{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T19:13:00Z","timestamp":1767985980339,"version":"3.49.0"},"reference-count":76,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T00:00:00Z","timestamp":1617840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T00:00:00Z","timestamp":1617840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/50011\/2020"],"award-info":[{"award-number":["UIDB\/50011\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDP\/50011\/2020"],"award-info":[{"award-number":["UIDP\/50011\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["LSRE-LCM- UID\/EQU\/50020\/2019"],"award-info":[{"award-number":["LSRE-LCM- UID\/EQU\/50020\/2019"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BD\/150671\/2020"],"award-info":[{"award-number":["SFRH\/BD\/150671\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["IF\/01634\/2015"],"award-info":[{"award-number":["IF\/01634\/2015"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["POCI-01-0145-FEDER-031268"],"award-info":[{"award-number":["POCI-01-0145-FEDER-031268"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["CEECIND\/00383\/2017"],"award-info":[{"award-number":["CEECIND\/00383\/2017"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Solution Chem"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1007\/s10953-021-01062-x","type":"journal-article","created":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T07:02:42Z","timestamp":1617865362000},"page":"243-278","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Overview on Protein Extraction and Purification Using Ionic-Liquid-Based Processes"],"prefix":"10.1007","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2028-586X","authenticated-orcid":false,"given":"Jo\u00e3o C. F.","family":"Nunes","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2101-8309","authenticated-orcid":false,"given":"Mafalda R.","family":"Almeida","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6531-3978","authenticated-orcid":false,"given":"Joaquim L.","family":"Faria","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6469-4871","authenticated-orcid":false,"given":"Cl\u00e1udia G.","family":"Silva","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8895-0614","authenticated-orcid":false,"given":"M\u00e1rcia C.","family":"Neves","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5611-4080","authenticated-orcid":false,"given":"Mara G.","family":"Freire","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9128-6275","authenticated-orcid":false,"given":"Ana P. M.","family":"Tavares","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2021,4,8]]},"reference":[{"key":"1062_CR1","unstructured":"Bruce, A., Alexander, J., Julian, L., Martin, R., Keith, R., Walter, P.: Proteins function. In: Molecular Biology of the Cell. Garland Science, New York (2002)"},{"key":"1062_CR2","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1590\/S1517-83822013005000041","volume":"44","author":"C Rabert","year":"2013","unstructured":"Rabert, C., Weinacker, D., Pessoa, A., Jr., Far\u00edas, J.G.: Recombinants proteins for industrial uses: utilization of Pichia pastoris expression system. Braz. J. Microbiol. 44, 351\u2013356 (2013). https:\/\/doi.org\/10.1590\/S1517-83822013005000041","journal-title":"Braz. J. Microbiol."},{"key":"1062_CR3","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1080\/15422119.2017.1279628","volume":"46","author":"SY Lee","year":"2017","unstructured":"Lee, S.Y., Khoiroh, I., Chien Wei, O., Ling, T., Pau Loke, S.: Recent advances in protein extraction using ionic liquid-based aqueous two-phase systems. Sep. Purif. Rev. 46, 291\u2013304 (2017). https:\/\/doi.org\/10.1080\/15422119.2017.1279628","journal-title":"Sep. Purif. Rev."},{"key":"1062_CR4","doi-asserted-by":"publisher","first-page":"6984","DOI":"10.1021\/acs.chemrev.6b00550","volume":"117","author":"SPM Ventura","year":"2017","unstructured":"Ventura, S.P.M., e Silva, F.A., Quental, M.V., Mondal, D., Freire, M.G., Coutinho, J.A.P.: Ionic-liquid-mediated extraction and separation processes for bioactive compounds: past, present, and future trends. Chem. Rev. 117, 6984\u20137052 (2017). https:\/\/doi.org\/10.1021\/acs.chemrev.6b00550","journal-title":"Chem. Rev."},{"key":"1062_CR5","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1002\/(SICI)1097-4660(199704)68:4<351::AID-JCTB613>3.0.CO;2-4","volume":"68","author":"KR Seddon","year":"1997","unstructured":"Seddon, K.R.: Ionic Liquids for clean technology. J. Chem. Technol. Biotechnol. 68, 351\u2013356 (1997). https:\/\/doi.org\/10.1002\/(SICI)1097-4660(199704)68:4%3c351::AID-JCTB613%3e3.0.CO;2-4","journal-title":"J. Chem. Technol. Biotechnol."},{"key":"1062_CR6","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/j.ijbiomac.2012.06.020","volume":"51","author":"M Naushad","year":"2012","unstructured":"Naushad, M., ALOthman, Z.A., Khan, A.B., Ali, M.: Effect of ionic liquid on activity, stability, and structure of enzymes: areview. Int. J. Biol. Macromol. 51, 555\u2013560 (2012). https:\/\/doi.org\/10.1016\/j.ijbiomac.2012.06.020","journal-title":"Int. J. Biol. Macromol."},{"key":"1062_CR7","doi-asserted-by":"publisher","unstructured":"Zhang, J., Hu, B.: Liquid Liquid extraction (LLE). In: Separation and Purification Technologies in Biorefineries, pp. 61\u201378 (2013). https:\/\/doi.org\/10.1002\/9781118493441.ch3","DOI":"10.1002\/9781118493441.ch3"},{"key":"1062_CR8","doi-asserted-by":"publisher","first-page":"4966","DOI":"10.1039\/c2cs35151j","volume":"41","author":"MG Freire","year":"2012","unstructured":"Freire, M.G., Cl\u00e1udio, A.F.M., Ara\u00fajo, J.M.M., Coutinho, J.P., Marrucho, I.M., Lopes, J.N.C., Rebelo, L.P.N.: Aqueous biphasic systems: a boost brought about by using ionic liquids. Chem. Soc. Rev. 41, 4966\u20134995 (2012). https:\/\/doi.org\/10.1039\/c2cs35151j","journal-title":"Chem. Soc. Rev."},{"key":"1062_CR9","unstructured":"Castro, L., Pereira, P., Freire, M., Pedro, A.: Progress in the development of aqueous two-phase systems comprising ionic liquids for the downstream processing of protein-based biopharmaceuticals. Am. Pharm. Rev. 1\u20136 (2019)"},{"key":"1062_CR10","doi-asserted-by":"publisher","first-page":"135","DOI":"10.3389\/fchem.2019.00135","volume":"7","author":"L McQueen","year":"2019","unstructured":"McQueen, L., Lai, D.: Ionic liquid aqueous two-phase systems from a pharmaceutical perspective. Front. Chem. 7, 135 (2019). https:\/\/doi.org\/10.3389\/fchem.2019.00135","journal-title":"Front. Chem."},{"key":"1062_CR11","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.jbiotec.2015.03.028","volume":"206","author":"MM Pereira","year":"2015","unstructured":"Pereira, M.M., Pedro, S.N., Quental, M.V., Lima, \u00c1.S., Coutinho, J.A.P., Freire, M.G.: Enhanced extraction of bovine serum albumin with aqueous biphasic systems of phosphonium- and ammonium-based ionic liquids. J. Biotechnol. 206, 17\u201325 (2015). https:\/\/doi.org\/10.1016\/j.jbiotec.2015.03.028","journal-title":"J. Biotechnol."},{"key":"1062_CR12","doi-asserted-by":"publisher","first-page":"4471","DOI":"10.1021\/jp510984d","volume":"119","author":"Z Wang","year":"2015","unstructured":"Wang, Z., Pei, Y., Zhao, J., Li, Z., Chen, Y., Zhuo, K.: Formation of ether-functionalized ionic-liquid-based aqueous two-phase systems and their application in separation of protein and saccharides. J. Phys. Chem. B 119, 4471\u20134478 (2015). https:\/\/doi.org\/10.1021\/jp510984d","journal-title":"J. Phys. Chem. B"},{"key":"1062_CR13","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.ijbiomac.2017.02.001","volume":"98","author":"A \u010c\u00ed\u017eov\u00e1","year":"2017","unstructured":"\u010c\u00ed\u017eov\u00e1, A., Korcov\u00e1, J., Farka\u0161, P., Bystrick\u00fd, S.: Efficient separation of mannan\u2013protein mixtures by ionic liquid aqueous two-phase system, comparison with lectin affinity purification. Int. J. Biol. Macromol. 98, 314\u2013318 (2017). https:\/\/doi.org\/10.1016\/j.ijbiomac.2017.02.001","journal-title":"Int. J. Biol. Macromol."},{"key":"1062_CR14","doi-asserted-by":"publisher","first-page":"2878","DOI":"10.1007\/s13197-014-1319-5","volume":"52","author":"B Jiang","year":"2015","unstructured":"Jiang, B., Feng, Z., Liu, C., Xu, Y., Li, D., Ji, G.: Extraction and purification of wheat-esterase using aqueous two-phase systems of ionic liquid and salt. J. Food Sci. Technol. 52, 2878\u20132885 (2015). https:\/\/doi.org\/10.1007\/s13197-014-1319-5","journal-title":"J. Food Sci. Technol."},{"key":"1062_CR15","doi-asserted-by":"publisher","first-page":"14042","DOI":"10.1021\/acssuschemeng.8b02597","volume":"6","author":"JHPM Santos","year":"2018","unstructured":"Santos, J.H.P.M., Trigo, J.P., Maricato, \u00c9., Nunes, C., Coimbra, M.A., Ventura, S.P.M.: Fractionation of isochrysis galbana proteins, arabinans, and glucans using ionic-liquid-based aqueous biphasic systems. ACS Sustain. Chem. Eng. 6, 14042\u201314053 (2018). https:\/\/doi.org\/10.1021\/acssuschemeng.8b02597","journal-title":"ACS Sustain. Chem. Eng."},{"key":"1062_CR16","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1016\/j.procbio.2015.02.001","volume":"50","author":"JHPM Santos","year":"2015","unstructured":"Santos, J.H.P.M., e Silva, F.A., Coutinho, J.A.P., Ventura, S.P.M., Pessoa, A.: Ionic liquids as a novel class of electrolytes in polymeric aqueous biphasic systems. Process Biochem. 50, 661\u2013668 (2015). https:\/\/doi.org\/10.1016\/j.procbio.2015.02.001","journal-title":"Process Biochem."},{"key":"1062_CR17","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1002\/aic.15035","volume":"62","author":"M Vahidnia","year":"2015","unstructured":"Vahidnia, M., Pazuki, G., Abdolrahimi, S.: Impact of polyethylene glycol as additive on the formation and extraction behavior of ionic-liquid based aqueous two-phase system. AIChE J. 62, 264\u2013274 (2015). https:\/\/doi.org\/10.1002\/aic.15035","journal-title":"AIChE J."},{"key":"1062_CR18","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.1002\/biot.201500003","volume":"10","author":"MV Quental","year":"2015","unstructured":"Quental, M.V., Caban, M., Pereira, M.M., Stepnowski, P., Coutinho, J.A.P., Freire, M.G.: Enhanced extraction of proteins using cholinium-based ionic liquids as phase-forming components of aqueous biphasic systems. Biotechnol. J. 10, 1457\u20131466 (2015). https:\/\/doi.org\/10.1002\/biot.201500003","journal-title":"Biotechnol. J."},{"key":"1062_CR19","doi-asserted-by":"publisher","first-page":"3291","DOI":"10.1021\/acssuschemeng.5b00881","volume":"3","author":"CP Song","year":"2015","unstructured":"Song, C.P., Ramanan, R.N., Vijayaraghavan, R., MacFarlane, D.R., Chan, E.-S., Ooi, C.-W.: Green, aqueous two-phase systems based on cholinium aminoate ionic liquids with tunable hydrophobicity and charge density. ACS Sustain. Chem. Eng. 3, 3291\u20133298 (2015). https:\/\/doi.org\/10.1021\/acssuschemeng.5b00881","journal-title":"ACS Sustain. Chem. Eng."},{"key":"1062_CR20","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1016\/j.procbio.2015.03.020","volume":"50","author":"M Taha","year":"2015","unstructured":"Taha, M., Quental, M.V., Correia, I., Freire, M.G., Coutinho, J.A.P.: Extraction and stability of bovine serum albumin (BSA) using cholinium-based Good\u2019s buffers ionic liquids. Process Biochem. 50, 1158\u20131166 (2015). https:\/\/doi.org\/10.1016\/j.procbio.2015.03.020","journal-title":"Process Biochem."},{"key":"1062_CR21","doi-asserted-by":"publisher","first-page":"18567","DOI":"10.1039\/C6RA00607H","volume":"6","author":"BS Gupta","year":"2016","unstructured":"Gupta, B.S., Taha, M., Lee, M.-J.: Extraction of an active enzyme by self-buffering ionic liquids: a green medium for enzymatic research. RSC Adv. 6, 18567\u201318576 (2016). https:\/\/doi.org\/10.1039\/C6RA00607H","journal-title":"RSC Adv."},{"key":"1062_CR22","doi-asserted-by":"publisher","first-page":"106764","DOI":"10.1039\/C5RA16317J","volume":"5","author":"BS Gupta","year":"2015","unstructured":"Gupta, B.S., Taha, M., Lee, M.-J.: Self-buffering and biocompatible ionic liquid based biological media for enzymatic research. RSC Adv. 5, 106764\u2013106773 (2015). https:\/\/doi.org\/10.1039\/C5RA16317J","journal-title":"RSC Adv."},{"key":"1062_CR23","doi-asserted-by":"publisher","first-page":"3420","DOI":"10.1021\/acssuschemeng.5b01155","volume":"3","author":"SY Lee","year":"2015","unstructured":"Lee, S.Y., Vicente, F.A., e Silva, F.A., Sintra, T.E., Taha, M., Khoiroh, I., Coutinho, J.A.P., Show, P.L., Ventura, S.P.M.: Evaluating self-buffering ionic liquids for biotechnological applications. ACS Sustain. Chem. Eng. 3, 3420\u20133428 (2015). https:\/\/doi.org\/10.1021\/acssuschemeng.5b01155","journal-title":"ACS Sustain. Chem. Eng."},{"key":"1062_CR24","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.procbio.2017.08.020","volume":"63","author":"SY Lee","year":"2017","unstructured":"Lee, S.Y., Khoiroh, I., Coutinho, J.A.P., Show, P.L., Ventura, S.P.M.: Lipase production and purification by self-buffering ionic liquid-based aqueous biphasic systems. Process Biochem. 63, 221\u2013228 (2017). https:\/\/doi.org\/10.1016\/j.procbio.2017.08.020","journal-title":"Process Biochem."},{"key":"1062_CR25","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.seppur.2015.05.021","volume":"155","author":"RL Souza","year":"2015","unstructured":"Souza, R.L., Lima, R.A., Coutinho, J.A.P., Soares, C.M.F., Lima, \u00c1.S.: Aqueous two-phase systems based on cholinium salts and tetrahydrofuran and their use for lipase purification. Sep. Purif. Technol. 155, 118\u2013126 (2015). https:\/\/doi.org\/10.1016\/j.seppur.2015.05.021","journal-title":"Sep. Purif. Technol."},{"key":"1062_CR26","doi-asserted-by":"publisher","first-page":"3026","DOI":"10.1039\/C5GC00262A","volume":"17","author":"RL Souza","year":"2015","unstructured":"Souza, R.L., Ventura, S.P.M., Soares, C.M.F., Coutinho, J.A.P., Lima, \u00c1.S.: Lipase purification using ionic liquids as adjuvants in aqueous two-phase systems. Green Chem. 17, 3026\u20133034 (2015). https:\/\/doi.org\/10.1039\/C5GC00262A","journal-title":"Green Chem."},{"key":"1062_CR27","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.seppur.2017.05.001","volume":"196","author":"CA Suarez Ruiz","year":"2018","unstructured":"Suarez Ruiz, C.A., van den Berg, C., Wijffels, R.H., Eppink, M.H.M.: Rubisco separation using biocompatible aqueous two-phase systems. Sep. Purif. Technol. 196, 254\u2013261 (2018). https:\/\/doi.org\/10.1016\/j.seppur.2017.05.001","journal-title":"Sep. Purif. Technol."},{"key":"1062_CR28","doi-asserted-by":"publisher","first-page":"4781","DOI":"10.1002\/chem.201405693","volume":"21","author":"M Taha","year":"2015","unstructured":"Taha, M., Almeida, M.R., Silva, F.A.E., Domingues, P., Ventura, S.P.M., Coutinho, J.A.P., Freire, M.G.: Novel biocompatible and self-buffering ionic liquids for biopharmaceutical applications. Chemistry 21, 4781\u20134788 (2015). https:\/\/doi.org\/10.1002\/chem.201405693","journal-title":"Chemistry"},{"key":"1062_CR29","doi-asserted-by":"publisher","first-page":"6071","DOI":"10.1039\/C6GC01482H","volume":"18","author":"D Mondal","year":"2016","unstructured":"Mondal, D., Sharma, M., Quental, M.V., Tavares, A.P.M., Prasad, K., Freire, M.G.: Suitability of bio-based ionic liquids for the extraction and purification of IgG antibodies. Green Chem. 18, 6071\u20136081 (2016). https:\/\/doi.org\/10.1039\/C6GC01482H","journal-title":"Green Chem."},{"key":"1062_CR30","doi-asserted-by":"crossref","unstructured":"Ramalho, C.C., Neves, C.M.S.S., Quental, M. V, Coutinho, J.A.P., Freire, M.G.: Separation of immunoglobulin G using aqueous biphasic systems composed of cholinium-based ionic liquids and poly(propylene glycol). J. Chem. Technol. Biotechnol. 93, 1931\u20131939 (2018)","DOI":"10.1002\/jctb.5594"},{"key":"1062_CR31","doi-asserted-by":"publisher","first-page":"5671","DOI":"10.1039\/C9GC02733E","volume":"21","author":"EV Capela","year":"2019","unstructured":"Capela, E.V., Santiago, A.E., Rufino, A.F.C.S., Tavares, A.P.M., Pereira, M.M., Mohamadou, A., Aires-Barros, M.R., Coutinho, J.A.P., Azevedo, A.M., Freire, M.G.: Sustainable strategies based on glycine\u2013betaine analogue ionic liquids for the recovery of monoclonal antibodies from cell culture supernatants. Green Chem. 21, 5671\u20135682 (2019). https:\/\/doi.org\/10.1039\/C9GC02733E","journal-title":"Green Chem."},{"key":"1062_CR32","doi-asserted-by":"publisher","first-page":"15102","DOI":"10.1021\/acssuschemeng.9b03841","volume":"7","author":"FA Vicente","year":"2019","unstructured":"Vicente, F.A., Bairos, J., Roque, M., Coutinho, J.A.P., Ventura, S.P.M., Freire, M.G.: Use of ionic liquids as cosurfactants in mixed aqueous micellar two-phase systems to improve the simultaneous separation of immunoglobulin G and human serum albumin from expired human plasma. ACS Sustain. Chem. Eng. 7, 15102\u201315113 (2019). https:\/\/doi.org\/10.1021\/acssuschemeng.9b03841","journal-title":"ACS Sustain. Chem. Eng."},{"key":"1062_CR33","doi-asserted-by":"publisher","first-page":"20276","DOI":"10.1038\/srep20276","volume":"6","author":"H Passos","year":"2016","unstructured":"Passos, H., Lu\u00eds, A., Freire, M.: Thermoreversible (ionic-liquid-based) aqueous biphasic systems. Sci. Rep. 6, 20276 (2016). https:\/\/doi.org\/10.1038\/srep20276","journal-title":"Sci. Rep."},{"key":"1062_CR34","doi-asserted-by":"publisher","first-page":"116019","DOI":"10.1016\/j.seppur.2019.116019","volume":"233","author":"DCV Belchior","year":"2020","unstructured":"Belchior, D.C.V., Quental, M.V., Pereira, M.M., Mendon\u00e7a, C.M.N., Duarte, I.F., Freire, M.G.: Performance of tetraalkylammonium-based ionic liquids as constituents of aqueous biphasic systems in the extraction of ovalbumin and lysozyme. Sep. Purif. Technol. 233, 116019 (2020). https:\/\/doi.org\/10.1016\/j.seppur.2019.116019","journal-title":"Sep. Purif. Technol."},{"key":"1062_CR35","doi-asserted-by":"publisher","first-page":"2130","DOI":"10.1002\/chem.200601234","volume":"13","author":"Z Du","year":"2007","unstructured":"Du, Z., Yu, Y.-L., Wang, J.-H.: Extraction of proteins from biological fluids by use of an ionic liquid\/aqueous two-Phase system. Chem. A Eur. J. 13, 2130\u20132137 (2007). https:\/\/doi.org\/10.1002\/chem.200601234","journal-title":"Chem. A Eur. J."},{"key":"1062_CR36","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.bej.2009.05.005","volume":"46","author":"S Dreyer","year":"2009","unstructured":"Dreyer, S., Salim, P., Kragl, U.: Driving forces of protein partitioning in an ionic liquid-based aqueous two-phase system. Biochem. Eng. J. 46, 176\u2013185 (2009). https:\/\/doi.org\/10.1016\/j.bej.2009.05.005","journal-title":"Biochem. Eng. J."},{"key":"1062_CR37","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1016\/j.seppur.2008.10.010","volume":"64","author":"Y Pei","year":"2009","unstructured":"Pei, Y., Wang, J., Wu, K., Xuan, X., Lu, X.: Ionic liquid-based aqueous two-phase extraction of selected proteins. Sep. Purif. Technol. 64, 288\u2013295 (2009). https:\/\/doi.org\/10.1016\/j.seppur.2008.10.010","journal-title":"Sep. Purif. Technol."},{"key":"1062_CR38","doi-asserted-by":"publisher","first-page":"1554","DOI":"10.1007\/s11426-010-4025-9","volume":"53","author":"P Yuanchao","year":"2010","unstructured":"Yuanchao, P., Li, Z., Liu, L., Wang, J., Wang, H.: Selective separation of protein and saccharides by ionic liquids aqueous two-phase systems. Sci. China Chem. 53, 1554\u20131560 (2010). https:\/\/doi.org\/10.1007\/s11426-010-4025-9","journal-title":"Sci. China Chem."},{"key":"1062_CR39","doi-asserted-by":"publisher","first-page":"6445","DOI":"10.1039\/C3AN01301D","volume":"138","author":"X Lin","year":"2013","unstructured":"Lin, X., Wang, Y., Zeng, Q., Ding, X., Chen, J.: Extraction and separation of proteins by ionic liquid aqueous two-phase system. Analyst. 138, 6445\u20136453 (2013). https:\/\/doi.org\/10.1039\/C3AN01301D","journal-title":"Analyst."},{"key":"1062_CR40","doi-asserted-by":"publisher","unstructured":"Lehotay, S.J., Schenck, F.J.: Multiresidue methods: extraction. In: Encyclopedia of Separation Science, pp. 3409\u20133415. Elsevier (2000). https:\/\/doi.org\/10.1016\/b0-12-226770-2\/05621-0","DOI":"10.1016\/b0-12-226770-2\/05621-0"},{"key":"1062_CR41","doi-asserted-by":"publisher","unstructured":"Ke\u00e7ili, R., B\u00fcy\u00fcktiryaki, S., Dolak, I., Hussain, C.M.: The use of magnetic nanoparticles in sample preparation devices and tools. Handb. Nanomater. Anal. Chem. Mod. Trends Anal. 75\u201395 (2019). https:\/\/doi.org\/10.1016\/B978-0-12-816699-4.00005-0","DOI":"10.1016\/B978-0-12-816699-4.00005-0"},{"key":"1062_CR42","doi-asserted-by":"publisher","first-page":"3965","DOI":"10.1039\/c2jm14577d","volume":"22","author":"S Yuan","year":"2012","unstructured":"Yuan, S., Deng, Q., Fang, G., Pan, M., Zhai, X., Wang, S.: A novel ionic liquid polymer material with high binding capacity for proteins. J. Mater. Chem. 22, 3965\u20133972 (2012). https:\/\/doi.org\/10.1039\/c2jm14577d","journal-title":"J. Mater. Chem."},{"key":"1062_CR43","doi-asserted-by":"publisher","first-page":"8358","DOI":"10.1039\/c4ay01786b","volume":"6","author":"J Chen","year":"2014","unstructured":"Chen, J., Wang, Y., Ding, X., Huang, Y., Xu, K.: Magnetic solid-phase extraction of proteins based on hydroxy functional ionic liquid-modified magnetic nanoparticles. Anal. Methods 6, 8358\u20138367 (2014). https:\/\/doi.org\/10.1039\/c4ay01786b","journal-title":"Anal. Methods"},{"key":"1062_CR44","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.trac.2012.08.010","volume":"41","author":"N Fontanals","year":"2012","unstructured":"Fontanals, N., Borrull, F., Marc\u00e9, R.M.: Ionic liquids in solid-phase extraction. TrAC - Trends Anal. Chem. 41, 15\u201326 (2012). https:\/\/doi.org\/10.1016\/j.trac.2012.08.010","journal-title":"TrAC - Trends Anal. Chem."},{"key":"1062_CR45","doi-asserted-by":"publisher","first-page":"1629","DOI":"10.1016\/j.progpolymsci.2011.05.007","volume":"36","author":"D Mecerreyes","year":"2011","unstructured":"Mecerreyes, D.: Polymeric ionic liquids: broadening the properties and applications of polyelectrolytes. Prog. Polym. Sci. 36, 1629\u20131648 (2011). https:\/\/doi.org\/10.1016\/j.progpolymsci.2011.05.007","journal-title":"Prog. Polym. Sci."},{"key":"1062_CR46","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/j.progpolymsci.2008.12.001","volume":"34","author":"J Lu","year":"2009","unstructured":"Lu, J., Yan, F., Texter, J.: Advanced applications of ionic liquids in polymer science. Prog. Polym. Sci. 34, 431\u2013448 (2009). https:\/\/doi.org\/10.1016\/j.progpolymsci.2008.12.001","journal-title":"Prog. Polym. Sci."},{"key":"1062_CR47","doi-asserted-by":"publisher","first-page":"6339","DOI":"10.1039\/c7tb01234a","volume":"5","author":"M Dang","year":"2017","unstructured":"Dang, M., Deng, Q., Fang, G., Zhang, D., Liu, J., Wang, S.: Preparation of novel anionic polymeric ionic liquid materials and their potential application to protein adsorption. J. Mater. Chem. B. 5, 6339\u20136347 (2017). https:\/\/doi.org\/10.1039\/c7tb01234a","journal-title":"J. Mater. Chem. B."},{"key":"1062_CR48","unstructured":"Shaplov, A.S., Lozinskaya, E.I., Vygodskii, Y.S.: Polymer ionic liquids: synthesis, design and application in electrochemistry as ion conducting materials. In: Torriero, A.A.J., Shiddiky, M. (eds.) Electrochemical Properties and Applications of Ionic Liquids, pp. 203\u2013298. Nova Science Publishers Inc. (2010)"},{"key":"1062_CR49","doi-asserted-by":"publisher","first-page":"19114","DOI":"10.1039\/c9ra02265a","volume":"9","author":"X Jia","year":"2019","unstructured":"Jia, X., Hu, X., Wang, W., Du, C.: Non-covalent loading of ionic liquid-functionalized nanoparticles for bovine serum albumin: Experiments and theoretical analysis. RSC Adv. 9, 19114\u201319120 (2019). https:\/\/doi.org\/10.1039\/c9ra02265a","journal-title":"RSC Adv."},{"key":"1062_CR50","doi-asserted-by":"publisher","first-page":"52147","DOI":"10.1039\/c4ra05713a","volume":"4","author":"Y Liu","year":"2014","unstructured":"Liu, Y., Ma, R., Deng, Q., Zhang, L., Liu, C., Wang, S.: Preparation of ionic liquid polymer materials and their recognition properties for proteins. RSC Adv. 4, 52147\u201352154 (2014). https:\/\/doi.org\/10.1039\/c4ra05713a","journal-title":"RSC Adv."},{"key":"1062_CR51","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.carbpol.2019.04.081","volume":"218","author":"L Qian","year":"2019","unstructured":"Qian, L., Yang, M., Chen, H., Xu, Y., Zhang, S., Zhou, Q., He, B., Bai, Y., Song, W.: Preparation of a poly(ionic liquid)-functionalized cellulose aerogel and its application in protein enrichment and separation. Carbohydr. Polym. 218, 154\u2013162 (2019). https:\/\/doi.org\/10.1016\/j.carbpol.2019.04.081","journal-title":"Carbohydr. Polym."},{"key":"1062_CR52","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/j.talanta.2009.12.059","volume":"81","author":"Y Shu","year":"2010","unstructured":"Shu, Y., Chen, X.W., Wang, J.H.: Ionic liquid-polyvinyl chloride ionomer for highly selective isolation of basic proteins. Talanta 81, 637\u2013642 (2010). https:\/\/doi.org\/10.1016\/j.talanta.2009.12.059","journal-title":"Talanta"},{"key":"1062_CR53","doi-asserted-by":"publisher","first-page":"2066","DOI":"10.1039\/c3tb00576c","volume":"1","author":"Y Wei","year":"2013","unstructured":"Wei, Y., Li, Y., Tian, A., Fan, Y., Wang, X.: Ionic liquid modified magnetic microspheres for isolation of heme protein with high binding capacity. J. Mater. Chem. B 1, 2066\u20132071 (2013). https:\/\/doi.org\/10.1039\/c3tb00576c","journal-title":"J. Mater. Chem. B"},{"key":"1062_CR54","doi-asserted-by":"publisher","first-page":"5353","DOI":"10.1007\/s00216-013-6889-y","volume":"405","author":"G Zhao","year":"2013","unstructured":"Zhao, G., Chen, S., Chen, X.W., He, R.H.: Selective isolation of hemoglobin by use of imidazolium-modified polystyrene as extractant. Anal. Bioanal. Chem. 405, 5353\u20135358 (2013). https:\/\/doi.org\/10.1007\/s00216-013-6889-y","journal-title":"Anal. Bioanal. Chem."},{"key":"1062_CR55","doi-asserted-by":"publisher","first-page":"31496","DOI":"10.1039\/c5ra00036j","volume":"5","author":"XF Wang","year":"2015","unstructured":"Wang, X.F., Zhang, Y., Shu, Y., Chen, X.W., Wang, J.H.: Ionic liquid poly(3-n-dodecyl-1-vinylimidazolium) bromide as an adsorbent for the sorption of hemoglobin. RSC Adv. 5, 31496\u201331501 (2015). https:\/\/doi.org\/10.1039\/c5ra00036j","journal-title":"RSC Adv."},{"key":"1062_CR56","doi-asserted-by":"publisher","first-page":"7497","DOI":"10.1039\/c6cc02703b","volume":"52","author":"Y Kohno","year":"2016","unstructured":"Kohno, Y., Gin, D.L., Noble, R.D., Ohno, H.: A thermoresponsive poly(ionic liquid) membrane enables concentration of proteins from aqueous media. Chem. Commun. 52, 7497\u20137500 (2016). https:\/\/doi.org\/10.1039\/c6cc02703b","journal-title":"Chem. Commun."},{"key":"1062_CR57","doi-asserted-by":"publisher","first-page":"5229","DOI":"10.1039\/c4tb00663a","volume":"2","author":"C Liu","year":"2014","unstructured":"Liu, C., Deng, Q., Fang, G., Huang, X., Wang, S.: Facile synthesis of graphene doped poly(ionic liquid) boronate affinity material for specific capture of glycoproteins. J. Mater. Chem. B. 2, 5229\u20135237 (2014). https:\/\/doi.org\/10.1039\/c4tb00663a","journal-title":"J. Mater. Chem. B."},{"key":"1062_CR58","doi-asserted-by":"publisher","first-page":"2370","DOI":"10.1126\/science.291.5512.2370","volume":"291","author":"PM Rudd","year":"2001","unstructured":"Rudd, P.M., Elliott, T., Cresswell, P., Wilson, I.A., Dwek, R.A.: Glycosylation and the immune system. Science 291, 2370\u20132376 (2001). https:\/\/doi.org\/10.1126\/science.291.5512.2370","journal-title":"Science"},{"key":"1062_CR59","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1038\/nchembio.696","volume":"7","author":"CJ Jones","year":"2011","unstructured":"Jones, C.J., Larive, C.K.: Carbohydrates: Cracking the glycan sequence code. Nat. Chem. Biol. 7, 758\u2013759 (2011). https:\/\/doi.org\/10.1038\/nchembio.696","journal-title":"Nat. Chem. Biol."},{"key":"1062_CR60","doi-asserted-by":"publisher","first-page":"1703","DOI":"10.1007\/s10529-007-9456-9","volume":"29","author":"D Hekmat","year":"2007","unstructured":"Hekmat, D., Hebel, D., Joswig, S., Schmidt, M., Weuster-Botz, D.: Advanced protein crystallization using water-soluble ionic liquids as crystallization additives. Biotechnol. Lett. 29, 1703\u20131711 (2007). https:\/\/doi.org\/10.1007\/s10529-007-9456-9","journal-title":"Biotechnol. Lett."},{"key":"1062_CR61","doi-asserted-by":"publisher","first-page":"3463","DOI":"10.1021\/cg900140b","volume":"9","author":"RA Judge","year":"2009","unstructured":"Judge, R.A., Takahashi, S., Longenecker, K.L., Fry, E.H., Abad-Zapatero, C., Chiu, M.L.: The effect of ionic liquids on protein crystallization and X-ray diffraction resolution. Cryst. Growth Des. 9, 3463\u20133469 (2009). https:\/\/doi.org\/10.1021\/cg900140b","journal-title":"Cryst. Growth Des."},{"key":"1062_CR62","doi-asserted-by":"publisher","unstructured":"Xiao, H., Dang, L., Wang, Z.: Crystal morphology and molecular interaction of lysozyme affected by imidazolium-based ionic liquids in aqueous solutions. In: 5th International Conference on Bioinformatics and Biomedical Engineering, pp. 1\u20135. IEEE (2011). https:\/\/doi.org\/10.1109\/icbbe.2011.5780030","DOI":"10.1109\/icbbe.2011.5780030"},{"key":"1062_CR63","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1021\/ic951325x","volume":"35","author":"P Bon\u0125te","year":"1996","unstructured":"Bon\u0125te, P., Dias, A.P., Papageorgiou, N., Kalyanasundaram, K., Gr\u00e4tzel, M.: Hydrophobic, highly conductive ambient-temperature molten salts. Inorg. Chem. 35, 1168\u20131178 (1996). https:\/\/doi.org\/10.1021\/ic951325x","journal-title":"Inorg. Chem."},{"key":"1062_CR64","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1021\/cg701187t","volume":"8","author":"P Nockemann","year":"2008","unstructured":"Nockemann, P., Thijs, B., Van Hecke, K., Van Meervelt, L., Binnemans, K.: Polynuclear metal complexes obtained from the task-specific ionic liquid betainium bistriflimide. Cryst. Growth Des. 8, 1353\u20131363 (2008). https:\/\/doi.org\/10.1021\/cg701187t","journal-title":"Cryst. Growth Des."},{"key":"1062_CR65","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1007\/s11814-014-0057-8","volume":"31","author":"Z Wang","year":"2014","unstructured":"Wang, Z., Fang, W., Li, Y., Zhang, J., Gu, Q.: A new strategy for protein crystallization: effect of ionic liquids on lysozyme crystallization and morphology. Korean J. Chem. Eng. 31, 919\u2013923 (2014). https:\/\/doi.org\/10.1007\/s11814-014-0057-8","journal-title":"Korean J. Chem. Eng."},{"key":"1062_CR66","doi-asserted-by":"publisher","first-page":"112018","DOI":"10.1016\/j.molliq.2019.112018","volume":"296","author":"X Yu","year":"2019","unstructured":"Yu, X., Tian, N., Huang, F., Huang, X., Liu, C., Gao, S., Yang, Z., Wu, Y.: Evaluating the role of ionic liquids (ILs) in the crystallization of lysozyme. J. Mol. Liq. 296, 112018 (2019). https:\/\/doi.org\/10.1016\/j.molliq.2019.112018","journal-title":"J. Mol. Liq."},{"key":"1062_CR67","doi-asserted-by":"publisher","first-page":"2037","DOI":"10.1107\/S0907444999011774","volume":"55","author":"JA Garlitz","year":"1999","unstructured":"Garlitz, J.A., Summers, C.A., Flowers, R.A., Borgstahl, G.E.O.: Ethylammonium nitrate: a protein crystallization reagent. Acta Crystallogr. D 55, 2037\u20132038 (1999). https:\/\/doi.org\/10.1107\/S0907444999011774","journal-title":"Acta Crystallogr. D"},{"key":"1062_CR68","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1002\/crat.200800040","volume":"43","author":"X Li","year":"2008","unstructured":"Li, X., Xu, X., Dan, Y., Feng, J., Ge, L., Zhang, M.: The crystallization of lysozyme in the system of ionic liquid [BMIm][BF4]\u2013water. Cryst. Res. Technol. 43, 1062\u20131068 (2008). https:\/\/doi.org\/10.1002\/crat.200800040","journal-title":"Cryst. Res. Technol."},{"key":"1062_CR69","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1134\/S1063774509070268","volume":"54","author":"XX Li","year":"2009","unstructured":"Li, X.X., Xu, X.D., Dan, Y.Y., Zhang, M.L.: The crystallization of lysozyme and thaumatin with ionic liquid. Crystallogr. Rep. 54, 1285\u20131288 (2009). https:\/\/doi.org\/10.1134\/S1063774509070268","journal-title":"Crystallogr. Rep."},{"key":"1062_CR70","doi-asserted-by":"publisher","first-page":"2241","DOI":"10.1039\/c0an00244e","volume":"135","author":"X Chen","year":"2010","unstructured":"Chen, X., Ji, Y., Wang, J.: Improvement on the crystallization of lysozyme in the presence of hydrophilic ionic liquid. Analyst 135, 2241\u20132248 (2010). https:\/\/doi.org\/10.1039\/c0an00244e","journal-title":"Analyst"},{"key":"1062_CR71","doi-asserted-by":"publisher","first-page":"1777","DOI":"10.1021\/cg1017104","volume":"11","author":"DF Kennedy","year":"2011","unstructured":"Kennedy, D.F., Drummond, C.J., Peat, T.S., Newman, J.: Evaluating protic ionic liquids as protein crystallization additives. Cryst. Growth Des. 11, 1777\u20131785 (2011). https:\/\/doi.org\/10.1021\/cg1017104","journal-title":"Cryst. Growth Des."},{"key":"1062_CR72","doi-asserted-by":"publisher","first-page":"4912","DOI":"10.1039\/c2ce25129a","volume":"14","author":"M Kowacz","year":"2012","unstructured":"Kowacz, M., Mukhopadhyay, A., Carvalho, A.L., Esperan\u00e7a, J.M.S.S., Rom\u00e3o, M.J., Rebelo, L.P.N.: Hofmeister effects of ionic liquids in protein crystallization: direct and water-mediated interactions. CrystEngComm 14, 4912\u20134921 (2012). https:\/\/doi.org\/10.1039\/c2ce25129a","journal-title":"CrystEngComm"},{"key":"1062_CR73","doi-asserted-by":"publisher","first-page":"2994","DOI":"10.1021\/acs.cgd.5b00403","volume":"15","author":"M Kowacz","year":"2015","unstructured":"Kowacz, M., Marchel, M., Juknaite, L., Esperan\u00e7a, J.M.S.S., Rom\u00e3o, M.J., Carvalho, A.L., Rebelo, L.P.N.: Ionic-liquid-functionalized mineral particles for protein crystallization. Cryst. Growth 15, 2994\u20133003 (2015). https:\/\/doi.org\/10.1021\/acs.cgd.5b00403","journal-title":"Cryst. Growth"},{"key":"1062_CR74","doi-asserted-by":"publisher","first-page":"253","DOI":"10.3390\/cryst9050253","volume":"9","author":"BD Belviso","year":"2019","unstructured":"Belviso, B.D., Caliandro, R., Salehi, S.M., Di Profio, G., Caliandro, R.: Protein crystallization in ionic-liquid hydrogel composite membranes. Crystals 9, 253 (2019). https:\/\/doi.org\/10.3390\/cryst9050253","journal-title":"Crystals"},{"key":"1062_CR75","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1021\/cg060696t","volume":"7","author":"ML Pusey","year":"2007","unstructured":"Pusey, M.L., Paley, M.S., Turner, M.B., Rogers, R.D.: Protein crystallization using room temperature ionic liquids. Cryst. Growth Des. 7, 787\u2013793 (2007). https:\/\/doi.org\/10.1021\/cg060696t","journal-title":"Cryst. Growth Des."},{"key":"1062_CR76","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1007\/s12257-012-0096-0","volume":"17","author":"Z Wang","year":"2012","unstructured":"Wang, Z., Wang, Q., Dang, L.: Ionic liquids as selectors for controlling the crystallization nucleation of hen egg white lysozyme. Biotechnol. Bioprocess Eng. 17, 1025\u20131030 (2012). https:\/\/doi.org\/10.1007\/s12257-012-0096-0","journal-title":"Biotechnol. Bioprocess Eng."}],"container-title":["Journal of Solution Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10953-021-01062-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s10953-021-01062-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s10953-021-01062-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T16:17:30Z","timestamp":1646929050000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s10953-021-01062-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,8]]},"references-count":76,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["1062"],"URL":"https:\/\/doi.org\/10.1007\/s10953-021-01062-x","relation":{},"ISSN":["0095-9782","1572-8927"],"issn-type":[{"value":"0095-9782","type":"print"},{"value":"1572-8927","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,8]]},"assertion":[{"value":"30 September 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 February 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 April 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}