{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T08:29:49Z","timestamp":1768638589846,"version":"3.49.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2011,3,29]],"date-time":"2011-03-29T00:00:00Z","timestamp":1301356800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Mater Sci: Mater Med"],"published-print":{"date-parts":[[2011,4]]},"DOI":"10.1007\/s10856-011-4283-x","type":"journal-article","created":{"date-parts":[[2011,3,28]],"date-time":"2011-03-28T11:44:50Z","timestamp":1301312690000},"page":"809-817","source":"Crossref","is-referenced-by-count":34,"title":["Alpha-tricalcium phosphate (\u03b1-TCP): solid state synthesis from different calcium precursors and the hydraulic reactivity"],"prefix":"10.1007","volume":"22","author":[{"given":"Gulcin","family":"Cicek","sequence":"first","affiliation":[]},{"given":"Eda Ayse","family":"Aksoy","sequence":"additional","affiliation":[]},{"given":"Caner","family":"Durucan","sequence":"additional","affiliation":[]},{"given":"Nesrin","family":"Hasirci","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2011,3,29]]},"reference":[{"key":"4283_CR1","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1243\/0954411981534196","volume":"212","author":"FCM Driessens","year":"1998","unstructured":"Driessens FCM, Planell JA, Boltong MG, Khairoun I, Ginebra MP. Osteotransductive bone cements. Proc Instn Mech Eng. 1998;212:427\u201335.","journal-title":"Proc Instn Mech Eng"},{"key":"4283_CR2","doi-asserted-by":"crossref","first-page":"3130","DOI":"10.1002\/1521-3773(20020902)41:17<3130::AID-ANIE3130>3.0.CO;2-1","volume":"41","author":"SV Dorozhkin","year":"2002","unstructured":"Dorozhkin SV, Epple M. Biological and medical significance of calcium phosphates. Angew Chem Int Ed. 2002;41:3130\u201346.","journal-title":"Angew Chem Int Ed"},{"key":"4283_CR3","first-page":"241","volume-title":"Biomaterials in orthopedics","author":"K Serbetci","year":"2004","unstructured":"Serbetci K, Hasirci N. Recent developments in bone cements. In: Yaszemski MJ, Trantolo DJ, Lewandrowski K, Hasirci V, Altobelli DE, Wise DL, editors. Biomaterials in orthopedics. New York: Marcel-Dekker Inc; 2004. p. 241\u201386."},{"key":"4283_CR4","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1098\/rsif.2008.0151","volume":"5","author":"M Navarro","year":"2008","unstructured":"Navarro M, Michiardi A, Castano O, Planell JA. Biomaterials in orthopaedics. J R Soc Interface. 2008;5:1137\u201358.","journal-title":"J R Soc Interface"},{"key":"4283_CR5","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/S1369-7021(10)70014-6","volume":"13","author":"M Bohner","year":"2010","unstructured":"Bohner M. Resorbable biomaterials as bone graft substitutes. Mater Today. 2010;13:24\u201330.","journal-title":"Mater Today"},{"key":"4283_CR6","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0142-9418(03)00073-4","volume":"23","author":"K Serbetci","year":"2004","unstructured":"Serbetci K, Korkusuz F, Hasirci N. Thermal and mechanical properties of hydroxyapatite impregnated acrylic bone cements. Polym Test. 2004;23:145\u201355.","journal-title":"Polym Test"},{"key":"4283_CR7","doi-asserted-by":"crossref","first-page":"4077","DOI":"10.1002\/app.30488","volume":"113","author":"T Endogan","year":"2009","unstructured":"Endogan T, Serbetci K, Hasirci N. Effects of ingredients on thermal and mechanical properties of acrylic bone cements. J Appl Polym Sci. 2009;113:4077\u201384.","journal-title":"J Appl Polym Sci"},{"issue":"5205","key":"4283_CR8","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1126\/science.7892603","volume":"267","author":"BR Constantz","year":"1995","unstructured":"Constantz BR, Ison IC, Fulmer MT, Poser RD, Smith ST, VanWagoner M, Ross J, Goldstein SA, Jupiter JB, Rosenthal DI. Skeletal repair by in situ formation of the mineral phase of bone. Science. 1995;267(5205):1796\u20139.","journal-title":"Science"},{"key":"4283_CR9","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s005860100308","volume":"10","author":"PF Heini","year":"2001","unstructured":"Heini PF, Berlemann U. Bone substitutes in vertebroplasty. Eur Spine J. 2001;10:205\u201313.","journal-title":"Eur Spine J"},{"key":"4283_CR10","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s00586-006-0258-x","volume":"16","author":"G Maestretti","year":"2007","unstructured":"Maestretti G, Cremer C, Otten P, Jakob RP. Prospective study of standalone balloon kyphoplasty with calcium phosphate cement augmentation in traumatic fractures. Eur Spine J. 2007;16:601\u201310.","journal-title":"Eur Spine J"},{"key":"4283_CR11","first-page":"251","volume":"6","author":"KS Tenhuisen","year":"1996","unstructured":"Tenhuisen KS, Clark BA, Klimkiewicz M, Brown PW. A microstructural investigation of calcium hydroxyapatites synthesized from CaHPO4\u00b72H2O and Ca4(PO4)2O. Cells Mater. 1996;6:251\u201367.","journal-title":"Cells Mater"},{"key":"4283_CR12","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1111\/j.1151-2916.1991.tb07798.x","volume":"74","author":"PW Brown","year":"1991","unstructured":"Brown PW, Hocker N, Hoyle S. Variations in solution chemistry during the low-temperature formation of hydroxyapatite. J Am Ceram Soc. 1991;74:1848\u201354.","journal-title":"J Am Ceram Soc"},{"key":"4283_CR13","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/jbm.b.30715","volume":"82B","author":"M Yamada","year":"2007","unstructured":"Yamada M, Shiota M, Yamashita Y, Kasugai S. Histological and histomorphometrical comparative study of the degradation and osteoconductive characteristics of \u03b1- and \u03b2- tricalcium phosphate in block grafts. J Biomed Mater Res B Appl Biomater. 2007;82B:139\u201348.","journal-title":"J Biomed Mater Res B Appl Biomater"},{"key":"4283_CR14","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.injury.2010.02.017","volume":"41","author":"C Seebach","year":"2010","unstructured":"Seebach C, Schultheiss J, Wilhelm K, Frank J, Henrich D. Comparison of six bone-graft substitutes regarding to cell seeding efficiency, metabolism and growth behaviour of human mesenchymal stem cells (MSC) in vitro. Injury. 2010;41:731\u20138.","journal-title":"Injury"},{"key":"4283_CR15","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1023\/A:1014347814241","volume":"37","author":"C Durucan","year":"2002","unstructured":"Durucan C, Brown PW. Reactivity of \u03b1-tricalcium phosphate. J Mater Sci. 2002;37:963\u20139.","journal-title":"J Mater Sci"},{"key":"4283_CR16","doi-asserted-by":"crossref","first-page":"2808","DOI":"10.1111\/j.1151-2916.1999.tb02160.x","volume":"82","author":"MP Ginebra","year":"1999","unstructured":"Ginebra MP, Fern\u00e1ndez E, Driessens FCM, Planell JA. Modeling of the hydrolysis of \u03b1-tricalcium phosphate. J Am Ceram Soc. 1999;82:2808\u201312.","journal-title":"J Am Ceram Soc"},{"key":"4283_CR17","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1111\/j.1151-2916.2002.tb00397.x","volume":"85","author":"C Durucan","year":"2002","unstructured":"Durucan C, Brown PW. Kinetic model for \u03b1-tricalcium phosphate hydrolysis. J Am Ceram Soc. 2002;85:2013\u20138.","journal-title":"J Am Ceram Soc"},{"key":"4283_CR18","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1002\/jbm.b.30809","volume":"83B","author":"TJ Brunner","year":"2007","unstructured":"Brunner TJ, Bohner M, Dora C, Gerber C, Stark WJ. Comparison of amorphous TCP nanoparticles to micron-sized \u03b1-TCP as starting materials for calcium phosphate cements. J Biomed Mater Res B Appl Biomater. 2007;83B:400\u20137.","journal-title":"J Biomed Mater Res B Appl Biomater"},{"key":"4283_CR19","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1016\/j.biomaterials.2004.08.001","volume":"26","author":"CL Camire","year":"2005","unstructured":"Camire CL, Gbureck U, Hirsiger W, Bohner M. Correlating crystallinity and reactivity in an \u03b1-tricalcium phosphate. Biomaterials. 2005;26:2787\u201394.","journal-title":"Biomaterials"},{"key":"4283_CR20","doi-asserted-by":"crossref","first-page":"4072","DOI":"10.1039\/b707171j","volume":"17","author":"TJ Brunner","year":"2007","unstructured":"Brunner TJ, Grass RN, Bohner M, Stark WJ. Effect of particle size, crystal phase and crystallinity on the reactivity of tricalcium phosphate cements for bone reconstruction. J Mater Chem. 2007;17:4072\u20138.","journal-title":"J Mater Chem"},{"key":"4283_CR21","doi-asserted-by":"crossref","first-page":"3453","DOI":"10.1016\/j.biomaterials.2003.10.049","volume":"25","author":"MP Ginebra","year":"2004","unstructured":"Ginebra MP, Driessens FCM, Planell JA. Effect of particle size on the micro and nanostructural features of a calcium phosphate cement: a kinetic analysis. Biomaterials. 2004;25:3453\u201362.","journal-title":"Biomaterials"},{"key":"4283_CR22","doi-asserted-by":"crossref","first-page":"5669","DOI":"10.1039\/b811953h","volume":"18","author":"M Bohner","year":"2008","unstructured":"Bohner M, Brunner TJ, Stark WJ. Controlling the reactivity of calcium phosphate cements. J Mater Chem. 2008;18:5669\u201375.","journal-title":"J Mater Chem"},{"key":"4283_CR23","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1016\/j.biomaterials.2003.09.059","volume":"25","author":"A Bigi","year":"2004","unstructured":"Bigi A, Bracci B, Panzavolta S. Effect of added gelatin on the properties of calcium phosphate cement. Biomaterials. 2004;25:2893\u20139.","journal-title":"Biomaterials"},{"key":"4283_CR24","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S8756-3282(99)00130-1","volume":"25","author":"L Leroux","year":"1999","unstructured":"Leroux L, Hatim Z, Fr\u00e8che M, Lacout JL. Effects of various adjuvants (lactic acid, glycerol, and chitosan) on the injectability of a calcium phosphate cement. Bone. 1999;25:31\u20134.","journal-title":"Bone"},{"key":"4283_CR25","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.actbio.2008.01.006","volume":"4","author":"JV Rau","year":"2008","unstructured":"Rau JV, Generosi A, Smirnov VV, Ferro D, Rossi Albertini V, Barinov SM. Energy dispersive X-ray diffraction study of phase development during hardening of calcium phosphate bone cements with addition of chitosan. Acta Biomater. 2008;4:1089\u201394.","journal-title":"Acta Biomater"},{"key":"4283_CR26","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1007\/s10856-005-4754-z","volume":"16","author":"SJ Saint-Jean","year":"2005","unstructured":"Saint-Jean SJ, Camire CL, Nevsten P, Hansen S, Ginebra MP. Study of the reactivity and in vitro bioactivity of Sr-substituted \u03b1-TCP cements. J Mater Sci Mater Med. 2005;16:993\u20131001.","journal-title":"J Mater Sci Mater Med"},{"key":"4283_CR27","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/j.actbio.2009.10.014","volume":"6","author":"E Boanini","year":"2010","unstructured":"Boanini E, Panzavolta S, Rubini K, Gandolfi M, Bigi A. Effect of strontium and gelatin on the reactivity of \u03b1-tricalcium phosphate. Acta Biomater. 2010;6:936\u201342.","journal-title":"Acta Biomater"},{"key":"4283_CR28","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.actbio.2009.09.001","volume":"6","author":"S Pina","year":"2010","unstructured":"Pina S, Torres PM, Goetz-Neunhoeffer F, Neubauer J, Ferreira JMF. Newly developed Sr-substituted \u03b1-TCP bone cements. Acta Biomater. 2010;6:928\u201335.","journal-title":"Acta Biomater"},{"key":"4283_CR29","doi-asserted-by":"crossref","first-page":"3973","DOI":"10.1021\/cm070963y","volume":"19","author":"M Yashima","year":"2007","unstructured":"Yashima M, Kawaike Y. Crystal structure and site preference of Ba-doped \u03b1-Tricalcium phosphate (Ca1\u2212xBax)3(PO4)2 through High-Resolution Synchrotron Powder Diffraction (x\u00a0=\u00a00.05 to 0.15). Chem Mater. 2007;19:3973\u20139.","journal-title":"Chem Mater"},{"key":"4283_CR30","doi-asserted-by":"crossref","first-page":"3677","DOI":"10.1007\/s10853-005-0614-y","volume":"40","author":"E Fern\u00e1ndez","year":"2005","unstructured":"Fern\u00e1ndez E, Vlad MD, Hamcerencu M, Darie A, Torres R, L\u00f3pez J. Effect of iron on the setting properties of \u03b1-TCP bone cements. J Mater Sci. 2005;40:3677\u201382.","journal-title":"J Mater Sci"},{"key":"4283_CR31","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1016\/S0142-9612(01)00044-8","volume":"22","author":"FH Lin","year":"2001","unstructured":"Lin FH, Liao CJ, Chen KS, Sun JS, Lin CP. Petal-like apatite formed on the surface of tricalcium phosphate ceramic after soaking in distilled water. Biomaterials. 2001;22:2981\u201392.","journal-title":"Biomaterials"},{"key":"4283_CR32","doi-asserted-by":"crossref","first-page":"4155","DOI":"10.1016\/S0142-9612(02)00199-0","volume":"23","author":"X Yin","year":"2002","unstructured":"Yin X, Calderin L, Stott MJ, Sayer M. Density functional study of structural, electronic and vibrational properties of Mg- and Zn-doped tricalcium phosphate biomaterials. Biomaterials. 2002;23:4155\u201363.","journal-title":"Biomaterials"},{"key":"4283_CR33","doi-asserted-by":"crossref","first-page":"3379","DOI":"10.1016\/j.biomaterials.2004.09.017","volume":"26","author":"R Enderle","year":"2005","unstructured":"Enderle R, Gotz-Neunhoeffer F, Gobbels M, Muller FA, Greil P. Influence of magnesium doping on the phase transformation temperature of \u03b2-TCP ceramics examined by Rietveld refinement. Biomaterials. 2005;26:3379\u201384.","journal-title":"Biomaterials"},{"key":"4283_CR34","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s10856-009-3890-2","volume":"21","author":"S Pina","year":"2010","unstructured":"Pina S, Torres PMC, Ferreira JMF. Injectability of brushite-forming Mg-substituted and Sr-substituted \u03b1-TCP bone cements. J Mater Sci Mater Med. 2010;21:431\u20138.","journal-title":"J Mater Sci Mater Med"},{"key":"4283_CR35","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ceramint.2006.07.007","volume":"34","author":"S Kannan","year":"2008","unstructured":"Kannan S, Ventura JMG, Lemos AF, Barba A, Ferreira JMF. Effect of sodium addition on the preparation of hydroxyapatites and biphasic ceramics. Ceram Int. 2008;34:7\u201313.","journal-title":"Ceram Int"},{"key":"4283_CR36","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1016\/j.materresbull.2009.05.012","volume":"44","author":"N Matsumoto","year":"2009","unstructured":"Matsumoto N, Yoshida K, Hashimoto K, Toda Y. Thermal stability of \u03b2-tricalcium phosphate doped with monovalent metal ions. Mater Res Bull. 2009;44:1889\u201394.","journal-title":"Mater Res Bull"},{"key":"4283_CR37","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S0142-9612(96)00203-7","volume":"18","author":"L Yubao","year":"1997","unstructured":"Yubao L, Xingdong Z, de Groot K. Hydrolysis and phase transition of alpha-tricalcium phosphate. Biomaterials. 1997;18:737\u201341.","journal-title":"Biomaterials"},{"key":"4283_CR38","doi-asserted-by":"crossref","unstructured":"Welch JH, Gutt W. High-temperature studies of the system calcium oxide-phosphorus pentoxide. J Chem Soc. 1961:4442\u20134.","DOI":"10.1039\/JR9610004442"},{"key":"4283_CR39","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1021\/ic50051a007","volume":"6","author":"ER Kreidler","year":"1967","unstructured":"Kreidler ER, Hummel FA. Phase relationships in the system SrO-P2O5 and the influence of water vapor on the formation of Sr4P2O9. Inorg Chem. 1967;6:884\u201391.","journal-title":"Inorg Chem"},{"key":"4283_CR40","first-page":"363","volume-title":"Introduction to Ceramics","author":"WD Kingery","year":"1960","unstructured":"Kingery WD, Bowen HK, Uhlman DR. Introduction to Ceramics. 2nd ed. New York: Wiley; 1960. p. 363.","edition":"2"},{"key":"4283_CR41","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1007\/s10856-008-3395-4","volume":"19","author":"W Xue","year":"2008","unstructured":"Xue W, Dahlquist K, Banerjee A, Bandyopadhyay A, Bose S. Synthesis and characterization of tricalcium phosphate with Zn and Mg based dopants. J Mater Sci Mater Med. 2008;19:2669\u201377.","journal-title":"J Mater Sci Mater Med"},{"key":"4283_CR42","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/0022-4596(74)90030-9","volume":"10","author":"B Dickens","year":"1974","unstructured":"Dickens B, Schroeder LW, Brown WE. Crystallographic studies of the role of Mg as a stabilizing impurity in \u03b2-Ca3(PO4)2. The crystal structure of pure \u03b2-Ca3(PO4)2. J Solid State Chem. 1974;10:232\u201348.","journal-title":"J Solid State Chem"},{"key":"4283_CR43","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0022-4596(77)90002-0","volume":"22","author":"LW Schroeder","year":"1977","unstructured":"Schroeder LW, Dickens B, Brown WE. Crystallographic studies of the role of Mg as a stabilizing impurity in \u03b2-Ca3(PO4)2. II. Refinement of Mg-containing \u03b2-Ca3(PO4)2. J Solid State Chem. 1977;22:253\u201362.","journal-title":"J Solid State Chem"}],"container-title":["Journal of Materials Science: Materials in Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10856-011-4283-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10856-011-4283-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10856-011-4283-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,9]],"date-time":"2019-06-09T13:32:04Z","timestamp":1560087124000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10856-011-4283-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3,29]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["4283"],"URL":"https:\/\/doi.org\/10.1007\/s10856-011-4283-x","relation":{},"ISSN":["0957-4530","1573-4838"],"issn-type":[{"value":"0957-4530","type":"print"},{"value":"1573-4838","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,29]]}}}