{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T23:20:17Z","timestamp":1768000817950,"version":"3.49.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1-2","license":[{"start":{"date-parts":[[2014,10,17]],"date-time":"2014-10-17T00:00:00Z","timestamp":1413504000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cell Biochem"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1007\/s11010-014-2241-x","type":"journal-article","created":{"date-parts":[[2014,10,16]],"date-time":"2014-10-16T08:52:09Z","timestamp":1413449529000},"page":"143-153","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["LAP1 is a crucial protein for the maintenance of the nuclear envelope structure and cell cycle progression"],"prefix":"10.1007","volume":"399","author":[{"given":"Mariana","family":"Santos","sequence":"first","affiliation":[]},{"given":"Patr\u00edcia","family":"Costa","sequence":"additional","affiliation":[]},{"given":"Filipa","family":"Martins","sequence":"additional","affiliation":[]},{"given":"Edgar F.","family":"da Cruz e Silva","sequence":"additional","affiliation":[]},{"given":"Odete A. B.","family":"da Cruz e Silva","sequence":"additional","affiliation":[]},{"given":"Sandra","family":"Rebelo","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2014,10,17]]},"reference":[{"issue":"3","key":"2241_CR1","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/nrm2641","volume":"10","author":"S Guttinger","year":"2009","unstructured":"Guttinger S, Laurell E, Kutay U (2009) Orchestrating nuclear envelope disassembly and reassembly during mitosis. Nat Rev Mol Cell Biol 10(3):178\u2013191. doi: 10.1038\/nrm2641","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"4","key":"2241_CR2","doi-asserted-by":"crossref","first-page":"261","DOI":"10.4161\/nucl.25341","volume":"4","author":"JT Arnone","year":"2013","unstructured":"Arnone JT, Walters AD, Cohen-Fix O (2013) The dynamic nature of the nuclear envelope: lessons from closed mitosis. Nucleus 4(4):261\u2013266. doi: 10.4161\/nucl.25341","journal-title":"Nucleus"},{"key":"2241_CR3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1100\/tsw.2003.06","volume":"3","author":"R Foisner","year":"2003","unstructured":"Foisner R (2003) Cell cycle dynamics of the nuclear envelope. Sci World J 3:1\u201320. doi: 10.1100\/tsw.2003.06","journal-title":"Sci World J"},{"issue":"6","key":"2241_CR4","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1083\/jcb.151.6.1155","volume":"151","author":"RD Moir","year":"2000","unstructured":"Moir RD, Yoon M, Khuon S, Goldman RD (2000) Nuclear lamins A and B1: different pathways of assembly during nuclear envelope formation in living cells. J Cell Biol 151(6):1155\u20131168","journal-title":"J Cell Biol"},{"issue":"6","key":"2241_CR5","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1083\/jcb.200702026","volume":"178","author":"G Salpingidou","year":"2007","unstructured":"Salpingidou G, Smertenko A, Hausmanowa-Petrucewicz I, Hussey PJ, Hutchison CJ (2007) A novel role for the nuclear membrane protein emerin in association of the centrosome to the outer nuclear membrane. J Cell Biol 178(6):897\u2013904. doi: 10.1083\/jcb.200702026","journal-title":"J Cell Biol"},{"issue":"Pt 24","key":"2241_CR6","first-page":"4567","volume":"114","author":"KK Lee","year":"2001","unstructured":"Lee KK, Haraguchi T, Lee RS, Koujin T, Hiraoka Y, Wilson KL (2001) Distinct functional domains in emerin bind lamin A and DNA-bridging protein BAF. J Cell Sci 114(Pt 24):4567\u20134573","journal-title":"J Cell Sci"},{"issue":"6 Pt 1","key":"2241_CR7","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1083\/jcb.107.6.2029","volume":"107","author":"A Senior","year":"1988","unstructured":"Senior A, Gerace L (1988) Integral membrane proteins specific to the inner nuclear membrane and associated with the nuclear lamina. J Cell Biol 107(6 Pt 1):2029\u20132036","journal-title":"J Cell Biol"},{"issue":"15","key":"2241_CR8","doi-asserted-by":"crossref","first-page":"8822","DOI":"10.1074\/jbc.270.15.8822","volume":"270","author":"L Martin","year":"1995","unstructured":"Martin L, Crimaudo C, Gerace L (1995) cDNA cloning and characterization of lamina-associated polypeptide 1C (LAP1C), an integral protein of the inner nuclear membrane. J Biol Chem 270(15):8822\u20138828","journal-title":"J Biol Chem"},{"issue":"4","key":"2241_CR9","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/S0006-291X(02)00563-6","volume":"294","author":"Y Kondo","year":"2002","unstructured":"Kondo Y, Kondoh J, Hayashi D, Ban T, Takagi M, Kamei Y, Tsuji L, Kim J, Yoneda Y (2002) Molecular cloning of one isotype of human lamina-associated polypeptide 1s and a topological analysis using its deletion mutants. Biochem Biophys Res Commun 294(4):770\u2013778. doi: 10.1016\/S0006-291X(02)00563-6","journal-title":"Biochem Biophys Res Commun"},{"issue":"7","key":"2241_CR10","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/0092-8674(93)90355-T","volume":"73","author":"R Foisner","year":"1993","unstructured":"Foisner R, Gerace L (1993) Integral membrane proteins of the nuclear envelope interact with lamins and chromosomes, and binding is modulated by mitotic phosphorylation. Cell 73(7):1267\u20131279","journal-title":"Cell"},{"issue":"6","key":"2241_CR11","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1083\/jcb.137.6.1199","volume":"137","author":"L Yang","year":"1997","unstructured":"Yang L, Guan T, Gerace L (1997) Integral membrane proteins of the nuclear envelope are dispersed throughout the endoplasmic reticulum during mitosis. J Cell Biol 137(6):1199\u20131210","journal-title":"J Cell Biol"},{"issue":"31","key":"2241_CR12","doi-asserted-by":"crossref","first-page":"10762","DOI":"10.1073\/pnas.0805139105","volume":"105","author":"N Dephoure","year":"2008","unstructured":"Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP (2008) A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci USA 105(31):10762\u201310767. doi: 10.1073\/pnas.0805139105","journal-title":"Proc Natl Acad Sci USA"},{"key":"2241_CR13","doi-asserted-by":"crossref","unstructured":"Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M (2010) Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal 3(104):ra3. doi: 10.1126\/scisignal.2000475","DOI":"10.1126\/scisignal.2000475"},{"issue":"10","key":"2241_CR14","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.tcb.2009.06.005","volume":"19","author":"M Bollen","year":"2009","unstructured":"Bollen M, Gerlich DW, Lesage B (2009) Mitotic phosphatases: from entry guards to exit guides. Trends Cell Biol 19(10):531\u2013541. doi: 10.1016\/j.tcb.2009.06.005","journal-title":"Trends Cell Biol"},{"issue":"7289","key":"2241_CR15","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/nature08869","volume":"464","author":"B Neumann","year":"2010","unstructured":"Neumann B, Walter T, Heriche JK, Bulkescher J, Erfle H, Conrad C, Rogers P, Poser I, Held M, Liebel U, Cetin C, Sieckmann F, Pau G, Kabbe R, Wunsche A, Satagopam V, Schmitz MH, Chapuis C, Gerlich DW, Schneider R, Eils R, Huber W, Peters JM, Hyman AA, Durbin R, Pepperkok R, Ellenberg J (2010) Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes. Nature 464(7289):721\u2013727. doi: 10.1038\/nature08869","journal-title":"Nature"},{"issue":"6","key":"2241_CR16","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1083\/jcb.200411026","volume":"168","author":"RE Goodchild","year":"2005","unstructured":"Goodchild RE, Dauer WT (2005) The AAA+ protein torsinA interacts with a conserved domain present in LAP1 and a novel ER protein. J Cell Biol 168(6):855\u2013862. doi: 10.1083\/jcb.200411026","journal-title":"J Cell Biol"},{"issue":"6","key":"2241_CR17","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1177\/1533317508323572","volume":"23","author":"S Rebelo","year":"2008","unstructured":"Rebelo S, Vieira SI, da Cruz ESEF, da Cruz ESOA (2008) Monitoring \u201cDe Novo\u201d APP synthesis by taking advantage of the reversible effect of cycloheximide. Am J Alzheimers Dis Other Demen 23(6):602\u2013608. doi: 10.1177\/1533317508323572","journal-title":"Am J Alzheimers Dis Other Demen"},{"issue":"1","key":"2241_CR18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12031-007-0001-z","volume":"32","author":"S Rebelo","year":"2007","unstructured":"Rebelo S, Vieira SI, Esselmann H, Wiltfang J, da Cruz e Silva EF, da Cruz e Silva OA (2007) Tyr687 dependent APP endocytosis and Abeta production. J Mol Neurosci 32(1):1\u20138","journal-title":"J Mol Neurosci"},{"key":"2241_CR19","doi-asserted-by":"crossref","unstructured":"Santos M, Domingues CS, Costa P, Muller T, Galozzi S, Marcus K, da Cruz e Silva EF, da Cruz e Silva OAB, Rebelo S (2014) Identification of a novel human LAP1 isoform that is regulated by protein phosphorylation. PLoS One (Submitted)","DOI":"10.1371\/journal.pone.0113732"},{"issue":"10","key":"2241_CR20","doi-asserted-by":"crossref","first-page":"e76788","DOI":"10.1371\/journal.pone.0076788","volume":"8","author":"M Santos","year":"2013","unstructured":"Santos M, Rebelo S, Van Kleeff PJ, Kim CE, Dauer WT, Fardilha M, da Cruz ESOA, da Cruz ESEF (2013) The nuclear envelope protein, LAP1B, Is a novel protein phosphatase 1 substrate. PLoS One 8(10):e76788. doi: 10.1371\/journal.pone.0076788","journal-title":"PLoS One"},{"issue":"4","key":"2241_CR21","doi-asserted-by":"crossref","first-page":"761","DOI":"10.3233\/JAD-130095","volume":"35","author":"S Rebelo","year":"2013","unstructured":"Rebelo S, Domingues SC, Santos M, Fardilha M, Esteves SL, Vieira SI, Vintem AP, Wu W, da Cruz ESEF, da Cruz ESOA (2013) Identification of a novel complex AbetaPP:Fe65:PP1 that regulates AbetaPP Thr668 phosphorylation levels. J Alzheimers Dis 35(4):761\u2013775. doi: 10.3233\/JAD-130095","journal-title":"J Alzheimers Dis"},{"issue":"1","key":"2241_CR22","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/83751","volume":"27","author":"RJ Cho","year":"2001","unstructured":"Cho RJ, Huang M, Campbell MJ, Dong H, Steinmetz L, Sapinoso L, Hampton G, Elledge SJ, Davis RW, Lockhart DJ (2001) Transcriptional regulation and function during the human cell cycle. Nat Genet 27(1):48\u201354. doi: 10.1038\/83751","journal-title":"Nat Genet"},{"issue":"7","key":"2241_CR23","doi-asserted-by":"crossref","first-page":"4379","DOI":"10.1073\/pnas.062569899","volume":"99","author":"K Shedden","year":"2002","unstructured":"Shedden K, Cooper S (2002) Analysis of cell-cycle-specific gene expression in human cells as determined by microarrays and double-thymidine block synchronization. Proc Natl Acad Sci USA 99(7):4379\u20134384. doi: 10.1073\/pnas.062569899","journal-title":"Proc Natl Acad Sci USA"},{"issue":"11","key":"2241_CR24","first-page":"3233","volume":"62","author":"CM Meijden van der","year":"2002","unstructured":"van der Meijden CM, Lapointe DS, Luong MX, Peric-Hupkes D, Cho B, Stein JL, van Wijnen AJ, Stein GS (2002) Gene profiling of cell cycle progression through S-phase reveals sequential expression of genes required for DNA replication and nucleosome assembly. Cancer Res 62(11):3233\u20133243","journal-title":"Cancer Res"},{"issue":"6","key":"2241_CR25","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1007\/s004120050256","volume":"106","author":"MJ Hendzel","year":"1997","unstructured":"Hendzel MJ, Wei Y, Mancini MA, Van Hooser A, Ranalli T, Brinkley BR, Bazett-Jones DP, Allis CD (1997) Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation. Chromosoma 106(6):348\u2013360","journal-title":"Chromosoma"},{"issue":"6","key":"2241_CR26","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1074\/mcp.M900578-MCP200","volume":"9","author":"T Hosokawa","year":"2010","unstructured":"Hosokawa T, Saito T, Asada A, Fukunaga K, Hisanaga S (2010) Quantitative measurement of in vivo phosphorylation states of Cdk5 activator p35 by Phos-tag SDS-PAGE. Mol Cell Proteomics 9(6):1133\u20131143. doi: 10.1074\/mcp.M900578-MCP200","journal-title":"Mol Cell Proteomics"},{"issue":"4","key":"2241_CR27","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1074\/mcp.T500024-MCP200","volume":"5","author":"E Kinoshita","year":"2006","unstructured":"Kinoshita E, Kinoshita-Kikuta E, Takiyama K, Koike T (2006) Phosphate-binding tag, a new tool to visualize phosphorylated proteins. Mol Cell Proteomics 5(4):749\u2013757. doi: 10.1074\/mcp.T500024-MCP200","journal-title":"Mol Cell Proteomics"},{"issue":"16","key":"2241_CR28","doi-asserted-by":"crossref","first-page":"4839","DOI":"10.1093\/emboj\/16.16.4839","volume":"16","author":"C Maison","year":"1997","unstructured":"Maison C, Pyrpasopoulou A, Theodoropoulos PA, Georgatos SD (1997) The inner nuclear membrane protein LAP1 forms a native complex with B-type lamins and partitions with spindle-associated mitotic vesicles. EMBO J 16(16):4839\u20134850. doi: 10.1093\/emboj\/16.16.4839","journal-title":"EMBO J"},{"key":"2241_CR29","doi-asserted-by":"crossref","unstructured":"Gerace L, Foisner R (1994) Integral membrane proteins and dynamic organization of the nuclear envelope. Trends Cell Biol 4(4):127\u2013131. doi: 10.1016\/0962-8924(94)90067-1","DOI":"10.1016\/0962-8924(94)90067-1"},{"issue":"Pt 5","key":"2241_CR30","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1242\/jcs.113.5.779","volume":"113","author":"T Haraguchi","year":"2000","unstructured":"Haraguchi T, Koujin T, Hayakawa T, Kaneda T, Tsutsumi C, Imamoto N, Akazawa C, Sukegawa J, Yoneda Y, Hiraoka Y (2000) Live fluorescence imaging reveals early recruitment of emerin, LBR, RanBP2, and Nup153 to reforming functional nuclear envelopes. J Cell Sci 113(Pt 5):779\u2013794","journal-title":"J Cell Sci"},{"issue":"14","key":"2241_CR31","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1016\/j.yexcr.2010.05.017","volume":"316","author":"T Kuga","year":"2010","unstructured":"Kuga T, Nozaki N, Matsushita K, Nomura F, Tomonaga T (2010) Phosphorylation statuses at different residues of lamin B2, B1, and A\/C dynamically and independently change throughout the cell cycle. Exp Cell Res 316(14):2301\u20132312. doi: 10.1016\/j.yexcr.2010.05.017","journal-title":"Exp Cell Res"},{"issue":"47","key":"2241_CR32","doi-asserted-by":"crossref","first-page":"29693","DOI":"10.1074\/jbc.272.47.29693","volume":"272","author":"LJ Thompson","year":"1997","unstructured":"Thompson LJ, Bollen M, Fields AP (1997) Identification of protein phosphatase 1 as a mitotic lamin phosphatase. J Biol Chem 272(47):29693\u201329697","journal-title":"J Biol Chem"},{"issue":"6","key":"2241_CR33","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1073\/pnas.94.6.2168","volume":"94","author":"YG Kwon","year":"1997","unstructured":"Kwon YG, Lee SY, Choi Y, Greengard P, Nairn AC (1997) Cell cycle-dependent phosphorylation of mammalian protein phosphatase 1 by cdc2 kinase. Proc Natl Acad Sci USA 94(6):2168\u20132173","journal-title":"Proc Natl Acad Sci USA"},{"issue":"24","key":"2241_CR34","doi-asserted-by":"crossref","first-page":"7108","DOI":"10.1002\/j.1460-2075.1996.tb01102.x","volume":"15","author":"A Pyrpasopoulou","year":"1996","unstructured":"Pyrpasopoulou A, Meier J, Maison C, Simos G, Georgatos SD (1996) The lamin B receptor (LBR) provides essential chromatin docking sites at the nuclear envelope. EMBO J 15(24):7108\u20137119","journal-title":"EMBO J"},{"issue":"13","key":"2241_CR35","doi-asserted-by":"crossref","first-page":"13265","DOI":"10.1074\/jbc.M308854200","volume":"279","author":"M Takano","year":"2004","unstructured":"Takano M, Koyama Y, Ito H, Hoshino S, Onogi H, Hagiwara M, Furukawa K, Horigome T (2004) Regulation of binding of lamin B receptor to chromatin by SR protein kinase and cdc2 kinase in Xenopus egg extracts. J Biol Chem 279(13):13265\u201313271. doi: 10.1074\/jbc.M308854200","journal-title":"J Biol Chem"},{"issue":"Pt 12","key":"2241_CR36","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1242\/jcs.047373","volume":"122","author":"C Buch","year":"2009","unstructured":"Buch C, Lindberg R, Figueroa R, Gudise S, Onischenko E, Hallberg E (2009) An integral protein of the inner nuclear membrane localizes to the mitotic spindle in mammalian cells. J Cell Sci 122(Pt 12):2100\u20132107. doi: 10.1242\/jcs.047373","journal-title":"J Cell Sci"},{"issue":"1","key":"2241_CR37","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1083\/jcb.200509124","volume":"172","author":"M Crisp","year":"2006","unstructured":"Crisp M, Liu Q, Roux K, Rattner JB, Shanahan C, Burke B, Stahl PD, Hodzic D (2006) Coupling of the nucleus and cytoplasm: role of the LINC complex. J Cell Biol 172(1):41\u201353. doi: 10.1083\/jcb.200509124","journal-title":"J Cell Biol"},{"issue":"10","key":"2241_CR38","doi-asserted-by":"crossref","first-page":"3738","DOI":"10.1128\/MCB.26.10.3738-3751.2006","volume":"26","author":"F Haque","year":"2006","unstructured":"Haque F, Lloyd DJ, Smallwood DT, Dent CL, Shanahan CM, Fry AM, Trembath RC, Shackleton S (2006) SUN1 interacts with nuclear lamin A and cytoplasmic nesprins to provide a physical connection between the nuclear lamina and the cytoskeleton. Mol Cell Biol 26(10):3738\u20133751. doi: 10.1128\/MCB.26.10.3738-3751.2006","journal-title":"Mol Cell Biol"},{"issue":"21","key":"2241_CR39","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1093\/hmg\/ddh295","volume":"13","author":"JL Broers","year":"2004","unstructured":"Broers JL, Peeters EA, Kuijpers HJ, Endert J, Bouten CV, Oomens CW, Baaijens FP, Ramaekers FC (2004) Decreased mechanical stiffness in LMNA\u2212\/\u2212 cells is caused by defective nucleo-cytoskeletal integrity: implications for the development of laminopathies. Hum Mol Genet 13(21):2567\u20132580. doi: 10.1093\/hmg\/ddh295","journal-title":"Hum Mol Genet"},{"issue":"21","key":"2241_CR40","doi-asserted-by":"crossref","first-page":"9861","DOI":"10.1073\/pnas.0912877107","volume":"107","author":"CE Kim","year":"2010","unstructured":"Kim CE, Perez A, Perkins G, Ellisman MH, Dauer WT (2010) A molecular mechanism underlying the neural-specific defect in torsinA mutant mice. Proc Natl Acad Sci USA 107(21):9861\u20139866. doi: 10.1073\/pnas.0912877107","journal-title":"Proc Natl Acad Sci USA"},{"issue":"5","key":"2241_CR41","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.devcel.2009.10.016","volume":"17","author":"WT Dauer","year":"2009","unstructured":"Dauer WT, Worman HJ (2009) The nuclear envelope as a signaling node in development and disease. Dev Cell 17(5):626\u2013638. doi: 10.1016\/j.devcel.2009.10.016","journal-title":"Dev Cell"},{"issue":"7","key":"2241_CR42","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.nmd.2014.04.007","volume":"24","author":"G Kayman-Kurekci","year":"2014","unstructured":"Kayman-Kurekci G, Talim B, Korkusuz P, Sayar N, Sarioglu T, Oncel I, Sharafi P, Gundesli H, Balci-Hayta B, Purali N, Serdaroglu-Oflazer P, Topaloglu H, Dincer P (2014) Mutation in TOR1AIP1 encoding LAP1B in a form of muscular dystrophy: a novel gene related to nuclear envelopathies. Neuromuscular Disord 24(7):624\u2013633. doi: 10.1016\/j.nmd.2014.04.007","journal-title":"Neuromuscular Disord"},{"issue":"6","key":"2241_CR43","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.devcel.2013.08.012","volume":"26","author":"JY Shin","year":"2013","unstructured":"Shin JY, Mendez-Lopez I, Wang Y, Hays AP, Tanji K, Lefkowitch JH, Schulze PC, Worman HJ, Dauer WT (2013) Lamina-associated polypeptide-1 interacts with the muscular dystrophy protein emerin and is essential for skeletal muscle maintenance. Dev Cell 26(6):591\u2013603. doi: 10.1016\/j.devcel.2013.08.012","journal-title":"Dev Cell"}],"container-title":["Molecular and Cellular Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-014-2241-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11010-014-2241-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11010-014-2241-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T01:19:57Z","timestamp":1650417597000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11010-014-2241-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,17]]},"references-count":43,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["2241"],"URL":"https:\/\/doi.org\/10.1007\/s11010-014-2241-x","relation":{},"ISSN":["0300-8177","1573-4919"],"issn-type":[{"value":"0300-8177","type":"print"},{"value":"1573-4919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,17]]}}}