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However, the best parameter to assess flow is unknown. Recent studies suggest that transaortic flow rate (FR) is superior to currently used stroke volume index (SVi) in defining low-flow states. Therefore, we aimed to evaluate the prognostic value of FR and SVi in patients undergoing TAVI.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A single-centre retrospective analysis of all consecutive patients treated with TAVI for SAS between 2011 and 2019 was conducted. Low-FR was defined as &lt;\u2009200 mL\/s and low-SVi as &lt;\u200935 mL\/m<jats:sup>2<\/jats:sup>. Primary endpoint was all-cause five-year mortality, analyzed using Kaplan-Meier curves and Cox regression models. Secondary endpoint was variation of NYHA functional class six months after procedure. Patients were further stratified according to ejection fraction (EF\u2009&lt;\u200950%).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Of 489 cases, 59.5% were low-FR, and 43.1% low-SVi. Low-flow patients had superior surgical risk, worse renal function, and had a higher prevalence of coronary artery disease. Low-FR was associated with mortality (hazard ratio 1.36, <jats:italic>p<\/jats:italic>\u2009=\u20090.041), but not after adjustment to EuroSCORE II. Normal-SVi was not associated with survival, despite a significative <jats:italic>p<\/jats:italic>-trend for its continuous value. No associations were found for flow-status and NYHA recovery. When stratifying according to preserved and reduced EF, both FR and SVi did not predict all-cause mortality.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>In patients with SAS undergoing TAVI, a low-FR state was associated with higher mortality, as well as SVi, but not at a 35 mL\/m<jats:sup>2<\/jats:sup> cut off.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s10554-023-02992-x","type":"journal-article","created":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T20:01:45Z","timestamp":1700424105000},"page":"341-350","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prognostic value of flow-status in severe aortic stenosis patients undergoing percutaneous intervention"],"prefix":"10.1007","volume":"40","author":[{"given":"Diogo","family":"Santos-Ferreira","sequence":"first","affiliation":[]},{"given":"Isabel","family":"Fernandes","sequence":"additional","affiliation":[]},{"given":"S\u00edlvia O.","family":"Diaz","sequence":"additional","affiliation":[]},{"given":"Cl\u00e1udio","family":"Guerreiro","sequence":"additional","affiliation":[]},{"given":"Francisca","family":"Saraiva","sequence":"additional","affiliation":[]},{"given":"Ant\u00f3nio S.","family":"Barros","sequence":"additional","affiliation":[]},{"given":"Adelino","family":"Leite-Moreira","sequence":"additional","affiliation":[]},{"given":"Eul\u00e1lia","family":"Pereira","sequence":"additional","affiliation":[]},{"given":"Francisco","family":"Sampaio","sequence":"additional","affiliation":[]},{"given":"Jos\u00e9","family":"Ribeiro","sequence":"additional","affiliation":[]},{"given":"Pedro","family":"Braga","sequence":"additional","affiliation":[]},{"given":"Ricardo","family":"Fontes-Carvalho","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2023,11,19]]},"reference":[{"key":"2992_CR1","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1016\/j.jacc.2013.05.015","volume":"62","author":"RL Osnabrugge","year":"2013","unstructured":"Osnabrugge RL, Mylotte D, Head SJ et al (2013) Aortic stenosis in the elderly: Disease prevalence and number of candidates for transcatheter aortic valve replacement: a meta-analysis and modeling study. 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