{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T23:32:25Z","timestamp":1769038345250,"version":"3.49.0"},"reference-count":86,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2016,2,24]],"date-time":"2016-02-24T00:00:00Z","timestamp":1456272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UID\/AMB\/50017\/2013"],"award-info":[{"award-number":["UID\/AMB\/50017\/2013"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ecotoxicology"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1007\/s10646-016-1633-y","type":"journal-article","created":{"date-parts":[[2016,2,24]],"date-time":"2016-02-24T10:22:49Z","timestamp":1456309369000},"page":"745-758","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["The interactive effects of microcystin-LR and cylindrospermopsin on the growth rate of the freshwater algae Chlorella vulgaris"],"prefix":"10.1007","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3170-9533","authenticated-orcid":false,"given":"Carlos","family":"Pinheiro","sequence":"first","affiliation":[]},{"given":"Joana","family":"Azevedo","sequence":"additional","affiliation":[]},{"given":"Alexandre","family":"Campos","sequence":"additional","affiliation":[]},{"given":"V\u00edtor","family":"Vasconcelos","sequence":"additional","affiliation":[]},{"given":"Susana","family":"Loureiro","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2016,2,24]]},"reference":[{"key":"1633_CR1","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.envint.2009.10.010","volume":"36","author":"LL Amado","year":"2010","unstructured":"Amado LL, Monserrat JM (2010) Oxidative stress generation by microcystins in aquatic animals: why and how. Environ Int 36:226\u2013235. doi: 10.1016\/j.envint.2009.10.010","journal-title":"Environ Int"},{"key":"1633_CR2","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1529-8817.2006.00176.x","volume":"42","author":"P Babica","year":"2006","unstructured":"Babica P, Bl\u00e1ha L, Mar\u0161\u00e1lek B (2006) Exploring the natural role of microcystins\u2014a review of effects on photoautotrophic organisms. J Phycol 42:9\u201320. doi: 10.1111\/j.1529-8817.2006.00176.x","journal-title":"J Phycol"},{"key":"1633_CR3","doi-asserted-by":"crossref","first-page":"137","DOI":"10.2216\/06-24.1","volume":"46","author":"P Babica","year":"2007","unstructured":"Babica P, Hilscherov\u00e1 K, B\u00e1rtov\u00e1 K, Bl\u00e1ha L, Mar\u0161\u00e1lek B (2007) Effects of dissolved microcystins on growth of planktonic photoautotrophs. Phycologia 46:137\u2013142. doi: 10.2216\/06-24.1","journal-title":"Phycologia"},{"key":"1633_CR4","doi-asserted-by":"crossref","first-page":"6363","DOI":"10.1021\/es0497678","volume":"38","author":"T Backhaus","year":"2004","unstructured":"Backhaus T, Arrhenius A, Blanck H (2004) Toxicity of a mixture of dissimilarly acting substances to natural algal communities: predictive power and limitations of independent action and concentration addition. Environ Sci Technol 38:6363\u20136370. doi: 10.1021\/es0497678","journal-title":"Environ Sci Technol"},{"key":"1633_CR5","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1021\/np990498m","volume":"63","author":"R Banker","year":"2000","unstructured":"Banker R, Teltsch B, Sukenik A, Carmeli S (2000) 7-epicylindrospermopsin, a toxic minor metabolite of the cyanobacterium Aphanizomenon ovalisporum from Lake Kinneret, Israel. J Nat Prod 63:387\u2013389","journal-title":"J Nat Prod"},{"key":"1633_CR6","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1002\/tox.20601","volume":"26","author":"K B\u00e1rtov\u00e1","year":"2011","unstructured":"B\u00e1rtov\u00e1 K, Hilscherov\u00e1 K, Babica P, Mar\u0161\u00e1lek B, Bl\u00e1ha L (2011) Effects of microcystin and complex cyanobacterial samples on the growth and oxidative stress parameters in green alga Pseudokirchneriella subcapitata and comparison with the model oxidative stressor-herbicide paraquat. Environ Toxicol 26:641\u2013648. doi: 10.1002\/tox.20601","journal-title":"Environ Toxicol"},{"key":"1633_CR7","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s10750-012-1061-9","volume":"691","author":"V B-B\u00e9res","year":"2012","unstructured":"B-B\u00e9res V et al (2012) The effects of Microcystis aeruginosa (cyanobacterium) on Cryptomonas ovata (Cryptophyta) in laboratory cultures: why these organisms do not coexist in steady-state assemblages? Hydrobiologia 691:97\u2013107. doi: 10.1007\/s10750-012-1061-9","journal-title":"Hydrobiologia"},{"key":"1633_CR8","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0166-445X(02)00010-3","volume":"60","author":"JH Best","year":"2002","unstructured":"Best JH, Pflugmacher S, Wiegand C, Eddy FB, Metcalf JS, Codd GA (2002) Effects of enteric bacterial and cyanobacterial lipopolysaccharides, and of microcystin-LR, on glutathione S-transferase activities in zebra fish (Danio rerio). Aquat Toxicol 60:223\u2013231","journal-title":"Aquat Toxicol"},{"key":"1633_CR9","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.toxicon.2009.05.008","volume":"54","author":"D Beyer","year":"2009","unstructured":"Beyer D et al (2009) Cylindrospermopsin induces alterations of root histology and microtubule organization in common reed (Phragmites australis) plantlets cultured in vitro. Toxicon 54:440\u2013449. doi: 10.1016\/j.toxicon.2009.05.008","journal-title":"Toxicon"},{"key":"1633_CR10","doi-asserted-by":"crossref","first-page":"36","DOI":"10.2478\/v10102-009-0006-2","volume":"2","author":"L Bl\u00e1ha","year":"2009","unstructured":"Bl\u00e1ha L, Babica P, Mar\u0161\u00e1lek B (2009) Toxins produced in cyanobacterial water blooms\u2014toxicity and risks. Interdiscip Toxicol 2:36\u201341","journal-title":"Interdiscip Toxicol"},{"key":"1633_CR11","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.toxicon.2009.01.014","volume":"53","author":"L Bl\u00e1hov\u00e1","year":"2009","unstructured":"Bl\u00e1hov\u00e1 L, Oravec M, Mar\u0161\u00e1lek B, \u0160ejnohov\u00e1 L, \u0160imek Z, Bl\u00e1ha L (2009) The first occurrence of the cyanobacterial alkaloid toxin cylindrospermopsin in the Czech Republic as determined by immunochemical and LC\/MS methods. Toxicon 53:519\u2013524. doi: 10.1016\/j.toxicon.2009.01.014","journal-title":"Toxicon"},{"issue":"Supplement 2","key":"1633_CR12","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/S0048-9697(05)80100-7","volume":"134","author":"W Boedeker","year":"1993","unstructured":"Boedeker W, Drescher K, Altenburger R, Faust M, Grimme LH (1993) Combined effects of toxicants: the need and soundness of assessment approaches in ecotoxicology. Sci Total Environ 134(Supplement 2):931\u2013939","journal-title":"Sci Total Environ"},{"key":"1633_CR13","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.1021\/es052546x","volume":"40","author":"S Bogialli","year":"2006","unstructured":"Bogialli S, Bruno M, Curini R, Di Corcia A, Fanali C, Lagan\u00e0 A (2006) Monitoring algal toxins in lake water by liquid chromatography tandem mass spectrometry. Environ Sci Technol 40:2917\u20132923. doi: 10.1021\/es052546x","journal-title":"Environ Sci Technol"},{"key":"1633_CR14","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1002\/tox.20439","volume":"24","author":"L Brient","year":"2009","unstructured":"Brient L, Lengronne M, Bormans M, Fastner J (2009) First occurrence of cylindrospermopsin in freshwater in France. Environ Toxicol 24:415\u2013420. doi: 10.1002\/tox.20439","journal-title":"Environ Toxicol"},{"key":"1633_CR15","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/(SICI)1522-7278(199902)14:1<155::AID-TOX20>3.0.CO;2-Z","volume":"14","author":"RK Chiswell","year":"1999","unstructured":"Chiswell RK, Shaw GR, Eaglesham G, Smith MJ, Norris RL, Seawright AA, Moore MR (1999) Stability of cylindrospermopsin, the toxin from the cyanobacterium, Cylindrospermopsis raciborskii: effect of pH, temperature, and sunlight on decomposition. Environ Toxicol 14:155\u2013161","journal-title":"Environ Toxicol"},{"key":"1633_CR16","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1080\/09670269910001736462","volume":"34","author":"GA Codd","year":"1999","unstructured":"Codd GA, Bell SG, Kaya K, Ward CJ, Beattie KA, Metcalf JS (1999) Cyanobacterial toxins, exposure routes and human health. Eur J Phycol 34:405\u2013415. doi: 10.1017\/s0967026299002255","journal-title":"Eur J Phycol"},{"key":"1633_CR17","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/mnfr.200500162","volume":"50","author":"E Dittmann","year":"2006","unstructured":"Dittmann E, Wiegand C (2006) Cyanobacterial toxins\u2014occurrence, biosynthesis and impact on human affairs. Mol Nutr Food Res 50:7\u201317. doi: 10.1002\/mnfr.200500162","journal-title":"Mol Nutr Food Res"},{"key":"1633_CR18","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/(SICI)1522-7278(199902)14:1<151::AID-TOX19>3.0.CO;2-D","volume":"14","author":"GK Eaglesham","year":"1999","unstructured":"Eaglesham GK et al (1999) Use of HPLC-MS\/MS to monitor cylindrospermopsin, a blue-green algal toxin, for public health purposes. Environ Toxicol 14:151\u2013154. doi: 10.1002\/(sici)1522-7278(199902)14:1<151:aid-tox19>3.0.co;2-d","journal-title":"Environ Toxicol"},{"key":"1633_CR19","unstructured":"European Food Safety Authority (2015) Harmonisation of human and ecological risk assessment of combined exposure to multiple chemicals"},{"key":"1633_CR20","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1002\/(SICI)1522-7278(199902)14:1<5::AID-TOX3>3.0.CO;2-0","volume":"14","author":"IR Falconer","year":"1999","unstructured":"Falconer IR (1999) An overview of problems caused by toxic blue-green algae (cyanobacteria) in drinking and recreational water. Environ Toxicol 14:5\u201312","journal-title":"Environ Toxicol"},{"key":"1633_CR21","volume-title":"Cyanobacterial toxins of drinking water supplies: cylindrospermopsins and microcystins","author":"IR Falconer","year":"2005","unstructured":"Falconer IR, Humpage AR (2005) Cyanobacterial toxins of drinking water supplies: cylindrospermopsins and microcystins. CRC Press, Boca Raton"},{"key":"1633_CR22","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/tox.20194","volume":"21","author":"IR Falconer","year":"2006","unstructured":"Falconer IR, Humpage AR (2006) Cyanobacterial (blue-green algal) toxins in water supplies: cylindrospermopsins. Environ Toxicol 21:299\u2013304. doi: 10.1002\/tox.20194","journal-title":"Environ Toxicol"},{"key":"1633_CR23","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/(SICI)1522-7278(199902)14:1<13::AID-TOX4>3.0.CO;2-D","volume":"14","author":"J Fastner","year":"1999","unstructured":"Fastner J, Neumann U, Wirsing B, Weckesser J, Wiedner C, Nixdorf B, Chorus I (1999) Microcystins (hepatotoxic heptapeptides) in German fresh water bodies. Environ Toxicol 14:13\u201322. doi: 10.1002\/(sici)1522-7278(199902)14:1<13:aid-tox4>3.0.co;2-d","journal-title":"Environ Toxicol"},{"key":"1633_CR24","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/tox.20230","volume":"22","author":"J Fastner","year":"2007","unstructured":"Fastner J et al (2007) Occurrence of the cyanobacterial toxin cylindrospermopsin in northeast Germany. Environ Toxicol 22:26\u201332. doi: 10.1002\/tox.20230","journal-title":"Environ Toxicol"},{"key":"1633_CR25","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.aquatox.2008.05.012","volume":"89","author":"ALG Ferreira","year":"2008","unstructured":"Ferreira ALG, Loureiro S, Soares A (2008) Toxicity prediction of binary combinations of cadmium, carbendazim and low dissolved oxygen on Daphnia magna. Aquat Toxicol 89:28\u201339. doi: 10.1016\/j.aquatox.2008.05.012","journal-title":"Aquat Toxicol"},{"key":"1633_CR26","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.ecoenv.2015.02.002","volume":"116","author":"M Freitas","year":"2015","unstructured":"Freitas M, Azevedo J, Pinto E, Neves J, Campos A, Vasconcelos V (2015) Effects of microcystin-LR, cylindrospermopsin and a microcystin-LR\/cylindrospermopsin mixture on growth, oxidative stress and mineral content in lettuce plants (Lactuca sativa L.). Ecotoxicol Environ Safe 116:59\u201367. doi: 10.1016\/j.ecoenv.2015.02.002","journal-title":"Ecotoxicol Environ Safe"},{"key":"1633_CR27","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1002\/tox.1050","volume":"16","author":"SM Froscio","year":"2001","unstructured":"Froscio SM, Humpage AR, Burcham PC, Falconer IR (2001) Cell-free protein synthesis inhibition assay for the cyanobacterial toxin cylindrospermopsin. Environ Toxicol 16:408\u2013412","journal-title":"Environ Toxicol"},{"key":"1633_CR28","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.toxicon.2007.09.001","volume":"51","author":"SM Froscio","year":"2008","unstructured":"Froscio SM, Humpage AR, Wickramasinghe W, Shaw G, Falconer IR (2008) Interaction of the cyanobacterial toxin cylindrospermopsin with the eukaryotic protein synthesis system. Toxicon 51:191\u2013198. doi: 10.1016\/j.toxicon.2007.09.001","journal-title":"Toxicon"},{"key":"1633_CR29","doi-asserted-by":"crossref","first-page":"3279","DOI":"10.1002\/rcm.4243","volume":"23","author":"P Gallo","year":"2009","unstructured":"Gallo P, Fabbrocino S, Cerulo MG, Ferranti P, Bruno M, Serpe L (2009) Determination of cylindrospermopsin in freshwaters and fish tissue by liquid chromatography coupled to electrospray ion trap mass spectrometry. Rapid Commun Mass Spectrom 23:3279\u20133284. doi: 10.1002\/rcm.4243","journal-title":"Rapid Commun Mass Spectrom"},{"key":"1633_CR30","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1574-6941.2008.00439.x","volume":"64","author":"M Gantar","year":"2008","unstructured":"Gantar M, Berry JP, Thomas S, Wang ML, Perez R, Rein KS (2008) Allelopathic activity among Cyanobacteria and microalgae isolated from Florida freshwater habitats. FEMS Microbiol Ecol 64:55\u201364. doi: 10.1111\/j.1574-6941.2008.00439.x","journal-title":"FEMS Microbiol Ecol"},{"key":"1633_CR31","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.2174\/0929867023368845","volume":"9","author":"BM Gulledge","year":"2002","unstructured":"Gulledge BM, Aggen JB, Huang HB, Nairn AC, Chamberlin AR (2002) The microcystins and nodularins: cyclic polypeptide inhibitors of PP1 and PP2A. Curr Med Chem 9:1991\u20132003","journal-title":"Curr Med Chem"},{"key":"1633_CR32","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1080\/15287390590925465","volume":"68","author":"AR Humpage","year":"2005","unstructured":"Humpage AR, Fontaine F, Froscio S, Burcham P, Falconer IR (2005) Cylindrospermopsin genotoxicity and cytotoxicity: role of cytochrome P-450 and oxidative stress. J Toxicol Environ Health A 68:739\u2013753. doi: 10.1080\/15287390590925465","journal-title":"J Toxicol Environ Health A"},{"key":"1633_CR33","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/0043-1354(94)90093-0","volume":"28","author":"GJ Jones","year":"1994","unstructured":"Jones GJ, Orr PT (1994) Release and degradation of microcystin following algicide treatment of a Microcystis aeruginosa bloom in a recreational lake, as determined by HPLC and protein phosphatase inhibition assay. Water Res 28:871\u2013876","journal-title":"Water Res"},{"key":"1633_CR34","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1897\/04-431R.1","volume":"24","author":"MJ Jonker","year":"2005","unstructured":"Jonker MJ, Svendsen C, Bedaux JJM, Bongers M, Kammenga JE (2005) Significance testing of synergistic\/antagonistic, dose level-dependent, or dose ratio-dependent effects in mixture dose-response analysis. Environ Toxicol Chem 24:2701\u20132713","journal-title":"Environ Toxicol Chem"},{"key":"1633_CR35","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1046\/j.1462-2920.2000.00104.x","volume":"2","author":"KD Kearns","year":"2000","unstructured":"Kearns KD, Hunter MD (2000) Green algal extracellular products regulate antialgal toxin production in a cyanobacterium. Environ Microbiol 2:291\u2013297","journal-title":"Environ Microbiol"},{"key":"1633_CR36","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1007\/s002480000086","volume":"42","author":"KD Kearns","year":"2001","unstructured":"Kearns KD, Hunter MD (2001) Toxin-producing Anabaena flos-aquae induces settling of Chlamydomonas reinhardtii, a competing motile alga. Microb Ecol 42:80\u201386","journal-title":"Microb Ecol"},{"key":"1633_CR37","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/tox.20164","volume":"21","author":"A Kemp","year":"2006","unstructured":"Kemp A, John J (2006) Microcystins associated with Microcystis dominated blooms in the southwest wetlands, Western Australia. Environ Toxicol 21:125\u2013130. doi: 10.1002\/tox.20164","journal-title":"Environ Toxicol"},{"key":"1633_CR38","doi-asserted-by":"crossref","first-page":"542","DOI":"10.3390\/md8030542","volume":"8","author":"S Kinnear","year":"2010","unstructured":"Kinnear S (2010) Cylindrospermopsin: a decade of progress on bioaccumulation research. Mar Drugs 8:542\u2013564. doi: 10.3390\/md8030542","journal-title":"Mar Drugs"},{"key":"1633_CR39","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.chemosphere.2008.10.027","volume":"74","author":"M Kokoci\u0144ski","year":"2009","unstructured":"Kokoci\u0144ski M, Dziga D, Spoof L, Stefaniak K, Jurczak T, Mankiewicz-Boczek J, Meriluoto J (2009) First report of the cyanobacterial toxin cylindrospermopsin in the shallow, eutrophic lakes of western Poland. Chemosphere 74:669\u2013675. doi: 10.1016\/j.chemosphere.2008.10.027","journal-title":"Chemosphere"},{"key":"1633_CR40","volume-title":"Instructions for the preparation of modified nutrient solution Z8 for algae","author":"J Kotai","year":"1972","unstructured":"Kotai J (1972) Instructions for the preparation of modified nutrient solution Z8 for algae. Norwegian Institute for Water Research, Blindern"},{"key":"1633_CR41","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0043-1354(96)00353-3","volume":"31","author":"K Lahti","year":"1997","unstructured":"Lahti K, Rapala J, F\u00e4rdig M, Niemel\u00e4 M, Sivonen K (1997) Persistence of cyanobacterial hepatotoxin, microcystin-LR in particulate material and dissolved in lake water. Water Res 31:1005\u20131012","journal-title":"Water Res"},{"key":"1633_CR42","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.toxicon.2006.07.036","volume":"48","author":"J Lindsay","year":"2006","unstructured":"Lindsay J, Metcalf JS, Codd GA (2006) Protection against the toxicity of microcystin-LR and cylindrospermopsin in Artemia salina and Daphnia spp. by pre-treatment with cyanobacterial lipopolysaccharide (LPS). Toxicon 48:995\u20131001. doi: 10.1016\/j.toxicon.2006.07.036","journal-title":"Toxicon"},{"key":"1633_CR43","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1002\/etc.198","volume":"29","author":"S Loureiro","year":"2010","unstructured":"Loureiro S, Svendsen C, Ferreira ALG, Pinheiro C, Ribeiro F, Soares A (2010) Toxicity of three binary mixtures to Daphnia magna: comparing chemical modes of action and deviations from conceptual models. Environ Toxicol Chem 29:1716\u20131726. doi: 10.1002\/etc.198","journal-title":"Environ Toxicol Chem"},{"key":"1633_CR44","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0014-5793(90)80245-E","volume":"264","author":"C Mackintosh","year":"1990","unstructured":"Mackintosh C, Beattie KA, Klumpp S, Cohen P, Codd GA (1990) Cyanobacterial microcystin-LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants. FEBS Lett 264:187\u2013192","journal-title":"FEBS Lett"},{"key":"1633_CR45","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1111\/j.1469-8137.2007.02230.x","volume":"176","author":"C M\u00e1th\u00e9","year":"2007","unstructured":"M\u00e1th\u00e9 C et al (2007) Microcystin-LR, a cyanobacterial toxin, induces growth inhibition and histological alterations in common reed (Phragmites australis) plants regenerated from embryogenic calli. New Phytol 176:824\u2013835. doi: 10.1111\/j.1469-8137.2007.02230.x","journal-title":"New Phytol"},{"key":"1633_CR46","doi-asserted-by":"crossref","first-page":"3689","DOI":"10.3390\/md11103689","volume":"11","author":"C M\u00e1th\u00e9","year":"2013","unstructured":"M\u00e1th\u00e9 C, M-Hamvas M, Vasas G (2013) Microcystin-LR and cylindrospermopsin Induced alterations in chromatin organization of plant cells. Mar Drugs 11:3689\u20133717. doi: 10.3390\/md11103689","journal-title":"Mar Drugs"},{"key":"1633_CR47","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/tox.20469","volume":"25","author":"V Messineo","year":"2010","unstructured":"Messineo V, Melchiorre S, Di Corcia A, Gallo P, Bruno M (2010) Seasonal succession of Cylindrospermopsis raciborskii and Aphanizomenon ovalisporum blooms with cylindrospermopsin occurrence in the volcanic lake Albano, Central Italy. Environ Toxicol 25:18\u201327. doi: 10.1002\/tox.20469","journal-title":"Environ Toxicol"},{"key":"1633_CR48","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1574-6968.2004.tb09576.x","volume":"235","author":"JS Metcalf","year":"2004","unstructured":"Metcalf JS, Barakate A, Codd GA (2004) Inhibition of plant protein synthesis by the cyanobacterial hepatotoxin, cylindrospermopsin. FEMS Microbiol Lett 235:125\u2013129. doi: 10.1016\/j.femsle.2004.04.025","journal-title":"FEMS Microbiol Lett"},{"key":"1633_CR49","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1007\/s10646-008-0204-2","volume":"17","author":"ZA Mohamed","year":"2008","unstructured":"Mohamed ZA (2008) Polysaccharides as a protective response against microcystin-induced oxidative stress in Chlorella vulgaris and Scenedesmus quadricauda and their possible significance in the aquatic ecosystem. Ecotoxicology 17:504\u2013516. doi: 10.1007\/s10646-008-0204-2","journal-title":"Ecotoxicology"},{"key":"1633_CR50","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1080\/08865140302427","volume":"9","author":"JM Monserrat","year":"2003","unstructured":"Monserrat JM, Pinho GLL, Yunes JS (2003) Toxicological effects of hepatotoxins (microcystins) on aquatic organisms. Comments on Toxicology 9:89\u2013101","journal-title":"Comments on Toxicology"},{"key":"1633_CR51","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s10646-007-0173-x","volume":"17","author":"M Munkegaard","year":"2008","unstructured":"Munkegaard M, Abbaspoor M, Cedergreen N (2008) Organophosphorous insecticides as herbicide synergists on the green algae Pseudokirchneriella subcapitata and the aquatic plant Lemna minor. Ecotoxicology 17:29\u201335. doi: 10.1007\/s10646-007-0173-x","journal-title":"Ecotoxicology"},{"key":"1633_CR52","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1093\/jaoac\/80.2.408","volume":"80","author":"S Nagata","year":"1997","unstructured":"Nagata S, Tsutsumi T, Hasegawa A, Yoshida F, Ueno Y, Watanabe MF (1997) Enzyme immunoassay for direct determination of microcystins in environmental water. J AOAC Int 80:408\u2013417","journal-title":"J AOAC Int"},{"key":"1633_CR53","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1080\/15287390701434869","volume":"70","author":"C Neumann","year":"2007","unstructured":"Neumann C, Bain P, Shaw G (2007) Studies of the comparative in vitro toxicology of the cyanobacterial metabolite deoxycylindrospermopsin. J Toxicol Environ Health A 70:1679\u20131686. doi: 10.1080\/15287390701434869","journal-title":"J Toxicol Environ Health A"},{"key":"1633_CR54","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/(SICI)1522-7278(199902)14:1<163::AID-TOX21>3.0.CO;2-V","volume":"14","author":"RL Norris","year":"1999","unstructured":"Norris RL et al (1999) Deoxycylindrospermopsin, an analog of cylindrospermopsin from Cylindrospermopsis raciborskii. Environ Toxicol 14:163\u2013165","journal-title":"Environ Toxicol"},{"key":"1633_CR55","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S0041-0101(01)00243-4","volume":"40","author":"RLG Norris","year":"2002","unstructured":"Norris RLG et al (2002) Hepatic xenobiotic metabolism of cylindrospermopsin in vivo in the mouse. Toxicon 40:471\u2013476","journal-title":"Toxicon"},{"key":"1633_CR56","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.chemosphere.2012.04.008","volume":"89","author":"K Nov\u00e1kov\u00e1","year":"2012","unstructured":"Nov\u00e1kov\u00e1 K, Bl\u00e1ha L, Babica P (2012) Tumor promoting effects of cyanobacterial extracts are potentiated by anthropogenic contaminants\u2014Evidence from in vitro study. Chemosphere 89:30\u201337","journal-title":"Chemosphere"},{"key":"1633_CR57","doi-asserted-by":"crossref","DOI":"10.1787\/9789264069923-en","volume-title":"OECD Guidelines for the testing of chemicals 201, freshwater alga and cyanobacteria, growth inhibition test","author":"OECD","year":"2006","unstructured":"OECD (2006) OECD Guidelines for the testing of chemicals 201, freshwater alga and cyanobacteria, growth inhibition test. OECD, Paris"},{"key":"1633_CR58","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.toxicon.2009.10.001","volume":"55","author":"SA Oehrle","year":"2010","unstructured":"Oehrle SA, Southwell B, Westrick J (2010) Detection of various freshwater cyanobacterial toxins using ultra-performance liquid chromatography tandem mass spectrometry. Toxicon 55:965\u2013972. doi: 10.1016\/j.toxicon.2009.10.001","journal-title":"Toxicon"},{"key":"1633_CR59","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1897\/IEAM_2004-005R.1","volume":"1","author":"AW Olmstead","year":"2005","unstructured":"Olmstead AW, LeBlanc GA (2005) Toxicity assessment of environmentally relevant pollutant mixtures using a heuristic model. Integr Environ Assess Manag 1:114\u2013122. doi: 10.1897\/ieam_2004-005r.1","journal-title":"Integr Environ Assess Manag"},{"key":"1633_CR60","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/tox.20114","volume":"20","author":"DY Ou","year":"2005","unstructured":"Ou DY, Song LR, Gan NQ, Chen W (2005) Effects of microcystins on and toxin degradation by Poterioochromonas sp. Environ Toxicol 20:373\u2013380. doi: 10.1002\/tox.20114","journal-title":"Environ Toxicol"},{"key":"1633_CR61","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1126\/science.1155398","volume":"320","author":"HW Paerl","year":"2008","unstructured":"Paerl HW, Huisman J (2008) Climate\u2014blooms like it hot. Science 320:57\u201358. doi: 10.1126\/science.1155398","journal-title":"Science"},{"key":"1633_CR62","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1758-2229.2008.00004.x","volume":"1","author":"HW Paerl","year":"2009","unstructured":"Paerl HW, Huisman J (2009) Climate change: a catalyst for global expansion of harmful cyanobacterial blooms. Environ Microbiol Rep 1:27\u201337. doi: 10.1111\/j.1758-2229.2008.00004.x","journal-title":"Environ Microbiol Rep"},{"key":"1633_CR63","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1016\/j.watres.2011.08.002","volume":"46","author":"HW Paerl","year":"2012","unstructured":"Paerl HW, Paul VJ (2012) Climate change: links to global expansion of harmful cyanobacteria. Water Res 46:1349\u20131363. doi: 10.1016\/j.watres.2011.08.002","journal-title":"Water Res"},{"key":"1633_CR64","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s00128-009-9763-z","volume":"83","author":"S Pereira","year":"2009","unstructured":"Pereira S, Saker ML, Vale M, Vasconcelos VM (2009) Comparison of sensitivity of grasses (Lolium perenne L. and Festuca rubra L.) and lettuce (Lactuca sativa L.) exposed to water contaminated with microcystins. Bull Environ Contam Toxicol 83:81\u201384. doi: 10.1007\/s00128-009-9763-z","journal-title":"Bull Environ Contam Toxicol"},{"key":"1633_CR65","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.aquatox.2004.06.010","volume":"70","author":"S Pflugmacher","year":"2004","unstructured":"Pflugmacher S (2004) Promotion of oxidative stress in the aquatic macrophyte Ceratophyllum demersum during biotransformation of the cyanobacterial toxin microcystin-LR. Aquat Toxicol 70:169\u2013178. doi: 10.1016\/j.aquatox.2004.06.010","journal-title":"Aquat Toxicol"},{"key":"1633_CR66","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/S0304-4165(98)00107-X","volume":"1425","author":"S Pflugmacher","year":"1998","unstructured":"Pflugmacher S, Wiegand C, Oberemm A, Beattie KA, Krause E, Codd GA, Steinberg CEW (1998) Identification of an enzymatically formed glutathione conjugate of the cyanobacterial hepatotoxin microcystin-LR: the first step of detoxication. Biochim Biophys Acta 1425:527\u2013533","journal-title":"Biochim Biophys Acta"},{"key":"1633_CR67","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1002\/(SICI)1522-7278(199902)14:1<111::AID-TOX14>3.0.CO;2-3","volume":"14","author":"S Pflugmacher","year":"1999","unstructured":"Pflugmacher S, Codd GA, Steinberg CEW (1999) Effects of the cyanobacterial toxin microcystin-LR on detoxication enzymes in aquatic plants. Environ Toxicol 14:111\u2013115","journal-title":"Environ Toxicol"},{"key":"1633_CR68","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s10750-012-1372-x","volume":"705","author":"C Pinheiro","year":"2013","unstructured":"Pinheiro C, Azevedo J, Campos A, Loureiro S, Vasconcelos V (2013) Absence of negative allelopathic effects of cylindrospermopsin and microcystin-LR on selected marine and freshwater phytoplankton species. Hydrobiologia 705:27\u201342. doi: 10.1007\/s10750-012-1372-x","journal-title":"Hydrobiologia"},{"key":"1633_CR69","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.aquatox.2011.05.001","volume":"104","author":"LMD Pires","year":"2011","unstructured":"Pires LMD, Sarpe D, Brehm M, Ibelings BW (2011) Potential synergistic effects of microcystins and bacterial lipopolysaccharides on life history traits of Daphnia galeata raised on low and high food levels. Aquat toxicol 104:230\u2013242","journal-title":"Aquat toxicol"},{"key":"1633_CR70","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.hal.2008.10.009","volume":"8","author":"K Preu\u03b2el","year":"2009","unstructured":"Preu\u03b2el K, Wessel G, Fastner J, Chorus I (2009) Response of cylindrospermopsin production and release in Aphanizomenon flos-aquae (Cyanobacteria) to varying light and temperature conditions. Harmful Algae 8:645\u2013650. doi: 10.1016\/j.hal.2008.10.009","journal-title":"Harmful Algae"},{"key":"1633_CR71","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1016\/j.ecoenv.2011.06.009","volume":"74","author":"A Prieto","year":"2011","unstructured":"Prieto A, Campos A, Came\u00e1n A, Vasconcelos V (2011) Effects on growth and oxidative stress status of rice plants (Oryza sativa) exposed to two extracts of toxin-producing cyanobacteria (Aphanizomenon ovalisporum and Microcystis aeruginosa). Ecotoxicol Environ Saf 74:1973\u20131980. doi: 10.1016\/j.ecoenv.2011.06.009","journal-title":"Ecotoxicol Environ Saf"},{"key":"1633_CR72","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1080\/09670260500480926","volume":"41","author":"A Quesada","year":"2006","unstructured":"Quesada A, Moreno E, Carrasco D, Paniagua T, Wormer L, De Hoyos C, Sukenik A (2006) Toxicity of Aphanizomenon ovalisporum (Cyanobacteria) in a Spanish water reservoir. Eur J Phycol 41:39\u201345. doi: 10.1080\/09670260500480926","journal-title":"Eur J Phycol"},{"key":"1633_CR73","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.toxicon.2007.06.019","volume":"50","author":"J R\u00fccker","year":"2007","unstructured":"R\u00fccker J, St\u00fcken A, Nixdorf B, Fastner J, Chorus I, Wiedner C (2007) Concentrations of particulate and dissolved cylindrospermopsin in 21 Aphanizomenon-dominated temperate lakes. Toxicon 50:800\u2013809. doi: 10.1016\/j.toxicon.2007.06.019","journal-title":"Toxicon"},{"key":"1633_CR74","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1006\/bbrc.1995.2605","volume":"216","author":"M Runnegar","year":"1995","unstructured":"Runnegar M, Berndt N, Kong SM, Lee EYC, Zhang LF (1995a) In vivo and in vitro binding of microcystin to protein phosphatase 1 and 2A. Biochem Biophys Res Commun 216:162\u2013169","journal-title":"Biochem Biophys Res Commun"},{"key":"1633_CR75","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0006-2952(94)00466-8","volume":"49","author":"MT Runnegar","year":"1995","unstructured":"Runnegar MT, Kong SM, Zhong YZ, Lu SC (1995b) Inhibition of reduced glutathione synthesis by cyanobacterial alkaloid cylindrospermopsin in cultured rat hepatocytes. Biochem Pharmacol 49:219\u2013225","journal-title":"Biochem Pharmacol"},{"key":"1633_CR76","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1007\/s00248-006-9045-9","volume":"51","author":"B Sedmak","year":"2006","unstructured":"Sedmak B, Eler\u0161ek T (2006) Microcystins induce morphological and physiological changes in selected representative phytoplanktons. Microb Ecol 51:508\u2013515. doi: 10.1007\/s00248-006-9045-9","journal-title":"Microb Ecol"},{"key":"1633_CR77","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1093\/plankt\/20.4.691","volume":"20","author":"B Sedmak","year":"1998","unstructured":"Sedmak B, Kosi G (1998) The role of microcystins in heavy cyanobacterial bloom formation. J Plankton Res 20:691\u2013708","journal-title":"J Plankton Res"},{"key":"1633_CR78","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1002\/tox.20216","volume":"21","author":"L Spoof","year":"2006","unstructured":"Spoof L et al (2006) First observation of cylindrospermopsin in Anabaena lapponica isolated from the boreal environment (Finland). Environ Toxicol 21:552\u2013560. doi: 10.1002\/tox.20216","journal-title":"Environ Toxicol"},{"key":"1633_CR79","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/0041-0101(94)90008-6","volume":"32","author":"K Terao","year":"1994","unstructured":"Terao K et al (1994) Electron microscopic studies on experimental poisoning in mice induced by cylindrospermopsin isolated from blue-green alga Umezakia natans. Toxicon 32:833\u2013843","journal-title":"Toxicon"},{"key":"1633_CR80","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1021\/es00050a024","volume":"28","author":"K Tsuji","year":"1994","unstructured":"Tsuji K, Naito S, Kondo F, Ishikawa N, Watanabe MF, Suzuki M, Harada K (1994) Stability of microcystins from cyanobacteria: effect of light on decomposition and isomerization. Environ Sci Technol 28:173\u2013177","journal-title":"Environ Sci Technol"},{"key":"1633_CR81","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/mnfr.200600185","volume":"51","author":"ME Apeldoorn van","year":"2007","unstructured":"van Apeldoorn ME, van Egmond HP, Speijers GJA, Bakker GJI (2007) Toxins of cyanobacteria. Mol Nutr Food Res 51:7\u201360. doi: 10.1002\/mnfr.200600185","journal-title":"Mol Nutr Food Res"},{"key":"1633_CR82","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/elps.200305641","volume":"25","author":"G Vasas","year":"2004","unstructured":"Vasas G, G\u00e1sp\u00e1r A, P\u00e1ger C, Sur\u00e1nyi G, M\u00e1th\u00e9 C, Hamvas MM, Borbely G (2004) Analysis of cyanobacterial toxins (anatoxin-a, cylindrospermopsin, microcystin-LR) by capillary electrophoresis. Electrophoresis 25:108\u2013115. doi: 10.1002\/elps.200305641","journal-title":"Electrophoresis"},{"key":"1633_CR83","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.taap.2004.11.002","volume":"203","author":"C Wiegand","year":"2005","unstructured":"Wiegand C, Pflugmacher S (2005) Ecotoxicological effects of selected cyanobacterial secondary metabolites a short review. Toxicol Appl Pharmacol 203:201\u2013218. doi: 10.1016\/j.taap.2004.11.002","journal-title":"Toxicol Appl Pharmacol"},{"key":"1633_CR84","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.hal.2007.07.004","volume":"7","author":"L Wormer","year":"2008","unstructured":"Wormer L, Cir\u00e9s S, Carrasco D, Quesada A (2008) Cylindrospermopsin is not degraded by co-occurring natural bacterial communities during a 40-day study. Harmful Algae 7:206\u2013213. doi: 10.1016\/j.ha1.2007.07.004","journal-title":"Harmful Algae"},{"key":"1633_CR85","doi-asserted-by":"crossref","first-page":"3002","DOI":"10.1021\/es9036012","volume":"44","author":"L W\u00f6rmer","year":"2010","unstructured":"W\u00f6rmer L, Huerta-Fontela M, Cir\u00e9s S, Carrasco D, Quesada A (2010) Natural photodegradation of the cyanobacterial toxins microcystin and cylindrospermopsin. Environ Sci Technol 44:3002\u20133007. doi: 10.1021\/es9036012","journal-title":"Environ Sci Technol"},{"key":"1633_CR86","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10937400590889412","volume":"8","author":"RW Zurawell","year":"2005","unstructured":"Zurawell RW, Chen HR, Burke JM, Prepas EE (2005) Hepatotoxic cyanobacteria: a review of the biological importance of microcystins in freshwater environments. J Toxicol Env Health B Crit Rev 8:1\u201337. doi: 10.1080\/10937400590889412","journal-title":"J Toxicol Env Health B Crit Rev"}],"container-title":["Ecotoxicology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10646-016-1633-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10646-016-1633-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10646-016-1633-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T15:33:51Z","timestamp":1718379231000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10646-016-1633-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,24]]},"references-count":86,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["1633"],"URL":"https:\/\/doi.org\/10.1007\/s10646-016-1633-y","relation":{},"ISSN":["0963-9292","1573-3017"],"issn-type":[{"value":"0963-9292","type":"print"},{"value":"1573-3017","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,24]]}}}