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This paper aims to advance future research, including systematic reviews and randomized controlled trials (RCTs), on CPLBP management. We provide methodological and reporting recommendations derived from our conducted systematic reviews, offering practical guidance for conducting robust research on the effectiveness of rehabilitation interventions for CPLBP. Our systematic reviews contributed to the development of a WHO clinical guideline for CPLBP. Based on our experience, we have identified methodological issues and recommendations, which are compiled in a comprehensive table and discussed systematically within established frameworks for reporting and critically appraising RCTs. In conclusion, embracing the complexity of CPLBP involves recognizing its multifactorial nature and diverse contexts and planning for varying treatment responses. By embracing this complexity and emphasizing methodological rigor, research in the field can be improved, potentially leading to better care and outcomes for individuals with CPLBP.<\/jats:p>","DOI":"10.1007\/s10926-023-10140-4","type":"journal-article","created":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T14:05:47Z","timestamp":1700661947000},"page":"673-686","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Improving Rehabilitation Research to Optimize Care and Outcomes for People with Chronic Primary Low Back Pain: Methodological and Reporting Recommendations from a WHO Systematic Review Series"],"prefix":"10.1007","volume":"33","author":[{"given":"Carol","family":"Cancelliere","sequence":"first","affiliation":[]},{"given":"Hainan","family":"Yu","sequence":"additional","affiliation":[]},{"given":"Danielle","family":"Southerst","sequence":"additional","affiliation":[]},{"given":"Gaelan","family":"Connell","sequence":"additional","affiliation":[]},{"given":"Leslie","family":"Verville","sequence":"additional","affiliation":[]},{"given":"Andr\u00e9","family":"Bussi\u00e8res","sequence":"additional","affiliation":[]},{"given":"Douglas P.","family":"Gross","sequence":"additional","affiliation":[]},{"given":"Paulo","family":"Pereira","sequence":"additional","affiliation":[]},{"given":"Silvano","family":"Mior","sequence":"additional","affiliation":[]},{"given":"Andrea C.","family":"Tricco","sequence":"additional","affiliation":[]},{"given":"Christine","family":"Cedraschi","sequence":"additional","affiliation":[]},{"given":"Ginny","family":"Brunton","sequence":"additional","affiliation":[]},{"given":"Margareta","family":"Nordin","sequence":"additional","affiliation":[]},{"given":"Heather M.","family":"Shearer","sequence":"additional","affiliation":[]},{"given":"Jessica J.","family":"Wong","sequence":"additional","affiliation":[]},{"given":"Jill A.","family":"Hayden","sequence":"additional","affiliation":[]},{"given":"Rachel","family":"Ogilvie","sequence":"additional","affiliation":[]},{"given":"Dan","family":"Wang","sequence":"additional","affiliation":[]},{"given":"Pierre","family":"C\u00f4t\u00e9","sequence":"additional","affiliation":[]},{"given":"Cesar A.","family":"Hincapi\u00e9","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2023,11,22]]},"reference":[{"issue":"4","key":"10140_CR1","first-page":"607","volume":"50","author":"E Truumees","year":"2019","unstructured":"Truumees E, Sibbitt WL, Durbin M. 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CC (Carol Cancelliere), LV, DS, HY, GC, JJW, and HMS report funding from the Canadian Chiropractic Guideline Initiative. JAH and RO report funding from the Canadian Institutes of Health Research (CIHR) to support the \u2018exercise treatments for chronic low back pain\u2019 Cochrane review. ACT is funded by a Tier 2 Canada Research Chair in Knowledge Synthesis. CAH reports grants to the University of Zurich from the Foundation for the Education of Chiropractors in Switzerland, the Swiss National Science Foundation (SNSF), and the European Center for Chiropractic Research Excellence (ECCRE) outside the submitted work. SM reports grants from Canadian Chiropractic Association, Canadian Chiropractic Research Foundation, and Canadian Institute of Health Research outside of submitted work. JJW is supported by a Banting Postdoctoral Fellowship from CIHR and reports grants from the CIHR and Canadian Chiropractic Research Foundation (paid to university) and travel reimbursement for research meetings from the Chiropractic Academy of Research Leadership outside the submitted work. PC was not involved with any of the systematic reviews at any stage to inform the WHO practice guideline, since he is an external review group member.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This manuscript does not describe original research. Therefore, no ethical approval was obtained.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}