{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T03:13:34Z","timestamp":1778210014268,"version":"3.51.4"},"reference-count":127,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T00:00:00Z","timestamp":1740960000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T00:00:00Z","timestamp":1740960000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005727","name":"Universidade de Coimbra","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005727","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>NMDA receptors for the neurotransmitter glutamate are widely distributed in the central nervous system, playing important roles in brain development, function and plasticity. Alterations in their activity are also important mediators in neuropsychiatric and neurodegenerative disorders. The different NMDA receptor subunits (GluN1, GluN2A-D and GluN3A, B) share a similar structure and membrane topology, with an intracellular C-terminus tail responsible for the interaction with proteins important for the trafficking of the receptors, and to control their surface distribution and signalling activity. The latter sequence varies among subunits but consistently contains the majority of post-translational modification sites on NMDA receptors. These modifications, including phosphorylation, ubiquitination, and palmitoylation, regulate interactions with intracellular proteins. Differences in the amino acid sequence between NMDA receptor subunits lead to a differential regulation by post-translational modifications. Since NMDA receptors are formed by oligomerization of different subunits, and each subunit is regulated in a specific manner, this creates multiple possibilities for regulation of these receptors, with impact in synaptic function and plasticity. This review addresses the diversity of mechanisms involved in the post-translational modification of NMDA receptor subunits, and their impact on the activity and distribution of the receptors, as well as their function in nerve cells.<\/jats:p>","DOI":"10.1007\/s11064-025-04346-6","type":"journal-article","created":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T06:18:50Z","timestamp":1740982730000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Regulation of Synaptic NMDA Receptor Activity by Post-Translational Modifications"],"prefix":"10.1007","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4845-3183","authenticated-orcid":false,"given":"Emanuel","family":"Tahiri","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7536-6881","authenticated-orcid":false,"given":"Elisa","family":"Corti","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1474-0208","authenticated-orcid":false,"given":"Carlos B.","family":"Duarte","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2025,3,3]]},"reference":[{"key":"4346_CR1","doi-asserted-by":"publisher","first-page":"2909","DOI":"10.1523\/JNEUROSCI.05-11-02909.1985","volume":"5","author":"DT Monaghan","year":"1985","unstructured":"Monaghan DT, Cotman CW (1985) Distribution of N-methyl-D-aspartate-sensitive L-[3H]glutamate-binding sites in rat brain. J Neurosci 5:2909\u20132919","journal-title":"J Neurosci"},{"key":"4346_CR2","doi-asserted-by":"publisher","first-page":"6102","DOI":"10.1523\/JNEUROSCI.14-10-06102.1994","volume":"14","author":"RS Petralia","year":"1994","unstructured":"Petralia RS, Wang YX, Wenthold RJ (1994) The NMDA receptor subunits NR2A and NR2B show histological and ultrastructural localization patterns similar to those of NR1. J Neurosci 14:6102\u20136120","journal-title":"J Neurosci"},{"key":"4346_CR3","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1523\/JNEUROSCI.14-02-00667.1994","volume":"14","author":"RS Petralia","year":"1994","unstructured":"Petralia RS, Yokotani N, Wenthold RJ (1994) Light and electron microscope distribution of the NMDA receptor subunit NMDAR1 in the rat nervous system using a selective anti-peptide antibody. J Neurosci 14:667\u2013696","journal-title":"J Neurosci"},{"key":"4346_CR4","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1124\/pharmrev.120.000131","volume":"73","author":"KB Hansen","year":"2021","unstructured":"Hansen KB, Wollmuth LP, Bowie D, Furukawa H, Menniti FS, Sobolevsky AI, Swanson GT, Swanger SA, Greger IH, Nakagawa T, McBain CJ, Jayaraman V, Low CM, Dell\u2019Acqua ML, Diamond JS, Camp CR, Perszyk RE, Yuan H, Traynelis SF (2021) Structure, function, and pharmacology of glutamate receptor Ion channels. Pharmacol Rev 73:298\u2013487","journal-title":"Pharmacol Rev"},{"key":"4346_CR5","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1038\/nrn3504","volume":"14","author":"P Paoletti","year":"2013","unstructured":"Paoletti P, Bellone C, Zhou Q (2013) NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease. Nat Rev Neurosci 14:383\u2013400","journal-title":"Nat Rev Neurosci"},{"key":"4346_CR6","doi-asserted-by":"publisher","first-page":"2312","DOI":"10.1016\/j.neuron.2023.05.002","volume":"111","author":"JP Dupuis","year":"2023","unstructured":"Dupuis JP, Nicole O, Groc L (2023) NMDA receptor functions in health and disease: old actor, new dimensions. Neuron 111:2312\u20132328","journal-title":"Neuron"},{"key":"4346_CR7","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1186\/s12916-016-0712-5","volume":"14","author":"M Leboyer","year":"2016","unstructured":"Leboyer M, Berk M, Yolken RH, Tamouza R, Kupfer D, Groc L (2016) Immuno-psychiatry: an agenda for clinical practice and innovative research. BMC Med 14:173","journal-title":"BMC Med"},{"key":"4346_CR8","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1016\/j.tins.2023.05.002","volume":"46","author":"S Bossi","year":"2023","unstructured":"Bossi S, Pizzamiglio L, Paoletti P (2023) Excitatory GluN1\/GluN3A glycine receptors (eGlyRs) in brain signaling. Trends Neurosci 46:667\u2013681","journal-title":"Trends Neurosci"},{"key":"4346_CR9","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1016\/0042-6989(95)00208-1","volume":"36","author":"CB Duarte","year":"1996","unstructured":"Duarte CB, Santos PF, Carvalho AP (1996) [Ca2+]i regulation by glutamate receptor agonists in cultured chick retina cells. Vis Res 36:1091\u20131102","journal-title":"Vis Res"},{"key":"4346_CR10","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/0896-6273(94)90210-0","volume":"12","author":"H Monyer","year":"1994","unstructured":"Monyer H, Burnashev N, Laurie DJ, Sakmann B, Seeburg PH (1994) Developmental and regional expression in the rat brain and functional properties of four NMDA receptors. Neuron 12:529\u2013540","journal-title":"Neuron"},{"key":"4346_CR11","doi-asserted-by":"publisher","first-page":"2836","DOI":"10.1016\/S0021-9258(18)53849-7","volume":"268","author":"T Ishii","year":"1993","unstructured":"Ishii T, Moriyoshi K, Sugihara H, Sakurada K, Kadotani H, Yokoi M, Akazawa C, Shigemoto R, Mizuno N, Masu M et al (1993) Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits. J Biol Chem 268:2836\u20132843","journal-title":"J Biol Chem"},{"key":"4346_CR12","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1002\/cne.903470112","volume":"347","author":"C Akazawa","year":"1994","unstructured":"Akazawa C, Shigemoto R, Bessho Y, Nakanishi S, Mizuno N (1994) Differential expression of five N-methyl-D-aspartate receptor subunit mRNAs in the cerebellum of developing and adult rats. J Comp Neurol 347:150\u2013160","journal-title":"J Comp Neurol"},{"key":"4346_CR13","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1038\/368144a0","volume":"368","author":"M Sheng","year":"1994","unstructured":"Sheng M, Cummings J, Roldan LA, Jan YN, Jan LY (1994) Changing subunit composition of heteromeric NMDA receptors during development of rat cortex. Nature 368:144\u2013147","journal-title":"Nature"},{"key":"4346_CR14","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1046\/j.1471-4159.1997.68020469.x","volume":"68","author":"A Wenzel","year":"1997","unstructured":"Wenzel A, Fritschy JM, Mohler H, Benke D (1997) NMDA receptor heterogeneity during postnatal development of the rat brain: differential expression of the NR2A, NR2B, and NR2C subunit proteins. J Neurochem 68:469\u2013478","journal-title":"J Neurochem"},{"key":"4346_CR15","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1111\/jnc.14970","volume":"154","author":"M Vieira","year":"2020","unstructured":"Vieira M, Yong XLH, Roche KW, Anggono V (2020) Regulation of NMDA glutamate receptor functions by the GluN2 subunits. J Neurochem 154:121\u2013143","journal-title":"J Neurochem"},{"key":"4346_CR16","doi-asserted-by":"publisher","first-page":"108551","DOI":"10.1016\/j.neuropharm.2021.108551","volume":"190","author":"F Gardoni","year":"2021","unstructured":"Gardoni F, Di Luca M (2021) Protein-protein interactions at the NMDA receptor complex: from synaptic retention to synaptonuclear protein messengers. Neuropharmacology 190:108551","journal-title":"Neuropharmacology"},{"key":"4346_CR17","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3389\/fncel.2014.00394","volume":"8","author":"M Horak","year":"2014","unstructured":"Horak M, Petralia RS, Kaniakova M, Sans N (2014) ER to synapse trafficking of NMDA receptors. Front Cell Neurosci 8:394","journal-title":"Front Cell Neurosci"},{"key":"4346_CR18","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1113\/jphysiol.2007.137679","volume":"584","author":"AZ Harris","year":"2007","unstructured":"Harris AZ, Pettit DL (2007) Extrasynaptic and synaptic NMDA receptors form stable and uniform pools in rat hippocampal slices. J Physiol 584:509\u2013519","journal-title":"J Physiol"},{"key":"4346_CR19","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.neuroscience.2010.01.022","volume":"167","author":"RS Petralia","year":"2010","unstructured":"Petralia RS, Wang YX, Hua F, Yi Z, Zhou A, Ge L, Stephenson FA, Wenthold RJ (2010) Organization of NMDA receptors at extrasynaptic locations. Neuroscience 167:68\u201387","journal-title":"Neuroscience"},{"key":"4346_CR20","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1152\/jn.00458.2019","volume":"123","author":"A McQuate","year":"2020","unstructured":"McQuate A, Barria A (2020) Rapid exchange of synaptic and extrasynaptic NMDA receptors in hippocampal CA1 neurons. J Neurophysiol 123:1004\u20131014","journal-title":"J Neurophysiol"},{"key":"4346_CR21","doi-asserted-by":"publisher","first-page":"4180","DOI":"10.1523\/JNEUROSCI.19-10-04180.1999","volume":"19","author":"KR Tovar","year":"1999","unstructured":"Tovar KR, Westbrook GL (1999) The incorporation of NMDA receptors with a distinct subunit composition at nascent hippocampal synapses in vitro. J Neurosci 19:4180\u20134188","journal-title":"J Neurosci"},{"key":"4346_CR22","doi-asserted-by":"publisher","first-page":"18769","DOI":"10.1073\/pnas.0605238103","volume":"103","author":"L Groc","year":"2006","unstructured":"Groc L, Heine M, Cousins SL, Stephenson FA, Lounis B, Cognet L, Choquet D (2006) NMDA receptor surface mobility depends on NR2A-2B subunits. Proc Natl Acad Sci U S A 103:18769\u201318774","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4346_CR23","doi-asserted-by":"publisher","first-page":"4755","DOI":"10.1523\/JNEUROSCI.2014-22.2023","volume":"43","author":"S Kortus","year":"2023","unstructured":"Kortus S, Rehakova K, Klima M, Kolcheva M, Ladislav M, Langore E, Barackova P, Netolicky J, Misiachna A, Hemelikova K, Humpolickova J, Chalupska D, Silhan J, Kaniakova M, Hrcka Krausova B, Boura E, Zapotocky M, Horak M (2023) Subunit-dependent surface mobility and localization of NMDA receptors in hippocampal neurons measured using Nanobody Probes. J Neurosci 43:4755\u20134774","journal-title":"J Neurosci"},{"key":"4346_CR24","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1038\/nature19058","volume":"536","author":"AH Tang","year":"2016","unstructured":"Tang AH, Chen H, Li TP, Metzbower SR, MacGillavry HD, Blanpied TA (2016) A trans-synaptic nanocolumn aligns neurotransmitter release to receptors. Nature 536:210\u2013214","journal-title":"Nature"},{"key":"4346_CR25","doi-asserted-by":"publisher","first-page":"11264","DOI":"10.1038\/ncomms11264","volume":"7","author":"RA Frank","year":"2016","unstructured":"Frank RA, Komiyama NH, Ryan TJ, Zhu F, O\u2019Dell TJ, Grant SG (2016) NMDA receptors are selectively partitioned into complexes and supercomplexes during synapse maturation. Nat Commun 7:11264","journal-title":"Nat Commun"},{"key":"4346_CR26","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.conb.2017.05.019","volume":"45","author":"RA Frank","year":"2017","unstructured":"Frank RA, Grant SG (2017) Supramolecular organization of NMDA receptors and the postsynaptic density. Curr Opin Neurobiol 45:139\u2013147","journal-title":"Curr Opin Neurobiol"},{"key":"4346_CR27","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1016\/j.cell.2016.07.008","volume":"166","author":"M Zeng","year":"2016","unstructured":"Zeng M, Shang Y, Araki Y, Guo T, Huganir RL, Zhang M (2016) Phase transition in postsynaptic densities underlies formation of synaptic complexes and synaptic plasticity. Cell 166:1163\u20131175 e1112","journal-title":"Cell"},{"key":"4346_CR28","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.neuron.2018.09.012","volume":"100","author":"B Kellermayer","year":"2018","unstructured":"Kellermayer B, Ferreira JS, Dupuis J, Levet F, Grillo-Bosch D, Bard L, Linares-Loyez J, Bouchet D, Choquet D, Rusakov DA, Bon P, Sibarita JB, Cognet L, Sainlos M, Carvalho AL, Groc L (2018) Differential Nanoscale Topography and Functional Role of GluN2-NMDA receptor subtypes at glutamatergic synapses. Neuron 100:106\u2013119.e107","journal-title":"Neuron"},{"key":"4346_CR29","doi-asserted-by":"publisher","first-page":"108634","DOI":"10.1016\/j.neuropharm.2021.108634","volume":"195","author":"Y Ishchenko","year":"2021","unstructured":"Ishchenko Y, Carrizales MG, Koleske AJ (2021) Regulation of the NMDA receptor by its cytoplasmic domains: (how) is the tail wagging the dog? Neuropharmacology 195:108634","journal-title":"Neuropharmacology"},{"key":"4346_CR30","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.1126\/science.7569905","volume":"269","author":"HC Kornau","year":"1995","unstructured":"Kornau HC, Schenker LT, Kennedy MB, Seeburg PH (1995) Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95. Science 269:1737\u20131740","journal-title":"Science"},{"key":"4346_CR31","doi-asserted-by":"publisher","first-page":"2157","DOI":"10.1523\/JNEUROSCI.16-07-02157.1996","volume":"16","author":"M Niethammer","year":"1996","unstructured":"Niethammer M, Kim E, Sheng M (1996) Interaction between the C terminus of NMDA receptor subunits and multiple members of the PSD-95 family of membrane-associated guanylate kinases. J Neurosci 16:2157\u20132163","journal-title":"J Neurosci"},{"key":"4346_CR32","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/S0896-6273(00)80157-9","volume":"17","author":"BM Muller","year":"1996","unstructured":"Muller BM, Kistner U, Kindler S, Chung WJ, Kuhlendahl S, Fenster SD, Lau LF, Veh RW, Huganir RL, Gundelfinger ED, Garner CC (1996) SAP102, a novel postsynaptic protein that interacts with NMDA receptor complexes in vivo. Neuron 17:255\u2013265","journal-title":"Neuron"},{"key":"4346_CR33","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/S0896-6273(00)80284-6","volume":"17","author":"E Kim","year":"1996","unstructured":"Kim E, Cho KO, Rothschild A, Sheng M (1996) Heteromultimerization and NMDA receptor-clustering activity of Chapsyn-110, a member of the PSD-95 family of proteins. Neuron 17:103\u2013113","journal-title":"Neuron"},{"key":"4346_CR34","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/S0022-2836(03)00113-X","volume":"327","author":"JF Long","year":"2003","unstructured":"Long JF, Tochio H, Wang P, Fan JS, Sala C, Niethammer M, Sheng M, Zhang M (2003) Supramodular structure and synergistic target binding of the N-terminal tandem PDZ domains of PSD-95. J Mol Biol 327:203\u2013214","journal-title":"J Mol Biol"},{"key":"4346_CR35","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1016\/S1097-2765(01)00411-7","volume":"8","author":"AW McGee","year":"2001","unstructured":"McGee AW, Dakoji SR, Olsen O, Bredt DS, Lim WA, Prehoda KE (2001) Structure of the SH3-guanylate kinase module from PSD-95 suggests a mechanism for regulated assembly of MAGUK scaffolding proteins. Mol Cell 8:1291\u20131301","journal-title":"Mol Cell"},{"key":"4346_CR36","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1016\/S0092-8674(00)81307-0","volume":"85","author":"DA Doyle","year":"1996","unstructured":"Doyle DA, Lee A, Lewis J, Kim E, Sheng M, MacKinnon R (1996) Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ. Cell 85:1067\u20131076","journal-title":"Cell"},{"key":"4346_CR37","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.1523\/JNEUROSCI.20-03-01260.2000","volume":"20","author":"N Sans","year":"2000","unstructured":"Sans N, Petralia RS, Wang YX, Blahos J 2nd, Hell JW, Wenthold RJ (2000) A developmental change in NMDA receptor-associated proteins at hippocampal synapses. J Neurosci 20:1260\u20131271","journal-title":"J Neurosci"},{"key":"4346_CR38","doi-asserted-by":"publisher","first-page":"e202006101","DOI":"10.1083\/jcb.202006101","volume":"220","author":"M Petit-Pedrol","year":"2021","unstructured":"Petit-Pedrol M, Groc L (2021) Regulation of membrane NMDA receptors by dynamics and protein interactions. J Cell Biol 220:e202006101","journal-title":"J Cell Biol"},{"key":"4346_CR39","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.neuroscience.2007.12.051","volume":"158","author":"SL Cousins","year":"2009","unstructured":"Cousins SL, Kenny AV, Stephenson FA (2009) Delineation of additional PSD-95 binding domains within NMDA receptor NR2 subunits reveals differences between NR2A\/PSD-95 and NR2B\/PSD-95 association. Neuroscience 158:89\u201395","journal-title":"Neuroscience"},{"key":"4346_CR40","doi-asserted-by":"publisher","first-page":"13465","DOI":"10.1074\/jbc.M111.292862","volume":"287","author":"SL Cousins","year":"2012","unstructured":"Cousins SL, Stephenson FA (2012) Identification of N-methyl-D-aspartic acid (NMDA) receptor subtype-specific binding sites that mediate direct interactions with scaffold protein PSD-95. J Biol Chem 287:13465\u201313476","journal-title":"J Biol Chem"},{"key":"4346_CR41","doi-asserted-by":"publisher","first-page":"5157","DOI":"10.1074\/jbc.272.8.5157","volume":"272","author":"WG Tingley","year":"1997","unstructured":"Tingley WG, Ehlers MD, Kameyama K, Doherty C, Ptak JB, Riley CT, Huganir RL (1997) Characterization of protein kinase A and protein kinase C phosphorylation of the N-methyl-D-aspartate receptor NR1 subunit using phosphorylation site-specific antibodies. J Biol Chem 272:5157\u20135166","journal-title":"J Biol Chem"},{"key":"4346_CR42","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.neuint.2005.04.011","volume":"47","author":"AM Sanchez-Perez","year":"2005","unstructured":"Sanchez-Perez AM, Felipo V (2005) Serines 890 and 896 of the NMDA receptor subunit NR1 are differentially phosphorylated by protein kinase C isoforms. Neurochem Int 47:84\u201391","journal-title":"Neurochem Int"},{"key":"4346_CR43","doi-asserted-by":"publisher","first-page":"3063","DOI":"10.1523\/JNEUROSCI.21-09-03063.2001","volume":"21","author":"DB Scott","year":"2001","unstructured":"Scott DB, Blanpied TA, Swanson GT, Zhang C, Ehlers MD (2001) An NMDA receptor ER retention signal regulated by phosphorylation and alternative splicing. J Neurosci 21:3063\u20133072","journal-title":"J Neurosci"},{"key":"4346_CR44","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1016\/S0028-3908(03)00250-8","volume":"45","author":"DB Scott","year":"2003","unstructured":"Scott DB, Blanpied TA, Ehlers MD (2003) Coordinated PKA and PKC phosphorylation suppresses RXR-mediated ER retention and regulates the surface delivery of NMDA receptors. Neuropharmacology 45:755\u2013767","journal-title":"Neuropharmacology"},{"key":"4346_CR45","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1038\/88404","volume":"4","author":"B Vissel","year":"2001","unstructured":"Vissel B, Krupp JJ, Heinemann SF, Westbrook GL (2001) A use-dependent tyrosine dephosphorylation of NMDA receptors is independent of ion flux. Nat Neurosci 4:587\u2013596","journal-title":"Nat Neurosci"},{"key":"4346_CR46","doi-asserted-by":"publisher","first-page":"7096","DOI":"10.1523\/JNEUROSCI.0780-04.2004","volume":"24","author":"DB Scott","year":"2004","unstructured":"Scott DB, Michailidis I, Mu Y, Logothetis D, Ehlers MD (2004) Endocytosis and degradative sorting of NMDA receptors by conserved membrane-proximal signals. J Neurosci 24:7096\u20137109","journal-title":"J Neurosci"},{"key":"4346_CR47","doi-asserted-by":"publisher","first-page":"331","DOI":"10.3389\/fncel.2014.00331","volume":"8","author":"C Grau","year":"2014","unstructured":"Grau C, Arato K, Fernandez-Fernandez JM, Valderrama A, Sindreu C, Fillat C, Ferrer I, de la Luna S, Altafaj X (2014) DYRK1A-mediated phosphorylation of GluN2A at ser(1048) regulates the surface expression and channel activity of GluN1\/GluN2A receptors. Front Cell Neurosci 8:331","journal-title":"Front Cell Neurosci"},{"key":"4346_CR48","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.nbd.2008.07.024","volume":"32","author":"X Altafaj","year":"2008","unstructured":"Altafaj X, Ortiz-Abalia J, Fernandez M, Potier MC, Laffaire J, Andreu N, Dierssen M, Gonzalez-Garcia C, Cena V, Marti E, Fillat C (2008) Increased NR2A expression and prolonged decay of NMDA-induced calcium transient in cerebellum of TgDyrk1A mice, a mouse model of Down syndrome. Neurobiol Dis 32:377\u2013384","journal-title":"Neurobiol Dis"},{"key":"4346_CR49","doi-asserted-by":"publisher","first-page":"109338","DOI":"10.1016\/j.celrep.2021.109338","volume":"36","author":"XLH Yong","year":"2021","unstructured":"Yong XLH, Zhang L, Yang L, Chen X, Tan JZA, Yu X, Chandra M, Livingstone E, Widagdo J, Vieira MM, Roche KW, Lynch JW, Keramidas A, Collins BM, Anggono V (2021) Regulation of NMDA receptor trafficking and gating by activity-dependent CaMKIIalpha phosphorylation of the GluN2A subunit. Cell Rep 36:109338","journal-title":"Cell Rep"},{"key":"4346_CR50","doi-asserted-by":"publisher","first-page":"108104","DOI":"10.1016\/j.celrep.2020.108104","volume":"32","author":"M Mota Vieira","year":"2020","unstructured":"Mota Vieira M, Nguyen TA, Wu K, Badger JD 2nd, Collins BM, Anggono V, Lu W, Roche KW (2020) An Epilepsy-Associated GRIN2A rare variant disrupts CaMKIIalpha Phosphorylation of GluN2A and NMDA receptor trafficking. Cell Rep 32:108104","journal-title":"Cell Rep"},{"key":"4346_CR51","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/S0028-3908(02)00031-X","volume":"42","author":"JJ Krupp","year":"2002","unstructured":"Krupp JJ, Vissel B, Thomas CG, Heinemann SF, Westbrook GL (2002) Calcineurin acts via the C-terminus of NR2A to modulate desensitization of NMDA receptors. Neuropharmacology 42:593\u2013602","journal-title":"Neuropharmacology"},{"key":"4346_CR52","doi-asserted-by":"publisher","first-page":"126","DOI":"10.4161\/chan.23968","volume":"7","author":"BA Maki","year":"2013","unstructured":"Maki BA, Cole R, Popescu GK (2013) Two serine residues on GluN2A C-terminal tails control NMDA receptor current decay times. Channels (Austin) 7:126\u2013132","journal-title":"Channels (Austin)"},{"key":"4346_CR53","doi-asserted-by":"publisher","first-page":"11098","DOI":"10.1523\/JNEUROSCI.1207-04.2004","volume":"24","author":"M Townsend","year":"2004","unstructured":"Townsend M, Liu Y, Constantine-Paton M (2004) Retina-driven dephosphorylation of the NR2A subunit correlates with faster NMDA receptor kinetics at developing retinocollicular synapses. J Neurosci 24:11098\u201311107","journal-title":"J Neurosci"},{"key":"4346_CR54","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1111\/j.1471-4159.2004.02985.x","volume":"92","author":"ML Jones","year":"2005","unstructured":"Jones ML, Leonard JP (2005) PKC site mutations reveal differential modulation by insulin of NMDA receptors containing NR2A or NR2B subunits. J Neurochem 92:1431\u20131438","journal-title":"J Neurochem"},{"key":"4346_CR55","doi-asserted-by":"publisher","first-page":"7609","DOI":"10.1074\/jbc.M009922200","volume":"276","author":"F Gardoni","year":"2001","unstructured":"Gardoni F, Bellone C, Cattabeni F, Di Luca M (2001) Protein kinase C activation modulates alpha-calmodulin kinase II binding to NR2A subunit of N-methyl-D-aspartate receptor complex. J Biol Chem 276:7609\u20137613","journal-title":"J Biol Chem"},{"key":"4346_CR56","doi-asserted-by":"publisher","first-page":"2694","DOI":"10.1111\/j.1460-9568.2006.05140.x","volume":"24","author":"F Gardoni","year":"2006","unstructured":"Gardoni F, Polli F, Cattabeni F, Di Luca M (2006) Calcium-calmodulin-dependent protein kinase II phosphorylation modulates PSD-95 binding to NMDA receptors. Eur J Neurosci 24:2694\u20132704","journal-title":"Eur J Neurosci"},{"key":"4346_CR57","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1038\/634","volume":"1","author":"F Zheng","year":"1998","unstructured":"Zheng F, Gingrich MB, Traynelis SF, Conn PJ (1998) Tyrosine kinase potentiates NMDA receptor currents by reducing tonic zinc inhibition. Nat Neurosci 1:185\u2013191","journal-title":"Nat Neurosci"},{"key":"4346_CR58","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1038\/emboj.2011.453","volume":"31","author":"K Yang","year":"2012","unstructured":"Yang K, Trepanier C, Sidhu B, Xie YF, Li H, Lei G, Salter MW, Orser BA, Nakazawa T, Yamamoto T, Jackson MF, Macdonald JF (2012) Metaplasticity gated through differential regulation of GluN2A versus GluN2B receptors by Src family kinases. EMBO J 31:805\u2013816","journal-title":"EMBO J"},{"key":"4346_CR59","doi-asserted-by":"publisher","first-page":"12742","DOI":"10.1073\/pnas.211428098","volume":"98","author":"BS Li","year":"2001","unstructured":"Li BS, Sun MK, Zhang L, Takahashi S, Ma W, Vinade L, Kulkarni AB, Brady RO, Pant HC (2001) Regulation of NMDA receptors by cyclin-dependent kinase-5. Proc Natl Acad Sci U S A 98:12742\u201312747","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4346_CR60","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1038\/nn1119","volume":"6","author":"J Wang","year":"2003","unstructured":"Wang J, Liu S, Fu Y, Wang JH, Lu Y (2003) Cdk5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptors. Nat Neurosci 6:1039\u20131047","journal-title":"Nat Neurosci"},{"key":"4346_CR61","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1523\/JNEUROSCI.4582-03.2004","volume":"24","author":"MA Morabito","year":"2004","unstructured":"Morabito MA, Sheng M, Tsai LH (2004) Cyclin-dependent kinase 5 phosphorylates the N-terminal domain of the postsynaptic density protein PSD-95 in neurons. J Neurosci 24:865\u2013876","journal-title":"J Neurosci"},{"key":"4346_CR62","doi-asserted-by":"publisher","first-page":"10248","DOI":"10.1523\/JNEUROSCI.0546-04.2004","volume":"24","author":"HJ Chung","year":"2004","unstructured":"Chung HJ, Huang YH, Lau LF, Huganir RL (2004) Regulation of the NMDA receptor complex and trafficking by activity-dependent phosphorylation of the NR2B subunit PDZ ligand. J Neurosci 24:10248\u201310259","journal-title":"J Neurosci"},{"key":"4346_CR63","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.1016\/j.celrep.2012.09.024","volume":"2","author":"BS Chen","year":"2012","unstructured":"Chen BS, Gray JA, Sanz-Clemente A, Wei Z, Thomas EV, Nicoll RA, Roche KW (2012) SAP102 mediates synaptic clearance of NMDA receptors. Cell Rep 2:1120\u20131128","journal-title":"Cell Rep"},{"key":"4346_CR64","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.celrep.2019.06.030","volume":"28","author":"AM Chiu","year":"2019","unstructured":"Chiu AM, Wang J, Fiske MP, Hubalkova P, Barse L, Gray JA, Sanz-Clemente A (2019) NMDAR-Activated PP1 dephosphorylates GluN2B to Modulate NMDAR synaptic content. Cell Rep 28:332\u2013341.e335","journal-title":"Cell Rep"},{"key":"4346_CR65","doi-asserted-by":"publisher","first-page":"108615","DOI":"10.1016\/j.neuropharm.2021.108615","volume":"193","author":"V Rajani","year":"2021","unstructured":"Rajani V, Sengar AS, Salter MW (2021) Src and fyn regulation of NMDA receptors in health and disease. Neuropharmacology 193:108615","journal-title":"Neuropharmacology"},{"key":"4346_CR66","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1016\/S0028-3908(03)00308-3","volume":"45","author":"G Lavezzari","year":"2003","unstructured":"Lavezzari G, McCallum J, Lee R, Roche KW (2003) Differential binding of the AP-2 adaptor complex and PSD-95 to the C-terminus of the NMDA receptor subunit NR2B regulates surface expression. Neuropharmacology 45:729\u2013737","journal-title":"Neuropharmacology"},{"key":"4346_CR67","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1016\/j.neuron.2005.08.016","volume":"47","author":"K Prybylowski","year":"2005","unstructured":"Prybylowski K, Chang K, Sans N, Kan L, Vicini S, Wenthold RJ (2005) The synaptic localization of NR2B-containing NMDA receptors is controlled by interactions with PDZ proteins and AP-2. Neuron 47:845\u2013857","journal-title":"Neuron"},{"key":"4346_CR68","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1074\/jbc.M008085200","volume":"276","author":"T Nakazawa","year":"2001","unstructured":"Nakazawa T, Komai S, Tezuka T, Hisatsune C, Umemori H, Semba K, Mishina M, Manabe T, Yamamoto T (2001) Characterization of Fyn-mediated tyrosine phosphorylation sites on GluR epsilon 2 (NR2B) subunit of the N-methyl-D-aspartate receptor. J Biol Chem 276:693\u2013699","journal-title":"J Biol Chem"},{"key":"4346_CR69","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1074\/jbc.M705580200","volume":"283","author":"R Jurd","year":"2008","unstructured":"Jurd R, Thornton C, Wang J, Luong K, Phamluong K, Kharazia V, Gibb SL, Ron D (2008) Mind bomb-2 is an E3 ligase that ubiquitinates the N-methyl-D-aspartate receptor NR2B subunit in a phosphorylation-dependent manner. J Biol Chem 283:301\u2013310","journal-title":"J Biol Chem"},{"key":"4346_CR70","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1016\/j.neuron.2010.08.011","volume":"67","author":"A Sanz-Clemente","year":"2010","unstructured":"Sanz-Clemente A, Matta JA, Isaac JT, Roche KW (2010) Casein kinase 2 regulates the NR2 subunit composition of synaptic NMDA receptors. Neuron 67:984\u2013996","journal-title":"Neuron"},{"key":"4346_CR71","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1016\/j.neuron.2014.01.022","volume":"81","author":"F Plattner","year":"2014","unstructured":"Plattner F, Hernandez A, Kistler TM, Pozo K, Zhong P, Yuen EY, Tan C, Hawasli AH, Cooke SF, Nishi A, Guo A, Wiederhold T, Yan Z, Bibb JA (2014) Memory enhancement by targeting Cdk5 regulation of NR2B. Neuron 81:1070\u20131083","journal-title":"Neuron"},{"key":"4346_CR72","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1523\/JNEUROSCI.1900-07.2008","volume":"28","author":"S Zhang","year":"2008","unstructured":"Zhang S, Edelmann L, Liu J, Crandall JE, Morabito MA (2008) Cdk5 regulates the phosphorylation of tyrosine 1472 NR2B and the surface expression of NMDA receptors. J Neurosci 28:415\u2013424","journal-title":"J Neurosci"},{"key":"4346_CR73","doi-asserted-by":"crossref","unstructured":"Leal G, Comprido D, de Luca P, Morais E, Rodrigues L, Mele M, Santos AR, Costa RO, Pinto MJ, Patil S, Berentsen B, Afonso P, Carreto L, Li KW, Pinheiro P, Almeida RD, Santos MAS, Bramham CR, Duarte CB (2017) The RNA-Binding protein hnRNP K mediates the Effect of BDNF on dendritic mRNA metabolism and regulates synaptic NMDA receptors in hippocampal neurons. eNeuro 4:ENEURO.0268-17.2017.","DOI":"10.1523\/ENEURO.0268-17.2017"},{"key":"4346_CR74","doi-asserted-by":"crossref","unstructured":"Afonso P, De Luca P, Carvalho RS, Cortes L, Pinheiro P, Oliveiros B, Almeida RD, Mele M, Duarte CB (2019) BDNF increases synaptic NMDA receptor abundance by enhancing the local translation of Pyk2 in cultured hippocampal neurons. Sci Signal 12:eaav3577","DOI":"10.1126\/scisignal.aav3577"},{"key":"4346_CR75","doi-asserted-by":"publisher","first-page":"2712","DOI":"10.1007\/s11064-017-2274-0","volume":"42","author":"S Li","year":"2017","unstructured":"Li S, Cai J, Feng ZB, Jin ZR, Liu BH, Zhao HY, Jing HB, Wei TJ, Yang GN, Liu LY, Cui YJ, Xing GG (2017) BDNF contributes to spinal long-term potentiation and mechanical hypersensitivity Via fyn-mediated phosphorylation of NMDA receptor GluN2B subunit at Tyrosine 1472 in rats following spinal nerve ligation. Neurochem Res 42:2712\u20132729","journal-title":"Neurochem Res"},{"key":"4346_CR76","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/j.neuropharm.2013.04.005","volume":"C","author":"G Leal","year":"2014","unstructured":"Leal G, Comprido D, Duarte CB (2014) BDNF-induced local protein synthesis and synaptic plasticity. Neuropharmacol 76 Pt C:639\u2013656","journal-title":"Neuropharmacol 76 Pt"},{"key":"4346_CR77","doi-asserted-by":"publisher","first-page":"2867","DOI":"10.1038\/sj.emboj.7601156","volume":"25","author":"T Nakazawa","year":"2006","unstructured":"Nakazawa T, Komai S, Watabe AM, Kiyama Y, Fukaya M, Arima-Yoshida F, Horai R, Sudo K, Ebine K, Delawary M, Goto J, Umemori H, Tezuka T, Iwakura Y, Watanabe M, Yamamoto T, Manabe T (2006) NR2B tyrosine phosphorylation modulates fear learning as well as amygdaloid synaptic plasticity. EMBO J 25:2867\u20132877","journal-title":"EMBO J"},{"key":"4346_CR78","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1111\/j.1460-9568.2010.07348.x","volume":"32","author":"S Matsumura","year":"2010","unstructured":"Matsumura S, Kunori S, Mabuchi T, Katano T, Nakazawa T, Abe T, Watanabe M, Yamamoto T, Okuda-Ashitaka E, Ito S (2010) Impairment of CaMKII activation and attenuation of neuropathic pain in mice lacking NR2B phosphorylated at Tyr1472. Eur J Neurosci 32:798\u2013810","journal-title":"Eur J Neurosci"},{"key":"4346_CR79","doi-asserted-by":"publisher","first-page":"109612","DOI":"10.1016\/j.celrep.2021.109612","volume":"36","author":"X Shi","year":"2021","unstructured":"Shi X, Zhang Q, Li J, Liu X, Zhang Y, Huang M, Fang W, Xu J, Yuan T, Xiao L, Tang YQ, Wang XD, Luo J, Yang W (2021) Disrupting phosphorylation of Tyr-1070 at GluN2B selectively produces resilience to depression-like behaviors. Cell Rep 36:109612","journal-title":"Cell Rep"},{"key":"4346_CR80","doi-asserted-by":"publisher","first-page":"31670","DOI":"10.1074\/jbc.271.49.31670","volume":"271","author":"RV Omkumar","year":"1996","unstructured":"Omkumar RV, Kiely MJ, Rosenstein AJ, Min KT, Kennedy MB (1996) Identification of a phosphorylation site for calcium\/calmodulindependent protein kinase II in the NR2B subunit of the N-methyl-D-aspartate receptor. J Biol Chem 271:31670\u201331678","journal-title":"J Biol Chem"},{"key":"4346_CR81","doi-asserted-by":"publisher","first-page":"31272","DOI":"10.1074\/jbc.M111.233668","volume":"286","author":"H O\u2019Leary","year":"2011","unstructured":"O\u2019Leary H, Liu WH, Rorabaugh JM, Coultrap SJ, Bayer KU (2011) Nucleotides and phosphorylation bi-directionally modulate Ca2+\/calmodulin-dependent protein kinase II (CaMKII) binding to the N-methyl-D-aspartate (NMDA) receptor subunit GluN2B. J Biol Chem 286:31272\u201331281","journal-title":"J Biol Chem"},{"key":"4346_CR82","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/j.celrep.2013.02.011","volume":"3","author":"A Sanz-Clemente","year":"2013","unstructured":"Sanz-Clemente A, Gray JA, Ogilvie KA, Nicoll RA, Roche KW (2013) Activated CaMKII couples GluN2B and casein kinase 2 to control synaptic NMDA receptors. Cell Rep 3:607\u2013614","journal-title":"Cell Rep"},{"key":"4346_CR83","doi-asserted-by":"publisher","first-page":"28596","DOI":"10.1074\/jbc.R115.652750","volume":"290","author":"MP Lussier","year":"2015","unstructured":"Lussier MP, Sanz-Clemente A, Roche KW (2015) Dynamic regulation of N-Methyl-d-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors by posttranslational modifications. J Biol Chem 290:28596\u201328603","journal-title":"J Biol Chem"},{"key":"4346_CR84","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1002\/embj.201386356","volume":"33","author":"JP Dupuis","year":"2014","unstructured":"Dupuis JP, Ladepeche L, Seth H, Bard L, Varela J, Mikasova L, Bouchet D, Rogemond V, Honnorat J, Hanse E, Groc L (2014) Surface dynamics of GluN2B-NMDA receptors controls plasticity of maturing glutamate synapses. EMBO J 33:842\u2013861","journal-title":"EMBO J"},{"key":"4346_CR85","doi-asserted-by":"crossref","unstructured":"Tu G, Fu T, Yang F, Yao L, Xue W, Zhu F (2018) Prediction of GluN2B-CT1290\u20131310\/DAPK1 Interaction by Protein-Peptide docking and Molecular Dynamics Simulation. Molecules 23:3018.","DOI":"10.3390\/molecules23113018"},{"key":"4346_CR86","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.cell.2009.12.055","volume":"140","author":"W Tu","year":"2010","unstructured":"Tu W, Xu X, Peng L, Zhong X, Zhang W, Soundarapandian MM, Balel C, Wang M, Jia N, Zhang W, Lew F, Chan SL, Chen Y, Lu Y (2010) DAPK1 interaction with NMDA receptor NR2B subunits mediates brain damage in stroke. Cell 140:222\u2013234","journal-title":"Cell"},{"key":"4346_CR87","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1038\/mp.2017.85","volume":"23","author":"SX Li","year":"2018","unstructured":"Li SX, Han Y, Xu LZ, Yuan K, Zhang RX, Sun CY, Xu DF, Yuan M, Deng JH, Meng SQ, Gao XJ, Wen Q, Liu LJ, Zhu WL, Xue YX, Zhao M, Shi J, Lu L (2018) Uncoupling DAPK1 from NMDA receptor GluN2B subunit exerts rapid antidepressant-like effects. Mol Psychiatry 23:597\u2013608","journal-title":"Mol Psychiatry"},{"key":"4346_CR88","doi-asserted-by":"publisher","first-page":"590569","DOI":"10.3389\/fncel.2020.590569","volume":"14","author":"ME Schmidt","year":"2020","unstructured":"Schmidt ME, Caron NS, Aly AE, Lemarie FL, Dal Cengio L, Ko Y, Lazic N, Anderson L, Nguyen B, Raymond LA, Hayden MR (2020) DAPK1 promotes extrasynaptic GluN2B phosphorylation and striatal spine instability in the YAC128 mouse model of Huntington Disease. Front Cell Neurosci 14:590569","journal-title":"Front Cell Neurosci"},{"key":"4346_CR89","doi-asserted-by":"publisher","first-page":"2231","DOI":"10.1016\/j.celrep.2017.05.068","volume":"19","author":"DJ Goodell","year":"2017","unstructured":"Goodell DJ, Zaegel V, Coultrap SJ, Hell JW, Bayer KU (2017) DAPK1 mediates LTD by making CaMKII\/GluN2B binding LTP specific. Cell Rep 19:2231\u20132243","journal-title":"Cell Rep"},{"key":"4346_CR90","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/j.neuron.2009.04.015","volume":"62","author":"BS Chen","year":"2009","unstructured":"Chen BS, Roche KW (2009) Growth factor-dependent trafficking of cerebellar NMDA receptors via protein kinase B\/Akt phosphorylation of NR2C. Neuron 62:471\u2013478","journal-title":"Neuron"},{"key":"4346_CR91","doi-asserted-by":"publisher","first-page":"16583","DOI":"10.1074\/jbc.M513029200","volume":"281","author":"BS Chen","year":"2006","unstructured":"Chen BS, Braud S, Badger JD 2nd, Isaac JT, Roche KW (2006) Regulation of NR1\/NR2C N-methyl-D-aspartate (NMDA) receptors by phosphorylation. J Biol Chem 281:16583\u201316590","journal-title":"J Biol Chem"},{"key":"4346_CR92","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.pneurobio.2010.01.004","volume":"91","author":"MA Henson","year":"2010","unstructured":"Henson MA, Roberts AC, Perez-Otano I, Philpot BD (2010) Influence of the NR3A subunit on NMDA receptor functions. Prog Neurobiol 91:23\u201337","journal-title":"Prog Neurobiol"},{"key":"4346_CR93","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1038\/nrn.2016.92","volume":"17","author":"I Perez-Otano","year":"2016","unstructured":"Perez-Otano I, Larsen RS, Wesseling JF (2016) Emerging roles of GluN3-containing NMDA receptors in the CNS. Nat Rev Neurosci 17:623\u2013635","journal-title":"Nat Rev Neurosci"},{"key":"4346_CR94","doi-asserted-by":"crossref","unstructured":"Hurley EP, Mukherjee B, Fang LZ, Barnes JR, Barron JC, Nafar F, Hirasawa M, Parsons MP (2024) GluN3A and excitatory Glycine receptors in the adult Hippocampus. J Neurosci 44:e0401242024","DOI":"10.1523\/JNEUROSCI.0401-24.2024"},{"key":"4346_CR95","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1038\/nature715","volume":"415","author":"JE Chatterton","year":"2002","unstructured":"Chatterton JE, Awobuluyi M, Premkumar LS, Takahashi H, Talantova M, Shin Y, Cui J, Tu S, Sevarino KA, Nakanishi N, Tong G, Lipton SA, Zhang D (2002) Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits. Nature 415:793\u2013798","journal-title":"Nature"},{"key":"4346_CR96","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1126\/science.aax1522","volume":"366","author":"Y Otsu","year":"2019","unstructured":"Otsu Y, Darcq E, Pietrajtis K, Matyas F, Schwartz E, Bessaih T, Abi Gerges S, Rousseau CV, Grand T, Dieudonne S, Paoletti P, Acsady L, Agulhon C, Kieffer BL, Diana MA (2019) Control of aversion by glycine-gated GluN1\/GluN3A NMDA receptors in the adult medial habenula. Science 366:250\u2013254","journal-title":"Science"},{"key":"4346_CR97","doi-asserted-by":"publisher","first-page":"2438","DOI":"10.1016\/j.neuron.2022.05.016","volume":"110","author":"S Bossi","year":"2022","unstructured":"Bossi S, Dhanasobhon D, Ellis-Davies GCR, Frontera J, de Brito Van Velze M, Lourenco J, Murillo A, Lujan R, Casado M, Perez-Otano I, Bacci A, Popa D, Paoletti P, Rebola N (2022) GluN3A excitatory glycine receptors control adult cortical and amygdalar circuits. Neuron 110:2438\u20132454 e2438","journal-title":"Neuron"},{"key":"4346_CR98","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.bbrc.2007.06.179","volume":"361","author":"M Eriksson","year":"2007","unstructured":"Eriksson M, Samuelsson H, Samuelsson EB, Liu L, McKeehan WL, Benedikz E, Sundstrom E (2007) The NMDAR subunit NR3A interacts with microtubule-associated protein 1S in the brain. Biochem Biophys Res Commun 361:127\u2013132","journal-title":"Biochem Biophys Res Commun"},{"key":"4346_CR99","doi-asserted-by":"publisher","first-page":"4151","DOI":"10.1523\/JNEUROSCI.2721-12.2013","volume":"33","author":"D Chowdhury","year":"2013","unstructured":"Chowdhury D, Marco S, Brooks IM, Zandueta A, Rao Y, Haucke V, Wesseling JF, Tavalin SJ, Perez-Otano I (2013) Tyrosine phosphorylation regulates the endocytosis and surface expression of GluN3A-containing NMDA receptors. J Neurosci 33:4151\u20134164","journal-title":"J Neurosci"},{"key":"4346_CR100","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1038\/ncomms1871","volume":"3","author":"A Lundby","year":"2012","unstructured":"Lundby A, Secher A, Lage K, Nordsborg NB, Dmytriyev A, Lundby C, Olsen JV (2012) Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun 3:876","journal-title":"Nat Commun"},{"key":"4346_CR101","doi-asserted-by":"publisher","first-page":"1891","DOI":"10.1021\/pr201099u","volume":"11","author":"M Ghafari","year":"2012","unstructured":"Ghafari M, Hoger H, Keihan Falsafi S, Russo-Schlaff N, Pollak A, Lubec G (2012) Mass spectrometrical identification of hippocampal NMDA receptor subunits NR1, NR2A-D and five novel phosphorylation sites on NR2A and NR2B. J Proteome Res 11:1891\u20131896","journal-title":"J Proteome Res"},{"key":"4346_CR102","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1016\/j.cell.2010.12.001","volume":"143","author":"EL Huttlin","year":"2010","unstructured":"Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143:1174\u20131189","journal-title":"Cell"},{"key":"4346_CR103","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.pneurobio.2013.10.003","volume":"112","author":"MV Caldeira","year":"2014","unstructured":"Caldeira MV, Salazar IL, Curcio M, Canzoniero LM, Duarte CB (2014) Role of the ubiquitin-proteasome system in brain ischemia: friend or foe? Prog Neurobiol 112:50\u201369","journal-title":"Prog Neurobiol"},{"key":"4346_CR104","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1038\/nrm3099","volume":"12","author":"C Grabbe","year":"2011","unstructured":"Grabbe C, Husnjak K, Dikic I (2011) The spatial and temporal organization of ubiquitin networks. Nat Rev Mol Cell Biol 12:295\u2013307","journal-title":"Nat Rev Mol Cell Biol"},{"key":"4346_CR105","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1038\/cr.2016.39","volume":"26","author":"KN Swatek","year":"2016","unstructured":"Swatek KN, Komander D (2016) Ubiquitin modifications. Cell Res 26:399\u2013422","journal-title":"Cell Res"},{"key":"4346_CR106","doi-asserted-by":"publisher","first-page":"6165","DOI":"10.1523\/JNEUROSCI.3013-14.2015","volume":"35","author":"G Atkin","year":"2015","unstructured":"Atkin G, Moore S, Lu Y, Nelson RF, Tipper N, Rajpal G, Hunt J, Tennant W, Hell JW, Murphy GG, Paulson H (2015) Loss of F-box only protein 2 (Fbxo2) disrupts levels and localization of select NMDA receptor subunits, and promotes aberrant synaptic connectivity. J Neurosci 35:6165\u20136178","journal-title":"J Neurosci"},{"key":"4346_CR107","doi-asserted-by":"publisher","first-page":"104","DOI":"10.3389\/fphys.2019.00104","volume":"10","author":"Y Yoshida","year":"2019","unstructured":"Yoshida Y, Mizushima T, Tanaka K (2019) Sugar-recognizing Ubiquitin ligases: Action mechanisms and Physiology. Front Physiol 10:104","journal-title":"Front Physiol"},{"key":"4346_CR108","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1038\/s41398-018-0194-7","volume":"8","author":"A Yuan","year":"2018","unstructured":"Yuan A, Veeranna, Sershen H, Basavarajappa BS, Smiley JF, Hashim A, Bleiwas C, Berg M, Guifoyle DN, Subbanna S, Darji S, Kumar A, Rao MV, Wilson DA, Julien JP, Javitt DC, Nixon RA (2018) Neurofilament light interaction with GluN1 modulates neurotransmission and schizophrenia-associated behaviors. Transl Psychiatry 8:167","journal-title":"Transl Psychiatry"},{"key":"4346_CR109","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1016\/j.neuron.2011.12.033","volume":"73","author":"EY Yuen","year":"2012","unstructured":"Yuen EY, Wei J, Liu W, Zhong P, Li X, Yan Z (2012) Repeated stress causes cognitive impairment by suppressing glutamate receptor expression and function in prefrontal cortex. Neuron 73:962\u2013977","journal-title":"Neuron"},{"key":"4346_CR110","doi-asserted-by":"publisher","first-page":"1726","DOI":"10.1038\/s41418-023-01174-5","volume":"30","author":"J Gu","year":"2023","unstructured":"Gu J, Ke P, Guo H, Liu J, Liu Y, Tian X, Huang Z, Xu X, Xu D, Ma Y, Wang X, Xiao F (2023) KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility. Cell Death Differ 30:1726\u20131741","journal-title":"Cell Death Differ"},{"key":"4346_CR111","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1186\/s12915-018-0567-7","volume":"16","author":"M Zhu","year":"2018","unstructured":"Zhu M, Cortese GP, Waites CL (2018) Parkinson\u2019s disease-linked parkin mutations impair glutamatergic signaling in hippocampal neurons. BMC Biol 16:100","journal-title":"BMC Biol"},{"key":"4346_CR112","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.neuroscience.2015.10.054","volume":"311","author":"JN Cremer","year":"2015","unstructured":"Cremer JN, Amunts K, Schleicher A, Palomero-Gallagher N, Piel M, Rosch F, Zilles K (2015) Changes in the expression of neurotransmitter receptors in Parkin and DJ-1 knockout mice\u2013A quantitative multireceptor study. Neuroscience 311:539\u2013551","journal-title":"Neuroscience"},{"key":"4346_CR113","doi-asserted-by":"publisher","first-page":"e3000525","DOI":"10.1371\/journal.pbio.3000525","volume":"17","author":"F Zeng","year":"2019","unstructured":"Zeng F, Ma X, Zhu L, Xu Q, Zeng Y, Gao Y, Li G, Guo T, Zhang H, Tang X, Wang Z, Ye Z, Zheng L, Zhang H, Zheng Q, Li K, Lu J, Qi X, Luo H, Zhang X, Wang Z, Zhou Y, Yao Y, Ke R, Zhou Y, Liu Y, Sun H, Huang T, Shao Z, Xu H, Wang X (2019) The deubiquitinase USP6 affects memory and synaptic plasticity through modulating NMDA receptor stability. PLoS Biol 17:e3000525","journal-title":"PLoS Biol"},{"key":"4346_CR114","doi-asserted-by":"publisher","first-page":"515","DOI":"10.4196\/kjpp.2015.19.6.515","volume":"19","author":"S Kim","year":"2015","unstructured":"Kim S, Kim T, Lee HR, Kong YY, Kaang BK (2015) Mind Bomb-2 regulates Hippocampus-dependent memory formation and synaptic plasticity. Korean J Physiol Pharmacol 19:515\u2013522","journal-title":"Korean J Physiol Pharmacol"},{"key":"4346_CR115","doi-asserted-by":"crossref","unstructured":"Zhang ZY, Bai HH, Guo Z, Li HL, Diao XT, Zhang TY, Yao L, Ma JJ, Cao Z, Li YX, Bai X, Chen HK, Suo ZW, Yang X, Hu XD (2020) Ubiquitination and functional modification of GluN2B subunit-containing NMDA receptors by Cbl-b in the spinal cord dorsal horn. Sci Signal 13:eaaw1519","DOI":"10.1126\/scisignal.aaw1519"},{"key":"4346_CR116","doi-asserted-by":"publisher","first-page":"5125","DOI":"10.1073\/pnas.0601043103","volume":"103","author":"DP Tan","year":"2006","unstructured":"Tan DP, Liu QY, Koshiya N, Gu H, Alkon D (2006) Enhancement of long-term memory retention and short-term synaptic plasticity in cbl-b null mice. Proc Natl Acad Sci U S A 103:5125\u20135130","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4346_CR117","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.neuropharm.2013.04.035","volume":"74","author":"V Gautam","year":"2013","unstructured":"Gautam V, Trinidad JC, Rimerman RA, Costa BM, Burlingame AL, Monaghan DT (2013) Nedd4 is a specific E3 ubiquitin ligase for the NMDA receptor subunit GluN2D. Neuropharmacology 74:96\u2013107","journal-title":"Neuropharmacology"},{"key":"4346_CR118","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1038\/nature04769","volume":"441","author":"B Bingol","year":"2006","unstructured":"Bingol B, Schuman EM (2006) Activity-dependent dynamics and sequestration of proteasomes in dendritic spines. Nature 441:1144\u20131148","journal-title":"Nature"},{"key":"4346_CR119","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1042\/BST20160309","volume":"45","author":"K Lemonidis","year":"2017","unstructured":"Lemonidis K, Salaun C, Kouskou M, Diez-Ardanuy C, Chamberlain LH, Greaves J (2017) Substrate selectivity in the zDHHC family of S-acyltransferases. Biochem Soc Trans 45:751\u2013758","journal-title":"Biochem Soc Trans"},{"key":"4346_CR120","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1080\/10409238.2017.1409191","volume":"53","author":"SJ Won","year":"2018","unstructured":"Won SJ, Cheung See Kit M, Martin BR (2018) Protein depalmitoylases. Crit Rev Biochem Mol Biol 53:83\u201398","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"4346_CR121","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.neuron.2009.08.017","volume":"64","author":"T Hayashi","year":"2009","unstructured":"Hayashi T, Thomas GM, Huganir RL (2009) Dual palmitoylation of NR2 subunits regulates NMDA receptor trafficking. Neuron 64:213\u2013226","journal-title":"Neuron"},{"key":"4346_CR122","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1111\/bph.15050","volume":"178","author":"T Hayashi","year":"2021","unstructured":"Hayashi T (2021) Post-translational palmitoylation of ionotropic glutamate receptors in excitatory synaptic functions. Br J Pharmacol 178:784\u2013797","journal-title":"Br J Pharmacol"},{"key":"4346_CR123","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3389\/fnsyn.2019.00003","volume":"11","author":"R Kang","year":"2019","unstructured":"Kang R, Wang L, Sanders SS, Zuo K, Hayden MR, Raymond LA (2019) Altered regulation of Striatal neuronal N-Methyl-D-Aspartate receptor trafficking by Palmitoylation in Huntington Disease Mouse Model. Front Synaptic Neurosci 11:3","journal-title":"Front Synaptic Neurosci"},{"key":"4346_CR124","doi-asserted-by":"crossref","unstructured":"Suzuki N, Oota-Ishigaki A, Kaizuka T, Itoh M, Yamazaki M, Natsume R, Abe M, Sakimura K, Mishina M, Hayashi T (2024) Limb-Clasping Response in NMDA Receptor Palmitoylation-Deficient Mice. Mol Neurobiol 61:9125\u20139135","DOI":"10.1007\/s12035-024-04166-9"},{"key":"4346_CR125","doi-asserted-by":"publisher","first-page":"2119","DOI":"10.1523\/JNEUROSCI.2654-20.2021","volume":"41","author":"P Hubalkova","year":"2021","unstructured":"Hubalkova P, Ladislav M, Vyklicky V, Smejkalova T, Hrcka Krausova B, Kysilov B, Krusek J, Naimova Z, Korinek M, Chodounska H, Kudova E, Cerny J, Vyklicky L Jr (2021) Palmitoylation controls NMDA receptor function and steroid sensitivity. J Neurosci 41:2119\u20132134","journal-title":"J Neurosci"},{"key":"4346_CR126","doi-asserted-by":"crossref","unstructured":"Koster KP, Francesconi W, Berton F, Alahmadi S, Srinivas R, Yoshii A (2019) Developmental NMDA receptor dysregulation in the infantile neuronal ceroid lipofuscinosis mouse model. Elife 8:e40316","DOI":"10.7554\/eLife.40316"},{"key":"4346_CR127","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1042\/BST20220827","volume":"51","author":"E Corti","year":"2023","unstructured":"Corti E, Duarte CB (2023) The role of post-translational modifications in synaptic AMPA receptor activity. Biochem Soc Trans 51:315\u2013330","journal-title":"Biochem Soc Trans"}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-025-04346-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11064-025-04346-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-025-04346-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T05:01:45Z","timestamp":1745557305000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11064-025-04346-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,3]]},"references-count":127,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["4346"],"URL":"https:\/\/doi.org\/10.1007\/s11064-025-04346-6","relation":{},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"value":"0364-3190","type":"print"},{"value":"1573-6903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,3]]},"assertion":[{"value":"3 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 January 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 January 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 March 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"110"}}