{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:56:08Z","timestamp":1777337768265,"version":"3.51.4"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2012,2,29]],"date-time":"2012-02-29T00:00:00Z","timestamp":1330473600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ecotoxicology"],"published-print":{"date-parts":[[2012,5]]},"DOI":"10.1007\/s10646-012-0871-x","type":"journal-article","created":{"date-parts":[[2012,2,28]],"date-time":"2012-02-28T08:50:31Z","timestamp":1330419031000},"page":"1167-1176","source":"Crossref","is-referenced-by-count":130,"title":["Ecotoxicological effects of ciprofloxacin on freshwater species: data integration and derivation of toxicity thresholds for risk assessment"],"prefix":"10.1007","volume":"21","author":[{"given":"N.","family":"Martins","sequence":"first","affiliation":[]},{"given":"R.","family":"Pereira","sequence":"additional","affiliation":[]},{"given":"N.","family":"Abrantes","sequence":"additional","affiliation":[]},{"given":"J.","family":"Pereira","sequence":"additional","affiliation":[]},{"given":"F.","family":"Gon\u00e7alves","sequence":"additional","affiliation":[]},{"given":"C. R.","family":"Marques","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2012,2,29]]},"reference":[{"key":"871_CR1","unstructured":"ASTM (American Society for Testing and Materials) (1980) Standard practice for conducting acute toxicity tests with fishes, macroinvertebrates and amphibians. Report E-729-80. ASTM, Philadelphia"},{"key":"871_CR2","doi-asserted-by":"crossref","first-page":"3291","DOI":"10.1016\/S0045-6535(98)00560-8","volume":"38","author":"T Backhaus","year":"1999","unstructured":"Backhaus T, Grimme LH (1999) The toxicity of antibiotic agents to the luminescent bacterium Vibrio fischeri. Chemosphere 38:3291\u20133301","journal-title":"Chemosphere"},{"key":"871_CR3","unstructured":"Baird DJ, Soares AMVM, Girling A, Barber I, Bradley MC, Calow P (1989) The long-term maintenance of Daphnia magna Straus for use in ecotoxicity tests: problems and prospects. In: Lokke H, Tyle H., Bro-Rasmussen F (eds) Proceedings of the first European conference on ecotoxicology, Denmark, Lyngby, pp 144\u2013148"},{"key":"871_CR4","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1046\/j.1365-2435.1998.00201.x","volume":"12","author":"C Barata","year":"1998","unstructured":"Barata C, Baird DJ (1998) Phenotypic plasticity and constancy of life-history traits in laboratory clones of Daphnia magna Straus: effects of neonatal length. Funct Ecol 12:442\u2013452","journal-title":"Funct Ecol"},{"issue":"Suppl. 1","key":"871_CR5","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1007\/BF01650500","volume":"16","author":"T Bergan","year":"1988","unstructured":"Bergan T, Dalhoff A, Rohwedder R (1988) Pharmacokinetics of ciprofloxacin. Infection 16(Suppl. 1):S3\u2013S13","journal-title":"Infection"},{"key":"871_CR6","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1897\/02-576","volume":"23","author":"RA Brain","year":"2004","unstructured":"Brain RA, Johnson DJ, Richards SM, Sanderson H, Sibley PK, Solomon KR (2004) Effects of 25 pharmaceutical compounds to Lemna minor using a seven-day static renewal test. Environ Toxicol Chem 23:371\u2013382","journal-title":"Environ Toxicol Chem"},{"key":"871_CR7","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.scitotenv.2005.10.007","volume":"366","author":"KD Brown","year":"2006","unstructured":"Brown KD, Kulis J, Thomson B, Chapman TH, Mawhinney DB (2006) Occurrence of antibiotics in hospital, residential, and dairy effluent, municipal wastewater, and the Rio Grande in New Mexico. Sci Total Environ 366:772\u2013783","journal-title":"Sci Total Environ"},{"key":"871_CR8","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1046\/j.1365-2427.2000.00510.x","volume":"43","author":"CW Burns","year":"2000","unstructured":"Burns CW (2000) Crowding-induced changes in growth, reproduction and morphology of Daphnia. Freshw Biol 43:19\u201329","journal-title":"Freshw Biol"},{"key":"871_CR9","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1128\/AAC.25.3.319","volume":"25","author":"N-X Chin","year":"1984","unstructured":"Chin N-X, Neu HC (1984) Ciprofloxacin, a quinolone carboxylic acid compound active against aerobic and anaerobic bacteria. Antimicrob Agents Chemother 25:319\u2013326","journal-title":"Antimicrob Agents Chemother"},{"key":"871_CR10","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1006\/rtph.1998.1253","volume":"28","author":"FM Christensen","year":"1998","unstructured":"Christensen FM (1998) Pharmaceuticals in the environment\u2014a human risk? Regul Toxicol Pharm 28:212\u2013221","journal-title":"Regul Toxicol Pharm"},{"key":"871_CR11","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1289\/ehp.99107s6907","volume":"107","author":"CG Daughton","year":"1999","unstructured":"Daughton CG, Ternes TA (1999) Pharmaceuticals and personal care products in the environment: agents of subtle change? Environ Health Perspect 107:907\u2013938","journal-title":"Environ Health Perspect"},{"key":"871_CR12","unstructured":"EC (European Commission) (2003) Technical guidance document on risk assessment in support of Commission Directive 93\/67\/EEC on risk assessment for new notified substances, Commission Regulation (EC) No 1488\/94 on risk assessment for existing substances, Directive 98\/8\/EC of the European Parliament and of the Council concerning the placing of biocidal products on the market. Part II. Joint research Centre, Ispra"},{"key":"871_CR13","unstructured":"EC (European Commission) (2006) Regulation (EC) No 1907\/2006 of the European Parliament and of the Council concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), establishing a European Chemicals Agency, amending Directive 1999\/45\/EC and repealing Council Regulation (EEC) No 793\/93 and Commission Regulation (EC) No 1488\/94 as well as Council Directive 76\/769\/EEC and Commission Directives 91\/155\/EEC, 93\/67\/EEC, 93\/105\/EC and 2000\/21\/EC. In: Communities. O.J L 396, 30.12.2006"},{"key":"871_CR14","unstructured":"EMEA (2006) Guideline on the environmental risk assessment of medicinal products for human use. Doc. Ref. EMEA\/CHMP\/SWP\/4447\/00"},{"key":"871_CR15","unstructured":"EMEA (2008) Revised guideline on environmental impact assessment for veterinary medical products in support of VICH guidelines GL6 and GL38. European Medicines Agency. Committee for Medicinal Products for Veterinary use (CVMP), EMEA\/CVMP\/ERA\/418282\/2005-Rev. 1, 17 Nov 2008"},{"key":"871_CR16","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.aquatox.2005.09.009","volume":"76","author":"K Fent","year":"2006","unstructured":"Fent K, Weston AA, Caminada D (2006) Ecotoxicology of human pharmaceuticals review. Aquat Toxicol 76:122\u2013159","journal-title":"Aquat Toxicol"},{"key":"871_CR17","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1093\/jac\/dkl183","volume":"58","author":"M Ferech","year":"2006","unstructured":"Ferech M, Coenen S, Malhotra-Kumar S, Dvorakova K, Hendrickx E, Suetens C, Goossens H (2006) European surveillance of antimicrobial consumption (ESAC): outpatient quinolone use in Europe. J Antimicrob Chemother 58:423\u2013427","journal-title":"J Antimicrob Chemother"},{"key":"871_CR18","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1897\/03-246","volume":"23","author":"B Ferrari","year":"2004","unstructured":"Ferrari B, Mons R, Vollat B, Fraysse B, Pax\u00e9us N, Lo Giudice R, Pollio A, Garric J (2004) Environmental risk assessment of six human pharmaceuticals: are the current environmental risk assessment procedures sufficient for the protection of the aquatic environment? Environ Toxicol Chem 23:1344\u20131354","journal-title":"Environ Toxicol Chem"},{"key":"871_CR19","volume-title":"Probit Analysis","author":"DJ Finney","year":"1971","unstructured":"Finney DJ (1971) Probit Analysis, 3rd edn. Cambridge University Press, Cambridge","edition":"3"},{"issue":"7","key":"871_CR20","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1002\/etc.5620180729","volume":"18","author":"VE Forbes","year":"1999","unstructured":"Forbes VE, Calow P (1999) Is the per capita rate of increase a good measure of population-level effects in ecotoxicology? Environ Toxicol Chem 18(7):1544\u20131556","journal-title":"Environ Toxicol Chem"},{"key":"871_CR21","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/S0045-6535(99)00274-X","volume":"40","author":"K Froehner","year":"2000","unstructured":"Froehner K, Backhaus T, Grimme LH (2000) Bioassays with Vibrio fischeri for the assessment of delayed toxicity. Chemosphere 40:821\u2013828","journal-title":"Chemosphere"},{"key":"871_CR22","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.ecoenv.2007.10.015","volume":"71","author":"M Grung","year":"2008","unstructured":"Grung M, K\u00e4llqvist T, Sakshaug S, Skurtveit S, Thomas KV (2008) Environmental assessment of Norwegian priority pharmaceuticals based on the EMEA guideline. Ecotoxicol Environ Saf 71:328\u2013340","journal-title":"Ecotoxicol Environ Saf"},{"key":"871_CR23","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1093\/jac\/46.suppl_1.53","volume":"46","author":"B Halling-Sorensen","year":"2000","unstructured":"Halling-Sorensen B, Lutzhoft H, Andersen H, Ingerslev F (2000) Environmental risk assessment of antibiotics: comparison of mecillinam, trimethoprim and ciprofloxacin. J Antimicrob Chemother 46:53\u201358","journal-title":"J Antimicrob Chemother"},{"issue":"3","key":"871_CR24","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1002\/etc.5620170305","volume":"17","author":"A Hartmann","year":"1998","unstructured":"Hartmann A, Alder AC, Koller T, Widmer RM (1998) Identification of fluoroquinolone antibiotics as the main source of umuC genotoxicity in native hospital wastewater. Environ Toxicol Chem 17(3):377\u2013382","journal-title":"Environ Toxicol Chem"},{"key":"871_CR25","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.chemosphere.2006.12.097","volume":"68","author":"MD Hernando","year":"2007","unstructured":"Hernando MD, De Vettori S, Mart\u00ednez Bueno MJ, Fern\u00e1ndez-Alba A (2007) Toxicity evaluation with Vibrio fischeri test of organic chemicals used in aquaculture. Chemosphere 68:724\u2013730","journal-title":"Chemosphere"},{"key":"871_CR26","first-page":"30","volume":"120","author":"C Huang","year":"2001","unstructured":"Huang C, Renew JE, Semby KL, Pinkston K, Sedlak DL (2001) Assessment of potential antibiotic contaminants in water and preliminary occurrence analysis. Water Resour Update 120:30\u201340","journal-title":"Water Resour Update"},{"key":"871_CR27","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.scitotenv.2004.11.017","volume":"346","author":"M Isidori","year":"2005","unstructured":"Isidori M, Lavorgna M, Nardelli A, Pascarella L, Parrella A (2005) Toxic and genotoxic evaluation of six antibiotics on non-target organisms. Sci Total Environ 346:87\u201398","journal-title":"Sci Total Environ"},{"key":"871_CR28","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1289\/ehp.98106583","volume":"106","author":"KLE Kaiser","year":"1998","unstructured":"Kaiser KLE (1998) Correlations of Vibrio fischeri bacteria test data with bioassay data for other organisms. Environ Perspect 106:583\u2013591","journal-title":"Environ Perspect"},{"key":"871_CR29","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/jac\/dkg293","volume":"52","author":"K K\u00fcmmerer","year":"2003","unstructured":"K\u00fcmmerer K (2003) Significance of antibiotics in the environment. J Antimicrob Chemother 52:5\u20137","journal-title":"J Antimicrob Chemother"},{"key":"871_CR30","doi-asserted-by":"crossref","first-page":"3421","DOI":"10.1021\/es048143z","volume":"39","author":"RH Lindberg","year":"2005","unstructured":"Lindberg RH, Wennberg P, Johansson MI, Tysklind M, Andersson BAV (2005) Screening of human antibiotic substances and determination of weekly mass flows in five sewage treatment plants in Sweden. Environ Sci Technol 39:3421\u20133429","journal-title":"Environ Sci Technol"},{"key":"871_CR31","unstructured":"McCallum H (2000) Population parameters: estimation for ecological models. Methods in ecology. Blackwell Science Ltd, Oxford, vol. 5, pp 139\u2013156"},{"key":"871_CR32","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.2307\/1938671","volume":"67","author":"JS Meyer","year":"1986","unstructured":"Meyer JS, Ingersoll CG, McDonald LL, Boyce MS (1986) Estimating uncertainty in population growth rates: jackknife vs. bootstrap techniques. Ecology 67:1156\u20131166","journal-title":"Ecology"},{"issue":"1","key":"871_CR33","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1897\/07-028.1","volume":"27","author":"XP Ni","year":"2008","unstructured":"Ni XP, Wang X, Chen J, Zitko V, An T (2008) Response of the freshwater Chlorella vulgaris to trichloroisocyanuric acid and ciprofloxacin. Environ Toxicol Chem 27(1):168\u2013173","journal-title":"Environ Toxicol Chem"},{"key":"871_CR34","doi-asserted-by":"crossref","DOI":"10.1787\/9789264069961-en","volume-title":"Fish, acute toxicity test, no. 203","author":"OECD","year":"1992","unstructured":"OECD (1992) Fish, acute toxicity test, no. 203. Organization for Economic Cooperation and Development, Paris"},{"key":"871_CR35","volume-title":"Daphnia magna reproduction test. Guidelines for testing of chemicals, no. 202, part II","author":"OECD","year":"1998","unstructured":"OECD (1998) Daphnia magna reproduction test. Guidelines for testing of chemicals, no. 202, part II. Organization for Economic Cooperation and Development, Paris"},{"key":"871_CR36","doi-asserted-by":"crossref","DOI":"10.1787\/9789264069947-en","volume-title":"Daphnia sp., acute immobilization test. Guidelines for testing of chemicals, no. 202","author":"OECD","year":"2004","unstructured":"OECD (2004) Daphnia sp., acute immobilization test. Guidelines for testing of chemicals, no. 202. Organization for Economic Cooperation and Development, Paris"},{"key":"871_CR37","doi-asserted-by":"crossref","DOI":"10.1787\/9789264069923-en","volume-title":"Freshwater alga and cyanobacteria, growth inhibition test, no. 201","author":"OECD","year":"2006","unstructured":"OECD (2006a) Freshwater alga and cyanobacteria, growth inhibition test, no. 201. Organization for Economic Cooperation and Development, Paris"},{"key":"871_CR38","volume-title":"Lemna sp. Growth inhibition test, no. 201","author":"OECD","year":"2006","unstructured":"OECD (2006b) Lemna sp. Growth inhibition test, no. 201. Organization for Economic Cooperation and Development, Paris"},{"key":"871_CR39","doi-asserted-by":"crossref","first-page":"2924","DOI":"10.1002\/jssc.200700363","volume":"30","author":"A Pena","year":"2007","unstructured":"Pena A, Chmielova D, Lino CM, Solich P (2007) Determination of fluoroquinolone antibiotics in surface waters from Mondego River by high performance liquid chromatography using amonolithic column. J Sep Sci 30:2924\u20132928","journal-title":"J Sep Sci"},{"issue":"1","key":"871_CR40","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1051\/limn\/2004001","volume":"40","author":"JL Pereira","year":"2004","unstructured":"Pereira JL, Marques CR, Gon\u00e7alvez F (2004) Allometric relations for Ceriodaphnia spp. and Daphnia spp. Ann Limnol Int J Lim 40(1):11\u201314","journal-title":"Ann Limnol Int J Lim"},{"key":"871_CR41","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1111\/j.1461-0248.2006.00966.x","volume":"9","author":"R Relyea","year":"2006","unstructured":"Relyea R, Hoverman J (2006) Assessing the ecology in ecotoxicology: a review and synthesis in freshwater systems. Ecol Lett 9:1157\u20131171","journal-title":"Ecol Lett"},{"key":"871_CR42","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1897\/04-210R.1","volume":"24","author":"AA Robinson","year":"2005","unstructured":"Robinson AA, Belden JB, Lydy MJ (2005) Toxicity of fluoroquinolone antibiotics to aquatic organisms. Environ Toxicol Chem 24:423\u2013430","journal-title":"Environ Toxicol Chem"},{"key":"871_CR43","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1016\/j.jhazmat.2008.09.073","volume":"164","author":"JL Santos","year":"2009","unstructured":"Santos JL, Apar\u00edcio I, Callej\u00f3n M, Alonso E (2009) Occurrence of pharmaceutically active compounds during 1-year period in wastewaters from four wastewater treatment plants in Seville (Spain). J Hazard Mater 164:1509\u20131516","journal-title":"J Hazard Mater"},{"key":"871_CR44","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jhazmat.2009.10.100","volume":"175","author":"LHMLM Santos","year":"2010","unstructured":"Santos LHMLM, Ara\u00fajo AN, Fachini A, Pena A, Delerue-Matos C, Montenegro MCBSM (2010) Review\u2014ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment. J Hazard Mater 175:45\u201395","journal-title":"J Hazard Mater"},{"key":"871_CR45","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1007\/s00216-008-2020-1","volume":"391","author":"M Seifrtov\u00e1","year":"2008","unstructured":"Seifrtov\u00e1 M, Pena A, Lino CM, Solich P (2008) Determination of fluoroquinolone antibiotics in hospital and municipal wastewaters in Coimbra by liquid chromatography with a monolithic column and fluorescence detection. Anal Bioanal Chem 391:799\u2013805","journal-title":"Anal Bioanal Chem"},{"key":"871_CR46","unstructured":"Sobral OMF (1997) Ecotoxicidade de efluentes de ind\u00fastrias de pasta de papel resultantes de diferentes processos de pr\u00e9-branqueamento. Dissertation MSc, Universidade de Coimbra, Coimbra"},{"issue":"6","key":"871_CR47","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0002-9343(91)90312-L","volume":"91","author":"F S\u00f6rgel","year":"1991","unstructured":"S\u00f6rgel F, Naber KG, Kinzig M, Mahr G, Muth P (1991) Comparative pharmacokinetics of ciprofloxacin and temafloxacin in humans: a review. Am J Med 91(6):51\u201366","journal-title":"Am J Med"},{"key":"871_CR48","volume-title":"Handbook of phycological methods: culture methods and growth measurements","author":"JR Stein","year":"1973","unstructured":"Stein JR (1973) Handbook of phycological methods: culture methods and growth measurements. University Press, London"},{"key":"871_CR49","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/j.1365-2427.1993.tb00826.x","volume":"30","author":"H Stibor","year":"1993","unstructured":"Stibor H, Lampert W (1993) Estimating the size at maturity in field populations of Daphnia (cladocera). Freshw Biol 30:433\u2013438","journal-title":"Freshw Biol"},{"key":"871_CR50","unstructured":"Streuff B, Luchtemberg H (1987) Pharmaceutical formulations of ciprofloxacin. United States Patent 5286754:1\u20136"},{"key":"871_CR51","doi-asserted-by":"crossref","first-page":"3397","DOI":"10.1021\/es0003021","volume":"35","author":"J Tolls","year":"2001","unstructured":"Tolls J (2001) Sorption of veterinary pharmaceuticals in soils: a review. Environ Sci Technol 35:3397\u20133406","journal-title":"Environ Sci Technol"},{"key":"871_CR52","doi-asserted-by":"crossref","first-page":"29","DOI":"10.2165\/00003495-199958002-00006","volume":"58","author":"J Turnidge","year":"1999","unstructured":"Turnidge J (1999) Pharmacokinetics and pharmacodynamics of fluoroquinolones. Drugs 58:29\u201336","journal-title":"Drugs"},{"issue":"1","key":"871_CR53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.chemosphere.2010.04.011","volume":"80","author":"E Grinten Van der","year":"2010","unstructured":"Van der Grinten E, Pikkemaat MG, Van den Brandhof E, Stroomberg GJ, Kraak MHS (2010) Comparing the sensitivity of algal, cyanobacterial and bacterial bioassays to different groups of antibiotics. Chemosphere 80(1):1\u20136","journal-title":"Chemosphere"},{"issue":"4","key":"871_CR54","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1023\/A:1018910431216","volume":"11","author":"X Yu","year":"1994","unstructured":"Yu X, Zipp GL, Davidson GWR (1994) The effects of temperature and pH on the solubility of quinolone compounds: estimation of heat of fusion. Pharm Res 11(4):522\u2013527","journal-title":"Pharm Res"},{"key":"871_CR55","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1128\/AAC.28.4.524","volume":"28","author":"H-J Zeiler","year":"1985","unstructured":"Zeiler H-J (1985) Evaluation of the in vitro bactericidal action of ciprofloxacin on cells of Escherichia coli in the logarithmic and stationary phases of growth. Antimicrob Agents Chemother 28:524\u2013527","journal-title":"Antimicrob Agents Chemother"},{"key":"871_CR56","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/BF01977490","volume":"3","author":"H-J Zeiler","year":"1984","unstructured":"Zeiler H-J, Grohe K (1984) The in vitro and in vivo activity of ciprofloxacin. Eur J Clin Microbiol 3:339\u2013343","journal-title":"Eur J Clin Microbiol"}],"container-title":["Ecotoxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10646-012-0871-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10646-012-0871-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10646-012-0871-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T20:25:06Z","timestamp":1559247906000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10646-012-0871-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,29]]},"references-count":56,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["871"],"URL":"https:\/\/doi.org\/10.1007\/s10646-012-0871-x","relation":{},"ISSN":["0963-9292","1573-3017"],"issn-type":[{"value":"0963-9292","type":"print"},{"value":"1573-3017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,29]]}}}