{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T10:38:55Z","timestamp":1753439935036},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2014,6,20]],"date-time":"2014-06-20T00:00:00Z","timestamp":1403222400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Clin Exp Metastasis"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1007\/s10585-014-9659-0","type":"journal-article","created":{"date-parts":[[2014,6,19]],"date-time":"2014-06-19T10:43:15Z","timestamp":1403174595000},"page":"689-696","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Metadherin expression and lung relapse in patients with colorectal carcinoma"],"prefix":"10.1007","volume":"31","author":[{"given":"Sandra","family":"Casimiro","sequence":"first","affiliation":[]},{"given":"Afonso","family":"Fernandes","sequence":"additional","affiliation":[]},{"given":"Ant\u00f3nio Gouveia","family":"Oliveira","sequence":"additional","affiliation":[]},{"given":"Marco","family":"Franco","sequence":"additional","affiliation":[]},{"given":"Ricardo","family":"Pires","sequence":"additional","affiliation":[]},{"given":"Mafalda","family":"Peres","sequence":"additional","affiliation":[]},{"given":"Margarida","family":"Matias","sequence":"additional","affiliation":[]},{"given":"Joana","family":"Tato-Costa","sequence":"additional","affiliation":[]},{"given":"Nuno","family":"Guerra","sequence":"additional","affiliation":[]},{"given":"Madalena","family":"Ramos","sequence":"additional","affiliation":[]},{"given":"Jorge","family":"Cruz","sequence":"additional","affiliation":[]},{"given":"Luis","family":"Costa","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2014,6,20]]},"reference":[{"issue":"12","key":"9659_CR1","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1002\/ijc.25516","volume":"127","author":"J Ferlay","year":"2010","unstructured":"Ferlay J et al (2010) Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 127(12):2893\u20132917","journal-title":"Int J Cancer"},{"issue":"6","key":"9659_CR2","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1245\/s10434-010-0985-4","volume":"17","author":"SB Edge","year":"2010","unstructured":"Edge SB, Compton CC (2010) The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol 17(6):1471\u20131474","journal-title":"Ann Surg Oncol"},{"issue":"16","key":"9659_CR3","doi-asserted-by":"crossref","first-page":"3408","DOI":"10.1200\/JCO.2004.05.063","volume":"22","author":"AB Benson 3rd","year":"2004","unstructured":"Benson AB 3rd et al (2004) American Society of Clinical Oncology recommendations on adjuvant chemotherapy for stage II colon cancer. J Clin Oncol 22(16):3408\u20133419","journal-title":"J Clin Oncol"},{"issue":"3","key":"9659_CR4","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1002\/ijc.28071","volume":"133","author":"Y Liu","year":"2013","unstructured":"Liu Y et al (2013) Increased expression of metadherin protein predicts worse disease-free and overall survival in laryngeal squamous cell carcinoma. Int J Cancer 133(3):671\u2013679","journal-title":"Int J Cancer"},{"issue":"2","key":"9659_CR5","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.canep.2012.10.007","volume":"37","author":"ZF Ke","year":"2013","unstructured":"Ke ZF et al (2013) Expression characteristics of astrocyte elevated gene-1 (AEG-1) in tongue carcinoma and its correlation with poor prognosis. Cancer Epidemiol 37(2):179\u2013185","journal-title":"Cancer Epidemiol"},{"issue":"1","key":"9659_CR6","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s12032-012-0383-9","volume":"30","author":"ZF Ke","year":"2013","unstructured":"Ke ZF et al (2013) AEG-1 expression characteristics in human non-small cell lung cancer and its relationship with apoptosis. Med Oncol 30(1):383","journal-title":"Med Oncol"},{"issue":"3","key":"9659_CR7","doi-asserted-by":"crossref","first-page":"e42","DOI":"10.1111\/j.1743-7563.2012.01541.x","volume":"8","author":"J Zhou","year":"2012","unstructured":"Zhou J et al (2012) Metadherin is a novel prognostic marker for bladder cancer progression and overall patient survival. Asia Pac J Clin Oncol 8(3):e42\u2013e48","journal-title":"Asia Pac J Clin Oncol"},{"issue":"7","key":"9659_CR8","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/j.humpath.2011.08.017","volume":"43","author":"S Sun","year":"2012","unstructured":"Sun S et al (2012) Overexpression of astrocyte-elevated gene-1 is closely correlated with poor prognosis in human non-small cell lung cancer and mediates its metastasis through up-regulation of matrix metalloproteinase-9 expression. Hum Pathol 43(7):1051\u20131060","journal-title":"Hum Pathol"},{"issue":"6","key":"9659_CR9","first-page":"2073","volume":"27","author":"Z Gong","year":"2012","unstructured":"Gong Z et al (2012) Prognostic significance of metadherin overexpression in hepatitis B virus-related hepatocellular carcinoma. Oncol Rep 27(6):2073\u20132079","journal-title":"Oncol Rep"},{"issue":"6","key":"9659_CR10","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1111\/j.1365-2559.2012.04182.x","volume":"60","author":"C Li","year":"2012","unstructured":"Li C et al (2012) Elevated expression of astrocyte elevated gene-1 (AEG-1) is correlated with cisplatin-based chemoresistance and shortened outcome in patients with stages III\u2013IV serous ovarian carcinoma. Histopathology 60(6):953\u2013963","journal-title":"Histopathology"},{"issue":"6","key":"9659_CR11","doi-asserted-by":"crossref","first-page":"2833","DOI":"10.7314\/APJCP.2012.13.6.2833","volume":"13","author":"ME Baygi","year":"2012","unstructured":"Baygi ME, Nikpour P (2012) Deregulation of MTDH gene expression in gastric cancer. Asian Pac J Cancer Prev 13(6):2833\u20132836","journal-title":"Asian Pac J Cancer Prev"},{"issue":"2\u20133","key":"9659_CR12","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3233\/CBM-2012-0268","volume":"11","author":"HY Liu","year":"2012","unstructured":"Liu HY et al (2012) AEG-1 is associated with clinical outcome in neuroblastoma patients. Cancer Biomark 11(2\u20133):115\u2013121","journal-title":"Cancer Biomark"},{"issue":"24","key":"9659_CR13","doi-asserted-by":"crossref","first-page":"7539","DOI":"10.1158\/1078-0432.CCR-11-2102","volume":"17","author":"AB Hui","year":"2011","unstructured":"Hui AB et al (2011) Significance of dysregulated metadherin and microRNA-375 in head and neck cancer. Clin Cancer Res 17(24):7539\u20137550","journal-title":"Clin Cancer Res"},{"issue":"23","key":"9659_CR14","doi-asserted-by":"crossref","first-page":"7294","DOI":"10.1158\/1078-0432.CCR-11-1327","volume":"17","author":"K Zhu","year":"2011","unstructured":"Zhu K et al (2011) Metadherin promotes hepatocellular carcinoma metastasis through induction of epithelial\u2013mesenchymal transition. Clin Cancer Res 17(23):7294\u20137302","journal-title":"Clin Cancer Res"},{"key":"9659_CR15","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1186\/1479-5876-9-205","volume":"9","author":"WT Liao","year":"2011","unstructured":"Liao WT et al (2011) Astrocyte elevated gene-1 (AEG-1) is a marker for aggressive salivary gland carcinoma. J Transl Med 9:205","journal-title":"J Transl Med"},{"issue":"5","key":"9659_CR16","first-page":"1133","volume":"26","author":"W Sun","year":"2011","unstructured":"Sun W et al (2011) Astrocyte elevated gene-1 overexpression in human primary gallbladder carcinomas: an unfavorable and independent prognostic factor. Oncol Rep 26(5):1133\u20131142","journal-title":"Oncol Rep"},{"issue":"6","key":"9659_CR17","doi-asserted-by":"crossref","first-page":"539","DOI":"10.4161\/cbt.12.6.16301","volume":"12","author":"F Wang","year":"2011","unstructured":"Wang F et al (2011) Oncogenic roles of astrocyte elevated gene-1 (AEG-1) in osteosarcoma progression and prognosis. Cancer Biol Ther 12(6):539\u2013548","journal-title":"Cancer Biol Ther"},{"issue":"2","key":"9659_CR18","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s12032-010-9475-6","volume":"28","author":"X Jian-bo","year":"2011","unstructured":"Jian-bo X et al (2011) Astrocyte-elevated gene-1 overexpression is associated with poor prognosis in gastric cancer. Med Oncol 28(2):455\u2013462","journal-title":"Med Oncol"},{"issue":"4","key":"9659_CR19","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1097\/IGC.0b013e3182145561","volume":"21","author":"C Li","year":"2011","unstructured":"Li C et al (2011) AEG -1 overexpression: a novel indicator for peritoneal dissemination and lymph node metastasis in epithelial ovarian cancers. Int J Gynecol Cancer 21(4):602\u2013608","journal-title":"Int J Gynecol Cancer"},{"issue":"7","key":"9659_CR20","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1111\/IGC.0b013e3181ef8e21","volume":"20","author":"H Song","year":"2010","unstructured":"Song H et al (2010) Expression of astrocyte elevated gene-1: a novel marker of the pathogenesis, progression, and poor prognosis for endometrial cancer. Int J Gynecol Cancer 20(7):1188\u20131196","journal-title":"Int J Gynecol Cancer"},{"issue":"6","key":"9659_CR21","doi-asserted-by":"crossref","first-page":"522","DOI":"10.4149\/neo_2010_06_522","volume":"57","author":"W Chen","year":"2010","unstructured":"Chen W et al (2010) Overexpression of AEG-1 in renal cell carcinoma and its correlation with tumor nuclear grade and progression. Neoplasma 57(6):522\u2013529","journal-title":"Neoplasma"},{"issue":"5","key":"9659_CR22","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1093\/carcin\/bgp064","volume":"30","author":"C Yu","year":"2009","unstructured":"Yu C et al (2009) Overexpression of astrocyte elevated gene-1 (AEG-1) is associated with esophageal squamous cell carcinoma (ESCC) progression and pathogenesis. Carcinogenesis 30(5):894\u2013901","journal-title":"Carcinogenesis"},{"issue":"3","key":"9659_CR23","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1172\/JCI36460","volume":"119","author":"BK Yoo","year":"2009","unstructured":"Yoo BK et al (2009) Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression. J Clin Invest 119(3):465\u2013477","journal-title":"J Clin Invest"},{"issue":"1","key":"9659_CR24","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ccr.2008.11.013","volume":"15","author":"G Hu","year":"2009","unstructured":"Hu G et al (2009) MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancer. Cancer Cell 15(1):9\u201320","journal-title":"Cancer Cell"},{"issue":"11","key":"9659_CR25","doi-asserted-by":"crossref","first-page":"3319","DOI":"10.1158\/1078-0432.CCR-07-4054","volume":"14","author":"J Li","year":"2008","unstructured":"Li J et al (2008) Astrocyte elevated gene-1 is a novel prognostic marker for breast cancer progression and overall patient survival. Clin Cancer Res 14(11):3319\u20133326","journal-title":"Clin Cancer Res"},{"issue":"4","key":"9659_CR26","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S1535-6108(04)00079-0","volume":"5","author":"DM Brown","year":"2004","unstructured":"Brown DM, Ruoslahti E (2004) Metadherin, a cell surface protein in breast tumors that mediates lung metastasis. Cancer Cell 5(4):365\u2013374","journal-title":"Cancer Cell"},{"issue":"50","key":"9659_CR27","doi-asserted-by":"crossref","first-page":"21300","DOI":"10.1073\/pnas.0910936106","volume":"106","author":"L Emdad","year":"2009","unstructured":"Emdad L et al (2009) Astrocyte elevated gene-1 (AEG-1) functions as an oncogene and regulates angiogenesis. Proc Natl Acad Sci USA 106(50):21300\u201321305","journal-title":"Proc Natl Acad Sci USA"},{"issue":"8","key":"9659_CR28","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1038\/sj.onc.1210713","volume":"27","author":"SG Lee","year":"2008","unstructured":"Lee SG et al (2008) Astrocyte elevated gene-1 activates cell survival pathways through PI3K-Akt signaling. Oncogene 27(8):1114\u20131121","journal-title":"Oncogene"},{"issue":"6871","key":"9659_CR29","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/415530a","volume":"415","author":"LJ van \u2018t Veer","year":"2002","unstructured":"van \u2018t Veer LJ et al (2002) Gene expression profiling predicts clinical outcome of breast cancer. Nature 415(6871):530\u2013536","journal-title":"Nature"},{"issue":"1","key":"9659_CR30","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.yexcr.2004.06.026","volume":"300","author":"DE Britt","year":"2004","unstructured":"Britt DE et al (2004) Identification of a novel protein, LYRIC, localized to tight junctions of polarized epithelial cells. Exp Cell Res 300(1):134\u2013148","journal-title":"Exp Cell Res"},{"key":"9659_CR31","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/1479-5876-10-109","volume":"10","author":"S Gnosa","year":"2012","unstructured":"Gnosa S et al (2012) Expression of AEG-1 mRNA and protein in colorectal cancer patients and colon cancer cell lines. J Transl Med 10:109","journal-title":"J Transl Med"},{"issue":"10","key":"9659_CR32","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1007\/s00384-010-1009-3","volume":"25","author":"H Song","year":"2010","unstructured":"Song H et al (2010) Prognostic significance of AEG-1 expression in colorectal carcinoma. Int J Colorectal Dis 25(10):1201\u20131209","journal-title":"Int J Colorectal Dis"},{"issue":"4","key":"9659_CR33","doi-asserted-by":"crossref","first-page":"2858","DOI":"10.1007\/s12032-012-0186-z","volume":"29","author":"T Jiang","year":"2012","unstructured":"Jiang T et al (2012) Clinical implications of AEG-1 in liver metastasis of colorectal cancer. Med Oncol 29(4):2858\u20132863","journal-title":"Med Oncol"},{"issue":"12","key":"9659_CR34","doi-asserted-by":"crossref","first-page":"10497","DOI":"10.1007\/s11033-012-1933-0","volume":"39","author":"N Wang","year":"2012","unstructured":"Wang N et al (2012) Prognostic impact of Metadherin-SND1 interaction in colon cancer. Mol Biol Rep 39(12):10497\u201310504","journal-title":"Mol Biol Rep"},{"issue":"31","key":"9659_CR35","doi-asserted-by":"crossref","first-page":"12938","DOI":"10.1073\/pnas.0901451106","volume":"106","author":"BK Yoo","year":"2009","unstructured":"Yoo BK et al (2009) Identification of genes conferring resistance to 5-fluorouracil. Proc Natl Acad Sci USA 106(31):12938\u201312943","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"9659_CR36","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1158\/1535-7163.MCT-08-0759","volume":"8","author":"C Morales","year":"2009","unstructured":"Morales C et al (2009) Dihydrofolate reductase amplification and sensitization to methotrexate of methotrexate-resistant colon cancer cells. Mol Cancer Ther 8(2):424\u2013432","journal-title":"Mol Cancer Ther"},{"issue":"4","key":"9659_CR37","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/labinvest.3780265","volume":"81","author":"S Glockner","year":"2001","unstructured":"Glockner S et al (2001) Amplification of growth regulatory genes in intraductal breast cancer is associated with higher nuclear grade but not with the progression to invasiveness. Lab Invest 81(4):565\u2013571","journal-title":"Lab Invest"},{"issue":"6","key":"9659_CR38","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1016\/S0002-9440(10)65059-6","volume":"156","author":"U Lehmann","year":"2000","unstructured":"Lehmann U et al (2000) Detection of gene amplification in archival breast cancer specimens by laser-assisted microdissection and quantitative real-time polymerase chain reaction. Am J Pathol 156(6):1855\u20131864","journal-title":"Am J Pathol"},{"key":"9659_CR39","doi-asserted-by":"crossref","first-page":"v93","DOI":"10.1093\/annonc\/mdq222","volume":"21","author":"E Cutsem Van","year":"2010","unstructured":"Van Cutsem E et al (2010) Advanced colorectal cancer: ESMO Clinical Practice Guidelines for treatment. Ann Oncol 21:v93\u2013v97","journal-title":"Ann Oncol"},{"issue":"3","key":"9659_CR40","doi-asserted-by":"crossref","first-page":"449","DOI":"10.3892\/etm.2011.443","volume":"3","author":"H Nozawa","year":"2012","unstructured":"Nozawa H et al (2012) Synchronous and metachronous lung metastases in patients with colorectal cancer: a 20-year monocentric experience. Exp Ther Med 3(3):449\u2013456","journal-title":"Exp Ther Med"},{"issue":"5","key":"9659_CR41","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/S0039-6109(02)00051-8","volume":"82","author":"C Penna","year":"2002","unstructured":"Penna C, Nordlinger B (2002) Colorectal metastasis (liver and lung). Surg Clin N Am 82(5):1075\u20131090","journal-title":"Surg Clin N Am"},{"issue":"10","key":"9659_CR42","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1007\/s00384-010-1009-3","volume":"25","author":"HT Song","year":"2010","unstructured":"Song HT et al (2010) Prognostic significance of AEG-1 expression in colorectal carcinoma. Int J Colorectal Dis 25(10):1201\u20131209","journal-title":"Int J Colorectal Dis"}],"container-title":["Clinical & Experimental Metastasis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10585-014-9659-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10585-014-9659-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10585-014-9659-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,11]],"date-time":"2019-08-11T18:20:29Z","timestamp":1565547629000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10585-014-9659-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,20]]},"references-count":42,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["9659"],"URL":"https:\/\/doi.org\/10.1007\/s10585-014-9659-0","relation":{},"ISSN":["0262-0898","1573-7276"],"issn-type":[{"value":"0262-0898","type":"print"},{"value":"1573-7276","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,20]]}}}