{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T06:21:07Z","timestamp":1769062867812,"version":"3.49.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2012,12,29]],"date-time":"2012-12-29T00:00:00Z","timestamp":1356739200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Bioenerg Biomembr"],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.1007\/s10863-012-9497-1","type":"journal-article","created":{"date-parts":[[2012,12,28]],"date-time":"2012-12-28T10:04:18Z","timestamp":1356689058000},"page":"261-270","source":"Crossref","is-referenced-by-count":28,"title":["Mechanism of inhibition of mitochondrial ATP synthase by 17\u03b2\u2212Estradiol"],"prefix":"10.1007","volume":"45","author":[{"given":"Ant\u00f3nio J. M.","family":"Moreno","sequence":"first","affiliation":[]},{"given":"Paula I.","family":"Moreira","sequence":"additional","affiliation":[]},{"given":"Jos\u00e9 B. A.","family":"Cust\u00f3dio","sequence":"additional","affiliation":[]},{"given":"Maria S.","family":"Santos","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2012,12,29]]},"reference":[{"key":"9497_CR1","first-page":"1022","volume":"295","author":"RM Abreu","year":"2000","unstructured":"Abreu RM, Santos DL, Moreno AJM (2000) Effects of carvedilol and its analog BM-910228 on mitochondrial function and oxidative stress. J Pharmacol Exp Ther 295:1022\u20131030","journal-title":"J Pharmacol Exp Ther"},{"key":"9497_CR2","doi-asserted-by":"crossref","first-page":"3290","DOI":"10.1016\/S0021-9258(18)93127-3","volume":"244","author":"RA Alberty","year":"1969","unstructured":"Alberty RA (1969) J Biol Chem 244:3290\u20133302","journal-title":"J Biol Chem"},{"key":"9497_CR3","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.exger.2010.01.015","volume":"45","author":"C \u00c1lvarez-Delgado","year":"2010","unstructured":"\u00c1lvarez-Delgado C, Mendoza-Rodr\u00edguez A, Picazo O, Cerb\u00f3n M (2010) Different expression of alpha and beta mitochondrial estrogen receptors in the aging rat brain: interaction with respiratory complex V. Exp Gerontol 45:580\u2013585","journal-title":"Exp Gerontol"},{"key":"9497_CR4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1471-4159.2009.06133.x","volume":"110","author":"S Arnold","year":"2009","unstructured":"Arnold S, Beyer C (2009) J Neurochem 110:1\u201310","journal-title":"J Neurochem"},{"key":"9497_CR5","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0014-5793(70)80139-9","volume":"7","author":"A Azzi","year":"1970","unstructured":"Azzi A, Santato M (1970) Energy dependent interaction of oligomycin and dicyclo hexylcarbodiimide with the mitochondrial membrane. FEBS Lett 7:135\u2013138","journal-title":"FEBS Lett"},{"key":"9497_CR6","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.bbadis.2009.09.007","volume":"1802","author":"C Borr\u00e1s","year":"2010","unstructured":"Borr\u00e1s C, Gambini J, L\u00f3pez-Grueso R, Pallard\u00f3 F, Vina J (2010) Biochim Biophys Acta 1802:205\u2013211","journal-title":"Biochim Biophys Acta"},{"key":"9497_CR7","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0014-2999(02)01490-5","volume":"441","author":"N Bouaziz","year":"2002","unstructured":"Bouaziz N, Redon M, Quere L, Remacle J, Michiels C (2002) ATP-synthase of Rhodobacter capsulatus: coupling of proton flow through F0 to reactions in F1 under the ATP synthesis and slip conditions. Eur J Pharmacol 441:35\u201345","journal-title":"Eur J Pharmacol"},{"key":"9497_CR8","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1146\/annurev.biochem.66.1.717","volume":"66","author":"PD Boyer","year":"1997","unstructured":"Boyer PD (1997) The ATP synthase \u2013 a splendid molecular machine. Ann Rev Biochem 66:717\u2013749","journal-title":"Ann Rev Biochem"},{"key":"9497_CR9","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.exer.2003.09.027","volume":"78","author":"PR Cammarata","year":"2004","unstructured":"Cammarata PR, Chu S, Moor A, Wang Z, Yang SH, Simpkins JW (2004) Subcellular distribution of native estrogen receptor alpha and beta subtypes in cultured human lens epithelial cells. Exp Eye Res 78:861\u2013871","journal-title":"Exp Eye Res"},{"key":"9497_CR10","first-page":"65","volume":"17","author":"B Chance","year":"1956","unstructured":"Chance B, Williams GR (1956) The respiratory chain and oxidative phosphorylation. Adv Enzymol 17:65\u2013134","journal-title":"Adv Enzymol"},{"key":"9497_CR11","doi-asserted-by":"crossref","first-page":"E1011","DOI":"10.1152\/ajpendo.00508.2003","volume":"286","author":"JQ Chen","year":"2004","unstructured":"Chen JQ, Delannoy M, Cooke C, Yager JD (2004) Mitochondrial localization of ERalpha and ERbeta in human MCF7 cells. Am J Physiol Endocrinol Metab 286:E1011\u2013E1022","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"9497_CR12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1477-3163-4-1","volume":"4","author":"Q Felty","year":"2005","unstructured":"Felty Q, Roy D (2005) Estrogen, mitochondria, and growth of cancer and non-cancer cells. J Carcinog 4:1\u201318","journal-title":"J Carcinog"},{"key":"9497_CR13","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0014-5793(99)00160-X","volume":"445","author":"BA Feniouk","year":"1999","unstructured":"Feniouk BA, Cherepanov DA, Junge W, Mulkidjanian AY (1999) ATP-synthase of Rhodobacter capsulatus: coupling of proton flow through F0 to reactions in F1 under the ATP synthesis and slip conditions. FEBS Lett 445:409\u2013414","journal-title":"FEBS Lett"},{"key":"9497_CR14","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.bbabio.2004.10.010","volume":"1706","author":"BA Feniouk","year":"2005","unstructured":"Feniouk BA, Mulkidjanian AY, Junge W (2005) Proton slip in the ATP synthase of Rhodobacter capsulatus: induction, proton conduction, and nucleotide dependence. Biochim Biophys Acta 1706:184\u2013194","journal-title":"Biochim Biophys Acta"},{"key":"9497_CR15","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1007\/978-3-642-67530-0_6","volume-title":"Membrane biochemistry. A laboratory manual on transport and bioenergetics","author":"P Gazotti","year":"1979","unstructured":"Gazotti P, Malmstron K, Crompton M (1979) In: Carafoli E, Semenza G (eds) Membrane biochemistry. A laboratory manual on transport and bioenergetics. Springer-Verlag New York. Inc, New York, pp 62\u201369"},{"key":"9497_CR16","doi-asserted-by":"crossref","first-page":"13632","DOI":"10.1073\/pnas.0706290104","volume":"104","author":"JR Gledhill","year":"2007","unstructured":"Gledhill JR, Montgomery MG, Leslie AGW, Walker JE (2007) Proc Natl Acad Sci USA 104:13632\u201313637","journal-title":"Proc Natl Acad Sci USA"},{"key":"9497_CR17","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/S0021-9258(18)57021-6","volume":"177","author":"AG Gornall","year":"1949","unstructured":"Gornall AG, Bardawill NCJ, David MM (1949) Determination of serum proteins by means of the biuret reaction. J Biol Chem 177:751\u2013766","journal-title":"J Biol Chem"},{"key":"9497_CR18","doi-asserted-by":"crossref","first-page":"3167","DOI":"10.1210\/en.2007-1227","volume":"149","author":"RW Irwin","year":"2008","unstructured":"Irwin RW, Yao J, Hamilton RT, Cadenas E, Brinton RD, Nielson J (2008) Endocrinology 149:3167\u20133175","journal-title":"Endocrinology"},{"key":"9497_CR19","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/nature02212","volume":"427","author":"H Itoh","year":"2004","unstructured":"Itoh H, Takahashi A, Adachi K, Noji H, Yasuda R, Yoshida M, Kinosita K (2004) Mechanically driven ATP synthesis by F1-ATPase. Nature 427:465\u2013468","journal-title":"Nature"},{"key":"9497_CR20","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/BF01868720","volume":"49","author":"N Kamo","year":"1979","unstructured":"Kamo N, Muratsugu M, Hongoh R, Kobatake V (1979) Membrane potential of mitochondria measured with an electrode sensitive to tetraphenyl phosphonium and relationship between proton electrochemical potential and phosphorylation potential in steady state. J Membr Biol 49:105\u2013121","journal-title":"J Membr Biol"},{"key":"9497_CR21","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1385\/ENDO:15:2:165","volume":"15","author":"JL Kipp","year":"2001","unstructured":"Kipp JL, Ramirez VD (2001) Effect of estradiol, diethylstilbestrol, and resveratrol on F0F1-ATPase activity from mitochondrial preparations of rat heart, liver, and brain. Endocrine 15:165\u2013175","journal-title":"Endocrine"},{"key":"9497_CR22","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1152\/jappl.2001.91.4.1860","volume":"91","author":"ER Levin","year":"2001","unstructured":"Levin ER (2001) Cell localization, physiology, and nongenomic actions of estrogen receptors. J Appl Physiol 91:1860\u20131867","journal-title":"J Appl Physiol"},{"key":"9497_CR23","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/nrm1009","volume":"4","author":"R Losel","year":"2003","unstructured":"Losel R, Wehling M (2003) Nongenomic actions of steroid hormones. Nat Rev Mol Cell Biol 4:46\u201356","journal-title":"Nat Rev Mol Cell Biol"},{"key":"9497_CR24","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/0005-2728(84)90087-2","volume":"767","author":"A Masini","year":"1984","unstructured":"Masini A, Ceccarelli-Stanzani D, Muscatello U (1984) An investigation on the effect of oligomycin on state-4 respiration in isolated rat-liver mitochondria. Biochim Biophys Acta 767:130\u2013137","journal-title":"Biochim Biophys Acta"},{"key":"9497_CR25","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1080\/gye.16.5.373.377","volume":"16","author":"F Massart","year":"2002","unstructured":"Massart F, Paolini S, Piscitelli E, Brandi ML, Solaini G (2002) Dose-dependent inhibition of mitochondrial ATP synthase by 17 beta-estradiol. Gynecol Endocrinol 16:373\u2013377","journal-title":"Gynecol Endocrinol"},{"key":"9497_CR26","doi-asserted-by":"crossref","first-page":"3817","DOI":"10.1097\/00001756-199712010-00031","volume":"8","author":"MP Mattson","year":"1997","unstructured":"Mattson MP, Robison N, Guo Q (1997) Estrogens stabilize mitochondrial function and protect neural cells against the pro-apoptotic action of mutant presenilin-1. Neuroreport 8:3817\u20133821","journal-title":"Neuroreport"},{"key":"9497_CR27","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1095\/biolreprod58.2.531","volume":"58","author":"RK Moats","year":"1998","unstructured":"Moats RK, Ramirez VD (1998) Rapid uptake and binding of estradiol-17beta-6-(O-carboxymethyl)oxime:125I-labeled BSA by female rat liver. Biol Reprod 58:531\u2013538","journal-title":"Biol Reprod"},{"key":"9497_CR28","doi-asserted-by":"crossref","first-page":"10143","DOI":"10.1074\/jbc.M510249200","volume":"281","author":"PI Moreira","year":"2006","unstructured":"Moreira PI, Cust\u00f3dio J, Moreno AJ, Oliveira CR, Santos MS (2006) Tamoxifen and estradiol interact with the flavin mononucleotide site of complex I leading to mitochondrial failure. J Biol Chem 281:10143\u201310152","journal-title":"J Biol Chem"},{"key":"9497_CR29","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jsbmb.2010.09.004","volume":"123","author":"PI Moreira","year":"2011","unstructured":"Moreira PI, Cust\u00f3dio JBA, Nunes E, Oliveira PJ, Moreno A, Sei\u00e7a R, Oliveira CR, Santos MS (2011) Mitochondria from distinct tissues are differently affected by 17\u03b2-estradiol and tamoxifen. J Steroid Biochem Mol Biol 123:8\u201316","journal-title":"J Steroid Biochem Mol Biol"},{"key":"9497_CR30","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/S0005-2728(09)91004-0","volume":"1060","author":"AJ Moreno","year":"1991","unstructured":"Moreno AJ, Madeira VM (1991) Mitochondrial bioenergetics as affected by DDT. Biochim Biophys Acta 1060:166\u2013174","journal-title":"Biochim Biophys Acta"},{"key":"9497_CR31","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/0005-2736(77)90035-9","volume":"464","author":"M Muratsugu","year":"1977","unstructured":"Muratsugu M, Kamo N, Kurihara K, Kobatake Y (1977) Selective electrode for dibenzyl dimethyl ammonium cation as indicator of the membrane potential in biological systems. Biochim Biophys Acta 464:613\u2013619","journal-title":"Biochim Biophys Acta"},{"key":"9497_CR32","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/j.steroids.2011.04.009","volume":"76","author":"A Nadal-Caselhas","year":"2011","unstructured":"Nadal-Caselhas A, Proenza AM, Llad\u00f3 I, Gianotti M (2011) Steroids 76:1051\u20131056","journal-title":"Steroids"},{"key":"9497_CR33","doi-asserted-by":"crossref","first-page":"297","DOI":"10.2174\/1568007043337193","volume":"3","author":"J Nilsen","year":"2004","unstructured":"Nilsen J, Brinton RD (2004) Mitochondria as therapeutic targets of estrogen action in the central nervous system. Curr Drugs Targets CNS Neurol Disord 3:297\u2013313","journal-title":"Curr Drugs Targets CNS Neurol Disord"},{"key":"9497_CR34","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2202-7-74","volume":"7","author":"J Nilsen","year":"2006","unstructured":"Nilsen J, Chen S, Irwin RW, Iwamoto S, Brinton RD (2006) Estrogen protects neuronal cells from amyloid beta-induced apoptosis via regulation of mitochondrial proteins and function. BMC Neurosci 7:7\u201374","journal-title":"BMC Neurosci"},{"key":"9497_CR35","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0006-3002(62)90709-6","volume":"59","author":"M Nishimura","year":"1962","unstructured":"Nishimura M, Ito B, Chance B (1962) Studies on bacterial photophosphorylation. III. A sensitive and rapid method of determination of photophosphorylation. Biochim Biophys Acta 59:177\u2013182","journal-title":"Biochim Biophys Acta"},{"key":"9497_CR36","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1091\/mbc.E05-11-1013","volume":"17","author":"A Pedram","year":"2006","unstructured":"Pedram A, Razandi M, Wallace DC, Levin ER (2006) Mol Biol Cell 17:2125\u20132137","journal-title":"Mol Biol Cell"},{"key":"9497_CR37","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1196\/annals.1342.032","volume":"1048","author":"S Petrovic","year":"2005","unstructured":"Petrovic S, Demajo M, Horvat A (2005) Estradiol affects calcium transport across mitochondrial membrane in different brain regions. Ann N Y Acad Sci 1048:341\u2013343","journal-title":"Ann N Y Acad Sci"},{"key":"9497_CR38","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.neuroscience.2011.06.030","volume":"192","author":"S Petrovic","year":"2011","unstructured":"Petrovic S, Velickovic N, Stanojevic I, Milosevic M, Drakulic D, Stanojlovic M, Horvat A (2011) Inhibition of mitochondrial Na+-dependent Ca2+ efflux by 17\u03b2-estradiol in the rat hippocampus. Neuroscience 192:195\u2013204","journal-title":"Neuroscience"},{"key":"9497_CR39","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1126\/science.283.5407.1488","volume":"283","author":"M Saraste","year":"1999","unstructured":"Saraste M (1999) Oxidative phosphorylation at the fin de si\u00e8cle. Science 283:1488\u20131493","journal-title":"Science"},{"key":"9497_CR40","first-page":"1179","volume":"19","author":"M Singh","year":"1999","unstructured":"Singh M, S\u00e9t\u00e1l\u00f3 G Jr, Guan X, Warren M, Toran-Allerand CD (1999) Estrogen-induced activation of mitogen-activated protein kinase in cerebral cortical explants: convergence of estrogen and neurotrophin signaling pathways. J Neurochem 19:1179\u20131188","journal-title":"J Neurochem"},{"key":"9497_CR41","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/0005-2728(69)90103-0","volume":"172","author":"CS Tsou","year":"1969","unstructured":"Tsou CS, van Dam K (1969) Biochim Biophys Acta 172:174\u2013176","journal-title":"Biochim Biophys Acta"},{"key":"9497_CR42","doi-asserted-by":"crossref","first-page":"11126","DOI":"10.1021\/bi048975+","volume":"43","author":"P Turina","year":"2004","unstructured":"Turina P, Giovannini F, Gubellini BA, Melandri BA (2004) Physiological ligands ADP and Pi modulate the degree of intrinsic coupling in the ATP synthase of the photosynthetic bacterium Rhodobacter capsulatus. Biochemistry 43:11126\u201311134","journal-title":"Biochemistry"},{"key":"9497_CR43","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.bbabio.2006.04.018","volume":"1757","author":"P Turina","year":"2006","unstructured":"Turina P, Rebecchi A, D\u2019Alessandro M, Anefors S, Melandri BA (2006) Modulation of proton pumping efficiency in bacterial ATP synthases. Biochim Biophys Acta 1757:320\u2013325","journal-title":"Biochim Biophys Acta"},{"key":"9497_CR44","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.bbabio.2006.01.001","volume":"1757","author":"JE Walker","year":"2006","unstructured":"Walker JE, Dickson VK (2006) The peripheral stalk of the mitochondrial ATP synthase. Biochim Biophys Acta 1757:286\u2013296","journal-title":"Biochim Biophys Acta"},{"key":"9497_CR45","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1046\/j.1471-4159.2001.00271.x","volume":"77","author":"J Wang","year":"2001","unstructured":"Wang J, Green PS, Simpkins JW (2001) Estradiol protects against ATP depletion, mitochondrial membrane potential decline and the generation of reactive oxygen species induced by 3-nitroproprionic acid in SK-N-SH human neuroblastoma cells. J Neurochem 77:804\u2013811","journal-title":"J Neurochem"},{"key":"9497_CR46","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.tibs.2006.12.006","volume":"32","author":"J Weber","year":"2007","unstructured":"Weber J (2007) ATP synthase\u2014the structure of the stator stalk. Trends Biochem Sci 32:53\u201356","journal-title":"Trends Biochem Sci"},{"key":"9497_CR47","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/B978-0-12-394816-8.00010-6","volume":"64","author":"J Yao","year":"2012","unstructured":"Yao J, Brinton RD (2012) Estrogen regulation of mitochondrial bioenergetics: implications for prevention of Alzheimer\u2019s Disease. Adv Pharmacol 64:327\u2013371","journal-title":"Adv Pharmacol"},{"key":"9497_CR48","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0014-2999(99)00012-6","volume":"368","author":"J Zheng","year":"1999","unstructured":"Zheng J, Ramirez VD (1999a) Rapid inhibition of rat brain mitochondrial proton F0F1-ATPase activity by estrogens: comparison with Na+, K+ -ATPase of porcine cortex. Eur J Pharmacol 368:95\u2013102","journal-title":"Eur J Pharmacol"},{"key":"9497_CR49","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1006\/bbrc.1999.1063","volume":"261","author":"J Zheng","year":"1999","unstructured":"Zheng J, Ramirez VD (1999b) Piceatannol, a stilbene phytochemical, inhibits mitochondrial F0F1-ATPase activity by targeting the F1 complex. Biochem Biophys Res Commun 261:499\u2013503","journal-title":"Biochem Biophys Res Commun"},{"key":"9497_CR50","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0960-0760(98)00161-7","volume":"68","author":"J Zheng","year":"1999","unstructured":"Zheng J, Ramirez VD (1999c) Purification and identification of an estrogen binding protein from rat brain: oligomycin sensitivity-conferring protein (OSCP), a subunit of mitochondrial F0F1-ATP synthase\/ATPase. J Steroid Biochem Mol Biol 68:65\u201375","journal-title":"J Steroid Biochem Mol Biol"},{"key":"9497_CR51","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1038\/sj.bjp.0703397","volume":"130","author":"J Zheng","year":"2000","unstructured":"Zheng J, Ramirez VD (2000) Br J Pharmacol 130:1115\u20131123","journal-title":"Br J Pharmacol"}],"container-title":["Journal of Bioenergetics and Biomembranes"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10863-012-9497-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10863-012-9497-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10863-012-9497-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,4]],"date-time":"2022-02-04T19:42:55Z","timestamp":1644003775000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10863-012-9497-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,29]]},"references-count":51,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["9497"],"URL":"https:\/\/doi.org\/10.1007\/s10863-012-9497-1","relation":{},"ISSN":["0145-479X","1573-6881"],"issn-type":[{"value":"0145-479X","type":"print"},{"value":"1573-6881","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,29]]}}}