{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:53:10Z","timestamp":1768351990923,"version":"3.49.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2020,3,7]],"date-time":"2020-03-07T00:00:00Z","timestamp":1583539200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,3,7]],"date-time":"2020-03-07T00:00:00Z","timestamp":1583539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Polym Res"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1007\/s10965-020-02053-0","type":"journal-article","created":{"date-parts":[[2020,3,7]],"date-time":"2020-03-07T13:02:27Z","timestamp":1583586147000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Development of novel 3D scaffolds using BioExtruder by varying the content of hydroxyapatite and silica in PCL matrix for bone tissue engineering"],"prefix":"10.1007","volume":"27","author":[{"given":"Nandini A.","family":"Pattanashetti","sequence":"first","affiliation":[]},{"given":"Tania","family":"Viana","sequence":"additional","affiliation":[]},{"given":"Nuno","family":"Alves","sequence":"additional","affiliation":[]},{"given":"Geoffrey R.","family":"Mitchell","sequence":"additional","affiliation":[]},{"given":"Mahadevappa Y.","family":"Kariduraganavar","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2020,3,7]]},"reference":[{"issue":"4","key":"2053_CR1","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1093\/rb\/rby013","volume":"5","author":"TM De Witte","year":"2018","unstructured":"De Witte TM, Fratila-Apachitei LE, Zadpoor AA, Peppas NA (2018) Bone tissue engineering via growth factor delivery: from scaffolds to complex matrices. Regen Biomater 5(4):197\u2013211","journal-title":"Regen Biomater"},{"issue":"5","key":"2053_CR2","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1615\/CritRevBiomedEng.v40.i5.10","volume":"40","author":"AR Amini","year":"2012","unstructured":"Amini AR, Laurencin CT, Nukavarapu SP (2012) Bone tissue engineering: recent advances and challenges. Crit Rev Biomed Eng 40(5):363\u2013408","journal-title":"Crit Rev Biomed Eng"},{"issue":"6","key":"2053_CR3","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1016\/j.drudis.2014.04.010","volume":"19","author":"AR Shrivats","year":"2014","unstructured":"Shrivats AR, McDermott MC, Hollinger JO (2014) Bone tissue engineering: state of the union. Drug Discov Today 19(6):781\u2013786","journal-title":"Drug Discov Today"},{"issue":"5110","key":"2053_CR4","first-page":"920","volume":"260","author":"R Langer","year":"1993","unstructured":"Langer R, Vacanti JP (1993). Tissue Eng 260(5110):920\u2013926","journal-title":"Tissue Eng"},{"key":"2053_CR5","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1007\/s10965-018-1543-1","volume":"25","author":"SK Jaganathan","year":"2018","unstructured":"Jaganathan SK, Mani MP, Palaniappan SK, Rathanasamy R (2018) Fabrication and characterisation of nanofibrous polyurethane scaffold incorporated with corn and neem oil using single stage electrospinning technique for bone tissue engineering applications. J Polym Res 25:146","journal-title":"J Polym Res"},{"key":"2053_CR6","doi-asserted-by":"publisher","first-page":"29","DOI":"10.22203\/eCM.v005a03","volume":"5","author":"E Sachlos","year":"2003","unstructured":"Sachlos E, Czernuszka JT (2003) Making tissue engineering scaffolds work. Eur cells mater 5:29\u201340","journal-title":"Eur cells mater"},{"key":"2053_CR7","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1201\/9781315371184-22","volume-title":"Green polymer composites technology","author":"NA Pattanashetti","year":"2016","unstructured":"Pattanashetti NA, Hiremath C, Alves N, Kariduraganavar MY (2016) Advances in polymers and tissue engineering scaffolds. In: Inamuddin S (ed) Green polymer composites technology. CRC Press, Boca Raton, pp 343\u2013354"},{"issue":"5","key":"2053_CR8","first-page":"539","volume":"24","author":"W Jiang","year":"2013","unstructured":"Jiang W, Shi J, Li W, Sun K (2013) Three dimensional melt-deposition of polycaprolactone\/bio-derived hydroxyapatite composite into scaffold for bone repair. Aust J Biol Sci 24(5):539\u2013550","journal-title":"Aust J Biol Sci"},{"key":"2053_CR9","doi-asserted-by":"crossref","unstructured":"Domingos M, Dinucci D, Cometa S, Alderighi M, Bartolo PJ, Chiellini F (2009) Polycaprolactone scaffolds fabricated via bioextrusion for tissue engineering applications. Int J Biomater 1-9","DOI":"10.1155\/2009\/239643"},{"key":"2053_CR10","doi-asserted-by":"publisher","first-page":"S22","DOI":"10.1016\/j.injury.2011.06.008","volume":"42","author":"G Hannink","year":"2011","unstructured":"Hannink G, Arts JJC (2011) Bioresorbability, porosity and mechanical strength of bone substitutes: what is optimal for bone regeneration? Injury Int J Care Injured 42:S22\u2013S25","journal-title":"Injury Int J Care Injured"},{"key":"2053_CR11","doi-asserted-by":"publisher","first-page":"5713","DOI":"10.1007\/s10853-009-3770-7","volume":"44","author":"MI Sabir","year":"2009","unstructured":"Sabir MI, Xu X, Li L (2009) A review on biodegradable polymeric materials for bone tissue engineering applications. J Mater Sci 44:5713\u20135724","journal-title":"J Mater Sci"},{"issue":"1","key":"2053_CR12","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.jconrel.2011.09.064","volume":"158","author":"TK Dash","year":"2012","unstructured":"Dash TK, Konkimalla VB (2012) Poly-\u0454-caprolactone based formulations for drug delivery and tissue engineering: a review. J Control Release 158(1):15\u201333","journal-title":"J Control Release"},{"issue":"10","key":"2053_CR13","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1016\/j.progpolymsci.2010.04.002","volume":"35","author":"MA Woodruff","year":"2010","unstructured":"Woodruff MA, Hutmacher DW (2010) The return of a forgotten polymer\u2014Polycaprolactone in the 21st century. Prog Poly Sci 35(10):1217\u20131256","journal-title":"Prog Poly Sci"},{"key":"2053_CR14","unstructured":"Stevanovic S, Chavanne P, Braissant O, Pieles U, Gruner P, Schumacher R (2013) Improvement of mechanical properties of 3d printed hydroxyapatite scaffolds by polymeric infiltration. Bioceram Dev Appl 1\u20133"},{"issue":"8","key":"2053_CR15","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1016\/j.micron.2006.03.006","volume":"37","author":"AE Porter","year":"2006","unstructured":"Porter AE (2006) Nanoscale characterization of the interface between bone and hydroxyapatite implants and the effect of silicon on bone apposition. Micron 37(8):681\u2013688","journal-title":"Micron"},{"issue":"1","key":"2053_CR16","first-page":"23","volume":"1","author":"RB Heimann","year":"2002","unstructured":"Heimann RB (2002) Materials science of crystalline bioceramics: a review of basic properties and applications. CMU J 1(1):23\u201346","journal-title":"CMU J"},{"key":"2053_CR17","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/s10965-019-1706-8","volume":"26","author":"AS Silva","year":"2019","unstructured":"Silva AS, Rodrigues BVM, Oliveira FC, Carvalho JO, Vasconcellos LMR, Ara\u00fajo JCR, Marciano FR, Lobo AO (2019) Characterization and in vitro and in vivo assessment of poly(butyleneadipate-co-terephthalate)\/nano-hydroxyapatite composites as scaffolds for bone tissue engineering. J Polym Res 26:53","journal-title":"J Polym Res"},{"key":"2053_CR18","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.msec.2013.11.013","volume":"35","author":"AF Khan","year":"2014","unstructured":"Khan AF, Saleema M, Afzal A, Ali A, Khan A, Khan AR (2014) Bioactive behavior of silicon substituted calcium phosphate based bioceramics for bone regeneration. Mater Sci Eng C 35:245\u2013252","journal-title":"Mater Sci Eng C"},{"issue":"1","key":"2053_CR19","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1002\/jbm.a.32657","volume":"94","author":"B Chuenjitkuntaworn","year":"2010","unstructured":"Chuenjitkuntaworn B, Inrung W, Damrongsri D, Mekaapiruk K, Supaphol P, Pavasant P (2010) Polycaprolactone\/hydroxyapatite composite scaffolds: preparation, characterization, and in vitro and in vivo biological responses of human primary bone cells. J Biomed Mater Res A 94(1):241\u2013251","journal-title":"J Biomed Mater Res A"},{"key":"2053_CR20","doi-asserted-by":"crossref","unstructured":"Rodriguez G, Dias J, d'\u00c1vila MA, B\u00e1rtolo P (2013) Influence of hydroxyapatite on extruded 3D scaffolds. 3rd International Conference on Tissue Engineering. ICTE2013 Procedia Engineering 59:263\u2013269","DOI":"10.1016\/j.proeng.2013.05.120"},{"key":"2053_CR21","doi-asserted-by":"publisher","first-page":"3303","DOI":"10.1016\/j.biomaterials.2003.10.006","volume":"25","author":"AE Porter","year":"2004","unstructured":"Porter AE, Patel N, Skepper JN, Best SM, Bonfield W (2004) Effect of sintered silicate-substituted hydroxyapatite on remodelling processes at the bone\u2013implant interface. Biomaterials 25:3303\u20133314","journal-title":"Biomaterials"},{"key":"2053_CR22","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1385\/BTER:89:3:239","volume":"89","author":"CD Seaborn","year":"2002","unstructured":"Seaborn CD, Nielsen FH (2002) Dietary silicon and arginine affect mineral element composition of rat femur and vertebra. Biol Trace Elem Res 89:239\u2013250","journal-title":"Biol Trace Elem Res"},{"key":"2053_CR23","first-page":"94","volume":"11","author":"KR Martin","year":"2007","unstructured":"Martin KR (2007) The chemistry of silica and its potential health benefits. J Nutr Health Aging 11:94\u201397","journal-title":"J Nutr Health Aging"},{"issue":"17\u201318","key":"2053_CR24","doi-asserted-by":"publisher","first-page":"1867","DOI":"10.1089\/ten.tea.2012.0167","volume":"18","author":"N Ganesh","year":"2012","unstructured":"Ganesh N, Jayakumar R, Koyakutty M, Mony U, Nair SV (2012) Embedded silica nanoparticles in poly(Caprolactone) Nanofibrous scaffolds enhanced Osteogenic potential for bone tissue engineering. Tissue Eng A 18(17\u201318):1867\u20131881","journal-title":"Tissue Eng A"},{"issue":"3","key":"2053_CR25","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.ijbiomac.2009.06.009","volume":"45","author":"K Madhumathia","year":"2009","unstructured":"Madhumathia K, Sudheesh Kumara PT, Kavyaa KC, Furuikeb T, Tamurab H, Nair SV, Jayakumara R (2009) Novel chitin\/nanosilica composite scaffolds for bone tissue engineering applications. Int J Biol Macromol 45(3):289\u2013292","journal-title":"Int J Biol Macromol"},{"key":"2053_CR26","doi-asserted-by":"publisher","first-page":"2038","DOI":"10.1002\/jbm.a.34511","volume":"101A","author":"LM Olmo","year":"2013","unstructured":"Olmo LM, Ortega VV, Alcaraz-Ba\u00f1os M, Guirado LC, Reg\u00ed MV, Arcos D, Baeza A (2013) In-vivo behavior of Si-hydroxyapatite\/polycaprolactone\/DMB scaffolds fabricated by 3D printing. J Biomed Mater Res A 101A:2038\u20132048","journal-title":"J Biomed Mater Res A"},{"key":"2053_CR27","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1108\/13552541211193502","volume":"18","author":"M Domingos","year":"2012","unstructured":"Domingos M, Chiellini F, Gloria A, Ambrosio L, Bartolo P, Chiellini E (2012) Effect of process parameters on the morphological and mechanical properties of 3D bioextruded poly(1-caprolactone) scaffolds. Rapid Prototyp J 18:56\u201367","journal-title":"Rapid Prototyp J"},{"key":"2053_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2009\/239643","volume":"2009","author":"M Domingos","year":"2009","unstructured":"Domingos M, Dinucci D, Cometa S, Alderighi M, Bartolo PJ, Chiellini F (2009) Polycaprolactone scaffolds fabricated via bioextrusion for tissue engineering applications. Int J Biomater 2009:1\u20139","journal-title":"Int J Biomater"},{"key":"2053_CR29","doi-asserted-by":"publisher","first-page":"5997","DOI":"10.1016\/j.actbio.2012.12.031","volume":"9","author":"M Domingos","year":"2013","unstructured":"Domingos M, Intranuovo F, Gloria A, Gristina R, Ambrosio L, Bartolo PJ, Favia P (2013) Improved osteoblast cell affinity on plasma-modified 3-D extruded PCL scaffolds. Acta Biomater 9:5997\u20136005","journal-title":"Acta Biomater"},{"key":"2053_CR30","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1177\/0883911514521919","volume":"29","author":"AR Costa-Pinto","year":"2014","unstructured":"Costa-Pinto AR, Martins AM, Castelhano-Carlos MJ, Correlo VM, Sol PC, Longatto-Filho A, Battacharya M, Reis RL, Nuno MN (2014) In vitro degradation and in vivo biocompatibility of chitosan-poly(butylene succinate) fiber mesh scaffolds. J Bioact Compat Polym 29:137\u2013151","journal-title":"J Bioact Compat Polym"},{"key":"2053_CR31","doi-asserted-by":"publisher","first-page":"2111","DOI":"10.1039\/C9NJ05118J","volume":"44","author":"NA Pattanashetti","year":"2020","unstructured":"Pattanashetti NA, Hiremath C, Naik SR, Heggannavar GB, Kariduraganavar MY (2020) Development of nanofibrous scaffolds by varying the TiO2 content in crosslinked PVA for bone tissue engineering. New J Chem 44:2111\u20132121","journal-title":"New J Chem"},{"issue":"3","key":"2053_CR32","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/j.biomaterials.2009.09.063","volume":"31","author":"CM Murphy","year":"2010","unstructured":"Murphy CM, Haugh MG, O\u2019Brien FJ (2010) The effect of mean pore size on cell attachment, proliferation and migration in collagen\u2013glycosaminoglycan scaffolds for bone tissue engineering. Biomaterials 31(3):461\u2013466","journal-title":"Biomaterials"},{"issue":"12","key":"2053_CR33","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1023\/A:1008959103864","volume":"9","author":"D Baksh","year":"1998","unstructured":"Baksh D, Davies JE, Kim S (1998) Three-dimensional matrices of calcium polyphosphates support bone growth in vitro and in vivo. J Mater Sci Mater Med 9(12):743\u2013748","journal-title":"J Mater Sci Mater Med"},{"key":"2053_CR34","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1163\/1568562041526487","volume":"15","author":"SJ Lee","year":"2004","unstructured":"Lee SJ, Lee IW, Lee YM, Lee HB, Khang G (2004) Macroporous biodegradable natural\/ synthetic hybrid scaffolds as small intestine submucosa impregnated poly-(D, L-lactide-co-glycolide) for tissue-engineered bone. J Biomater Sci Polym Ed 15:1003\u20131017","journal-title":"J Biomater Sci Polym Ed"},{"key":"2053_CR35","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.msec.2017.12.023","volume":"85","author":"AGB Castro","year":"2018","unstructured":"Castro AGB, Diba M, Kersten M, Jansen A, van den Beucken JJJP, Yang F (2018) Development of a PCL-silica nanoparticles composite membrane for guided bone regeneration. Mater Sci Eng C 85:154\u2013161","journal-title":"Mater Sci Eng C"},{"issue":"1","key":"2053_CR36","first-page":"31","volume":"12","author":"SIA Razak","year":"2012","unstructured":"Razak SIA, Sharif NFA, Rahman WAWA (2012) Biodegradable polymers and their bone Appications: a review. Int J Basic Appl Sci 12(1):31\u201349","journal-title":"Int J Basic Appl Sci"},{"key":"2053_CR37","unstructured":"Shin K, Koh Y, Kim H (2013) Synthesis and characterization of drug-loaded poly(\ud700-caprolactone)\/Silica hybrid Nanofibrous scaffolds. J Nanomaters 1\u201312"},{"key":"2053_CR38","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.cej.2014.04.009","volume":"250","author":"H Lee","year":"2014","unstructured":"Lee H, Hwang H, Kim Y, Jeon H, Kim GH (2014) Physical and bioactive properties of multi-layered PCL\/silica composite scaffolds for bone tissue regeneration. Chem Eng J 250:399\u2013408","journal-title":"Chem Eng J"},{"key":"2053_CR39","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.colsurfb.2013.04.006","volume":"109","author":"JA Sowjanya","year":"2013","unstructured":"Sowjanya JA, Singh J, Mohita T, Sarvanan S, Moorthi A, Srinivasan N (2013) Selvamurugan N. biocomposite scaffolds containing chitosan\/alginate\/nano-silica for bone tissue engineering. Colloids Surf B: Biointerfaces 109:294\u2013300","journal-title":"Colloids Surf B: Biointerfaces"},{"issue":"4","key":"2053_CR40","doi-asserted-by":"publisher","first-page":"6818","DOI":"10.3390\/ijms16046818","volume":"16","author":"C Gao","year":"2015","unstructured":"Gao C, Wei P, Feng P, Xiao T, Shuai C, Peng S (2015) Nano SiO2 and MgO improve the properties of porous \u03b2-TCP scaffolds via advanced manufacturing technology. Int J Mol Sci 16(4):6818\u20136830","journal-title":"Int J Mol Sci"}],"container-title":["Journal of Polymer Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10965-020-02053-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s10965-020-02053-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s10965-020-02053-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,7]],"date-time":"2021-03-07T00:22:38Z","timestamp":1615076558000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s10965-020-02053-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,7]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["2053"],"URL":"https:\/\/doi.org\/10.1007\/s10965-020-02053-0","relation":{},"ISSN":["1022-9760","1572-8935"],"issn-type":[{"value":"1022-9760","type":"print"},{"value":"1572-8935","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,7]]},"assertion":[{"value":"28 September 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 February 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 March 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"There are no conflicts to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"87"}}