{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T19:30:09Z","timestamp":1758396609437,"version":"3.37.3"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T00:00:00Z","timestamp":1700006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T00:00:00Z","timestamp":1700006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Interv Card Electrophysiol"],"DOI":"10.1007\/s10840-023-01685-8","type":"journal-article","created":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T06:01:41Z","timestamp":1700028101000},"page":"1133-1143","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association between the number of altered late potential criteria and increased arrhythmic risk in Brugada syndrome patients"],"prefix":"10.1007","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6672-7542","authenticated-orcid":false,"given":"Joana","family":"Brito","sequence":"first","affiliation":[]},{"given":"Nuno","family":"Cortez-Dias","sequence":"additional","affiliation":[]},{"given":"Gustavo Lima","family":"da Silva","sequence":"additional","affiliation":[]},{"given":"Afonso Nunes","family":"Ferreira","sequence":"additional","affiliation":[]},{"given":"In\u00eas Aguiar","family":"Ricardo","sequence":"additional","affiliation":[]},{"given":"Nelson","family":"Cunha","sequence":"additional","affiliation":[]},{"given":"Pedro Silv\u00e9rio","family":"Ant\u00f3nio","sequence":"additional","affiliation":[]},{"given":"Irina","family":"Neves","sequence":"additional","affiliation":[]},{"given":"Sandra","family":"Paiva","sequence":"additional","affiliation":[]},{"given":"Ana","family":"Paix\u00e3o","sequence":"additional","affiliation":[]},{"given":"Fernanda","family":"Gaspar","sequence":"additional","affiliation":[]},{"given":"Ad\u00edlia","family":"Silva","sequence":"additional","affiliation":[]},{"given":"Andreia","family":"Magalh\u00e3es","sequence":"additional","affiliation":[]},{"given":"Pedro","family":"Marques","sequence":"additional","affiliation":[]},{"given":"Fausto J.","family":"Pinto","sequence":"additional","affiliation":[]},{"given":"Jo\u00e3o","family":"de Sousa","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2023,11,15]]},"reference":[{"issue":"6","key":"1685_CR1","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1016\/0735-1097(92)90253-J","volume":"20","author":"P Brugada","year":"1992","unstructured":"Brugada P, Brugada J. Right Bundle Branch Block, Persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. JACC. 1992;20(6):1391\u20136.","journal-title":"JACC"},{"key":"1685_CR2","first-page":"1","volume":"2022","author":"K Zeppenfeld","year":"2022","unstructured":"Zeppenfeld K, Tfelt-Hansen J, Riva M, Winkel BG, Blom NA, Charron P, et al. ESC guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. Eur Heart J Online. 2022;2022:1\u2013130.","journal-title":"Eur Heart J Online"},{"issue":"1","key":"1685_CR3","doi-asserted-by":"publisher","first-page":"13","DOI":"10.15420\/aer.2018.73.2","volume":"8","author":"C Pappone","year":"2019","unstructured":"Pappone C, Santinelli V. Brugada syndrome: progress in diagnosis and management. Arrhythm Electrophysiol Rev. 2019;8(1):13\u20138.","journal-title":"Arrhythm Electrophysiol Rev"},{"issue":"12","key":"1685_CR4","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.1161\/CIRCULATIONAHA.110.972612","volume":"123","author":"K Nademanee","year":"2011","unstructured":"Nademanee K, Veerakul G, Chandanamattha P, Chaothawee L, Ariyachaipanich A, Jirasirirojanakorn K, et al. Prevention of ventricular fibrillation episodes in Brugada syndrome by catheter ablation over the anterior right ventricular outflow tract epicardium. Circulation. 2011;123(12):1270\u20139.","journal-title":"Circulation"},{"issue":"4","key":"1685_CR5","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1016\/j.hrthm.2013.05.023","volume":"11","author":"F Sacher","year":"2014","unstructured":"Sacher F, Jesel L, Jais P, Ha\u00efssaguerre M. Insight into the mechanism of Brugada syndrome: epicardial substrate and modification during ajmaline testing. Heart Rhythm. 2014;11(4):732\u20134.","journal-title":"Heart Rhythm"},{"issue":"6","key":"1685_CR6","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1161\/CIRCEP.115.003220","volume":"8","author":"J Brugada","year":"2015","unstructured":"Brugada J, Pappone C, Berruezo A, Giannelli L, Santinelli V. Brugada syndrome phenotype elimination by epicardial substrate ablation. Circ Arrhythm Electrophysiol. 2015;8(6):1373\u201381.","journal-title":"Circ Arrhythm Electrophysiol."},{"key":"1685_CR7","doi-asserted-by":"crossref","unstructured":"Pappone C, Brugada J, Vicedomini G, Ciconte G, Manguso F, Saviano M, et al. Electrical substrate elimination in 135 consecutive patients with Brugada syndrome. Circ Arrhythm Electrophysiol. 2017;10(5):1\u201313.","DOI":"10.1161\/CIRCEP.117.005053"},{"issue":"11","key":"1685_CR8","doi-asserted-by":"publisher","first-page":"2151","DOI":"10.1016\/j.hrthm.2016.07.025","volume":"13","author":"P Zhang","year":"2016","unstructured":"Zhang P, Tung R, Zhang Z, Sheng X. Characterization of the epicardial substrate for catheter ablation of Brugada syndrome. Heart Rhythm. 2016;13(11):2151\u20138.","journal-title":"Heart Rhythm"},{"issue":"5","key":"1685_CR9","doi-asserted-by":"crossref","first-page":"305.e1","DOI":"10.1016\/j.repc.2014.01.010","volume":"33","author":"N Cortez-Dias","year":"2014","unstructured":"Cortez-Dias N, Pl\u00e1cido R, Marta L, Bernardes A, Sobral S, Carpinteiro L, et al. Epicardial ablation for prevention of ventricular fibrillation in a patient with Brugada syndrome. Rev Port Cardiol. 2014;33(5):305.e1-305.e7.","journal-title":"Rev Port Cardiol"},{"issue":"5","key":"1685_CR10","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1016\/0735-1097(91)90822-Q","volume":"17","author":"G Breithardt","year":"1991","unstructured":"Breithardt G, Cain ME, El-Sherif N, Flowers NC, Hombach V, Janse M, et al. Standards for analysis of ventricular late potentials using high-resolution or signal-averaged electrocardiography: a statement by a task force committee of the European Society of Cardiology, the American Heart Association, and the American College of Ca. J Am Coll Cardiol. 1991;17(5):999\u20131006.","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"1685_CR11","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.hrthm.2010.10.007","volume":"8","author":"GS Kamath","year":"2000","unstructured":"Kamath GS, Zareba W, Delaney J, Koneru JN, McKenna W, Gear K, et al. Value of the signal-averaged electrocardiogram in arrhythmogenic right ventricular cardiomyopathy\/dysplasia. Heart Rhythm. 2000;8(2):256\u201362.","journal-title":"Heart Rhythm"},{"issue":"12","key":"1685_CR12","first-page":"1900","volume":"21","author":"G Ciconte","year":"2019","unstructured":"Ciconte G, Santinelli V, Vicedomini G, Borrelli V, Monasky MM, Micaglio E, et al. Non-invasive assessment of the arrhythmogenic substrate in Brugada syndrome using signal-averaged electrocardiogram: clinical implications from a prospective clinical trial. Europace. 2019;21(12):1900\u201310.","journal-title":"Europace"},{"issue":"1","key":"1685_CR13","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1046\/j.1540-8167.2005.04313.x","volume":"16","author":"Y Ajiro","year":"2005","unstructured":"Ajiro Y, Hagiwara N, Kasanuki H. Assessment of markers for identifying patients at risk for life-threatening arrhythmic events in Brugada syndrome. J Cardiovasc Electrophysiol. 2005;16(1):45\u201351.","journal-title":"J Cardiovasc Electrophysiol"},{"issue":"6","key":"1685_CR14","doi-asserted-by":"publisher","first-page":"1628","DOI":"10.1016\/S0735-1097(01)01197-4","volume":"37","author":"T Ikeda","year":"2001","unstructured":"Ikeda T, Sakurada H, Sakabe K, Sakata T, Takami M, Tezuka N, et al. Assessment of noninvasive markers in identifying patients at risk in the Brugada syndrome: insight into risk stratification. J Am Coll Cardiol. 2001;37(6):1628\u201334.","journal-title":"J Am Coll Cardiol"},{"issue":"8","key":"1685_CR15","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.1016\/j.hrthm.2009.05.007","volume":"6","author":"Z Huang","year":"2009","unstructured":"Huang Z, Patel C, Li W, Xie Q, Wu R, Zhang L, et al. Role of signal-averaged electrocardiograms in arrhythmic risk stratification of patients with Brugada syndrome: a prospective study. Heart Rhythm. 2009;6(8):1156\u201362.","journal-title":"Heart Rhythm"},{"issue":"12","key":"1685_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.hrthm.2013.05.014","volume":"10","author":"SG Priori","year":"2013","unstructured":"Priori SG, Wilde AA, Horie M, Cho Y, Behr ER, Berul C, et al. Executive summary: HRS\/EHRA\/APHRS expert consensus statement on the diagnosis and management of patients with inherited primary arrhythmia syndromes. Heart Rhythm. 2013;10(12):1\u201362.","journal-title":"Heart Rhythm"},{"issue":"41","key":"1685_CR17","doi-asserted-by":"publisher","first-page":"2793","DOI":"10.1093\/eurheartj\/ehv316","volume":"36","author":"SG Priori","year":"2015","unstructured":"Priori SG, Blomstrom-Lundqvist C, Mazzanti A, Bloma N, Borggrefe M, Camm J, et al. 2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death the Task Force for the Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death of the Europea. Eur Heart J. 2015;36(41):2793\u20132867l.","journal-title":"Eur Heart J"},{"issue":"15","key":"1685_CR18","doi-asserted-by":"publisher","first-page":"1631","DOI":"10.1016\/j.jacc.2018.02.022","volume":"71","author":"C Pappone","year":"2018","unstructured":"Pappone C, Ciconte G, Manguso F, Vicedomini G, Mecarocci V, Conti M, et al. Assessing the malignant ventricular arrhythmic substrate in patients with Brugada syndrome. J Am Coll Cardiol. 2018;71(15):1631\u201346.","journal-title":"J Am Coll Cardiol"},{"issue":"22","key":"1685_CR19","doi-asserted-by":"publisher","first-page":"2747","DOI":"10.1016\/j.jacc.2018.09.037","volume":"72","author":"M Pieroni","year":"2018","unstructured":"Pieroni M, Notarstefano P, Oliva A, Campuzano O, Santangeli P, Coll M, et al. Electroanatomic and pathologic right ventricular outflow tract abnormalities in patients with Brugada syndrome. J Am Coll Cardiol. 2018;72(22):2747\u201357.","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"1685_CR20","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/j.hrthm.2019.11.019","volume":"17","author":"C Pappone","year":"2020","unstructured":"Pappone C, Mecarocci V, Manguso F, Ciconte G, Vicedomini G, Sturla F, et al. New electromechanical substrate abnormalities in high-risk patients with Brugada syndrome. Heart Rhythm. 2020;17(4):637\u201345.","journal-title":"Heart Rhythm"},{"key":"1685_CR21","doi-asserted-by":"crossref","unstructured":"Koruth JS, Aryana A, Dukkipati SR, Pak HN, Kim YH, Sosa EA, et al. Unusual complications of percutaneous epicardial access and epicardial mapping and ablation of cardiac arrhythmias.\u00a0Circ\u00a0 Arrhythm\u00a0 Electrophysiol\u00a0. 2011;4(6):882\u20138.","DOI":"10.1161\/CIRCEP.111.965731"},{"key":"1685_CR22","doi-asserted-by":"crossref","unstructured":"Sacher F, Roberts-Thomson K, Maury P, Tedrow U, Nault I, Steven D, et al. Epicardial ventricular tachycardia ablation. A multicenter safety study. J Am Coll Cardiol . 2010;55(21):2366\u201372.","DOI":"10.1016\/j.jacc.2009.10.084"},{"issue":"1","key":"1685_CR23","doi-asserted-by":"publisher","first-page":"45","DOI":"10.15420\/ecr.2018.31.2","volume":"14","author":"DG Iglesias","year":"2019","unstructured":"Iglesias DG, Rub\u00edn J, P\u00e9rez D, Mor\u00eds C, Calvo D. Insights for stratification of risk in Brugada syndrome. Eur Cardiol Rev. 2019;14(1):45\u20139.","journal-title":"Eur Cardiol Rev"},{"issue":"2","key":"1685_CR24","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.jacep.2020.08.032","volume":"7","author":"S Honarbakhsh","year":"2021","unstructured":"Honarbakhsh S, Providencia R, Garcia-Hernandez J, Martin CA, Hunter RJ, Lim WY, et al. A Primary prevention clinical risk score model for patients with Brugada syndrome (BRUGADA-RISK). JACC Clin Electrophysiol. 2021;7(2):210\u201322.","journal-title":"JACC Clin Electrophysiol"},{"issue":"3","key":"1685_CR25","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.jacep.2021.12.001","volume":"8","author":"AD Krahn","year":"2021","unstructured":"Krahn AD, Behr ER, Hamilton R, Probst V, Laksman Z, Han HC. Brugada syndrome. JACC Clin Electrophysiol. 2021;8(3):386\u2013405.","journal-title":"JACC Clin Electrophysiol"},{"key":"1685_CR26","doi-asserted-by":"crossref","unstructured":"Takahashi H, Takagi M, Yoshio T, Yoh M, Shiojima I. Analysis of site-specific late potentials using a novel Holter signal-averaged electrocardiography in patients with Brugada syndrome. Heart Rhythm. 2022;19(10):1650\u20138.","DOI":"10.1016\/j.hrthm.2022.05.005"},{"key":"1685_CR27","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1161\/CIRCEP.111.969865","volume":"5","author":"A Abe","year":"2012","unstructured":"Abe A, Kobayashi K, Yuzawa H, Sato H, Fukunaga S, Fujino T, et al. Comparison of late potentials for 24 hours between Brugada syndrome and arrhythmogenic right ventricular cardiomyopathy using a novel signal-averaging system based on Holter ECG. Circ Arrhythmia Eletrophysiology. 2012;5:789\u201395.","journal-title":"Circ Arrhythmia Eletrophysiology"},{"issue":"3","key":"1685_CR28","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1253\/circj.CJ-12-0932","volume":"77","author":"K Yoshioka","year":"2013","unstructured":"Yoshioka K, Amino M, Zareba W, Shima M, Matsuzaki A, Fujii T, et al. Identification of high-risk Brugada syndrome patients by combined analysis of late potential and T-wave amplitude variability on ambulatory electrocardiograms. Circ J. 2013;77(3):610\u20138.","journal-title":"Circ J"},{"issue":"1","key":"1685_CR29","first-page":"52","volume":"76","author":"JA \u00c1lvarez-G\u00f3mez","year":"2006","unstructured":"\u00c1lvarez-G\u00f3mez JA, S\u00e1nchez MD, Stanley J, Rodolfo BS, Hevia JC, Sarduy DB, et al. Marcadores el\u00e9ctricos no invasores en pacientes con s\u00edndrome de Brugada. Arch Cardiol Mex. 2006;76(1):52\u20138.","journal-title":"Arch Cardiol Mex."},{"issue":"66","key":"1685_CR30","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.jelectrocard.2021.03.011","volume":"1","author":"M Lopez-Blazquez","year":"2021","unstructured":"Lopez-Blazquez M, Field E, Tollit J, Walsh H, Addis A, French N, et al. Clinical significance of inferolateral early repolarisation and late potentials in children with Brugada syndrome. J Electrocardiol. 2021;1(66):79\u201383.","journal-title":"J Electrocardiol"},{"key":"1685_CR31","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.jelectrocard.2023.08.018","volume":"81","author":"K Hashimoto","year":"2023","unstructured":"Hashimoto K, Harada N. Recent progress of Holter-based late potential for predicting serious cardiac events and its implications and future challenges. J Electrocardiol. 2023;81:136\u201341.","journal-title":"J Electrocardiol."},{"issue":"3","key":"1685_CR32","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1620\/tjem.240.191","volume":"240","author":"M Nakano","year":"2016","unstructured":"Nakano M, Fukuda K, Kondo M, Segawa M, Hirano M, Chiba T, et al. Prognostic significance of late potentials in outpatients with type 2 Brugada electrocardiogram. Tohoku J Exp Med. 2016;240(3):191\u20138.","journal-title":"Tohoku J Exp Med"},{"issue":"8","key":"1685_CR33","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1046\/j.1540-8167.2002.00742.x","volume":"13","author":"L Eckardt","year":"2002","unstructured":"Eckardt L, Bruns HJ, Paul M, Kirchhof P, Schulze-Bahr E, Wichter T, et al. Body surface area of ST elevation and the presence of late potentials correlate to the inducibility of ventricular tachyarrhythmias in Brugada syndrome. J Cardiovasc Eletrophysiology. 2002;13(8):742\u20139.","journal-title":"J Cardiovasc Eletrophysiology"}],"container-title":["Journal of Interventional Cardiac Electrophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10840-023-01685-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10840-023-01685-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10840-023-01685-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T09:21:00Z","timestamp":1722331260000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10840-023-01685-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,15]]},"references-count":33,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,8]]}},"alternative-id":["1685"],"URL":"https:\/\/doi.org\/10.1007\/s10840-023-01685-8","relation":{},"ISSN":["1572-8595"],"issn-type":[{"type":"electronic","value":"1572-8595"}],"subject":[],"published":{"date-parts":[[2023,11,15]]},"assertion":[{"value":"20 September 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 October 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 November 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All patients provided written informed consent. The Institutional Ethics Committee on human research at our institution approved the collection and review of these data.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Drs. Cortez-Dias and Sousa received travel and consulting fees from Biosense Webster, Boston Scientific and Abott Medical. All other authors have reported that they have no relationships relevant to the contents of this paper to disclosure.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}