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The ERA inferred transcriptomic levels of canonical receptivity markers from biopsies obtained at standard timing. Demographic and treatment-related variables were analyzed by age group. The proportion of non-receptive ERA results (pre- and post-receptive combined) was compared using Fisher\u2019s exact test. Univariable and multivariable logistic regression assessed associations between predictors and non-receptive ERA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 210 patients, 205 were included. Age distribution was\u2009&lt;\u200935 (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200935, 17%), 35\u201337 (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200958, 28.3%), 38\u201340 (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200953, 25.8%), and\u2009\u2265\u200941 (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200959, 28.8%). Overall, 166 (81.0%) ERAs were receptive, 33 (16.1%) pre-receptive, and 6 (2.9%) post-receptive. BMI, infertility diagnosis, and prior implantation or miscarriage history did not differ by age. Non-receptive ERA proportions were 20% (&lt;\u200935), 17.2% (35\u201337), 17.0% (38\u201340), and 22.0% (\u2265\u200941) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.52). In multivariable analysis adjusting for BMI and number of prior failed euploid transfers, age was not associated with non-receptive ERA (aOR 0.98, 95% CI 0.34\u20132.30,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.97).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Uterine age was not associated with increased odds of non-receptive ERA, suggesting that the test does not capture age-related changes in endometrial receptivity. Although endometrial aging is implicated in reduced embryo transfer success, the ERA should not be ordered solely on the basis of uterine age. The ERA may not reliably detect age-related endometrial differences in the window of implantation at a clinical level.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s10815-026-03824-2","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T05:32:14Z","timestamp":1770615134000},"page":"1169-1177","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Endometrial aging and uterine receptivity: endometrial receptivity analysis (ERA) outcomes in female patients of diverse age groups"],"prefix":"10.1007","volume":"43","author":[{"given":"Kaia M.","family":"Schwartz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahar D.","family":"Yilmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meagan","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelle I.","family":"Cedars","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hakan","family":"Cakmak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,9]]},"reference":[{"key":"3824_CR1","unstructured":"Mathews TJ, Hamilton BE. 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