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The current limitation is the signal-to-noise ratio that one can obtain during a planetary transit, which is in turn ultimately limited by telescope size. This limitation will be overcome by ANDES, an optical and near-infrared high-resolution spectrograph for the Extremely Large Telescope, which is currently in Phase B development. ANDES will be a powerful transformational instrument for exoplanet science. It will enable the study of giant planet atmospheres, allowing not only an exquisite determination of atmospheric composition, but also the study of isotopic compositions, dynamics and weather patterns, mapping the planetary atmospheres and probing atmospheric formation and evolution models. The unprecedented angular resolution of ANDES, will also allow us to explore the initial conditions in which planets form in proto-planetary disks. The main science case of ANDES, however, is the study of small, rocky exoplanet atmospheres, including the potential for biomarker detections, and the ability to reach this science case is driving its instrumental design. Here we discuss our simulations and the observing strategies to achieve this specific science goal. Since ANDES will be operational at the same time as NASA\u2019s JWST and ESA\u2019s ARIEL missions, it will provide enormous synergies in the characterization of planetary atmospheres at high and low spectral resolution. Moreover, ANDES will be able to probe for the first time the atmospheres of several giant and small planets in reflected light. In particular, we show how ANDES will be able to unlock the reflected light atmospheric signal of a golden sample of nearby non-transiting habitable zone earth-sized planets within a few tenths of nights, a scientific objective that no other currently approved astronomical facility will be able to reach.<\/jats:p>","DOI":"10.1007\/s10686-025-10000-4","type":"journal-article","created":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T00:40:59Z","timestamp":1746492059000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Ground-breaking exoplanet science with the ANDES spectrograph at the ELT"],"prefix":"10.1007","volume":"59","author":[{"given":"Enric","family":"Palle","sequence":"first","affiliation":[]},{"given":"Katia","family":"Biazzo","sequence":"additional","affiliation":[]},{"given":"Emeline","family":"Bolmont","sequence":"additional","affiliation":[]},{"given":"Paul","family":"Molli\u00e8re","sequence":"additional","affiliation":[]},{"given":"Katja","family":"Poppenhaeger","sequence":"additional","affiliation":[]},{"given":"Jayne","family":"Birkby","sequence":"additional","affiliation":[]},{"given":"Matteo","family":"Brogi","sequence":"additional","affiliation":[]},{"given":"Gael","family":"Chauvin","sequence":"additional","affiliation":[]},{"given":"Andrea","family":"Chiavassa","sequence":"additional","affiliation":[]},{"given":"Jens","family":"Hoeijmakers","sequence":"additional","affiliation":[]},{"given":"Emmanuel","family":"Lellouch","sequence":"additional","affiliation":[]},{"given":"Christophe","family":"Lovis","sequence":"additional","affiliation":[]},{"given":"Roberto","family":"Maiolino","sequence":"additional","affiliation":[]},{"given":"Lisa","family":"Nortmann","sequence":"additional","affiliation":[]},{"given":"Hannu","family":"Parviainen","sequence":"additional","affiliation":[]},{"given":"Lorenzo","family":"Pino","sequence":"additional","affiliation":[]},{"given":"Martin","family":"Turbet","sequence":"additional","affiliation":[]},{"given":"Jesse","family":"Weder","sequence":"additional","affiliation":[]},{"given":"Simon","family":"Albrecht","sequence":"additional","affiliation":[]},{"given":"Simone","family":"Antoniucci","sequence":"additional","affiliation":[]},{"given":"Susana C.","family":"Barros","sequence":"additional","affiliation":[]},{"given":"Andre","family":"Beaudoin","sequence":"additional","affiliation":[]},{"given":"Bjorn","family":"Benneke","sequence":"additional","affiliation":[]},{"given":"Isabelle","family":"Boisse","sequence":"additional","affiliation":[]},{"given":"Aldo S.","family":"Bonomo","sequence":"additional","affiliation":[]},{"given":"Francesco","family":"Borsa","sequence":"additional","affiliation":[]},{"given":"Alexis","family":"Brandeker","sequence":"additional","affiliation":[]},{"given":"Wolfgang","family":"Brandner","sequence":"additional","affiliation":[]},{"given":"Lars A.","family":"Buchhave","sequence":"additional","affiliation":[]},{"given":"Anne-Laure","family":"Cheffot","sequence":"additional","affiliation":[]},{"given":"Robin","family":"Deborde","sequence":"additional","affiliation":[]},{"given":"Florian","family":"Debras","sequence":"additional","affiliation":[]},{"given":"Rene","family":"Doyon","sequence":"additional","affiliation":[]},{"given":"Paolo","family":"Di Marcantonio","sequence":"additional","affiliation":[]},{"given":"Paolo","family":"Giacobbe","sequence":"additional","affiliation":[]},{"given":"Jonay I.","family":"Gonz\u00e1lez Hern\u00e1ndez","sequence":"additional","affiliation":[]},{"given":"Ravit","family":"Helled","sequence":"additional","affiliation":[]},{"given":"Laura","family":"Kreidberg","sequence":"additional","affiliation":[]},{"given":"Pedro","family":"Machado","sequence":"additional","affiliation":[]},{"given":"Jesus","family":"Maldonado","sequence":"additional","affiliation":[]},{"given":"Alessandro","family":"Marconi","sequence":"additional","affiliation":[]},{"given":"B. 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