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However, the best timing for prognostic assessment remains uncertain. Our aim was to determine the impact of RV longitudinal function parameters and RV-PA coupling on mortality in patients undergoing TAVI.\u00a0 Retrospective, single center, analysis including patients with AS who underwent TAVI between 2007 and 2021. Echocardiographic evaluation was performed before, shortly after the procedure, and during follow-up. RV-PA uncoupling was defined as a TAPSE\/PASP ratio&lt;0.55\u00a0(severe RV uncoupling was defined as TAPSE\/PASP ratio&lt;0.32.\u00a0The effect of RV parameters on all-cause mortality up to 12 months was assessed.\u00a0 Among the 577 patients included, pre-procedural TAPSE\/PASP ratio data were available for 205. RV-PA uncoupling was present in 113 patients (55.1%), with severe uncoupling observed in 31 (15.1%). Within the first 12 months after TAVI, 51 patients (9%) died. Severe RV-PA uncoupling was associated with mortality in univariable Cox regression; however, this association was lost after adjusting for EuroSCORE II. A significant association was found between the TAPSE\/PASP ratio (per 0.1-unit increase) after the procedure and the primary endpoint (HR: 0.73; 95% CI: 0.56, 0.97; p=0.029). Higher postprocedural PASP (HR: 1.04; 95% CI: 1.02, 1.06; p&lt;0.001\u00a0was also associated with all-cause mortality.\u00a0 V-PA uncoupling and PASP after TAVI are associated with all-cause mortality in patients and may be valuable for patient selection and for planning post-procedural care.<\/jats:p>","DOI":"10.1007\/s10554-024-03165-0","type":"journal-article","created":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T07:02:04Z","timestamp":1719558124000},"page":"1745-1753","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Impact of right ventricle-pulmonary artery coupling in patients undergoing transcatheter aortic valve implantation"],"prefix":"10.1007","volume":"40","author":[{"given":"L\u00edgia Fernandes","family":"Mendes","sequence":"first","affiliation":[]},{"given":"Mariana","family":"Brand\u00e3o","sequence":"additional","affiliation":[]},{"given":"Silvia O.","family":"Diaz","sequence":"additional","affiliation":[]},{"given":"Marta Catarina","family":"Almeida","sequence":"additional","affiliation":[]},{"given":"Ant\u00f3nio S.","family":"Barros","sequence":"additional","affiliation":[]},{"given":"Francisca","family":"Saraiva","sequence":"additional","affiliation":[]},{"given":"Jos\u00e9","family":"Ribeiro","sequence":"additional","affiliation":[]},{"given":"Alberto","family":"Rodrigues","sequence":"additional","affiliation":[]},{"given":"Pedro","family":"Braga","sequence":"additional","affiliation":[]},{"given":"Ricardo Fontes","family":"Carvalho","sequence":"additional","affiliation":[]},{"given":"Francisco","family":"Sampaio","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2024,6,28]]},"reference":[{"key":"3165_CR1","unstructured":"Ancona R, Pinto SC (2020) Epidemiology of aortic valve stenosis (AS) and of aortic valve incompetence (AI): is the prevalence of AS\/AI similar in different parts of the world? 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