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Over the last years, the development of new drugs able to inhibit <jats:italic>Pseudomonas aeruginosa<\/jats:italic> by interfering with its ability to form biofilms has become a promising strategy in drug discovery. Identifying molecules able to interfere with biofilm formation is difficult, but further developing these molecules by rationally improving their activity is particularly challenging, as it requires knowledge of the specific protein target that is inhibited. This work describes the development of a machine learning multitechnique consensus workflow to predict the protein targets of molecules with confirmed inhibitory activity against biofilm formation by <jats:italic>Pseudomonas aeruginosa<\/jats:italic>. It uses a specialized database containing all the known targets implicated in biofilm formation by <jats:italic>Pseudomonas aeruginosa.<\/jats:italic> The experimentally confirmed inhibitors available on ChEMBL, together with chemical descriptors, were used as the input features for a combination of nine different classification models, yielding a consensus method to predict the most likely target of a ligand. The implemented algorithm is freely available at <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/github.com\/BioSIM-Research-Group\/TargIDe\">https:\/\/github.com\/BioSIM-Research-Group\/TargIDe<\/jats:ext-link> under licence GNU General Public Licence (GPL) version 3 and can easily be improved as more data become available.<\/jats:p>","DOI":"10.1007\/s10822-023-00505-5","type":"journal-article","created":{"date-parts":[[2023,4,22]],"date-time":"2023-04-22T02:02:19Z","timestamp":1682128939000},"page":"265-278","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["TargIDe: a machine-learning workflow for target identification of molecules with antibiofilm activity against Pseudomonas aeruginosa"],"prefix":"10.1007","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5153-2395","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Carneiro","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0156-2545","authenticated-orcid":false,"given":"Rita P.","family":"Magalh\u00e3es","sequence":"additional","affiliation":[]},{"given":"Victor M.","family":"de la Oliva Roque","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3355-4398","authenticated-orcid":false,"given":"Manuel","family":"Sim\u00f5es","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1176-552X","authenticated-orcid":false,"given":"Diogo","family":"Pratas","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6560-5284","authenticated-orcid":false,"given":"S\u00e9rgio F.","family":"Sousa","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2023,4,22]]},"reference":[{"key":"505_CR1","doi-asserted-by":"publisher","first-page":"7457","DOI":"10.1039\/c2ob25835h","volume":"10","author":"RJ Worthington","year":"2012","unstructured":"Worthington RJ, Richards JJ, Melander C (2012) Small molecule control of bacterial biofilms. 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