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Heat capacity measurements were taken for clearly specified polymorphs, a liquid phase (including subcooled liquid) and a glassy amorphous phase, if feasible. For 5,5-diphenylhydantoin, a heat capacity anomaly was detected in the temperature range 160 to 190\u00a0K and interpreted based on additional calorimetric and temperature-variable crystallographic measurements as a sequence of two phase transitions, which are reported for the first time in this work. Based on the determined phase behavior and heat capacity data from near 0\u00a0K, standard thermodynamic functions for crystalline and liquid phases were calculated for all APIs studied. This work significantly extends the availability of reliable heat capacity data and related thermodynamic properties for APIs required for modeling their solubility and other applications involving thermodynamic modeling.<\/jats:p>","DOI":"10.1007\/s10973-024-13220-6","type":"journal-article","created":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T15:01:49Z","timestamp":1720623709000},"page":"6179-6193","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Heat capacities of active pharmaceutical ingredients nifedipine, griseofulvin, probucol and 5,5-diphenylhydantoin"],"prefix":"10.1007","volume":"149","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2839-8546","authenticated-orcid":false,"given":"Vojt\u011bch","family":"\u0160tejfa","sequence":"first","affiliation":[]},{"given":"Olga","family":"Vojt\u00ed\u0161kov\u00e1","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4145-7982","authenticated-orcid":false,"given":"V\u00e1clav","family":"Pokorn\u00fd","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6913-2667","authenticated-orcid":false,"given":"Jan","family":"Rohl\u00ed\u010dek","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9048-1036","authenticated-orcid":false,"given":"Kv\u011btoslav","family":"R\u016f\u017ei\u010dka","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5707-0670","authenticated-orcid":false,"given":"Michal","family":"Fulem","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2024,7,10]]},"reference":[{"key":"13220_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jct.2021.106585","volume":"163","author":"V \u0160tejfa","year":"2021","unstructured":"\u0160tejfa V, Pokorn\u00fd V, Mathers A, R\u016f\u017ei\u010dka K, Fulem M. 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