{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T16:29:38Z","timestamp":1745252978836,"version":"3.37.3"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T00:00:00Z","timestamp":1539043200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Metab Brain Dis"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1007\/s11011-018-0327-y","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T15:28:56Z","timestamp":1539098936000},"page":"141-152","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Adipocyte proteome and secretome influence inflammatory and hormone pathways in glioma"],"prefix":"10.1007","volume":"34","author":[{"given":"J.","family":"Almeida","sequence":"first","affiliation":[]},{"given":"J.","family":"Costa","sequence":"additional","affiliation":[]},{"given":"P.","family":"Coelho","sequence":"additional","affiliation":[]},{"given":"V.","family":"Cea","sequence":"additional","affiliation":[]},{"given":"M.","family":"Galesio","sequence":"additional","affiliation":[]},{"given":"J. P.","family":"Noronha","sequence":"additional","affiliation":[]},{"given":"M. S.","family":"Diniz","sequence":"additional","affiliation":[]},{"given":"C.","family":"Prud\u00eancio","sequence":"additional","affiliation":[]},{"given":"R.","family":"Soares","sequence":"additional","affiliation":[]},{"given":"C.","family":"Sala","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8933-3984","authenticated-orcid":false,"given":"R\u00faben","family":"Fernandes","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2018,10,9]]},"reference":[{"key":"327_CR1","first-page":"629","volume":"21","author":"T Aoki","year":"2002","unstructured":"Aoki T, Kato S, Fox JC, Okamoto K, Sakata K, Morimatsu M, Shigemori M (2002) Inhibition of autocrine fibroblast growth factor signaling by the adenovirus-mediated expression of an antisense transgene or a dominant negative receptor in human glioma cells in vitro. Int J Oncol 21:629\u2013636","journal-title":"Int J Oncol"},{"key":"327_CR2","doi-asserted-by":"publisher","first-page":"dju384","DOI":"10.1093\/jnci\/dju384","volume":"107","author":"MN Bainbridge","year":"2014","unstructured":"Bainbridge MN, Armstrong GN, Gramatges MM et al (2014) Germline mutations in Shelterin complex genes are associated with familial glioma. JNCI J Natl Cancer Inst 107:dju384\u2013dju384. \n                    https:\/\/doi.org\/10.1093\/jnci\/dju384","journal-title":"JNCI J Natl Cancer Inst"},{"key":"327_CR3","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1038\/sj.bjc.6604445","volume":"99","author":"VS Benson","year":"2008","unstructured":"Benson VS, Pirie K, Green J et al (2008) Lifestyle factors and primary glioma and meningioma tumours in the million women study cohort. Br J Cancer 99:185\u2013190. \n                    https:\/\/doi.org\/10.1038\/sj.bjc.6604445","journal-title":"Br J Cancer"},{"key":"327_CR4","doi-asserted-by":"publisher","first-page":"6365","DOI":"10.1038\/sj.onc.1207751","volume":"23","author":"EE Calle","year":"2004","unstructured":"Calle EE, Thun MJ (2004) Obesity and cancer. Oncogene 23:6365\u20136378. \n                    https:\/\/doi.org\/10.1038\/sj.onc.1207751","journal-title":"Oncogene"},{"key":"327_CR5","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1056\/NEJM199910073411501","volume":"341","author":"EE Calle","year":"1999","unstructured":"Calle EE, Thun MJ, Petrelli JM, Rodriguez C, Heath CW Jr (1999) Body-mass index and mortality in a prospective cohort of U.S. adults. N Engl J Med 341:1097\u20131105. \n                    https:\/\/doi.org\/10.1056\/NEJM199910073411501","journal-title":"N Engl J Med"},{"key":"327_CR6","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/s11060-007-9400-9","volume":"85","author":"M Candolfi","year":"2007","unstructured":"Candolfi M, Curtin JF, Nichols WS, Muhammad AKMG, King GD, Pluhar GE, McNiel EA, Ohlfest JR, Freese AB, Moore PF, Lerner J, Lowenstein PR, Castro MG (2007) Intracranial glioblastoma models in preclinical neuro-oncology: neuropathological characterization and tumor progression. J Neuro-Oncol 85:133\u2013148. \n                    https:\/\/doi.org\/10.1007\/s11060-007-9400-9","journal-title":"J Neuro-Oncol"},{"key":"327_CR7","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1016\/j.cmet.2013.08.008","volume":"18","author":"Y Cao","year":"2013","unstructured":"Cao Y (2013) Angiogenesis and vascular functions in modulation of obesity, adipose metabolism, and insulin sensitivity. Cell Metab 18:478\u2013489. \n                    https:\/\/doi.org\/10.1016\/j.cmet.2013.08.008","journal-title":"Cell Metab"},{"key":"327_CR8","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1038\/nm0603-653","volume":"9","author":"P Carmeliet","year":"2003","unstructured":"Carmeliet P (2003) Angiogenesis in health and disease. Nat Med 9:653\u2013660. \n                    https:\/\/doi.org\/10.1038\/nm0603-653","journal-title":"Nat Med"},{"key":"327_CR9","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.cell.2012.03.009","volume":"149","author":"J Chen","year":"2012","unstructured":"Chen J, McKay RMM, Parada LFF (2012) Malignant glioma: lessons from genomics, mouse models, and stem cells. Cell 149:36\u201347. \n                    https:\/\/doi.org\/10.1016\/j.cell.2012.03.009","journal-title":"Cell"},{"key":"327_CR10","doi-asserted-by":"publisher","first-page":"1697","DOI":"10.1002\/jcb.25463","volume":"117","author":"P Coelho","year":"2015","unstructured":"Coelho P, Almeida J, Prud\u00eancio C, Fernandes R, Soares R (2015) Effect of adipocyte Secretome in melanoma progression and Vasculogenic mimicry. J Cell Biochem 117:1697\u20131706. \n                    https:\/\/doi.org\/10.1002\/jcb.25463","journal-title":"J Cell Biochem"},{"key":"327_CR11","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/j.bbadis.2013.06.003","volume":"1842","author":"S Corvera","year":"2014","unstructured":"Corvera S, Gealekman O (2014) Adipose tissue angiogenesis: impact on obesity and type-2 diabetes. Biochim Biophys Acta 1842:463\u2013472. \n                    https:\/\/doi.org\/10.1016\/j.bbadis.2013.06.003","journal-title":"Biochim Biophys Acta"},{"key":"327_CR12","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1111\/j.1600-0463.2004.apm11207-0802.x","volume":"112","author":"C Costa","year":"2004","unstructured":"Costa C, Soares R, Schmitt F (2004) Angiogenesis: now and then. APMIS 112:402\u2013412. \n                    https:\/\/doi.org\/10.1111\/j.1600-0463.2004.apm11207-0802.x","journal-title":"APMIS"},{"key":"327_CR13","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1007\/s10456-007-9074-0","volume":"10","author":"C Costa","year":"2007","unstructured":"Costa C, Incio J, Soares R (2007) Angiogenesis and chronic inflammation: cause or consequence? Angiogenesis 10:149\u2013166. \n                    https:\/\/doi.org\/10.1007\/s10456-007-9074-0","journal-title":"Angiogenesis"},{"key":"327_CR14","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/705027","volume":"2013","author":"M Delehedde","year":"2013","unstructured":"Delehedde M, Devenyns L, Maurage C-A, Viv\u00e8s RR (2013) Endocan in cancers: a lesson from a circulating dermatan sulfate proteoglycan. Int J Cell Biol 2013:705027. \n                    https:\/\/doi.org\/10.1155\/2013\/705027","journal-title":"Int J Cell Biol"},{"key":"327_CR15","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1038\/s41416-018-0009-x","volume":"118","author":"L Disney-Hogg","year":"2018","unstructured":"Disney-Hogg L, Sud A, Law PJ, Cornish AJ, Kinnersley B, Ostrom QT, Labreche K, Eckel-Passow JE, Armstrong GN, Claus EB, Il\u2019yasova D, Schildkraut J, Barnholtz-Sloan JS, Olson SH, Bernstein JL, Lai RK, Swerdlow AJ, Simon M, Hoffmann P, N\u00f6then MM, J\u00f6ckel KH, Chanock S, Rajaraman P, Johansen C, Jenkins RB, Melin BS, Wrensch MR, Sanson M, Bondy ML, Houlston RS (2018) Influence of obesity-related risk factors in the aetiology of glioma. Br J Cancer 118:1020\u20131027. \n                    https:\/\/doi.org\/10.1038\/s41416-018-0009-x","journal-title":"Br J Cancer"},{"doi-asserted-by":"publisher","unstructured":"Donohoe CL, Lysaght J, O \u2018sullivan J, Reynolds J V (2016) Emerging concepts linking obesity with the hallmarks of cancer. \n                    https:\/\/doi.org\/10.1016\/j.tem.2016.08.004","key":"327_CR16","DOI":"10.1016\/j.tem.2016.08.004"},{"key":"327_CR17","doi-asserted-by":"publisher","first-page":"D649","DOI":"10.1093\/nar\/gkx1132","volume":"46","author":"A Fabregat","year":"2018","unstructured":"Fabregat A, Jupe S, Matthews L, Sidiropoulos K, Gillespie M, Garapati P, Haw R, Jassal B, Korninger F, May B, Milacic M, Roca CD, Rothfels K, Sevilla C, Shamovsky V, Shorser S, Varusai T, Viteri G, Weiser J, Wu G, Stein L, Hermjakob H, D\u2019Eustachio P (2018) The Reactome pathway knowledgebase. Nucleic Acids Res 46:D649\u2013D655. \n                    https:\/\/doi.org\/10.1093\/nar\/gkx1132","journal-title":"Nucleic Acids Res"},{"key":"327_CR18","doi-asserted-by":"publisher","first-page":"10.25.1","DOI":"10.1002\/0471142727.mb1025s88","volume":"10","author":"RL Gundry","year":"2009","unstructured":"Gundry RL, White MY, Murray CI et al (2009) Preparation of proteins and peptides for mass spectrometry analysis in a bottom-up proteomics workflow. Curr Protoc Mol Biol Chapter 10:10.25.1\u201310.25.23. \n                    https:\/\/doi.org\/10.1002\/0471142727.mb1025s88","journal-title":"Curr Protoc Mol Biol Chapter"},{"key":"327_CR19","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","volume":"144","author":"D Hanahan","year":"2011","unstructured":"Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144:646\u2013674. \n                    https:\/\/doi.org\/10.1016\/j.cell.2011.02.013","journal-title":"Cell"},{"key":"327_CR20","doi-asserted-by":"publisher","first-page":"2400","DOI":"10.1002\/stem.2053","volume":"33","author":"A Hossain","year":"2015","unstructured":"Hossain A, Gumin J, Gao F, Figueroa J, Shinojima N, Takezaki T, Priebe W, Villarreal D, Kang SG, Joyce C, Sulman E, Wang Q, Marini FC, Andreeff M, Colman H, Lang FF (2015) Mesenchymal stem cells isolated from human gliomas increase proliferation and maintain stemness of glioma stem cells through the IL-6\/gp130\/STAT3 pathway. Stem Cells 33:2400\u20132415. \n                    https:\/\/doi.org\/10.1002\/stem.2053","journal-title":"Stem Cells"},{"key":"327_CR21","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1146\/annurev-med-100711-143028","volume":"64","author":"JT Huse","year":"2013","unstructured":"Huse JT, Holland E, DeAngelis LM (2013) Glioblastoma: molecular analysis and clinical implications. Annu Rev Med 64:59\u201370. \n                    https:\/\/doi.org\/10.1146\/annurev-med-100711-143028","journal-title":"Annu Rev Med"},{"key":"327_CR22","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1038\/nrc3174","volume":"11","author":"MJ Khandekar","year":"2011","unstructured":"Khandekar MJ, Cohen P, Spiegelman BM (2011) Molecular mechanisms of cancer development in obesity. Nat Rev Cancer 11:886\u2013895. \n                    https:\/\/doi.org\/10.1038\/nrc3174","journal-title":"Nat Rev Cancer"},{"key":"327_CR23","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1016\/S1474-4422(14)70085-7","volume":"13","author":"AJ Kiliaan","year":"2014","unstructured":"Kiliaan AJ, Arnoldussen IA, Gustafson DR (2014) Adipokines: a link between obesity and dementia? IArnoldussen@anatumcnnl. Lancet Neurol 13:913\u2013923. \n                    https:\/\/doi.org\/10.1016\/S1474-4422(14)70085-7","journal-title":"Lancet Neurol"},{"key":"327_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2012\/870807","volume":"2012","author":"JE Lawrence","year":"2012","unstructured":"Lawrence JE, Cook NJ, Rovin RA, Winn RJ (2012) Leptin Promotes Glioblastoma. Neurol Res Int 2012:1\u20136. \n                    https:\/\/doi.org\/10.1155\/2012\/870807","journal-title":"Neurol Res Int"},{"key":"327_CR25","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1160\/TH13-01-0073","volume":"110","author":"AY Lemoine","year":"2013","unstructured":"Lemoine AY, Ledoux S, Larger E (2013) Adipose tissue angiogenesis in obesity. Thromb Haemost 110:661\u2013669. \n                    https:\/\/doi.org\/10.1160\/TH13-01-0073","journal-title":"Thromb Haemost"},{"key":"327_CR26","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1093\/cvr\/cvm007","volume":"78","author":"HR Lijnen","year":"2008","unstructured":"Lijnen HR (2008) Angiogenesis and obesity. Cardiovasc Res 78:286\u2013293. \n                    https:\/\/doi.org\/10.1093\/cvr\/cvm007","journal-title":"Cardiovasc Res"},{"key":"327_CR27","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1007\/s12307-011-0064-9","volume":"4","author":"NA Lokman","year":"2011","unstructured":"Lokman NA, Ween MP, Oehler MK, Ricciardelli C (2011) The role of annexin A2 in tumorigenesis and cancer progression. Cancer Microenviron 4:199\u2013208. \n                    https:\/\/doi.org\/10.1007\/s12307-011-0064-9","journal-title":"Cancer Microenviron"},{"unstructured":"Luisa A, Stefano D, Enciso-mora V, et al (2012) Association between glioma susceptibility molecular etiologies. 1\u20136","key":"327_CR28"},{"key":"327_CR29","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1007\/s11060-014-1377-6","volume":"117","author":"F Matano","year":"2014","unstructured":"Matano F, Yoshida D, Ishii Y, Tahara S, Teramoto A, Morita A (2014) Endocan, a new invasion and angiogenesis marker of pituitary adenomas. J Neuro-Oncol 117:485\u2013491. \n                    https:\/\/doi.org\/10.1007\/s11060-014-1377-6","journal-title":"J Neuro-Oncol"},{"key":"327_CR30","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1097\/NEN.0b013e3181a52a7f","volume":"68","author":"C-A Maurage","year":"2009","unstructured":"Maurage C-A, Adam E, Min\u00e9o J-F, Sarrazin S, Debunne M, Siminski RM, Baroncini M, Lassalle P, Blond S, Delehedde M (2009) Endocan expression and localization in human glioblastomas. J Neuropathol Exp Neurol 68:633\u2013641. \n                    https:\/\/doi.org\/10.1097\/NEN.0b013e3181a52a7f","journal-title":"J Neuropathol Exp Neurol"},{"key":"327_CR31","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.lfs.2015.08.009","volume":"139","author":"F Mendon\u00e7a","year":"2015","unstructured":"Mendon\u00e7a F, Soares R (2015) Obesity and cancer phenotype: is angiogenesis a missed link? Life Sci 139:16\u201323. \n                    https:\/\/doi.org\/10.1016\/j.lfs.2015.08.009","journal-title":"Life Sci"},{"key":"327_CR32","doi-asserted-by":"publisher","first-page":"8349","DOI":"10.1158\/0008-5472.CAN-09-1669","volume":"69","author":"SC Moore","year":"2009","unstructured":"Moore SC, Rajaraman P, Dubrow R, Darefsky AS, Koebnick C, Hollenbeck A, Schatzkin A, Leitzmann MF (2009) Height, body mass index, and physical activity in relation to glioma risk. Cancer Res 69:8349\u20138355. \n                    https:\/\/doi.org\/10.1158\/0008-5472.CAN-09-1669","journal-title":"Cancer Res"},{"key":"327_CR33","doi-asserted-by":"publisher","first-page":"1823","DOI":"10.1016\/j.jprot.2010.03.007","volume":"73","author":"SP Niclou","year":"2010","unstructured":"Niclou SP, Fack F, Rajcevic U (2010) Glioma proteomics: status and perspectives. J Proteome 73:1823\u20131838. \n                    https:\/\/doi.org\/10.1016\/j.jprot.2010.03.007","journal-title":"J Proteome"},{"key":"327_CR34","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1093\/neuonc\/nou087","volume":"16","author":"QT Ostrom","year":"2014","unstructured":"Ostrom QT, Bauchet L, Davis FG, Deltour I, Fisher JL, Langer CE, Pekmezci M, Schwartzbaum JA, Turner MC, Walsh KM, Wrensch MR, Barnholtz-Sloan JS (2014) The epidemiology of glioma in adults: a \u201cstate of the science\u201d review. Neuro-Oncology 16:896\u2013913. \n                    https:\/\/doi.org\/10.1093\/neuonc\/nou087","journal-title":"Neuro-Oncology"},{"key":"327_CR35","doi-asserted-by":"publisher","first-page":"74","DOI":"10.3322\/canjclin.55.2.74","volume":"55","author":"DM Parkin","year":"2002","unstructured":"Parkin DM, Bray F, Ferlay J, Pisani P (2002) Global cancer statistics. CA Cancer J Clin 55:74\u2013108","journal-title":"CA Cancer J Clin"},{"key":"327_CR36","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1056\/NEJMc086380","volume":"359","author":"W Patrick","year":"2008","unstructured":"Patrick W, Kesari S (2008) Malignant Gliomas in Adults. N Engl J Med 359:492\u2013507. \n                    https:\/\/doi.org\/10.1056\/NEJMc086380","journal-title":"N Engl J Med"},{"key":"327_CR37","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1002\/jcb.22725","volume":"111","author":"A Pirraco","year":"2010","unstructured":"Pirraco A, Coelho P, Rocha A, Costa R, Vasques L, Soares R (2010) Imatinib targets PDGF signaling in melanoma and host smooth muscle neighboring cells. J Cell Biochem 111:433\u2013441. \n                    https:\/\/doi.org\/10.1002\/jcb.22725","journal-title":"J Cell Biochem"},{"issue":"Suppl 2","key":"327_CR38","doi-asserted-by":"publisher","first-page":"97S","DOI":"10.1038\/oby.2002.202","volume":"10","author":"FX Pi-Sunyer","year":"2002","unstructured":"Pi-Sunyer FX (2002) The obesity epidemic: pathophysiology and consequences of obesity. Obes Res 10(Suppl 2):97S\u2013104S. \n                    https:\/\/doi.org\/10.1038\/oby.2002.202","journal-title":"Obes Res"},{"key":"327_CR39","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1016\/j.bbabio.2010.11.004","volume":"1807","author":"PL Prieto-Hontoria","year":"2011","unstructured":"Prieto-Hontoria PL, P\u00e9rez-Matute P, Fern\u00e1ndez-Galilea M, Bustos M, Mart\u00ednez JA, Moreno-Aliaga MJ (2011) Role of obesity-associated dysfunctional adipose tissue in cancer: a molecular nutrition approach. Biochim Biophys Acta 1807:664\u2013678. \n                    https:\/\/doi.org\/10.1016\/j.bbabio.2010.11.004","journal-title":"Biochim Biophys Acta"},{"key":"327_CR40","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1146\/annurev.med.080708.082713","volume":"61","author":"DL Roberts","year":"2010","unstructured":"Roberts DL, Dive C, Renehan AG (2010) Biological mechanisms linking obesity and cancer risk: new perspectives. Annu Rev Med 61:301\u2013316. \n                    https:\/\/doi.org\/10.1146\/annurev.med.080708.082713","journal-title":"Annu Rev Med"},{"key":"327_CR41","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/0003-2697(92)90061-B","volume":"203","author":"J Rosenfeld","year":"1992","unstructured":"Rosenfeld J, Capdevielle J, Guillemot JC, Ferrara P (1992) In-gel digestion of proteins for internal sequence analysis after one- or two-dimensional gel electrophoresis. Anal Biochem 203:173\u2013179. \n                    https:\/\/doi.org\/10.1016\/0003-2697(92)90061-B","journal-title":"Anal Biochem"},{"key":"327_CR42","doi-asserted-by":"publisher","first-page":"2856","DOI":"10.1038\/nprot.2006.468","volume":"1","author":"A Shevchenko","year":"2006","unstructured":"Shevchenko A, Tomas H, Havlis J et al (2006) In-gel digestion for mass spectrometric characterization of proteins and proteomes. Nat Protoc 1:2856\u20132860. \n                    https:\/\/doi.org\/10.1038\/nprot.2006.468","journal-title":"Nat Protoc"},{"key":"327_CR43","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1007\/s11060-013-1150-2","volume":"114","author":"EM Siegel","year":"2013","unstructured":"Siegel EM, Nabors LB, Thompson RC, Olson JJ, Browning JE, Madden MH, Han G, Egan KM (2013) Prediagnostic body weight and survival in high grade glioma. J Neuro-Oncol 114:79\u201384. \n                    https:\/\/doi.org\/10.1007\/s11060-013-1150-2","journal-title":"J Neuro-Oncol"},{"key":"327_CR44","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1002\/path.4192","volume":"230","author":"M Sielska","year":"2013","unstructured":"Sielska M, Przanowski P, Wylot B, Gabrusiewicz K, Maleszewska M, Kijewska M, Zawadzka M, Kucharska J, Vinnakota K, Kettenmann H, Kotulska K, Grajkowska W, Kaminska B (2013) Distinct roles of CSF family cytokines in macrophage infiltration and activation in glioma progression and injury response. J Pathol 230:310\u2013321. \n                    https:\/\/doi.org\/10.1002\/path.4192","journal-title":"J Pathol"},{"key":"327_CR45","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1111\/j.1349-7006.2006.00208.x","volume":"97","author":"T Szatmari","year":"2006","unstructured":"Szatmari T, Lumniczky K, Desaknai S, Trajcevski S, Hidvegi EJ, Hamada H, Safrany G (2006) Detailed characterization of the mouse glioma 261 tumor model for experimental glioblastoma therapy. Cancer Sci 97:546\u2013553. \n                    https:\/\/doi.org\/10.1111\/j.1349-7006.2006.00208.x","journal-title":"Cancer Sci"},{"key":"327_CR46","doi-asserted-by":"publisher","first-page":"2569","DOI":"10.1158\/1055-9965.EPI-09-0372","volume":"18","author":"RCM Kruijsdijk van","year":"2009","unstructured":"van Kruijsdijk RCM, van der Wall E, Visseren FLJ (2009) Obesity and Cancer: the role of dysfunctional adipose tissue. Cancer Epidemiol Biomark Prev 18:2569\u20132578. \n                    https:\/\/doi.org\/10.1158\/1055-9965.EPI-09-0372","journal-title":"Cancer Epidemiol Biomark Prev"},{"key":"327_CR47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0013710","volume":"5","author":"C Verpelli","year":"2010","unstructured":"Verpelli C, Bertani G, Cea V, Patti M, Bikfalvi A, Bello L, Sala C (2010) Anti-angiogenic therapy induces integrin-linked kinase 1 up-regulation in a mouse model of glioblastoma. PLoS One 5:1\u201312. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0013710","journal-title":"PLoS One"},{"key":"327_CR48","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1080\/0284186X.2017.1330554","volume":"56","author":"MKH Wiedmann","year":"2017","unstructured":"Wiedmann MKH, Brunborg C, Di Ieva A et al (2017) Overweight, obesity and height as risk factors for meningioma, glioma, pituitary adenoma and nerve sheath tumor: a large population-based prospective cohort study. Acta Oncol (Madr) 56:1302\u20131309. \n                    https:\/\/doi.org\/10.1080\/0284186X.2017.1330554","journal-title":"Acta Oncol (Madr)"},{"key":"327_CR49","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1634\/theoncologist.2009-0285","volume":"15","author":"KY Wolin","year":"2010","unstructured":"Wolin KY, Carson K, Colditz G a (2010) Obesity and Cancer. Oncologist 15:556\u2013565. \n                    https:\/\/doi.org\/10.1634\/theoncologist.2009-0285","journal-title":"Oncologist"},{"key":"327_CR50","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1007\/s11060-013-1334-9","volume":"116","author":"M Xu","year":"2014","unstructured":"Xu M, Yao Y, Hua W, Wu Z, Zhong P, Mao Y, Zhou L, Luo F, Chu Y (2014) Mouse glioma immunotherapy mediated by A2B5+ GL261 cell lysate-pulsed dendritic cells. J Neuro-Oncol 116:497\u2013504. \n                    https:\/\/doi.org\/10.1007\/s11060-013-1334-9","journal-title":"J Neuro-Oncol"},{"key":"327_CR51","doi-asserted-by":"publisher","first-page":"477","DOI":"10.3892\/ijo.2013.1962","volume":"43","author":"L Yi","year":"2013","unstructured":"Yi L, Zhou C, Wang B et al (2013) Implantation of GL261 neurospheres into C57\/BL6 mice: a more reliable syngeneic graft model for research on glioma-initiating cells. Int J Oncol 43:477\u2013484. \n                    https:\/\/doi.org\/10.3892\/ijo.2013.1962","journal-title":"Int J Oncol"},{"key":"327_CR52","doi-asserted-by":"publisher","first-page":"E333","DOI":"10.1152\/ajpendo.90760.2008","volume":"296","author":"J Yin","year":"2008","unstructured":"Yin J, Gao Z, He Q, Zhou D, Guo ZK, Ye J (2008) Role of hypoxia in obesity-induced disorders of glucose and lipid metabolism in adipose tissue. AJP Endocrinol Metab 296:E333\u2013E342. \n                    https:\/\/doi.org\/10.1152\/ajpendo.90760.2008","journal-title":"AJP Endocrinol Metab"},{"key":"327_CR53","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.1016\/j.yexcr.2007.02.009","volume":"313","author":"N Young","year":"2007","unstructured":"Young N, Van Brocklyn JR (2007) Roles of sphingosine-1-phosphate (S1P) receptors in malignant behavior of glioma cells. Differential effects of S1P2 on cell migration and invasiveness. Exp Cell Res 313:1615\u20131627. \n                    https:\/\/doi.org\/10.1016\/j.yexcr.2007.02.009","journal-title":"Exp Cell Res"},{"key":"327_CR54","doi-asserted-by":"publisher","first-page":"14346","DOI":"10.1523\/JNEUROSCI.3299-11.2011","volume":"31","author":"H Zhai","year":"2011","unstructured":"Zhai H, Acharya S, Gravanis I, Mehmood S, Seidman RJ, Shroyer KR, Hajjar KA, Tsirka SE (2011) Annexin A2 promotes glioma cell invasion and tumor progression. J Neurosci 31:14346\u201314360. \n                    https:\/\/doi.org\/10.1523\/JNEUROSCI.3299-11.2011","journal-title":"J Neurosci"},{"key":"327_CR55","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1007\/s12094-012-0855-6","volume":"14","author":"X Zhang","year":"2012","unstructured":"Zhang X, Liu S, Guo C, Zong J, Sun MZ (2012) The association of annexin A2 and cancers. Clin Transl Oncol 14:634\u2013640. \n                    https:\/\/doi.org\/10.1007\/s12094-012-0855-6","journal-title":"Clin Transl Oncol"}],"container-title":["Metabolic Brain Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11011-018-0327-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-018-0327-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11011-018-0327-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,8]],"date-time":"2019-10-08T19:09:53Z","timestamp":1570561793000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11011-018-0327-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,9]]},"references-count":55,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["327"],"URL":"https:\/\/doi.org\/10.1007\/s11011-018-0327-y","relation":{},"ISSN":["0885-7490","1573-7365"],"issn-type":[{"type":"print","value":"0885-7490"},{"type":"electronic","value":"1573-7365"}],"subject":[],"published":{"date-parts":[[2018,10,9]]},"assertion":[{"value":"12 April 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 September 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"No human participants, tissues or cells were used, other than commercially available cell lines, that require prior ethical approval to the corresponding ethic committees.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical considerations"}},{"value":"The authors declare that there are no conflicts of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}