{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T18:26:07Z","timestamp":1763663167713},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2014,2,20]],"date-time":"2014-02-20T00:00:00Z","timestamp":1392854400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Biol Rep"],"published-print":{"date-parts":[[2014,5]]},"DOI":"10.1007\/s11033-014-3197-3","type":"journal-article","created":{"date-parts":[[2014,2,19]],"date-time":"2014-02-19T19:16:39Z","timestamp":1392837399000},"page":"3349-3357","source":"Crossref","is-referenced-by-count":13,"title":["Thymidylate synthase polymorphisms are associated to therapeutic outcome of advanced non-small cell lung cancer patients treated with platinum-based chemotherapy"],"prefix":"10.1007","volume":"41","author":[{"given":"Aurea","family":"Lima","sequence":"first","affiliation":[]},{"given":"V\u00edtor","family":"Seabra","sequence":"additional","affiliation":[]},{"given":"Sandra","family":"Martins","sequence":"additional","affiliation":[]},{"given":"Ana","family":"Coelho","sequence":"additional","affiliation":[]},{"given":"Ant\u00f3nio","family":"Ara\u00fajo","sequence":"additional","affiliation":[]},{"given":"Rui","family":"Medeiros","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2014,2,20]]},"reference":[{"issue":"14","key":"3197_CR1","doi-asserted-by":"crossref","first-page":"3175","DOI":"10.1200\/JCO.2005.10.462","volume":"23","author":"AJ Alberg","year":"2005","unstructured":"Alberg AJ, Brock MV, Samet JM (2005) Epidemiology of lung cancer: looking to the future. J Clin Oncol 23(14):3175\u20133185. doi: 10.1200\/JCO.2005.10.462","journal-title":"J Clin Oncol"},{"issue":"1","key":"3197_CR2","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1097\/JTO.0b013e31819151f8","volume":"4","author":"J Beane","year":"2009","unstructured":"Beane J, Spira A, Lenburg ME (2009) Clinical impact of high-throughput gene expression studies in lung cancer. J Thorac Oncol 4(1):109\u2013118. doi: 10.1097\/JTO.0b013e31819151f8","journal-title":"J Thorac Oncol"},{"key":"3197_CR3","unstructured":"National Comprehensive Cancer Network (2012) NCCN clinical practice guidelines in oncology (NCCN guidelines)\u2014non-small cell lung cancer. Version 2. http:\/\/www.tri-kobe.org\/nccn\/guideline\/lung\/english\/small.pdf . Accessed 29 April 2013"},{"issue":"2","key":"3197_CR4","first-page":"99","volume":"1603","author":"JW Watters","year":"2003","unstructured":"Watters JW, McLeod HL (2003) Cancer pharmacogenomics: current and future applications. Biochim Biophys Acta 1603(2):99\u2013111. doi: 10.1016\/S0304-419X(03)00003-9","journal-title":"Biochim Biophys Acta"},{"issue":"11","key":"3197_CR5","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.2217\/pgs.13.118","volume":"14","author":"A Lima","year":"2013","unstructured":"Lima A, Azevedo R, Sousa H, Seabra V, Medeiros R (2013) Current approaches for TYMS polymorphisms and their importance in molecular epidemiology and pharmacogenetics. Pharmacogenomics 14(11):1337\u20131351. doi: 10.2217\/pgs.13.118","journal-title":"Pharmacogenomics"},{"key":"3197_CR6","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1146\/annurev.bi.64.070195.003445","volume":"64","author":"CW Carreras","year":"1995","unstructured":"Carreras CW, Santi DV (1995) The catalytic mechanism and structure of thymidylate synthase. Annu Rev Biochem 64:721\u2013762. doi: 10.1146\/annurev.bi.64.070195.003445","journal-title":"Annu Rev Biochem"},{"issue":"3","key":"3197_CR7","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1247\/csf.20.191","volume":"20","author":"N Horie","year":"1995","unstructured":"Horie N, Aiba H, Oguro K, Hojo H, Takeishi K (1995) Functional analysis and DNA polymorphism of the tandemly repeated sequences in the 5\u2032-terminal regulatory region of the human gene for thymidylate synthase. Cell Struct Funct 20(3):191\u2013197","journal-title":"Cell Struct Funct"},{"issue":"2","key":"3197_CR8","first-page":"73","volume":"473","author":"PV Danenberg","year":"1977","unstructured":"Danenberg PV (1977) Thymidylate synthetase\u2014a target enzyme in cancer chemotherapy. Biochim Biophys Acta 473(2):73\u201392. doi: 10.1016\/0304-419X(77)90001-4","journal-title":"Biochim Biophys Acta"},{"issue":"2","key":"3197_CR9","first-page":"383","volume":"19","author":"S Marsh","year":"2001","unstructured":"Marsh S, McKay JA, Cassidy J, McLeod HL (2001) Polymorphism in the thymidylate synthase promoter enhancer region in colorectal cancer. Int J Oncol 19(2):383\u2013386","journal-title":"Int J Oncol"},{"issue":"3","key":"3197_CR10","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1093\/nar\/15.3.1259","volume":"15","author":"S Kaneda","year":"1987","unstructured":"Kaneda S, Takeishi K, Ayusawa D, Shimizu K, Seno T, Altman S (1987) Role in translation of a triple tandemly repeated sequence in the 5\u2032-untranslated region of human thymidylate synthase mRNA. Nucleic Acids Res 15(3):1259\u20131270. doi: 10.1093\/nar\/15.3.1259","journal-title":"Nucleic Acids Res"},{"issue":"12","key":"3197_CR11","first-page":"4096","volume":"7","author":"K Kawakami","year":"2001","unstructured":"Kawakami K, Salonga D, Park JM, Danenberg KD, Uetake H, Brabender J, Omura K, Watanabe G, Danenberg PV (2001) Different lengths of a polymorphic repeat sequence in the thymidylate synthase gene affect translational efficiency but not its gene expression. Clin Cancer Res 7(12):4096\u20134101","journal-title":"Clin Cancer Res"},{"issue":"1","key":"3197_CR12","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/sj.tpj.6500012","volume":"1","author":"ST Pullarkat","year":"2001","unstructured":"Pullarkat ST, Stoehlmacher J, Ghaderi V, Xiong YP, Ingles SA, Sherrod A, Warren R, Tsao-Wei D, Groshen S, Lenz HJ (2001) Thymidylate synthase gene polymorphism determines response and toxicity of 5-FU chemotherapy. Pharmacogenomics J 1(1):65\u201370","journal-title":"Pharmacogenomics J"},{"issue":"4B","key":"3197_CR13","first-page":"3249","volume":"19","author":"K Kawakami","year":"1999","unstructured":"Kawakami K, Omura K, Kanehira E, Watanabe Y (1999) Polymorphic tandem repeats in the thymidylate synthase gene is associated with its protein expression in human gastrointestinal cancers. Anticancer Res 19(4B):3249\u20133252","journal-title":"Anticancer Res"},{"issue":"33","key":"3197_CR14","doi-asserted-by":"crossref","first-page":"20277","DOI":"10.1016\/S0021-9258(17)30501-X","volume":"265","author":"S Kaneda","year":"1990","unstructured":"Kaneda S, Nalbantoglu J, Takeishi K, Shimizu K, Gotoh O, Seno T, Ayusawa D (1990) Structural and functional analysis of the human thymidylate synthase gene. J Biol Chem 265(33):20277\u201320284","journal-title":"J Biol Chem"},{"issue":"11","key":"3197_CR15","first-page":"2898","volume":"63","author":"MV Mandola","year":"2003","unstructured":"Mandola MV, Stoehlmacher J, Muller-Weeks S, Cesarone G, Yu MC, Lenz HJ, Ladner RD (2003) A novel single nucleotide polymorphism within the 5\u2032 tandem repeat polymorphism of the thymidylate synthase gene abolishes USF-1 binding and alters transcriptional activity. Cancer Res 63(11):2898\u20132904","journal-title":"Cancer Res"},{"issue":"18","key":"3197_CR16","first-page":"6004","volume":"63","author":"K Kawakami","year":"2003","unstructured":"Kawakami K, Watanabe G (2003) Identification and functional analysis of single nucleotide polymorphism in the tandem repeat sequence of thymidylate synthase gene. Cancer Res 63(18):6004\u20136007","journal-title":"Cancer Res"},{"issue":"12","key":"3197_CR17","first-page":"1381","volume":"9","author":"CM Ulrich","year":"2000","unstructured":"Ulrich CM, Bigler J, Velicer CM, Greene EA, Farin FM, Potter JD (2000) Searching expressed sequence tag databases: discovery and confirmation of a common polymorphism in the thymidylate synthase gene. Cancer Epidemiol Biomark Prev 9(12):1381\u20131385","journal-title":"Cancer Epidemiol Biomark Prev"},{"issue":"17","key":"3197_CR18","doi-asserted-by":"crossref","first-page":"5880","DOI":"10.1158\/1078-0432.CCR-04-0169","volume":"10","author":"T Lecomte","year":"2004","unstructured":"Lecomte T, Ferraz JM, Zinzindohoue F, Loriot MA, Tregouet DA, Landi B, Berger A, Cugnenc PH, Jian R, Beaune P, Laurent-Puig P (2004) Thymidylate synthase gene polymorphism predicts toxicity in colorectal cancer patients receiving 5-fluorouracil-based chemotherapy. Clin Cancer Res 10(17):5880\u20135888. doi: 10.1158\/1078-0432","journal-title":"Clin Cancer Res"},{"issue":"10","key":"3197_CR19","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1200\/JCO.2005.03.5253","volume":"24","author":"E Dotor","year":"2006","unstructured":"Dotor E, Cuatrecases M, Martinez-Iniesta M, Navarro M, Vilardell F, Guino E, Pareja L, Figueras A, Mollevi DG, Serrano T, de Oca J, Peinado MA, Moreno V, Germa JR, Capella G, Villanueva A (2006) Tumor thymidylate synthase 1494del6 genotype as a prognostic factor in colorectal cancer patients receiving fluorouracil-based adjuvant treatment. J Clin Oncol 24(10):1603\u20131611. doi: 10.1200\/JCO.2005.03.5253","journal-title":"J Clin Oncol"},{"issue":"4 Suppl","key":"3197_CR20","doi-asserted-by":"crossref","first-page":"225S","DOI":"10.1378\/chest.89.4_Supplement.225S","volume":"89","author":"CF Mountain","year":"1986","unstructured":"Mountain CF (1986) A new international staging system for lung cancer. Chest 89(4 Suppl):225S\u2013233S. doi: 10.1378\/chest.89.4_Supplement.225S","journal-title":"Chest"},{"issue":"6","key":"3197_CR21","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1378\/chest.111.6.1710","volume":"111","author":"CF Mountain","year":"1997","unstructured":"Mountain CF (1997) Revisions in the international system for staging lung cancer. Chest 111(6):1710\u20131717","journal-title":"Chest"},{"key":"3197_CR22","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1177\/117693430500100003","volume":"1","author":"L Excoffier","year":"2005","unstructured":"Excoffier L, Laval G, Schneider S (2005) Arlequin (version 3.0): an integrated software package for population genetics data analysis. Evol Bioinform Online 1:47\u201350. doi: 10.4137\/EBO.S0","journal-title":"Evol Bioinform Online"},{"issue":"2","key":"3197_CR23","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1086\/338688","volume":"70","author":"DJ Schaid","year":"2002","unstructured":"Schaid DJ, Rowland CM, Tines DE, Jacobson RM, Poland GA (2002) Score tests for association between traits and haplotypes when linkage phase is ambiguous. Am J Hum Genet 70(2):425\u2013434. doi: 10.1086\/338688","journal-title":"Am J Hum Genet"},{"issue":"2","key":"3197_CR24","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/FPC.0b013e3282f4aea6","volume":"18","author":"G Lurje","year":"2008","unstructured":"Lurje G, Zhang W, Yang D, Groshen S, Hendifar AE, Husain H, Nagashima F, Chang HM, Fazzone W, Ladner RD, Pohl A, Ning Y, Iqbal S, El-Khoueiry A, Lenz HJ (2008) Thymidylate synthase haplotype is associated with tumor recurrence in stage II and stage III colon cancer. Pharmacogenet Genomics 18(2):161\u2013168. doi: 10.1097\/FPC.0b013e3282f4aea6","journal-title":"Pharmacogenet Genomics"},{"issue":"5","key":"3197_CR25","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1086\/379378","volume":"73","author":"M Stephens","year":"2003","unstructured":"Stephens M, Donnelly P (2003) A comparison of bayesian methods for haplotype reconstruction from population genotype data. Am J Hum Genet 73(5):1162\u20131169. doi: 10.1086\/379378","journal-title":"Am J Hum Genet"},{"issue":"7","key":"3197_CR26","first-page":"1407","volume":"55","author":"PG Johnston","year":"1995","unstructured":"Johnston PG, Lenz HJ, Leichman CG, Danenberg KD, Allegra CJ, Danenberg PV, Leichman L (1995) Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors. Cancer Res 55(7):1407\u20131412","journal-title":"Cancer Res"},{"issue":"5","key":"3197_CR27","first-page":"1243","volume":"4","author":"HJ Lenz","year":"1998","unstructured":"Lenz HJ, Hayashi K, Salonga D, Danenberg KD, Danenberg PV, Metzger R, Banerjee D, Bertino JR, Groshen S, Leichman LP, Leichman CG (1998) p53 Point mutations and thymidylate synthase messenger RNA levels in disseminated colorectal cancer: an analysis of response and survival. Clin Cancer Res 4(5):1243\u20131250","journal-title":"Clin Cancer Res"},{"issue":"7","key":"3197_CR28","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1200\/JCO.2002.07.039","volume":"20","author":"D Edler","year":"2002","unstructured":"Edler D, Glimelius B, Hallstrom M, Jakobsen A, Johnston PG, Magnusson I, Ragnhammar P, Blomgren H (2002) Thymidylate synthase expression in colorectal cancer: a prognostic and predictive marker of benefit from adjuvant fluorouracil-based chemotherapy. J Clin Oncol 20(7):1721\u20131728","journal-title":"J Clin Oncol"},{"issue":"11","key":"3197_CR29","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1111\/j.1349-7006.2002.tb01227.x","volume":"93","author":"K Kawakami","year":"2002","unstructured":"Kawakami K, Ishida Y, Danenberg KD, Omura K, Watanabe G, Danenberg PV (2002) Functional polymorphism of the thymidylate synthase gene in colorectal cancer accompanied by frequent loss of heterozygosity. Jpn J Cancer Res 93(11):1221\u20131229","journal-title":"Jpn J Cancer Res"},{"issue":"2","key":"3197_CR30","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1158\/1078-0432.CCR-1198-03","volume":"10","author":"A DiPaolo","year":"2004","unstructured":"DiPaolo A, Chu E (2004) The role of thymidylate synthase as a molecular biomarker. Clin Cancer Res 10(2):411\u2013412. doi: 10.1158\/1078-0432","journal-title":"Clin Cancer Res"},{"issue":"3","key":"3197_CR31","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1177\/147323001003800313","volume":"38","author":"MH Kristensen","year":"2010","unstructured":"Kristensen MH, Pedersen PL, Melsen GV, Ellehauge J, Mejer J (2010) Variants in the dihydropyrimidine dehydrogenase, methylenetetrahydrofolate reductase and thymidylate synthase genes predict early toxicity of 5-fluorouracil in colorectal cancer patients. J Int Med Res 38(3):870\u2013883. doi: 10.1177\/147323001003800313","journal-title":"J Int Med Res"},{"issue":"19","key":"3197_CR32","doi-asserted-by":"crossref","first-page":"9369","DOI":"10.1158\/0008-5472.CAN-06-2165","volume":"66","author":"JR Brody","year":"2006","unstructured":"Brody JR, Hucl T, Gallmeier E, Winter JM, Kern SE, Murphy KM (2006) Genomic copy number changes affecting the thymidylate synthase (TYMS) gene in cancer: a model for patient classification to aid fluoropyrimidine therapy. Cancer Res 66(19):9369\u20139373. doi: 10.1158\/0008-5472.CAN-06-2165","journal-title":"Cancer Res"},{"issue":"12","key":"3197_CR33","doi-asserted-by":"crossref","first-page":"2832","DOI":"10.1200\/JCO.2002.09.091","volume":"20","author":"MC Etienne","year":"2002","unstructured":"Etienne MC, Chazal M, Laurent-Puig P, Magne N, Rosty C, Formento JL, Francoual M, Formento P, Renee N, Chamorey E, Bourgeon A, Seitz JF, Delpero JR, Letoublon C, Pezet D, Milano G (2002) Prognostic value of tumoral thymidylate synthase and p53 in metastatic colorectal cancer patients receiving fluorouracil-based chemotherapy: phenotypic and genotypic analyses. J Clin Oncol 20(12):2832\u20132843","journal-title":"J Clin Oncol"},{"issue":"2","key":"3197_CR34","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1158\/1078-0432.CCR-0200-03","volume":"10","author":"K Uchida","year":"2004","unstructured":"Uchida K, Hayashi K, Kawakami K, Schneider S, Yochim JM, Kuramochi H, Takasaki K, Danenberg KD, Danenberg PV (2004) Loss of heterozygosity at the thymidylate synthase (TS) locus on chromosome 18 affects tumor response and survival in individuals heterozygous for a 28-bp polymorphism in the TS gene. Clin Cancer Res 10(2):433\u2013439. doi: 10.1158\/1078-0432.CCR-0200-03","journal-title":"Clin Cancer Res"},{"issue":"9","key":"3197_CR35","doi-asserted-by":"crossref","first-page":"3089","DOI":"10.1073\/pnas.0308716101","volume":"101","author":"TL Wang","year":"2004","unstructured":"Wang TL, Diaz LA Jr, Romans K, Bardelli A, Saha S, Galizia G, Choti M, Donehower R, Parmigiani G, Shih Ie M, Iacobuzio-Donahue C, Kinzler KW, Vogelstein B, Lengauer C, Velculescu VE (2004) Digital karyotyping identifies thymidylate synthase amplification as a mechanism of resistance to 5-fluorouracil in metastatic colorectal cancer patients. Proc Natl Acad Sci USA 101(9):3089\u20133094. doi: 10.1073\/pnas.0308716101","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4","key":"3197_CR36","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1111\/j.1349-7006.2007.00424.x","volume":"98","author":"A Ooyama","year":"2007","unstructured":"Ooyama A, Okayama Y, Takechi T, Sugimoto Y, Oka T, Fukushima M (2007) Genome-wide screening of loci associated with drug resistance to 5-fluorouracil-based drugs. Cancer Sci 98(4):577\u2013583. doi: 10.1111\/j.1349-7006.2007.00424.x","journal-title":"Cancer Sci"},{"issue":"7","key":"3197_CR37","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1200\/JCO.2005.06.219","volume":"23","author":"A Jakobsen","year":"2005","unstructured":"Jakobsen A, Nielsen JN, Gyldenkerne N, Lindeberg J (2005) Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphism in normal tissue as predictors of fluorouracil sensitivity. J Clin Oncol 23(7):1365\u20131369. doi: 10.1200\/JCO.2005.06.219","journal-title":"J Clin Oncol"},{"issue":"4","key":"3197_CR38","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.3892\/ol.2013.1175","volume":"5","author":"WJ Li","year":"2013","unstructured":"Li WJ, Jiang H, Fang XJ, Ye HL, Liu MH, Liu YW, Chen Q, Zhang L, Zhang JY, Yuan CL, Zhang QY (2013) Polymorphisms in thymidylate synthase and reduced folate carrier (SLC19A1) genes predict survival outcome in advanced non-small cell lung cancer patients treated with pemetrexed-based chemotherapy. Oncol Lett 5(4):1165\u20131170. doi: 10.3892\/ol.2013.1175ol-05-04-1165","journal-title":"Oncol Lett"},{"key":"3197_CR39","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1423-0127-20-5","volume":"20","author":"X Wang","year":"2013","unstructured":"Wang X, Wang Y, Cheng J, Ha M (2013) Association of thymidylate synthase gene 3\u2032-untranslated region polymorphism with sensitivity of non-small cell lung cancer to pemetrexed treatment: TS gene polymorphism and pemetrexed sensitivity in NSCLC. J Biomed Sci 20:5. doi: 10.1186\/1423-0127-20-51423-0127-20-5","journal-title":"J Biomed Sci"},{"issue":"5","key":"3197_CR40","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1097\/00008571-200405000-00007","volume":"14","author":"MV Mandola","year":"2004","unstructured":"Mandola MV, Stoehlmacher J, Zhang W, Groshen S, Yu MC, Iqbal S, Lenz HJ, Ladner RD (2004) A 6\u00a0bp polymorphism in the thymidylate synthase gene causes message instability and is associated with decreased intratumoral TS mRNA levels. Pharmacogenetics 14(5):319\u2013327","journal-title":"Pharmacogenetics"},{"issue":"4","key":"3197_CR41","first-page":"839","volume":"11","author":"S Merkelbach-Bruse","year":"2004","unstructured":"Merkelbach-Bruse S, Hans V, Mathiak M, Sanguedolce R, Alessandro R, Ruschoff J, Buttner R, Houshdaran F, Gullotti L (2004) Associations between polymorphisms in the thymidylate synthase gene, the expression of thymidylate synthase mRNA and the microsatellite instability phenotype of colorectal cancer. Oncol Rep 11(4):839\u2013843","journal-title":"Oncol Rep"},{"issue":"12","key":"3197_CR42","first-page":"3361","volume":"62","author":"CM Ulrich","year":"2002","unstructured":"Ulrich CM, Bigler J, Bostick R, Fosdick L, Potter JD (2002) Thymidylate synthase promoter polymorphism, interaction with folate intake, and risk of colorectal adenomas. Cancer Res 62(12):3361\u20133364","journal-title":"Cancer Res"},{"issue":"6","key":"3197_CR43","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1002\/ijc.20489","volume":"112","author":"F Graziano","year":"2004","unstructured":"Graziano F, Kawakami K, Watanabe G, Ruzzo A, Humar B, Santini D, Catalano V, Ficarelli R, Merriman T, Panunzi S, Testa E, Cascinu S, Bearzi I, Tonini G, Magnani M (2004) Association of thymidylate synthase polymorphisms with gastric cancer susceptibility. Int J Cancer 112(6):1010\u20131014. doi: 10.1002\/ijc.20489","journal-title":"Int J Cancer"},{"issue":"10","key":"3197_CR44","doi-asserted-by":"crossref","first-page":"3778","DOI":"10.1158\/1078-0432.CCR-04-2428","volume":"11","author":"K Kawakami","year":"2005","unstructured":"Kawakami K, Graziano F, Watanabe G, Ruzzo A, Santini D, Catalano V, Bisonni R, Arduini F, Bearzi I, Cascinu S, Muretto P, Perrone G, Rabitti C, Giustini L, Tonini G, Pizzagalli F, Magnani M (2005) Prognostic role of thymidylate synthase polymorphisms in gastric cancer patients treated with surgery and adjuvant chemotherapy. Clin Cancer Res 11(10):3778\u20133783. doi: 10.1158\/1078-0432.CCR-04-2428","journal-title":"Clin Cancer Res"},{"issue":"1","key":"3197_CR45","first-page":"219","volume":"34","author":"ME Fernandez-Contreras","year":"2009","unstructured":"Fernandez-Contreras ME, Sanchez-Hernandez JJ, Gonzalez E, Herraez B, Dominguez I, Lozano M, Garcia De Paredes ML, Munoz A, Gamallo C (2009) Combination of polymorphisms within 5\u2032 and 3\u2032 untranslated regions of thymidylate synthase gene modulates survival in 5 fluorouracil-treated colorectal cancer patients. Int J Oncol 34(1):219\u2013229. doi: 10.3892\/ijo_00000144","journal-title":"Int J Oncol"}],"container-title":["Molecular Biology Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-014-3197-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11033-014-3197-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11033-014-3197-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,27]],"date-time":"2022-03-27T01:53:28Z","timestamp":1648346008000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11033-014-3197-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2,20]]},"references-count":45,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["3197"],"URL":"https:\/\/doi.org\/10.1007\/s11033-014-3197-3","relation":{},"ISSN":["0301-4851","1573-4978"],"issn-type":[{"value":"0301-4851","type":"print"},{"value":"1573-4978","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,2,20]]}}}