{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T18:58:32Z","timestamp":1769626712245,"version":"3.49.0"},"reference-count":67,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T00:00:00Z","timestamp":1768867200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":8,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/http:\/\/dx.doi.org\/10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["#UIDB\/50006\/2020; DOI 10.54499\/UIDB\/50006\/2020; UIDB\/QUI\/00100\/2020(CQE\/IST"],"award-info":[{"award-number":["#UIDB\/50006\/2020; DOI 10.54499\/UIDB\/50006\/2020; UIDB\/QUI\/00100\/2020(CQE\/IST"]}],"id":[{"id":"10.13039\/http:\/\/dx.doi.org\/10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Mater Sci: Mater Med"],"DOI":"10.1007\/s10856-025-06924-0","type":"journal-article","created":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T16:35:52Z","timestamp":1768926952000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Calcium ionic replacement in sodium trimetaphosphate particles: a novel strategy for bone tissue engineering"],"prefix":"10.1007","volume":"37","author":[{"given":"Gabriel Pereira","family":"Nunes","sequence":"first","affiliation":[]},{"given":"Carla","family":"Ferreira-Baptista","sequence":"additional","affiliation":[]},{"given":"Alberto Carlos Botazzo","family":"Delbem","sequence":"additional","affiliation":[]},{"given":"Catarina","family":"Santos","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9391-9574","authenticated-orcid":false,"given":"Maria Helena","family":"Fernandes","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2026,1,20]]},"reference":[{"key":"6924_CR1","doi-asserted-by":"publisher","DOI":"10.5037\/jomr.2024.15202","volume":"15","author":"P Abayov","year":"2024","unstructured":"Abayov P, Sarikov R, Nazarenko LM, Babich O, Haimov E, Juodzbalys G. Outcome difference between short and longer dental implants placed simultaneously with alveolar bone augmentation: a systematic review and meta-analysis. J Oral Maxillofac Res. 2024;15:e2. https:\/\/doi.org\/10.5037\/jomr.2024.15202.","journal-title":"J Oral Maxillofac Res"},{"key":"6924_CR2","doi-asserted-by":"publisher","first-page":"4117","DOI":"10.3390\/ma16114117","volume":"16","author":"MP Ferraz","year":"2023","unstructured":"Ferraz MP. Bone grafts in dental medicine: an overview of autografts, allografts and synthetic materials. Materials. 2023;16:4117 https:\/\/doi.org\/10.3390\/ma16114117.","journal-title":"Materials"},{"key":"6924_CR3","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1097\/bot.0000000000001420","volume":"33","author":"P Baldwin","year":"2019","unstructured":"Baldwin P, Li DJ, Auston DA, Mir HS, Yoon RS, Koval KJ. Autograft, allograft, and bone graft substitutes: clinical evidence and indications for use in the setting of orthopaedic trauma surgery. J Orthop Trauma. 2019;33:203\u201313. https:\/\/doi.org\/10.1097\/bot.0000000000001420.","journal-title":"J Orthop Trauma"},{"key":"6924_CR4","doi-asserted-by":"publisher","first-page":"3836","DOI":"10.3390\/ijms25073836","volume":"25","author":"MP Ferraz","year":"2024","unstructured":"Ferraz MP. An overview on the big players in bone tissue engineering: biomaterials, scaffolds and cells. Int J Mol Sci. 2024;25:3836 https:\/\/doi.org\/10.3390\/ijms25073836.","journal-title":"Int J Mol Sci"},{"key":"6924_CR5","doi-asserted-by":"publisher","DOI":"10.1186\/s40824-019-0157-y","volume":"23","author":"H-S Sohn","year":"2019","unstructured":"Sohn H-S, Oh J-K. Review of bone graft and bone substitutes with an emphasis on fracture surgeries. Biomater Res. 2019;23:9. https:\/\/doi.org\/10.1186\/s40824-019-0157-y.","journal-title":"Biomater Res"},{"key":"6924_CR6","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1097\/SCS.0b013e318241dcba","volume":"23","author":"GF Rogers","year":"2012","unstructured":"Rogers GF, Greene AK. Autogenous bone graft: basic science and clinical implications. J Craniofac Surg. 2012;23:323\u20137. https:\/\/doi.org\/10.1097\/SCS.0b013e318241dcba.","journal-title":"J Craniofac Surg"},{"key":"6924_CR7","doi-asserted-by":"publisher","first-page":"2133","DOI":"10.1016\/s0140-6736(24)00757-8","volume":"403","author":"Collaborators","year":"2024","unstructured":"Collaborators. GDaI. Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021. Lancet. 2024;403:2133\u201361. https:\/\/doi.org\/10.1016\/s0140-6736(24)00757-8.","journal-title":"Lancet"},{"key":"6924_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2022.157330","volume":"848","author":"Q Wang","year":"2022","unstructured":"Wang Q, Wang X, Li R. Does population aging reduce environmental pressures from urbanization in 156 countries?. Sci Total Environ. 2022;848:157330. https:\/\/doi.org\/10.1016\/j.scitotenv.2022.157330.","journal-title":"Sci Total Environ"},{"key":"6924_CR9","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/1749-799x-9-18","volume":"9","author":"A Oryan","year":"2014","unstructured":"Oryan A, Alidadi S, Moshiri A, Maffulli N. Bone regenerative medicine: classic options, novel strategies, and future directions. J Orthop Surg Res. 2014;9:18 https:\/\/doi.org\/10.1186\/1749-799x-9-18.","journal-title":"J Orthop Surg Res"},{"key":"6924_CR10","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.msec.2015.05.027","volume":"55","author":"N Shadjou","year":"2015","unstructured":"Shadjou N, Hasanzadeh M. Bone tissue engineering using silica-based mesoporous nanobiomaterials: recent progress. Mater Sci Eng C Mater Biol Appl. 2015;55:401\u20139. https:\/\/doi.org\/10.1016\/j.msec.2015.05.027.","journal-title":"Mater Sci Eng C Mater Biol Appl"},{"key":"6924_CR11","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1016\/j.msec.2017.02.158","volume":"75","author":"Y Song","year":"2017","unstructured":"Song Y, Zhang C, Wang P, Wang L, Bao C, Weir MD, et al. Engineering bone regeneration with novel cell-laden hydrogel microfiber-injectable calcium phosphate scaffold. Mater Sci Eng C Mater Biol Appl. 2017;75:895\u2013905. https:\/\/doi.org\/10.1016\/j.msec.2017.02.158.","journal-title":"Mater Sci Eng C Mater Biol Appl"},{"key":"6924_CR12","doi-asserted-by":"publisher","first-page":"7442","DOI":"10.1039\/C6RA26124H","volume":"7","author":"A Haider","year":"2017","unstructured":"Haider A, Haider S, Han SS, Kang IKJRA. Recent advances in the synthesis, functionalization and biomedical applications of hydroxyapatite: a review. RSC Adv. 2017;7:7442\u201358. https:\/\/doi.org\/10.1039\/C6RA26124H.","journal-title":"RSC Adv"},{"key":"6924_CR13","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2022.1051678","volume":"10","author":"Kumari","year":"2022","unstructured":"Kumari, Katiyar S, Darshna S, Anand A, Singh D, Singh BN, et al. Design strategies for composite matrix and multifunctional polymeric scaffolds with enhanced bioactivity for bone tissue engineering. Front Chem. 2022;10:1051678. https:\/\/doi.org\/10.3389\/fchem.2022.1051678.","journal-title":"Front Chem"},{"key":"6924_CR14","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1007\/s10856-006-0432-z","volume":"17","author":"LL Hench","year":"2006","unstructured":"Hench LL. The story of Bioglass. J Mater Sci Mater Med. 2006;17:967\u201378. https:\/\/doi.org\/10.1007\/s10856-006-0432-z.","journal-title":"J Mater Sci Mater Med"},{"key":"6924_CR15","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1002\/jbm.820050611","volume":"5","author":"LL Hench","year":"1971","unstructured":"Hench LL, Splinter R, Allen WC, Greenlee. TKJJoBMR. Bonding mechanisms at the interface of ceramic prosthetic materials. J Biomed Mater Res Part A. 1971;5:117\u201341. https:\/\/doi.org\/10.1002\/jbm.820050611.","journal-title":"J Biomed Mater Res Part A"},{"key":"6924_CR16","doi-asserted-by":"publisher","first-page":"3822","DOI":"10.3390\/polym15183822","volume":"15","author":"O Mishchenko","year":"2023","unstructured":"Mishchenko O, Yanovska A, Kosinov O, Maksymov D, Moskalenko R, Ramanavicius A, et al. Synthetic calcium\u2013phosphate materials for bone grafting. Polymers. 2023;15:3822 https:\/\/doi.org\/10.3390\/polym15183822.","journal-title":"Polymers"},{"key":"6924_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2022.105508","volume":"142","author":"GP Nunes","year":"2022","unstructured":"Nunes GP, Danelon M, Pessan JP, Capalbo LC, Junior NAN, Matos AA, et al. Fluoride and trimetaphosphate association as a novel approach for remineralization and antiproteolytic activity in dentin tissue. Archives Oral Biol. 2022;142:105508. https:\/\/doi.org\/10.1016\/j.archoralbio.2022.105508.","journal-title":"Archives Oral Biol"},{"key":"6924_CR18","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1177\/0022034510385241","volume":"90","author":"L Gu","year":"2011","unstructured":"Gu L, Kim YK, Liu Y, Ryou H, Wimmer CE, Dai L, et al. Biomimetic analogs for collagen biomineralization. J Dent Res. 2011;90:82\u20137. https:\/\/doi.org\/10.1177\/0022034510385241.","journal-title":"J Dent Res"},{"key":"6924_CR19","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/j.dental.2011.01.008","volume":"27","author":"Y Liu","year":"2011","unstructured":"Liu Y, Li N, Qi Y, Niu LN, Elshafiy S, Mao J, et al. The use of sodium trimetaphosphate as a biomimetic analog of matrix phosphoproteins for remineralization of artificial caries-like dentin. Dent Mater. 2011;27:465\u201377. https:\/\/doi.org\/10.1016\/j.dental.2011.01.008.","journal-title":"Dent Mater"},{"key":"6924_CR20","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1002\/jbm.a.31397","volume":"85","author":"X Li","year":"2008","unstructured":"Li X, Chang J. Preparation of bone-like apatite-collagen nanocomposites by a biomimetic process with phosphorylated collagen. J Biomed Mater Res A. 2008;85:293\u2013300. https:\/\/doi.org\/10.1002\/jbm.a.31397.","journal-title":"J Biomed Mater Res A"},{"key":"6924_CR21","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1016\/j.jfoodeng.2006.04.009","volume":"79","author":"K Zhang","year":"2007","unstructured":"Zhang K, Li Y, Ren Y. Research on the phosphorylation of soy protein isolate with sodium tripoly phosphate. J Food Eng. 2007;79:1233\u20137. https:\/\/doi.org\/10.1016\/j.jfoodeng.2006.04.009.","journal-title":"J Food Eng"},{"key":"6924_CR22","doi-asserted-by":"publisher","first-page":"2899","DOI":"10.3390\/molecules26102899","volume":"26","author":"EP Milan","year":"2021","unstructured":"Milan EP, Rodrigues M\u00c1V, Martins VCA, Plepis AMG, Fuhrmann-Lieker T, Horn MM. Mineralization of phosphorylated fish skin collagen\/mangosteen scaffolds as potential materials for bone tissue regeneration. Molecules. 2021;26:2899 https:\/\/doi.org\/10.3390\/molecules26102899.","journal-title":"Molecules"},{"key":"6924_CR23","doi-asserted-by":"publisher","first-page":"3021","DOI":"10.1007\/s00784-018-2384-3","volume":"22","author":"CO Favretto","year":"2018","unstructured":"Favretto CO, Delbem ACB, Moraes JCS, Camargo ER, de Toledo PTA, Pedrini D. Dentinal tubule obliteration using toothpastes containing sodium trimetaphosphate microparticles or nanoparticles. Clin Oral Investig. 2018;22:3021\u20139. https:\/\/doi.org\/10.1007\/s00784-018-2384-3.","journal-title":"Clin Oral Investig"},{"key":"6924_CR24","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1016\/j.dental.2010.07.008","volume":"26","author":"LS Gu","year":"2010","unstructured":"Gu LS, Kim J, Kim YK, Liu Y, Dickens SH, Pashley DH, et al. A chemical phosphorylation-inspired design for Type I collagen biomimetic remineralization. Dent Mater. 2010;26:1077\u201389. https:\/\/doi.org\/10.1016\/j.dental.2010.07.008.","journal-title":"Dent Mater"},{"key":"6924_CR25","doi-asserted-by":"publisher","first-page":"3147","DOI":"10.1002\/jbm.b.34640","volume":"108","author":"MM Joglekar","year":"2020","unstructured":"Joglekar MM, Ghosh D, Anandan D, Yatham P, Jayant RD, Nambiraj NA, et al. Crosslinking of gum-based composite scaffolds for enhanced strength and stability: a comparative study between sodium trimetaphosphate and glutaraldehyde. J Biomed Mater Res B Appl Biomater. 2020;108:3147\u201354. https:\/\/doi.org\/10.1002\/jbm.b.34640.","journal-title":"J Biomed Mater Res B Appl Biomater"},{"key":"6924_CR26","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1007\/s10856-006-0698-1","volume":"18","author":"NB Th\u00e9baud","year":"2007","unstructured":"Th\u00e9baud NB, Pierron D, Bareille R, Le Visage C, Letourneur D, Bordenave L. Human endothelial progenitor cell attachment to polysaccharide-based hydrogels: a pre-requisite for vascular tissue engineering. J Mater Sci Mater Med. 2007;18:339\u201345. https:\/\/doi.org\/10.1007\/s10856-006-0698-1.","journal-title":"J Mater Sci Mater Med"},{"key":"6924_CR27","doi-asserted-by":"publisher","unstructured":"Nunes GP, Mor\u00e1bito MJSD, Ervolino E,Nagata MJH, Neto FNS, de Camargo ER, et al. In Vivo Assessment of Trimetaphosphate Nanocomposite-Based Polyamide-6 Scaffolds Enhanced With Silver Nanoparticles for Bone Regeneration. J Biomed Mater Res B Appl Biomater. 2025;113:e35623. https:\/\/doi.org\/10.1002\/jbm.b.35623.","DOI":"10.1002\/jbm.b.35623"},{"key":"6924_CR28","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1007\/5584_2018_249","volume":"1107","author":"C Millan","year":"2018","unstructured":"Millan C, Vivanco JF, Benjumeda-Wijnhoven IM, Bjelica S, Santibanez JF. Mesenchymal stem cells and calcium phosphate bioceramics: implications in periodontal bone regeneration. Adv Exp Med Biol. 2018;1107:91\u2013112. https:\/\/doi.org\/10.1007\/5584_2018_249.","journal-title":"Adv Exp Med Biol"},{"key":"6924_CR29","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.1007\/s10856-010-4011-y","volume":"21","author":"GY Jung","year":"2010","unstructured":"Jung GY, Park YJ, Han JS. Effects of HA released calcium ion on osteoblast differentiation. J Mater Sci Mater Med. 2010;21:1649\u201354. https:\/\/doi.org\/10.1007\/s10856-010-4011-y.","journal-title":"J Mater Sci Mater Med"},{"key":"6924_CR30","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1016\/s0142-9612(00)00261-1","volume":"22","author":"RM Pilliar","year":"2001","unstructured":"Pilliar RM, Filiaggi MJ, Wells JD, Grynpas MD, Kandel RA. Porous calcium polyphosphate scaffolds for bone substitute applications 8 in vitro characterization. Biomaterials. 2001;22:963\u201372. https:\/\/doi.org\/10.1016\/s0142-9612(00)00261-1.","journal-title":"Biomaterials"},{"key":"6924_CR31","doi-asserted-by":"publisher","first-page":"631","DOI":"10.2138\/rmg.2002.48.17","volume":"48","author":"KA Gross","year":"2002","unstructured":"Gross KA, Berndt CC. Biomedical application of apatites. Rev Mineral Geochem. 2002;48:631\u201372. https:\/\/doi.org\/10.2138\/rmg.2002.48.17.","journal-title":"Rev Mineral Geochem"},{"key":"6924_CR32","doi-asserted-by":"publisher","first-page":"5601","DOI":"10.1023\/A:1004412131566","volume":"33","author":"M Watanabe","year":"1998","unstructured":"Watanabe M, Yoshida K, Sakurai M, Sato S. Synthesis and thermal behaviour of alkaline earth cyclo-octaphosphates. J Mater Sci. 1998;33:5601\u20136. https:\/\/doi.org\/10.1023\/A:1004412131566.","journal-title":"J Mater Sci"},{"key":"6924_CR33","doi-asserted-by":"publisher","first-page":"2553","DOI":"10.1002\/jbm.b.34072","volume":"106","author":"JG Amaral","year":"2018","unstructured":"Amaral JG, Pessan JP, Souza JAS, Moraes JCS, Delbem ACB. Cyclotriphosphate associated to fluoride increases hydroxyapatite resistance to acid attack. J Biomed Mater Res B Appl Biomater. 2018;106:2553\u201364. https:\/\/doi.org\/10.1002\/jbm.b.34072.","journal-title":"J Biomed Mater Res B Appl Biomater"},{"key":"6924_CR34","doi-asserted-by":"publisher","unstructured":"Zhang Y, Shu T, Wang S, Liu Z, Cheng Y, Li A, et al. The osteoinductivity of calcium phosphate-based biomaterials: a tight interaction with bone healing. Front Bioeng Biotechnol. 2022;10. https:\/\/doi.org\/10.3389\/fbioe.2022.911180.","DOI":"10.3389\/fbioe.2022.911180"},{"key":"6924_CR35","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1302\/2046-3758.510.Bjr-2016-0133.R1","volume":"5","author":"DB Raina","year":"2016","unstructured":"Raina DB, Gupta A, Petersen MM, Hettwer W, McNally M, T\u00e4gil M, et al. Muscle as an osteoinductive niche for local bone formation with the use of a biphasic calcium sulphate\/hydroxyapatite biomaterial. Bone Jt Res. 2016;5:500\u201311. https:\/\/doi.org\/10.1302\/2046-3758.510.Bjr-2016-0133.R1.","journal-title":"Bone Jt Res"},{"key":"6924_CR36","doi-asserted-by":"publisher","first-page":"2855","DOI":"10.1002\/adfm.200701261","volume":"18","author":"M Chaouat","year":"2008","unstructured":"Chaouat M, Le Visage C, Baille WE, Escoubet B, Chaubet F, Mateescu MA, et al. A novel cross-linked poly(vinyl alcohol) (PVA) for vascular grafts. Advanced Funct Mater. 2008;18:2855\u201361. https:\/\/doi.org\/10.1002\/adfm.200701261.","journal-title":"Advanced Funct Mater"},{"key":"6924_CR37","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2024.105330","volume":"150","author":"GP Nunes","year":"2024","unstructured":"Nunes GP, Marques MT, de Toledo PTA, Alves RO, Martins TP, Delbem ACB. Effect of a novel low-concentration hydrogen peroxide bleaching gel containing nano-sized sodium trimetaphosphate and fluoride. J Dent. 2024;150:105330. https:\/\/doi.org\/10.1016\/j.jdent.2024.105330.","journal-title":"J Dent"},{"key":"6924_CR38","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.jdent.2017.10.013","volume":"68","author":"S Akabane","year":"2018","unstructured":"Akabane S, Delbem AC, Pessan J, Garcia L, Emerenciano N, Gon\u00e7alves DF, et al. In situ effect of the combination of fluoridated toothpaste and fluoridated gel containing sodium trimetaphosphate on enamel demineralization. J Dent. 2018;68:59\u201365. https:\/\/doi.org\/10.1016\/j.jdent.2017.10.013.","journal-title":"J Dent"},{"key":"6924_CR39","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1007\/s10856-018-6085-x","volume":"29","author":"S Lanouar","year":"2018","unstructured":"Lanouar S, Aid-Launais R, Oliveira A, Bidault L, Closs B, Labour M-N, et al. Effect of cross-linking on the physicochemical and in vitro properties of pullulan\/dextran microbeads. J Mater Sci Mater Med. 2018;29:77 https:\/\/doi.org\/10.1007\/s10856-018-6085-x.","journal-title":"J Mater Sci Mater Med"},{"key":"6924_CR40","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-30989-y","volume":"13","author":"LZ Feng","year":"2022","unstructured":"Feng LZ, Wang JJ, Ma T, Yin YC, Song KH, Li ZD, et al. Biomimetic non-classical crystallization drives hierarchical structuring of efficient circularly polarized phosphors. Nat Commun. 2022;13:3339. https:\/\/doi.org\/10.1038\/s41467-022-30989-y.","journal-title":"Nat Commun"},{"key":"6924_CR41","doi-asserted-by":"publisher","first-page":"3851","DOI":"10.1021\/ie201085b","volume":"51","author":"D Pham Minh","year":"2012","unstructured":"Pham Minh D, Ramaroson J, Nzihou A, Sharrock P. One-step synthesis of sodium trimetaphosphate (Na3P3O9) from sodium chloride and orthophosphoric acid. Ind Eng Chem Res. 2012;51:3851\u20134. https:\/\/doi.org\/10.1021\/ie201085b.","journal-title":"Ind Eng Chem Res"},{"key":"6924_CR42","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.tca.2009.01.014","volume":"487","author":"K Nahdi","year":"2009","unstructured":"Nahdi K, F\u00e9rid M, Ayadi MT. Chemical preparation and thermal behavior of neodymium cyclotriphosphate pentahydrate NdP3O9\u00b75H2O: a study by Controlled Rate Thermal Analysis (CRTA). Thermochim Acta. 2009;487:54\u20139. https:\/\/doi.org\/10.1016\/j.tca.2009.01.014.","journal-title":"Thermochim Acta"},{"key":"6924_CR43","unstructured":"Braz R, OA Cavalcanti. Extraction, structural modification and characterization of lotus roots polysaccharides (Nelumbo nucifera Gaertn). Excipient with potential application in modified drug delivery systems. Latin Am J Pharm. 2007;26:706\u201310."},{"key":"6924_CR44","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1016\/j.materresbull.2005.12.007","volume":"41","author":"A Jouini","year":"2006","unstructured":"Jouini A, F\u00e9rid M, G\u00e2con J-C, Grosvalet L, Thozet A, Trabelsi-Ayadi M. Crystal structure, vibrational spectra and optical properties of praseodymium cyclotriphosphate PrP3O9\u00b73H2O. Mater Res Bull. 2006;41:1370\u20137. https:\/\/doi.org\/10.1016\/j.materresbull.2005.12.007.","journal-title":"Mater Res Bull"},{"key":"6924_CR45","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1002\/jbm.a.30573","volume":"76","author":"BM Whited","year":"2006","unstructured":"Whited BM, Skrtic D, Love BJ, Goldstein AS. Osteoblast response to zirconia-hybridized pyrophosphate-stabilized amorphous calcium phosphate. J Biomed Mater Res A. 2006;76:596\u2013604. https:\/\/doi.org\/10.1002\/jbm.a.30573.","journal-title":"J Biomed Mater Res A"},{"key":"6924_CR46","doi-asserted-by":"publisher","DOI":"10.1186\/s12938-023-01067-1","volume":"22","author":"P Jin","year":"2023","unstructured":"Jin P, Liu L, Cheng L, Chen X, Xi S, Jiang T. Calcium-to-phosphorus releasing ratio affects osteoinductivity and osteoconductivity of calcium phosphate bioceramics in bone tissue engineering. Biomed Eng Online. 2023;22:12. https:\/\/doi.org\/10.1186\/s12938-023-01067-1.","journal-title":"Biomed Eng Online"},{"key":"6924_CR47","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1002\/term.376","volume":"5","author":"JR Popp","year":"2011","unstructured":"Popp JR, Laflin KE, Love BJ, Goldstein AS. In vitro evaluation of osteoblastic differentiation on amorphous calcium phosphate-decorated poly(lactic-co-glycolic acid) scaffolds. J Tissue Eng Regen Med. 2011;5:780\u20139. https:\/\/doi.org\/10.1002\/term.376.","journal-title":"J Tissue Eng Regen Med"},{"key":"6924_CR48","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1089\/ten.1998.4.293","volume":"4","author":"RO Oreffo","year":"1998","unstructured":"Oreffo RO, Driessens FC, Planell JA, Triffitt JT. Effects of novel calcium phosphate cements on human bone marrow fibroblastic cells. Tissue Eng. 1998;4:293\u2013303. https:\/\/doi.org\/10.1089\/ten.1998.4.293.","journal-title":"Tissue Eng"},{"key":"6924_CR49","doi-asserted-by":"publisher","first-page":"3307","DOI":"10.1016\/j.biomaterials.2009.02.044","volume":"30","author":"M Motskin","year":"2009","unstructured":"Motskin M, Wright DM, Muller K, Kyle N, Gard TG, Porter AE, et al. Hydroxyapatite nano and microparticles: correlation of particle properties with cytotoxicity and biostability. Biomaterials. 2009;30:3307\u201317. https:\/\/doi.org\/10.1016\/j.biomaterials.2009.02.044.","journal-title":"Biomaterials"},{"key":"6924_CR50","doi-asserted-by":"publisher","first-page":"5385","DOI":"10.1016\/j.biomaterials.2009.07.002","volume":"30","author":"JL Xu","year":"2009","unstructured":"Xu JL, Khor KA, Sui JJ, Zhang JH, Chen WN. Protein expression profiles in osteoblasts in response to differentially shaped hydroxyapatite nanoparticles. Biomaterials. 2009;30:5385\u201391. https:\/\/doi.org\/10.1016\/j.biomaterials.2009.07.002.","journal-title":"Biomaterials"},{"key":"6924_CR51","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1242\/jcs.115.3.599","volume":"115","author":"KA Christensen","year":"2002","unstructured":"Christensen KA, Myers JT, Swanson JA. pH-dependent regulation of lysosomal calcium in macrophages. J Cell Sci. 2002;115:599\u2013607. https:\/\/doi.org\/10.1242\/jcs.115.3.599.","journal-title":"J Cell Sci"},{"key":"6924_CR52","doi-asserted-by":"publisher","first-page":"350","DOI":"10.3390\/jfb14070350","volume":"14","author":"PTA Toledo","year":"2023","unstructured":"Toledo PTA, Anselmi C, Dal-Fabbro R, Mahmoud AH, Abel AK, Becker ML, et al. Calcium trimetaphosphate-loaded electrospun poly(Ester Urea) nanofibers for periodontal tissue engineering. J Funct Biomater. 2023;14:350 https:\/\/doi.org\/10.3390\/jfb14070350.","journal-title":"J Funct Biomater"},{"key":"6924_CR53","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.126524","volume":"252","author":"GF Sekar Jeyakumar","year":"2023","unstructured":"Sekar Jeyakumar GF, Velswamy P, Gunasekaran D, Panneerselvam Manimegalai N, Manikantan Syamala K, Tiruchirappalli Sivagnanam U. Enhancing the effectiveness of Alkaline Phosphatase and bone matrix proteins by tunable metal-organic composite for accelerated mineralization. Int J Biol Macromol. 2023;252:126524. https:\/\/doi.org\/10.1016\/j.ijbiomac.2023.126524.","journal-title":"Int J Biol Macromol"},{"key":"6924_CR54","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/421746","volume":"2015","author":"R Florencio-Silva","year":"2015","unstructured":"Florencio-Silva R, Sasso GR, Sasso-Cerri E, Sim\u00f5es MJ, Cerri PS. Biology of bone tissue: structure, function, and factors that influence bone cells. Biomed Res Int. 2015;2015:421746. https:\/\/doi.org\/10.1155\/2015\/421746.","journal-title":"Biomed Res Int"},{"key":"6924_CR55","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1089\/ten.TEB.2016.0454","volume":"23","author":"HC Blair","year":"2017","unstructured":"Blair HC, Larrouture QC, Li Y, Lin H, Beer-Stoltz D, Liu L, et al. Osteoblast differentiation and bone matrix formation in vivo and in vitro. Tissue Eng Part B Rev. 2017;23:268\u201380. https:\/\/doi.org\/10.1089\/ten.TEB.2016.0454.","journal-title":"Tissue Eng Part B Rev"},{"key":"6924_CR56","doi-asserted-by":"publisher","unstructured":"Komori T Bone development by Hedgehog and Wnt signaling, Runx2, and Sp7. J Bone Miner Metab. 2024. https:\/\/doi.org\/10.1007\/s00774-024-01551-1.","DOI":"10.1007\/s00774-024-01551-1"},{"key":"6924_CR57","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2024.1450328","volume":"15","author":"Y Hao","year":"2024","unstructured":"Hao Y, Yang N, Sun M, Yang S, Chen X. The role of calcium channels in osteoporosis and their therapeutic potential. Front Endocrinol. 2024;15:1450328. https:\/\/doi.org\/10.3389\/fendo.2024.1450328.","journal-title":"Front Endocrinol"},{"key":"6924_CR58","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1152\/physrev.2001.81.1.239","volume":"81","author":"EM Brown","year":"2001","unstructured":"Brown EM, MacLeod RJ. Extracellular calcium sensing and extracellular calcium signaling. Physiol Rev. 2001;81:239\u201397. https:\/\/doi.org\/10.1152\/physrev.2001.81.1.239.","journal-title":"Physiol Rev"},{"key":"6924_CR59","doi-asserted-by":"publisher","first-page":"1684","DOI":"10.1126\/science.1063187","volume":"294","author":"JD Hartgerink","year":"2001","unstructured":"Hartgerink JD, Beniash E, Stupp SI. Self-assembly and mineralization of peptide-amphiphile nanofibers. Science. 2001;294:1684\u20138. https:\/\/doi.org\/10.1126\/science.1063187.","journal-title":"Science"},{"key":"6924_CR60","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.actbio.2020.07.038","volume":"120","author":"YX Ma","year":"2021","unstructured":"Ma YX, Hoff SE, Huang XQ, Liu J, Wan QQ, Song Q, et al. Involvement of prenucleation clusters in calcium phosphate mineralization of collagen. Acta Biomater. 2021;120:213\u201323. https:\/\/doi.org\/10.1016\/j.actbio.2020.07.038.","journal-title":"Acta Biomater"},{"key":"6924_CR61","doi-asserted-by":"publisher","first-page":"2403","DOI":"10.1002\/jbm.a.36747","volume":"107","author":"T Du","year":"2019","unstructured":"Du T, Niu X, Hou S, Li Z, Li P, Fan Y. Apatite minerals derived from collagen phosphorylation modification induce the hierarchical intrafibrillar mineralization of collagen fibers. J Biomed Mater Res A. 2019;107:2403\u201313. https:\/\/doi.org\/10.1002\/jbm.a.36747.","journal-title":"J Biomed Mater Res A"},{"key":"6924_CR62","doi-asserted-by":"publisher","first-page":"7049","DOI":"10.1074\/jbc.M412680200","volume":"280","author":"M Zayzafoon","year":"2005","unstructured":"Zayzafoon M, Fulzele K, McDonald JM. Calmodulin and calmodulin-dependent kinase IIalpha regulate osteoblast differentiation by controlling c-fos expression. J Biol Chem. 2005;280:7049\u201359. https:\/\/doi.org\/10.1074\/jbc.M412680200.","journal-title":"J Biol Chem"},{"key":"6924_CR63","doi-asserted-by":"publisher","first-page":"3205","DOI":"10.1016\/j.biomaterials.2012.01.020","volume":"33","author":"AM Barradas","year":"2012","unstructured":"Barradas AM, Fernandes HA, Groen N, Chai YC, Schrooten J, van de Peppel J, et al. A calcium-induced signaling cascade leading to osteogenic differentiation of human bone marrow-derived mesenchymal stromal cells. Biomaterials. 2012;33:3205\u201315. https:\/\/doi.org\/10.1016\/j.biomaterials.2012.01.020.","journal-title":"Biomaterials"},{"key":"6924_CR64","doi-asserted-by":"publisher","first-page":"41921","DOI":"10.1074\/jbc.M304470200","volume":"278","author":"GR Beck Jr","year":"2003","unstructured":"Beck GR Jr, Knecht N. Osteopontin regulation by inorganic phosphate is ERK1\/2-, protein kinase C-, and proteasome-dependent. J Biol Chem. 2003;278:41921\u20139. https:\/\/doi.org\/10.1074\/jbc.M304470200.","journal-title":"J Biol Chem"},{"key":"6924_CR65","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1038\/s41536-021-00178-4","volume":"6","author":"Y Huang","year":"2021","unstructured":"Huang Y, Wang X, Zhou D, Zhou W, Dai F, Lin H. Macrophages in heterotopic ossification: from mechanisms to therapy. NPJ Regen Med. 2021;6:70 https:\/\/doi.org\/10.1038\/s41536-021-00178-4.","journal-title":"NPJ Regen Med"},{"key":"6924_CR66","doi-asserted-by":"publisher","first-page":"2006","DOI":"10.1007\/s10439-021-02810-2","volume":"49","author":"KE Mosaad","year":"2021","unstructured":"Mosaad KE, Shoueir KR, Saied AH, Dewidar MM. New prospects in nano phased co-substituted hydroxyapatite enrolled in polymeric nanofiber mats for bone tissue engineering applications. Ann Biomed Eng. 2021;49:2006\u201329. https:\/\/doi.org\/10.1007\/s10439-021-02810-2.","journal-title":"Ann Biomed Eng"},{"key":"6924_CR67","doi-asserted-by":"publisher","unstructured":"Pr\u00f6hl A, Batinic M, Alkildani S, Hahn M, Radenkovic M, Najman S, et al. In vivo analysis of the biocompatibility and bone healing capacity of a novel bone grafting material combined with hyaluronic acid. Int J Mol Sci. 2021;22. https:\/\/doi.org\/10.3390\/ijms22094818.","DOI":"10.3390\/ijms22094818"}],"container-title":["Journal of Materials Science: Materials in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10856-025-06924-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10856-025-06924-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10856-025-06924-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T07:24:32Z","timestamp":1769585072000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10856-025-06924-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,20]]},"references-count":67,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["6924"],"URL":"https:\/\/doi.org\/10.1007\/s10856-025-06924-0","relation":{},"ISSN":["1573-4838"],"issn-type":[{"value":"1573-4838","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,20]]},"assertion":[{"value":"26 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"26"}}