{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T07:44:52Z","timestamp":1772783092018,"version":"3.50.1"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2013,1,29]],"date-time":"2013-01-29T00:00:00Z","timestamp":1359417600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Assist Reprod Genet"],"published-print":{"date-parts":[[2013,4]]},"DOI":"10.1007\/s10815-013-9938-8","type":"journal-article","created":{"date-parts":[[2013,1,28]],"date-time":"2013-01-28T03:50:04Z","timestamp":1359345004000},"page":"487-495","source":"Crossref","is-referenced-by-count":45,"title":["Caspase signalling pathways in human spermatogenesis"],"prefix":"10.1007","volume":"30","author":[{"given":"Carolina","family":"Almeida","sequence":"first","affiliation":[]},{"given":"Sofia","family":"Correia","sequence":"additional","affiliation":[]},{"given":"Eduardo","family":"Rocha","sequence":"additional","affiliation":[]},{"given":"\u00c2ngela","family":"Alves","sequence":"additional","affiliation":[]},{"given":"Lu\u00eds","family":"Ferraz","sequence":"additional","affiliation":[]},{"given":"Joquina","family":"Silva","sequence":"additional","affiliation":[]},{"given":"M\u00e1rio","family":"Sousa","sequence":"additional","affiliation":[]},{"given":"Alberto","family":"Barros","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2013,1,29]]},"reference":[{"issue":"5","key":"9938_CR1","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1093\/humrep\/deh727","volume":"20","author":"C Almeida","year":"2005","unstructured":"Almeida C, Cardoso MF, Sousa M, Viana P, Goncalves A, Silva J, et al. Quantitative study of caspase-3 activity in semen and after swim-up preparation in relation to sperm quality. Hum Reprod. 2005;20(5):1307\u201313. doi: 10.1093\/humrep\/deh727 .","journal-title":"Hum Reprod"},{"key":"9938_CR2","doi-asserted-by":"crossref","first-page":"e407","DOI":"10.1111\/j.1365-2605.2011.01151.x","volume":"34","author":"C Almeida","year":"2011","unstructured":"Almeida C, Cunha M, Ferraz L, Silva J, Barros A, Sousa M. Caspase-3 detection in human testicular spermatozoa from azoospermic and non-azoospermic patients. Int J Androl. 2011;34:e407\u201314.","journal-title":"Int J Androl"},{"key":"9938_CR3","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.rbmo.2009.10.002","volume":"19","author":"C Almeida","year":"2009","unstructured":"Almeida C, Sousa M, Barros A. Phosphatidylserine translocation in human spermatozoa from impaired spermatogenesis. Reprod Biomed Online. 2009;19:770\u20137.","journal-title":"Reprod Biomed Online"},{"issue":"5","key":"9938_CR4","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1016\/j.fertnstert.2007.09.058","volume":"90","author":"A Bozec","year":"2008","unstructured":"Bozec A, Amara S, Guarmit B, Selva J, Albert M, Rollet J, et al. Status of the executioner step of apoptosis in human with normal spermatogenesis and azoospermia. Fertil Steril. 2008;90(5):1723\u201331.","journal-title":"Fertil Steril"},{"issue":"1","key":"9938_CR5","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.cbpb.2008.05.010","volume":"151","author":"I Chowdhury","year":"2008","unstructured":"Chowdhury I, Tharakan B, Bhat GK. Caspases\u2014an update. Comp Biochem Physiol B Biochem Mol Biol. 2008;151(1):10\u201327.","journal-title":"Comp Biochem Physiol B Biochem Mol Biol"},{"issue":"7","key":"9938_CR6","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1093\/humrep\/15.7.1552","volume":"15","author":"ET Donnelly","year":"2000","unstructured":"Donnelly ET, O\u2019Connell M, McClure N, Lewis SEM. Differences in nuclear DNA fragmentation and mitochondrial integrity of semen and prepared human spermatozoa. Hum Reprod. 2000;15(7):1552\u201361.","journal-title":"Hum Reprod"},{"issue":"1","key":"9938_CR7","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.1749-0774.2002.tb00100.x","volume":"15","author":"J Eguchi","year":"2002","unstructured":"Eguchi J, Koji T, Nomata K, Yoshii A, Shin M, Kanetake H. Fas-Fas ligand as a possible mediator of spermatogenic cell apoptosis in human maturation-arrested testes. Hum Cell. 2002;15(1):61\u20138.","journal-title":"Hum Cell"},{"issue":"3","key":"9938_CR8","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1093\/molehr\/8.3.213","volume":"8","author":"S Francavilla","year":"2002","unstructured":"Francavilla S, D\u2019Abrizio P, Cordeschi G, Pelliccione F, Necozione S, Ulisse S, et al. Fas expression correlates with human germ cell degeneration in meiotic and post-meiotic arrest of spermatogenesis. Mol Hum Reprod. 2002;8(3):213\u201320.","journal-title":"Mol Hum Reprod"},{"issue":"4","key":"9938_CR9","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1093\/humrep\/15.4.830","volume":"15","author":"L Gandini","year":"2000","unstructured":"Gandini L, Lombardo F, Paoli D, Caponecchia L, Familiari G, Verlengia C, et al. Study of apoptotic DNA fragmentation in human spermatozoa. Hum Reprod. 2000;15(4):830\u20139.","journal-title":"Hum Reprod"},{"key":"9938_CR10","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1530\/ror.0.0040038","volume":"4","author":"APS Hikim","year":"1999","unstructured":"Hikim APS, Swerdloff RS. Hormonal and genetic control of germ cell apoptosis in the testis. Rev Reprod. 1999;4:38\u201347.","journal-title":"Rev Reprod"},{"issue":"3","key":"9938_CR11","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0092-8674(00)81873-5","volume":"88","author":"MD Jacobson","year":"1997","unstructured":"Jacobson MD, Weil M, Raff MC. Programmed cell death in animal development. Cell. 1997;88(3):347\u201354.","journal-title":"Cell"},{"issue":"1\u20132","key":"9938_CR12","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.anireprosci.2007.11.029","volume":"105","author":"L Johnson","year":"2008","unstructured":"Johnson L, Thompson Jr DL, Varner DD. Role of Sertoli cell number and function on regulation of spermatogenesis. Anim Reprod Sci. 2008;105(1\u20132):23\u201351.","journal-title":"Anim Reprod Sci"},{"key":"9938_CR13","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S0378-4320(00)00108-1","volume":"60","author":"L Johnson","year":"2000","unstructured":"Johnson L, Varner DD, Roberts ME, Smith TL, Keillor GE, Scrutchfield WL. Efficiency of spermatogenesis: a comparative approach. Anim Reprod Sci. 2000;60:471\u201380.","journal-title":"Anim Reprod Sci"},{"issue":"3","key":"9938_CR14","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1159\/000241681","volume":"83","author":"E Kandirali","year":"2008","unstructured":"Kandirali E, Cayan S, Armagan A, Erol B, Kadioglu A. Does the testicular apoptotic index vary with serum gonadotropins and testicular histopathology in infertile men? Urol Int. 2008;83(3):349\u201353.","journal-title":"Urol Int"},{"key":"9938_CR15","doi-asserted-by":"crossref","unstructured":"Kierszenbaum AL. Apoptosis during spermatogenesis: the thrill of being alive. Mol Reprod Develop. 2001;58(1):1\u20133.","DOI":"10.1002\/1098-2795(200101)58:1<1::AID-MRD1>3.0.CO;2-0"},{"issue":"3","key":"9938_CR16","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.fertnstert.2006.07.1524","volume":"87","author":"S-K Kim","year":"2007","unstructured":"Kim S-K, Yoon Y-D, Park Y-S, Seo JT, Kim J-H. Involvement of the Fas-Fas ligand system and active caspase-3 in abnormal apoptosis in human testes with maturation arrest and Sertoli cell-only syndrome. Fertil Steril. 2007;87(3):547\u201353.","journal-title":"Fertil Steril"},{"key":"9938_CR17","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1016\/S0022-5347(01)64130-2","volume":"158","author":"WW Lin","year":"1997","unstructured":"Lin WW, Lamb DJ, Wheeler TM, Abrams J, Lipshultz LI, Kim ED. Apoptotic frequency is increased in spermatogenic maturation arrest and hypospermatogenic states. J Urol. 1997;158:1791\u20133.","journal-title":"J Urol"},{"issue":"6","key":"9938_CR18","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/S0015-0282(97)00372-5","volume":"68","author":"WW Lin","year":"1997","unstructured":"Lin WW, Lamb DJ, Wheeler TM, Lipshultz LI, Kim ED. In situ end-labeling of human testicular tissue demonstrates increased apoptosis in conditions of abnormal spermatogenesis. Fertil Steril. 1997;68(6):1065\u20139.","journal-title":"Fertil Steril"},{"key":"9938_CR19","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1590\/S0001-37652003000400006","volume":"75","author":"CA Mandarim-de-Lacerda","year":"2003","unstructured":"Mandarim-de-Lacerda CA. Stereological tools in biomedical research. An Acad Bras Cienc. 2003;75:469\u201386.","journal-title":"An Acad Bras Cienc"},{"issue":"5","key":"9938_CR20","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1093\/humrep\/deh222","volume":"19","author":"C Marchetti","year":"2004","unstructured":"Marchetti C, Gallego MA, Deffosez A, Formstecher P, Marchetti P. Staining of human sperm with fluorochrome-labeled inhibitor of caspases to detect activated caspases: correlation with apoptosis and sperm parameters. Hum Reprod. 2004;19(5):1127\u201334.","journal-title":"Hum Reprod"},{"issue":"5","key":"9938_CR21","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1093\/humrep\/17.5.1257","volume":"17","author":"C Marchetti","year":"2002","unstructured":"Marchetti C, Obert G, Deffosez A, Formstecher P, Marchetti P. Study of mitochondrial membrane potential, reactive oxygen species, DNA fragmentation and cell viability by flow cytometry in human sperm. Hum Reprod. 2002;17(5):1257\u201365.","journal-title":"Hum Reprod"},{"issue":"1","key":"9938_CR22","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1093\/humrep\/del279","volume":"22","author":"RI McLachlan","year":"2007","unstructured":"McLachlan RI, Rajpert-De Meyts E, Hoei-Hansen CE, de Kretser DM, Skakkebaek NE. Histological evaluation of the human testis\u2013approaches to optimizing the clinical value of the assessment: mini review. Hum Reprod. 2007;22(1):2\u201316. doi: 10.1093\/humrep\/del279 .","journal-title":"Hum Reprod"},{"issue":"2","key":"9938_CR23","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s10741-007-9070-x","volume":"13","author":"M Movassagh","year":"2008","unstructured":"Movassagh M, Foo R. Simplified apoptotic cascades. Hear Fail Rev. 2008;13(2):111\u20139. doi: 10.1007\/s10741-007-9070-x .","journal-title":"Hear Fail Rev"},{"key":"9938_CR24","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0015-0282(00)00623-3","volume":"74","author":"GJ Oosterhuis","year":"2000","unstructured":"Oosterhuis GJ, Mulder AB, Kalsbeek-Batenburg E, Lambalk CB, Schoemaker J, Vermes I. Measuring apoptosis in human spermatozoa: a biological assay for semen quality? Fertil Steril. 2000;74:245\u201350.","journal-title":"Fertil Steril"},{"issue":"2 Pt 1","key":"9938_CR25","first-page":"E310","volume":"276","author":"V Pentikainen","year":"1999","unstructured":"Pentikainen V, Erkkila K, Dunkel L. Fas regulates germ cell apoptosis in the human testis in vitro. Am J Physiol. 1999;276(2 Pt 1):E310\u2013306.","journal-title":"Am J Physiol"},{"issue":"Suppl1","key":"9938_CR26","first-page":"31","volume":"25","author":"PM Petersen","year":"1999","unstructured":"Petersen PM, Giwercman A, Pakkenberg B. Stereological methods as efficient and unbiased tools to quantitate structures in the testis. Scand J Work Environ Health. 1999;25(Suppl1):31\u20133.","journal-title":"Scand J Work Environ Health"},{"issue":"7","key":"9938_CR27","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1093\/humrep\/17.7.1800","volume":"17","author":"M Sousa","year":"2002","unstructured":"Sousa M, Cremades N, Silva J, Oliveira C, Ferraz L, Teixeira da Silva J, et al. Predictive value of testicular histology in secretory azoospermic subgroups and clinical outcome after microinjection of fresh and frozen-thawed sperm and spermatids. Hum Reprod. 2002;17(7):1800\u201310.","journal-title":"Hum Reprod"},{"key":"9938_CR28","unstructured":"Stiblar-Martincic D. Morphometrical evaluation of germ cell apoptosis in infertile men. Folia Biol. 2009;55(6):233\u20137."},{"issue":"8","key":"9938_CR29","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1093\/molehr\/4.8.757","volume":"4","author":"J Tesarik","year":"1998","unstructured":"Tesarik J, Greco E, Cohen-Bacrie P, Mendoza C. Germ cell apoptosis in men with complete and incomplete spermiogenesis failure. Mol Hum Reprod. 1998;4(8):757\u201362. doi: 10.1093\/molehr\/4.8.757 .","journal-title":"Mol Hum Reprod"},{"issue":"5203","key":"9938_CR30","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1126\/science.7878464","volume":"267","author":"C Thompson","year":"1995","unstructured":"Thompson C. Apoptosis in the pathogenesis and treatment of disease. Science. 1995;267(5203):1456\u201362.","journal-title":"Science"},{"key":"9938_CR31","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.fertnstert.2006.07.1528","volume":"87","author":"S Varum","year":"2007","unstructured":"Varum S, Bento C, Sousa A, Gomes-Santos CS, Henriques NP, Almeida-Santos T, et al. Characterization of human sperm populations using conventional parameters, surface ubiquitination, and apoptotic markers. Fertil Steril. 2007;87:572\u201383.","journal-title":"Fertil Steril"},{"issue":"3","key":"9938_CR32","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0015-0282(03)00756-8","volume":"80","author":"X Wang","year":"2003","unstructured":"Wang X, Sharma RK, Sikka SC, Thomas AJ, Falcone T, Agarwal A. Oxidative stress is associated with increased apoptosis leading to spermatozoa DNA damage in patients with male factor infertility. Fertil Steril. 2003;80(3):531\u20135.","journal-title":"Fertil Steril"},{"issue":"10","key":"9938_CR33","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1093\/molehr\/8.11.984","volume":"8","author":"S-L Weng","year":"2002","unstructured":"Weng S-L, Taylor SL, Morshedi M, Schuffner A, Duran EH, Beebe S, et al. Caspase activity and apoptotic markers in ejaculated human sperm. Mol Hum Reprod. 2002;8(10):984\u201391.","journal-title":"Mol Hum Reprod"},{"key":"9938_CR34","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/j.1745-7262.2008.00295.x","volume":"10","author":"H Zhang","year":"2008","unstructured":"Zhang H, Chen Z, Ma C, Lu S, Wang L, Li X. Early apoptotic changes in human spermatozoa and their relationships with conventional semen parameters and sperm DNA fragmentation. Asian J Androl. 2008;10:227\u201335.","journal-title":"Asian J Androl"}],"container-title":["Journal of Assisted Reproduction and Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10815-013-9938-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10815-013-9938-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10815-013-9938-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T01:20:02Z","timestamp":1559265602000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10815-013-9938-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,29]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["9938"],"URL":"https:\/\/doi.org\/10.1007\/s10815-013-9938-8","relation":{},"ISSN":["1058-0468","1573-7330"],"issn-type":[{"value":"1058-0468","type":"print"},{"value":"1573-7330","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,29]]}}}