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Additionally, the beneficial effects of some elements on human health should be assessed to aid in interpreting the therapeutic action and effectiveness of pelotherapy on dermatological or osteomuscular disorders.\n Therefore, a methodology was developed to better understand the biogeochemical behavior of the elements in formulated peloids. Two peloids were formulated with the same clay and two different sulfurous mineral-medicinal waters for 90\u00a0days, with light stirring every 15\u00a0days. Bentonite clay, with a high content of smectite and Ca and Mg as the main exchangeable cations, and high heat capacity, was used. The selected mineral-medicinal waters were collected from two Portuguese thermal centers with recognized therapeutic efficacy for rheumatic, respiratory and dermatological pathologies. The peloids were used without drying and withdrawn directly from the maturation tank, and a mixture of bentonite and demineralized water was prepared as a reference sample. A stabilized, ready-to-use, artificial perspiration test was used to simulate the peloids\u2019 interaction with skin. Thirty-one elements extracted from the two prepared peloids were analyzed using ICP-MS. The data were analyzed and related to the mineralogical composition of the original clay and supernatant composition of the maturation tanks. The content of some potentially toxic elements and metals\u2019 bioaccessibility by perspiration showed very low solubility and undetectable amounts extracted from the studied samples. This analytical method provided reliable information on dermal exposure and the identification of some elements that may enter the systemic circulation, requiring implementation of surveillance and control measures.<\/jats:p>\n                  <jats:p>\n                    <jats:bold>Graphical abstract<\/jats:bold>\n                  <\/jats:p>","DOI":"10.1007\/s10653-023-01639-z","type":"journal-article","created":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T01:03:31Z","timestamp":1687309411000},"page":"6621-6641","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Bioaccessibility by perspiration uptake of minerals from two different sulfurous peloids"],"prefix":"10.1007","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5074-4137","authenticated-orcid":false,"given":"Carla Marina","family":"Bastos","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3636-3933","authenticated-orcid":false,"given":"Fernando","family":"Rocha","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6006-344X","authenticated-orcid":false,"given":"Carla","family":"Patinha","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0922-8290","authenticated-orcid":false,"given":"Paula","family":"Marinho-Reis","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2023,6,21]]},"reference":[{"key":"1639_CR1","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/j.ijpharm.2013.06.002","volume":"453","author":"C Aguzzi","year":"2013","unstructured":"Aguzzi, C., S\u00e1nchez-Espejo, R., Cerezo, P., Machado, J., Bonferoni, C., Rossi, S., Salcedo, I., & Viseras, C. 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