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AGPs have been suggested to play important roles in plant development processes, especially in sexual plant reproduction. Nevertheless, the functions of a large number of these molecules, remains to be discovered. In this review, we discuss two revolutionary genetic techniques that are able to decode the roles of these glycoproteins in an easy and efficient way. The RNA interference is a frequently technique used in plant biology that promotes genes silencing. The Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)\u2014associated protein 9 (CRISPR\/Cas9), emerged a few years ago as a revolutionary genome-editing technique that has allowed null mutants to be obtained in a wide variety of organisms, including plants. The two techniques have some differences between them and depending on the research objective, these may work as advantage or disadvantage. In the present work, we propose the use of the two techniques to obtain AGP mutants easily and quickly, helping to unravel the role of AGPs, surely a great asset for the future.<\/jats:p>","DOI":"10.1007\/s11033-020-05258-0","type":"journal-article","created":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T13:12:40Z","timestamp":1579180360000},"page":"2315-2325","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The best CRISPR\/Cas9 versus RNA interference approaches for Arabinogalactan proteins\u2019 study"],"prefix":"10.1007","volume":"47","author":[{"given":"Diana","family":"Moreira","sequence":"first","affiliation":[]},{"given":"Ana Marta","family":"Pereira","sequence":"additional","affiliation":[]},{"given":"Ana L\u00facia","family":"Lopes","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9421-2538","authenticated-orcid":false,"given":"S\u00edlvia","family":"Coimbra","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2020,1,16]]},"reference":[{"key":"5258_CR1","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1104\/pp.003459","volume":"129","author":"CJ Schultz","year":"2002","unstructured":"Schultz CJ, Rumsewicz MP, Johnson KL, Jones BJ, Gaspar YM, Bacic A (2002) Using genomic resources to guide research directions. 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