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Pattern electroretinogram (PERG) is a noninvasive technique that provides a retinal biopotential and is a highly sensitive indicator of changes in the macular area. Our aim was to evaluate if there are differences in the retinal response of an amblyopic eye compared with a normal eye (NE).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>We evaluated twenty-four adult volunteers, twelve amblyopes (mean 43.42\u2009\u00b1\u200912.72\u00a0years old), and twelve subjects with NE (mean 35.58\u2009\u00b1\u200912.85\u00a0years old). None of the subjects in the two groups had comorbidities. A complete optometric examination was performed including parameters such as visual acuity (VA) by far and near with ETDRS chart, eye alignment with cover test, and evaluation of retinal cells response with PERG.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The refractive error found in the NE group of subjects had a mean of \u2212\u20090.95\u2009\u00b1\u20091.65D, while the amblyopic group showed a mean of \u2212\u20092.03\u2009\u00b1\u20094.29D. The VA in amblyopic eyes had a mean of 0.38\u2009\u00b1\u20090.20 logMAR. Analyzing PERG data, we observed significant differences in the P50-N95 amplitudes of the amblyopic group compared with the NE group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001\u2013amblyopic eye vs. NE; <jats:italic>p<\/jats:italic>\u2009=\u20090.039\u2013fellow eye vs. NE).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Discussion<\/jats:title>\n            <jats:p>These findings suggest that amblyopic patients may also present other impairments beyond the visual cortex. PERGs seem to be an important complementary examination in the diagnosis of other impairments in amblyopia.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s10792-024-03042-8","type":"journal-article","created":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T10:02:32Z","timestamp":1708077752000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pattern electroretinography response in amblyopic adults"],"prefix":"10.1007","volume":"44","author":[{"given":"Andresa","family":"Fernandes","sequence":"first","affiliation":[]},{"given":"Nuno","family":"Pinto","sequence":"additional","affiliation":[]},{"given":"Ana Rita","family":"Tuna","sequence":"additional","affiliation":[]},{"given":"Francisco Miguel","family":"Brardo","sequence":"additional","affiliation":[]},{"given":"Maria Vaz","family":"Pato","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2024,2,16]]},"reference":[{"issue":"4","key":"3042_CR1","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/S1350-9462(00)00030-6","volume":"20","author":"GE Holder","year":"2001","unstructured":"Holder GE (2001) Pattern electroretinography (PERG) and an integrated approach to visual pathway diagnosis. 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