{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T04:56:55Z","timestamp":1777525015581,"version":"3.51.4"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1-2","license":[{"start":{"date-parts":[[2008,3,18]],"date-time":"2008-03-18T00:00:00Z","timestamp":1205798400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"published-print":{"date-parts":[[2008,6]]},"DOI":"10.1007\/s11010-008-9735-3","type":"journal-article","created":{"date-parts":[[2008,3,17]],"date-time":"2008-03-17T09:30:42Z","timestamp":1205746242000},"page":"1-10","source":"Crossref","is-referenced-by-count":10,"title":["Genomic regulation of intestinal amino acid transporters by aldosterone"],"prefix":"10.1007","volume":"313","author":[{"given":"Jo\u00e3o S.","family":"Amaral","sequence":"first","affiliation":[]},{"given":"Maria Jo\u00e3o","family":"Pinho","sequence":"additional","affiliation":[]},{"given":"Patr\u00edcio","family":"Soares-da-Silva","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2008,3,18]]},"reference":[{"key":"9735_CR1","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1111\/j.1523-1755.2004.00722.x","volume":"66","author":"MJ Pinho","year":"2004","unstructured":"Pinho MJ, Serrao MP, Gomes P, Hopfer U, Jose PA, Soares-da-Silva P (2004) Over-expression of renal LAT1 and LAT2 and enhanced l-DOPA uptake in SHR immortalized renal proximal tubular cells. Kidney Int 66:216\u2013226","journal-title":"Kidney Int"},{"key":"9735_CR2","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1161\/01.HYP.0000091822.00166.B1","volume":"42","author":"MJ Pinho","year":"2003","unstructured":"Pinho MJ, Gomes P, Serrao MP, Bonifacio MJ, Soares-da-Silva P (2003) Organ-specific overexpression of renal LAT2 and enhanced tubular l-DOPA uptake precede the onset of hypertension. Hypertension 42:613\u2013618","journal-title":"Hypertension"},{"key":"9735_CR3","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s00232-001-0136-8","volume":"186","author":"P Gomes","year":"2002","unstructured":"Gomes P, Soares-da-Silva P (2002) Na+-independent transporters, LAT-2 and b0,+, exchange l-DOPA with neutral and basic amino acids in two clonal renal cell lines. J Membr Biol 186:63\u201380","journal-title":"J Membr Biol"},{"key":"9735_CR4","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1111\/j.1476-5381.1994.tb13118.x","volume":"112","author":"P Soares-da-Silva","year":"1994","unstructured":"Soares-da-Silva P, Fernandes MH, Pinto-do-\u00d3 PC (1994) Cell inward transport of l-DOPA and 3-O-methyl-l-DOPA in rat renal tubules. Br J Pharmacol 112:611\u2013615","journal-title":"Br J Pharmacol"},{"key":"9735_CR5","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1681\/ASN.V391591","volume":"3","author":"P Soares-da-Silva","year":"1993","unstructured":"Soares-da-Silva P, Pestana M, Fernandes MH (1993) Involvement of tubular sodium in the formation of dopamine in the human renal cortex. J Am Soc Nephrol 3:1591\u20131599","journal-title":"J Am Soc Nephrol"},{"key":"9735_CR6","doi-asserted-by":"crossref","first-page":"F252","DOI":"10.1152\/ajprenal.00030.2004","volume":"287","author":"P Soares-da-Silva","year":"2004","unstructured":"Soares-da-Silva P, Serrao MP (2004) High- and low-affinity transport of l-leucine and l-DOPA by the hetero amino acid exchangers LAT1 and LAT2 in LLC-PK1 renal cells. Am J Physiol Ren Physiol 287:F252\u2013F261","journal-title":"Am J Physiol Ren Physiol"},{"key":"9735_CR7","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s00726-005-0242-5","volume":"29","author":"P Soares-da-Silva","year":"2005","unstructured":"Soares-da-Silva P, Serrao MP (2005) Apical and basolateral 4F2hc and the amino acid exchange of l-DOPA in renal LLC-PK1 cells. Amino Acids 29:213\u2013219","journal-title":"Amino Acids"},{"key":"9735_CR8","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1096\/fj.04-1787com","volume":"18","author":"P Soares-da-Silva","year":"2004","unstructured":"Soares-da-Silva P, Serrao MP, Pinho MJ, Bonifacio MJ (2004) Cloning and gene silencing of LAT2, the l-3,4-dihydroxyphenylalanine (l-DOPA) transporter, in pig renal LLC-PK1 epithelial cells. FASEB J 18:1489\u20131498","journal-title":"FASEB J"},{"key":"9735_CR9","first-page":"F243","volume":"274","author":"P Soares-da-Silva","year":"1998","unstructured":"Soares-da-Silva P, Serrao MP, Vieira-Coelho MA (1998) Apical and basolateral uptake and intracellular fate of dopamine precursor l-dopa in LLC-PK1 cells. Am J Physiol 274:F243\u2013F251","journal-title":"Am J Physiol"},{"key":"9735_CR10","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1365-201X.2005.01451.x","volume":"185","author":"P Soares-da-Silva","year":"2005","unstructured":"Soares-da-Silva P, Serrao P, Fraga S, Pinho MJ (2005) Expression and function of LAT1, a neutral amino acid exchanger, in renal porcine epithelial cell line LLC-PK. Acta Physiol Scand 185:71\u201378","journal-title":"Acta Physiol Scand"},{"key":"9735_CR11","doi-asserted-by":"crossref","first-page":"F1452","DOI":"10.1152\/ajprenal.00465.2006","volume":"292","author":"MJ Pinho","year":"2007","unstructured":"Pinho MJ, Serrao MP, Soares-da-Silva P (2007) High salt intake and the renal expression of amino acid transporters in spontaneously hypertensive rats. Am J Physiol Ren Physiol 292:F1452\u2013F1463","journal-title":"Am J Physiol Ren Physiol"},{"key":"9735_CR12","first-page":"A746","volume":"19","author":"MJ Pinho","year":"2005","unstructured":"Pinho MJ, Soares-da-Silva P (2005) Influence of aldosterone on the expression of renal LAT2 tranporter. FASEB J 19:A746","journal-title":"FASEB J"},{"key":"9735_CR13","first-page":"S232","volume":"23","author":"MJ Pinho","year":"2005","unstructured":"Pinho MJ, Soares-da-Silva P (2005) Aldosterone effects on the expression of renal l-type amino acid transporter 2. J Hypertens 23:S232","journal-title":"J Hypertens"},{"key":"9735_CR14","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.ejheart.2003.11.020","volume":"6","author":"M Alvelos","year":"2004","unstructured":"Alvelos M, Ferreira A, Bettencourt P, Serrao P, Pestana M, Cerqueira-Gomes M, Soares-Da-Silva P (2004) The effect of dietary sodium restriction on neurohumoral activity and renal dopaminergic response in patients with heart failure. Eur J Heart Fail 6:593\u2013599","journal-title":"Eur J Heart Fail"},{"key":"9735_CR15","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1042\/cs1000557","volume":"100","author":"A Ferreira","year":"2001","unstructured":"Ferreira A, Bettencourt P, Dias P, Pestana M, Serrao P, Soares-da-Silva P, Cerqueira-Gomes M (2001) Neurohormonal activation, the renal dopaminergic system and sodium handling in patients with severe heart failure under vasodilator therapy. Clin Sci (Lond) 100:557\u2013566","journal-title":"Clin Sci (Lond)"},{"key":"9735_CR16","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1067\/mhj.2002.120292","volume":"143","author":"A Ferreira","year":"2002","unstructured":"Ferreira A, Bettencourt P, Pimenta J, Frioes F, Pestana M, Soares-da-Silva P, Cerqueira-Gomes M (2002) The renal dopaminergic system, neurohumoral activation, and sodium handling in heart failure. Am Heart J 143:391\u2013397","journal-title":"Am Heart J"},{"key":"9735_CR17","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3109\/10641969709080803","volume":"19","author":"MA Vieira-Coelho","year":"1997","unstructured":"Vieira-Coelho MA, Gomes P, Serrao MP, Soares-da-Silva P (1997) Renal and intestinal autocrine monoaminergic systems: dopamine versus 5-hydroxytryptamine. Clin Exp Hypertens 19:43\u201358","journal-title":"Clin Exp Hypertens"},{"key":"9735_CR18","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/j.1440-1797.2006.00533.x","volume":"11","author":"B Sampaio-Maia","year":"2006","unstructured":"Sampaio-Maia B, Serrao P, Moura M, Pestana M (2006) Jejunal dopamine and Na,K-ATPase activity in early chronic renal insufficiency. Nephrology (Carlton) 11:63\u201367","journal-title":"Nephrology (Carlton)"},{"key":"9735_CR19","doi-asserted-by":"crossref","first-page":"F1033","DOI":"10.1152\/ajprenal.2000.279.6.F1033","volume":"279","author":"MA Vieira-Coelho","year":"2000","unstructured":"Vieira-Coelho MA, Serrao P, Guimaraes JT, Pestana M, Soares-da-Silva P (2000) Concerted action of dopamine on renal and intestinal Na+-K+-ATPase in the rat remnant kidney. Am J Physiol Ren Physiol 279:F1033\u2013F1044","journal-title":"Am J Physiol Ren Physiol"},{"key":"9735_CR20","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.ygcen.2006.01.008","volume":"147","author":"G Laverty","year":"2006","unstructured":"Laverty G, Elbrond VS, Arnason SS, Skadhauge E (2006) Endocrine regulation of ion transport in the avian lower intestine. Gen Comp Endocrinol 147:70\u201377","journal-title":"Gen Comp Endocrinol"},{"key":"9735_CR21","doi-asserted-by":"crossref","first-page":"R760","DOI":"10.1152\/ajpregu.00524.2005","volume":"291","author":"A Mate","year":"2006","unstructured":"Mate A, Barfull A, Hermosa AM, Gomez-Amores L, Vazquez CM, Planas JM (2006) Regulation of sodium-glucose cotransporter SGLT1 in the intestine of hypertensive rats. Am J Physiol Regul Integr Comp Physiol 291:R760\u2013R767","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"9735_CR22","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s00232-005-0772-5","volume":"206","author":"M Moreto","year":"2005","unstructured":"Moreto M, Cristia E, Perez-Bosque A, Afzal-Ahmed I, Amat C, Naftalin RJ (2005) Aldosterone reduces crypt colon permeability during low-sodium adaptation. J Membr Biol 206:43\u201351","journal-title":"J Membr Biol"},{"key":"9735_CR23","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0014-2999(02)01416-4","volume":"441","author":"S Fraga","year":"2002","unstructured":"Fraga S, Serrao MP, Soares-da-Silva P (2002) The l-3,4-dihydroxyphenylalanine transporter in human and rat epithelial intestinal cells is a type 2 hetero amino acid exchanger. Eur J Pharmacol 441:127\u2013135","journal-title":"Eur J Pharmacol"},{"key":"9735_CR24","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1093\/jn\/132.4.733","volume":"132","author":"S Fraga","year":"2002","unstructured":"Fraga S, Serrao MP, Soares-da-Silva P (2002) l-Type amino acid transporters in two intestinal epithelial cell lines function as exchangers with neutral amino acids. J Nutr 132:733\u2013738","journal-title":"J Nutr"},{"key":"9735_CR25","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s00726-005-0221-x","volume":"29","author":"S Fraga","year":"2005","unstructured":"Fraga S, Pinho MJ, Soares-da-Silva P (2005) Expression of LAT1 and LAT2 amino acid transporters in human and rat intestinal epithelial cells. Amino Acids 29:229\u2013233","journal-title":"Amino Acids"},{"key":"9735_CR26","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0960-0760(03)00202-4","volume":"85","author":"B Boldyreff","year":"2003","unstructured":"Boldyreff B, Wehling M (2003) Rapid aldosterone actions: from the membrane to signaling cascades to gene transcription and physiological effects. J Steroid Biochem Mol Biol 85:375\u2013381","journal-title":"J Steroid Biochem Mol Biol"},{"key":"9735_CR27","first-page":"97","volume":"19","author":"B Boldyreff","year":"2004","unstructured":"Boldyreff B, Wehling M (2004) Aldosterone: refreshing a slow hormone by swift action. News Physiol Sci 19:97\u2013100","journal-title":"News Physiol Sci"},{"key":"9735_CR28","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/0300-9629(85)90903-X","volume":"81","author":"J Lerner","year":"1985","unstructured":"Lerner J (1985) Effectors of amino acid transport processes in animal cell membranes. Comp Biochem Physiol A 81:713\u2013739","journal-title":"Comp Biochem Physiol A"},{"key":"9735_CR29","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s007260050024","volume":"18","author":"M Schwertfeger","year":"2000","unstructured":"Schwertfeger M, Roskos M, Fleck C (2000) Identification of the site of glucocorticoid action on neutral amino acid transport in superficial nephrons of rat kidney. Amino Acids 18:279\u2013288","journal-title":"Amino Acids"},{"key":"9735_CR30","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s004240050403","volume":"434","author":"B Spindler","year":"1997","unstructured":"Spindler B, Mastroberardino L, Custer M, Verrey F (1997) Characterization of early aldosterone-induced RNAs identified in A6 kidney epithelia. Pflugers Arch 434:323-331","journal-title":"Pflugers Arch"},{"key":"9735_CR31","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1469-7793.2000.00035.x","volume":"526","author":"CA Wagner","year":"2000","unstructured":"Wagner CA, Broer A, Albers A, Gamper N, Lang F, Broer S (2000) The heterodimeric amino acid transporter 4F2hc\/LAT1 is associated in Xenopus oocytes with a non-selective cation channel that is regulated by the serine\/threonine kinase sgk-1. J Physiol 526:35\u201346","journal-title":"J Physiol"},{"key":"9735_CR32","first-page":"494","volume":"16","author":"WH Atwill","year":"1965","unstructured":"Atwill WH, Boyarsky S, Glenn JF (1965) Effect of spironolactone on experimental renovascular hypertension. Surg Forum 16:494\u2013495","journal-title":"Surg Forum"},{"key":"9735_CR33","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1161\/01.HYP.31.1.451","volume":"31","author":"R Rocha","year":"1998","unstructured":"Rocha R, Chander PN, Khanna K, Zuckerman A, Stier CT Jr (1998) Mineralocorticoid blockade reduces vascular injury in stroke-prone hypertensive rats. Hypertension 31:451\u2013458","journal-title":"Hypertension"},{"key":"9735_CR34","doi-asserted-by":"crossref","first-page":"19738","DOI":"10.1074\/jbc.274.28.19738","volume":"274","author":"M Pineda","year":"1999","unstructured":"Pineda M, Fernandez E, Torrents D, Estevez R, Lopez C, Camps M, Lloberas J, Zorzano A, Palacin M (1999) Identification of a membrane protein, LAT-2, that co-expresses with 4F2 heavy chain, an l-type amino acid transport activity with broad specificity for small and large zwitterionic amino acids. J Biol Chem 274:19738\u201319744","journal-title":"J Biol Chem"},{"key":"9735_CR35","doi-asserted-by":"crossref","first-page":"34948","DOI":"10.1074\/jbc.274.49.34948","volume":"274","author":"G Rossier","year":"1999","unstructured":"Rossier G, Meier C, Bauch C, Summa V, Sordat B, Verrey F, Kuhn LC (1999) LAT2, a new basolateral 4F2hc\/CD98-associated amino acid transporter of kidney and intestine. J Biol Chem 274:34948\u201334954","journal-title":"J Biol Chem"},{"key":"9735_CR36","doi-asserted-by":"crossref","first-page":"19745","DOI":"10.1074\/jbc.274.28.19745","volume":"274","author":"H Segawa","year":"1999","unstructured":"Segawa H, Fukasawa Y, Miyamoto K, Takeda E, Endou H, Kanai Y (1999) Identification and functional characterization of a Na+-independent neutral amino acid transporter with broad substrate selectivity. J Biol Chem 274:19745\u201319751","journal-title":"J Biol Chem"},{"key":"9735_CR37","doi-asserted-by":"crossref","first-page":"3009","DOI":"10.1074\/jbc.274.5.3009","volume":"274","author":"E Nakamura","year":"1999","unstructured":"Nakamura E, Sato M, Yang H, Miyagawa F, Harasaki M, Tomita K, Matsuoka S, Noma A, Iwai K, Minato N (1999) 4F2 (CD98) heavy chain is associated covalently with an amino acid transporter and controls intracellular trafficking and membrane topology of 4F2 heterodimer. J Biol Chem 274:3009\u20133016","journal-title":"J Biol Chem"},{"key":"9735_CR38","doi-asserted-by":"crossref","first-page":"339","DOI":"10.2174\/1389200013338324","volume":"2","author":"Y Kanai","year":"2001","unstructured":"Kanai Y, Endou H (2001) Heterodimeric amino acid transporters: molecular biology and pathological and pharmacological relevance. Curr Drug Metab 2:339\u2013354","journal-title":"Curr Drug Metab"},{"key":"9735_CR39","first-page":"F319","volume":"277","author":"F Verrey","year":"1999","unstructured":"Verrey F (1999) Early aldosterone action: toward filling the gap between transcription and transport. Am J Physiol 277:F319\u2013F327","journal-title":"Am J Physiol"},{"issue":"Pt 2","key":"9735_CR40","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1042\/bj3240535","volume":"324","author":"S Broer","year":"1997","unstructured":"Broer S, Broer A, Hamprecht B (1997) Expression of the surface antigen 4F2hc affects system-l-like neutral-amino-acid-transport activity in mammalian cells. Biochem J 324(Pt 2):535\u2013541","journal-title":"Biochem J"},{"key":"9735_CR41","doi-asserted-by":"crossref","first-page":"5347","DOI":"10.1074\/jbc.275.8.5347","volume":"275","author":"WA Campbell","year":"2000","unstructured":"Campbell WA, Sah DE, Medina MM, Albina JE, Coleman WB, Thompson NL (2000) TA1\/LAT-1\/CD98 light chain and system l activity, but not 4F2\/CD98 heavy chain, respond to arginine availability in rat hepatic cells. Loss Of response in tumor cells. J Biol Chem 275:5347\u20135354","journal-title":"J Biol Chem"},{"issue":"Pt 1","key":"9735_CR42","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1469-7793.2000.t01-1-00013.x","volume":"523","author":"Y Kudo","year":"2000","unstructured":"Kudo Y, Boyd CA (2000) Heterodimeric amino acid transporters: expression of heavy but not light chains of CD98 correlates with induction of amino acid transport systems in human placental trophoblast. J Physiol 523(Pt 1):13\u201318","journal-title":"J Physiol"},{"key":"9735_CR43","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1016\/j.febslet.2005.03.065","volume":"579","author":"T Uchiyama","year":"2005","unstructured":"Uchiyama T, Matsuda Y, Wada M, Takahashi S, Fujita T (2005) Functional regulation of Na+-dependent neutral amino acid transporter ASCT2 by S-nitrosothiols and nitric oxide in Caco-2 cells. FEBS Lett 579:2499\u20132506","journal-title":"FEBS Lett"},{"key":"9735_CR44","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1177\/014860710102500265","volume":"25","author":"NE Avissar","year":"2001","unstructured":"Avissar NE, Ziegler TR, Wang HT, Gu LH, Miller JH, Iannoli P, Leibach FH, Ganapathy V, Sax HC (2001) Growth factors regulation of rabbit sodium-dependent neutral amino acid transporter ATB0 and oligopeptide transporter 1 mRNAs expression after enteretomy. J Parenter Enteral Nutr 25:65\u201372","journal-title":"J Parenter Enteral Nutr"},{"key":"9735_CR45","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.abb.2005.08.016","volume":"443","author":"CI Bungard","year":"2005","unstructured":"Bungard CI, McGivan JD (2005) Identification of the promoter elements involved in the stimulation of ASCT2 expression by glutamine availability in HepG2 cells and the probable involvement of FXR\/RXR dimers. Arch Biochem Biophys 443:53\u201359","journal-title":"Arch Biochem Biophys"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-008-9735-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11010-008-9735-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-008-9735-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T00:04:18Z","timestamp":1630886658000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11010-008-9735-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3,18]]},"references-count":45,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["9735"],"URL":"https:\/\/doi.org\/10.1007\/s11010-008-9735-3","relation":{},"ISSN":["0300-8177","1573-4919"],"issn-type":[{"value":"0300-8177","type":"print"},{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3,18]]}}}