors LB, Thompson RC, Olson JJ, Browning JE, Madden MH, Han G, Egan KM (2013) Prediagnostic body weight and survival in high grade glioma. J Neurooncol 114(1):79\u201384. https:\/\/doi.org\/10.1007\/s11060-013-1150-2","journal-title":"J Neurooncol"},{"issue":"12","key":"1388_CR15","doi-asserted-by":"publisher","first-page":"2195","DOI":"10.1007\/s10552-010-9639-x","volume":"21","author":"LW Jones","year":"2010","unstructured":"Jones LW, Ali-Osman F, Lipp E, Marcello JE, McCarthy B, McCoy L, Rice T, Wrensch M, Il\u2019yasova D (2010) Association between body mass index and mortality in patients with glioblastoma mutliforme. Cancer Causes Contr 21(12):2195\u20132201. https:\/\/doi.org\/10.1007\/s10552-010-9639-x","journal-title":"Cancer Causes Contr"},{"key":"1388_CR16","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1056\/NEJMoa043330","volume":"352","author":"R Stupp","year":"2005","unstructured":"Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJB (2005) Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 352:987\u2013996. https:\/\/doi.org\/10.1056\/NEJMoa043330","journal-title":"N Engl J Med"},{"issue":"1","key":"1388_CR17","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.ijrobp.2018.05.024","volume":"102","author":"M Potharaju","year":"2018","unstructured":"Potharaju M, Mangaleswaran B, Mathavan A, John R, Thamburaj V, Ghosh S, Ganesh S, Kalvakonda C, Loganathan M, Bapu S, Devi R, Verma RS (2018) Body mass index as a prognostic marker in glioblastoma multiforme: a clinical outcome. Int J Radiat Oncol Biol Phys 102(1):204\u2013209. https:\/\/doi.org\/10.1016\/j.ijrobp.2018.05.024","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"8","key":"1388_CR18","doi-asserted-by":"publisher","first-page":"1898","DOI":"10.1158\/0008-5472.CAN-17-3043","volume":"78","author":"Y Park","year":"2018","unstructured":"Park Y, Peterson LL, Colditz GA (2018) The plausibility of obesity paradox in cancer-point. Can Res 78(8):1898\u20131903. https:\/\/doi.org\/10.1158\/0008-5472.CAN-17-3043","journal-title":"Can Res"},{"issue":"9","key":"1388_CR19","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1007\/s11912-016-0539-4","volume":"18","author":"H Lennon","year":"2016","unstructured":"Lennon H, Sperrin M, Badrick E, Renehan AG (2016) The obesity paradox in cancer: a review. Curr Oncol Rep 18(9):56. https:\/\/doi.org\/10.1007\/s11912-016-0539-4","journal-title":"Curr Oncol Rep"},{"issue":"3","key":"1388_CR20","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1007\/s13668-019-00280-6","volume":"8","author":"DH Lee","year":"2019","unstructured":"Lee DH, Giovannucci EL (2019) The obesity paradox in cancer: epidemiologic insights and perspectives. Curr Nutr Rep 8(3):175\u2013181. https:\/\/doi.org\/10.1007\/s13668-019-00280-6","journal-title":"Curr Nutr Rep"},{"issue":"1","key":"1388_CR21","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.ygyno.2015.10.020","volume":"140","author":"AA Secord","year":"2016","unstructured":"Secord AA, Hasselblad V, Von Gruenigen VE, Gehrig PA, Modesitt SC, Bae-Jump V, Havrilesky LJ (2016) Body mass index and mortality in endometrial cancer: a systematic review and meta-analysis. Gynecol Oncol 140(1):184\u2013190. https:\/\/doi.org\/10.1016\/j.ygyno.2015.10.020","journal-title":"Gynecol Oncol"},{"issue":"9612","key":"1388_CR22","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/S0140-6736(08)60269-X","volume":"371","author":"AG Renehan","year":"2008","unstructured":"Renehan AG, Tyson M, Egger M, Heller RF, Zwahlen M (2008) Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet 371(9612):569\u2013578. https:\/\/doi.org\/10.1016\/S0140-6736(08)60269-X","journal-title":"Lancet"},{"key":"1388_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.canep.2016.02.010","volume":"42","author":"J Wang","year":"2016","unstructured":"Wang J, Yang DL, Chen ZZ, Gou BF (2016) Associations of body mass index with cancer incidence among populations, genders, and menopausal status: a systematic review and meta-analysis. Cancer Epidemiol 42:1\u20138. https:\/\/doi.org\/10.1016\/j.canep.2016.02.010","journal-title":"Cancer Epidemiol"},{"issue":"2","key":"1388_CR24","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.ejso.2018.09.012","volume":"45","author":"JHC Arkenbosch","year":"2018","unstructured":"Arkenbosch JHC, van Erning FN, Rutten HJ, Zimmerman D, de Wilt JHW, Beijer S (2018) The association between Body Mass Index and postoperative complications, 30-day mortality and long-term survival in Dutch patients with colorectal cancer. Eur J Surg Oncol 45(2):160\u2013166. https:\/\/doi.org\/10.1016\/j.ejso.2018.09.012","journal-title":"Eur J Surg Oncol"},{"issue":"2","key":"1388_CR25","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1016\/j.juro.2009.10.004","volume":"183","author":"HG Jeon","year":"2010","unstructured":"Jeon HG, Jeong IG, Lee JH, Lee CJ, Kwak C, Kim HH, Lee ES, Lee E (2010) Prognostic value of body mass index in Korean patients with renal cell carcinoma. J Urol 183(2):448\u2013454. https:\/\/doi.org\/10.1016\/j.juro.2009.10.004","journal-title":"J Urol"},{"key":"1388_CR26","doi-asserted-by":"publisher","first-page":"620","DOI":"10.3389\/fonc.2018.00620","volume":"8","author":"F Shahjehan","year":"2018","unstructured":"Shahjehan F, Merchea A, Cochuyt JJ, Li Z, Colibaseanu DT, Kasi PM (2018) Body mass index and long-term outcomes in patients with colorectal cancer. Front Oncol 8:620. https:\/\/doi.org\/10.3389\/fonc.2018.00620","journal-title":"Front Oncol"},{"issue":"3","key":"1388_CR27","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/S1470-2045(18)30078-0","volume":"19","author":"JL McQuade","year":"2018","unstructured":"McQuade JL, Daniel CR, Hess KR, Mak C, Wang DY, Rai RR, Park JJ, Haydu LE, Spencer C, Wongchenko M, Lane S, Lee DY, Kaper M, McKean M, Beckermann KE, Rubinstein SM, Rooney I, Musib L, Budha N, Hsu J, Nowicki TS, Avila A, Haas T, Puligandla M, Lee S, Fang S, Wargo JA, Gershenwald JE, Lee JE, Hwu P, Chapman PB, Sosman JA, Schadendorf D, Grob JJ, Flaherty KT, Walker D, Yan Y, McKenna E, Legos JJ, Carlino MS, Ribas A, Kirkwood JM, Long GV, Johnson DB, Menzies AM, Davies MA (2018) Association of body-mass index and outcomes in patients with metastatic melanoma treated with targeted therapy, immunotherapy, or chemotherapy: a retrospective, multicohort analysis. Lancet Oncol 19(3):310\u2013322. https:\/\/doi.org\/10.1016\/S1470-2045(18)30078-0","journal-title":"Lancet Oncol"},{"issue":"3","key":"1388_CR28","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1002\/ijc.27639","volume":"132","author":"Y Choi","year":"2012","unstructured":"Choi Y, Park B, Jeong BC, Seo SI, Jeon SS, Choi HY, Lee HM (2012) Body mass index and survival in patients with renal cell carcinoma: a clinical-based cohort and meta-analysis. Int J Cancer 132(3):625\u2013634. https:\/\/doi.org\/10.1002\/ijc.27639","journal-title":"Int J Cancer"},{"issue":"5","key":"1388_CR29","doi-asserted-by":"publisher","first-page":"348","DOI":"10.3109\/00365599.2012.678382","volume":"46","author":"\u00c5J Rogde","year":"2012","unstructured":"Rogde \u00c5J, Gudbrandsdottir G, Hjelle KM, Sand KE, Bostad L, Beisland C (2012) Obesity is associated with an improved cancer-specific survival, but an increased rate of postoperative complications after surgery for renal cell carcinoma. Scand J Urol Nephrol 46(5):348\u2013357. https:\/\/doi.org\/10.3109\/00365599.2012.678382","journal-title":"Scand J Urol Nephrol"},{"key":"1388_CR30","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1007\/s00432-009-0616-2","volume":"135","author":"AJ Schrader","year":"2009","unstructured":"Schrader AJ, Rustemeier J, Rustemeier JC, Timmesfeld N, Varga Z, Hegele A, Olbert PJ, Hofmann R (2009) Overweight is associated with improved cancer-specific survival in patients with organ-confined renal cell carcinoma. J Cancer Res Clin Oncol 135:1693\u20131699. https:\/\/doi.org\/10.1007\/s00432-009-0616-2","journal-title":"J Cancer Res Clin Oncol"},{"issue":"4","key":"1388_CR31","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1002\/cam4.634","volume":"5","author":"NM Tsang","year":"2016","unstructured":"Tsang NM, Pai PC, Chuang CC, Chuang WC, Tseng CK, Chang KP, Yen TC, Lin JD, Chang JT (2016) Overweight and obesity predict better overall survival rates in cancer patients with distant metastases. Cancer Med 5(4):665\u2013675. https:\/\/doi.org\/10.1002\/cam4.634","journal-title":"Cancer Med"},{"issue":"2","key":"1388_CR32","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/S1470-2045(19)30797-1","volume":"21","author":"A Sanchez","year":"2019","unstructured":"Sanchez A, Furberg H, Kuo F, Vuong L, Ged Y, Patil S, Ostrovnaya I, Petruzella S, Reising A, Patel P, Mano R, Coleman J, Russo P, Liu HC, Dannenberg JA, Chan AT, Motzer R, Voss H, Hakimi AA (2019) Transcriptomic signatures related to the obesity paradox in patients with clear cell renal cell carcinoma: a cohort study. Lancet Oncol 21(2):283\u2013293. https:\/\/doi.org\/10.1016\/S1470-2045(19)30797-1","journal-title":"Lancet Oncol"},{"issue":"30","key":"1388_CR33","doi-asserted-by":"publisher","first-page":"3655","DOI":"10.1200\/JCO.2016.66.7311","volume":"34","author":"L Albiges","year":"2016","unstructured":"Albiges L, Hakimi AA, Xie W, McKay RR, Simantov R, Lin X, Lee JL, Rini BI, Srinivas S, Bjarnason GA, Ernst S, Wood LA, Vaishamayan UN, Rha SY, Agarwal N, Yuasa T, Pal SK, Bamias A, Zabor EC, Skanderup AJ, Furberg H, Fay AP, de Velasco G, Preston MA, Wilson KM, Cho E, McDermott DF, Signoretti S, Heng DYC, Choueiri TK (2016) Body mass index and metastatic renal cell carcinoma: clinical and biological correlations. J Clin Oncol 34(30):3655\u20133663. https:\/\/doi.org\/10.1200\/JCO.2016.66.7311","journal-title":"J Clin Oncol"},{"issue":"3","key":"1388_CR34","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1016\/j.juro.2008.04.135","volume":"180","author":"A Horiguchi","year":"2008","unstructured":"Horiguchi A, Asano T, Asano T, Ito K, Sumitomo M, Hayakawa M (2008) Fatty acid synthase over expression is an indicator of tumor aggressiveness and poor prognosis in renal cell carcinoma. J Urol 180(3):1137\u20131140. https:\/\/doi.org\/10.1016\/j.juro.2008.04.135","journal-title":"J Urol"},{"issue":"24","key":"1388_CR35","doi-asserted-by":"publisher","first-page":"1862","DOI":"10.1093\/jnci\/djt310","volume":"105","author":"AA Hakimi","year":"2013","unstructured":"Hakimi AA, Furberg H, Zabor EC, Jacobsen A, Schultz N, Ciriello G, Mikklineni N, Fiegoli B, Kim PH, Voss MH, Shen H, Laird PW, Sander C, Reuter VE, Motzer RJ, Hsieh JJ, Russo P (2013) An epidemiologic and genomic investigation into the obesity paradox in renal cell carcinoma. J Natl Cancer Inst 105(24):1862\u20131870. https:\/\/doi.org\/10.1093\/jnci\/djt310","journal-title":"J Natl Cancer Inst"},{"key":"1388_CR36","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1038\/sj.bjc.6603350","volume":"95","author":"W Zhao","year":"2006","unstructured":"Zhao W, Kridel S, Thorburn A, Kooshki M, Little J, Hebbar S, Robbins M (2006) Fatty acid synthase: a novel target for antiglioma therapy. Br J Cancer 95:869\u2013878. https:\/\/doi.org\/10.1038\/sj.bjc.6603350","journal-title":"Br J Cancer"},{"key":"1388_CR37","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1007\/s11060-014-1452-z","volume":"118","author":"S Grube","year":"2014","unstructured":"Grube S, D\u00fcnisch P, Freitag D, Klausnitzer M, Sakr Y, Walter J, Kalff R, Ewald C (2014) Overexpression of fatty acid synthase in human gliomas correlates with the WHO tumor grade and inhibition with Orlistat reduces cell viability and triggers apoptosis. J Neurooncol 118:277\u2013287. https:\/\/doi.org\/10.1007\/s11060-014-1452-z","journal-title":"J Neurooncol"},{"issue":"10","key":"1388_CR38","doi-asserted-by":"publisher","first-page":"1478","DOI":"10.1016\/j.jtho.2017.07.022","volume":"12","author":"X Zhang","year":"2017","unstructured":"Zhang X, Liu Y, Shao H, Zheng X (2017) Obesity paradox in lung cancer prognosis: evolving biological insights and clinical implications. J Thorac Oncol 12(10):1478\u20131488. https:\/\/doi.org\/10.1016\/j.jtho.2017.07.022","journal-title":"J Thorac Oncol"}],"container-title":["Cancer Causes & Control"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10552-020-01388-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10552-020-01388-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10552-020-01388-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T05:19:51Z","timestamp":1615353591000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10552-020-01388-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,15]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["1388"],"URL":"https:\/\/doi.org\/10.1007\/s10552-020-01388-9","relation":{},"ISSN":["0957-5243","1573-7225"],"issn-type":[{"value":"0957-5243","type":"print"},{"value":"1573-7225","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,15]]},"assertion":[{"value":"11 August 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 December 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 January 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest, or non-financial interest in the subject matter or materials discussed in this manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}