{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T15:56:24Z","timestamp":1762271784227},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2014,3,13]],"date-time":"2014-03-13T00:00:00Z","timestamp":1394668800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharm Res"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1007\/s11095-014-1347-x","type":"journal-article","created":{"date-parts":[[2014,3,12]],"date-time":"2014-03-12T15:15:36Z","timestamp":1394637336000},"page":"2516-2528","source":"Crossref","is-referenced-by-count":34,"title":["Co-delivery of Sildenafil (Viagra\u00ae) and Crizotinib for Synergistic and Improved Anti-tumoral Therapy"],"prefix":"10.1007","volume":"31","author":[{"given":"Jo\u00e3o G.","family":"Marques","sequence":"first","affiliation":[]},{"given":"V\u00edtor M.","family":"Gaspar","sequence":"additional","affiliation":[]},{"given":"David","family":"Markl","sequence":"additional","affiliation":[]},{"given":"Elisabete C.","family":"Costa","sequence":"additional","affiliation":[]},{"given":"Eug\u00e9nia","family":"Gallardo","sequence":"additional","affiliation":[]},{"given":"Il\u00eddio J.","family":"Correia","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2014,3,13]]},"reference":[{"key":"1347_CR1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3322\/caac.21166","volume":"63","author":"R Siegel","year":"2013","unstructured":"Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA Cancer J Clin. 2013;63:11\u201330.","journal-title":"CA Cancer J Clin"},{"key":"1347_CR2","doi-asserted-by":"crossref","first-page":"69","DOI":"10.3322\/caac.20107","volume":"61","author":"A Jemal","year":"2011","unstructured":"Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61:69\u201390.","journal-title":"CA Cancer J Clin"},{"key":"1347_CR3","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1016\/S0140-6736(11)61351-2","volume":"378","author":"MH Forouzanfar","year":"2011","unstructured":"Forouzanfar MH, Foreman KJ, Delossantos AM, Lozano R, Lopez AD, Murray CJL, et al. Breast and cervical cancer in 187 countries between 1980 and 2010: a systematic analysis. Lancet. 2011;378:1461\u201384.","journal-title":"Lancet"},{"key":"1347_CR4","doi-asserted-by":"crossref","first-page":"38","DOI":"10.2106\/JBJS.K.01595","volume":"94","author":"R Bhumbra","year":"2012","unstructured":"Bhumbra R, Carter S, Jeys L, Tillman R, Abudu A, Sumathi V, et al. How does a poor response to chemotherapy affect outcomes in patients with osteosarcoma? J Bone Joint Surg (Br). 2012;94:38.","journal-title":"J Bone Joint Surg (Br)"},{"key":"1347_CR5","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1016\/j.biomaterials.2012.11.038","volume":"34","author":"R Liu","year":"2013","unstructured":"Liu R, Gilmore DM, Zubris KA, Xu X, Catalano PJ, Padera RF, et al. Prevention of nodal metastases in breast cancer following the lymphatic migration of paclitaxel-loaded expansile nanoparticles. Biomaterials. 2013;34:1810\u20139.","journal-title":"Biomaterials"},{"key":"1347_CR6","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1200\/JCO.20.6.1456","volume":"20","author":"IC Smith","year":"2002","unstructured":"Smith IC, Heys SD, Hutcheon AW, Miller ID, Payne S, Gilbert FJ, et al. Neoadjuvant chemotherapy in breast cancer: significantly enhanced response with docetaxel. J Clin Oncol. 2002;20:1456\u201366.","journal-title":"J Clin Oncol"},{"key":"1347_CR7","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1186\/bcr819","volume":"6","author":"J Chen","year":"2004","unstructured":"Chen J, Wang L, Yao Q, Ling R, Li K, Wang H. Drug concentrations in axillary lymph nodes after lymphatic chemotherapy on patients with breast cancer. Breast Cancer Res. 2004;6:474\u20137.","journal-title":"Breast Cancer Res"},{"key":"1347_CR8","doi-asserted-by":"crossref","first-page":"215","DOI":"10.3109\/09687688.2010.510804","volume":"27","author":"RN Saha","year":"2010","unstructured":"Saha RN, Vasanthakumar S, Bende G, Snehalatha M. Nanoparticulate drug delivery systems for cancer chemotherapy. Mol Membr Biol. 2010;27:215\u201331.","journal-title":"Mol Membr Biol"},{"key":"1347_CR9","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.ijpharm.2012.08.030","volume":"438","author":"ASA Lila","year":"2012","unstructured":"Lila ASA, Eldin NE, Ichihara M, Ishida T, Kiwada H. Multiple administration of PEG-coated liposomal oxaliplatin enhances its therapeutic efficacy: a possible mechanism and the potential for clinical application. Int J Pharm. 2012;438:176\u201383.","journal-title":"Int J Pharm"},{"key":"1347_CR10","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.ces.2005.06.019","volume":"61","author":"ZP Xu","year":"2006","unstructured":"Xu ZP, Zeng QH, Lu GQ, Yu AB. Inorganic nanoparticles as carriers for efficient cellular delivery. Chem Eng Sci. 2006;61:1027\u201340.","journal-title":"Chem Eng Sci"},{"key":"1347_CR11","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0169-409X(01)00222-8","volume":"53","author":"A R\u00f6sler","year":"2012","unstructured":"R\u00f6sler A, Vandermeulen GW, Klok H-A. Advanced drug delivery devices via self-assembly of amphiphilic block copolymers. Adv Drug Deliv Rev. 2012;53:95\u2013108.","journal-title":"Adv Drug Deliv Rev"},{"key":"1347_CR12","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.ejpb.2006.11.009","volume":"65","author":"K Letchfordand","year":"2007","unstructured":"Letchfordand K, Burt H. A review of the formation and classification of amphiphilic block copolymer nanoparticulate structures: micelles, nanospheres, nanocapsules and polymersomes. Eur J Pharm Biopharm. 2007;65:259\u201369.","journal-title":"Eur J Pharm Biopharm"},{"key":"1347_CR13","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.nano.2008.03.004","volume":"4","author":"JC Garay-Jimenez","year":"2008","unstructured":"Garay-Jimenez JC, Young A, Gergeres D, Greenhalgh K, Turos E. Methods for purifying and detoxifying sodium dodecyl sulfate\u2013stabilized polyacrylate nanoparticles. Nanomedicine: NBM. 2008;4:98\u2013105.","journal-title":"Nanomedicine: NBM"},{"key":"1347_CR14","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.nano.2011.05.016","volume":"8","author":"S Parveen","year":"2012","unstructured":"Parveen S, Misra R, Sahoo SK. Nanoparticles: a boon to drug delivery, therapeutics, diagnostics and imaging. Nanomedicine: NBM. 2012;8:147\u201366.","journal-title":"Nanomedicine: NBM"},{"key":"1347_CR15","doi-asserted-by":"crossref","first-page":"5148","DOI":"10.1016\/j.biomaterials.2011.03.071","volume":"32","author":"L Xiao","year":"2011","unstructured":"Xiao L, Xiong X, Sun X, Zhu Y, Yang H, Chen H, et al. Role of cellular uptake in the reversal of multidrug resistance by PEG-b-PLA polymeric micelles. Biomaterials. 2011;32:5148\u201357.","journal-title":"Biomaterials"},{"key":"1347_CR16","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1200\/JCO.20.3.719","volume":"20","author":"CL Vogel","year":"2002","unstructured":"Vogel CL, Cobleigh MA, Tripathy D, Gutheil JC, Harris LN, Fehrenbacher L, et al. Efficacy and safety of Trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer. J Clin Oncol. 2002;20:719\u201326.","journal-title":"J Clin Oncol"},{"key":"1347_CR17","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S1470-2045(06)70793-8","volume":"7","author":"M Yezhelyev","year":"2006","unstructured":"Yezhelyev M, Gao X, Xing Y, Alhajj A, Nie S, Oregan R. Emerging use of nanoparticles in diagnosis and treatment of breast cancer. Lancet Oncol. 2006;7:657\u201367.","journal-title":"Lancet Oncol"},{"key":"1347_CR18","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1097\/00001813-200401000-00012","volume":"15","author":"L Drucker","year":"2004","unstructured":"Drucker L, Afensiev F, Radnay J, Shapira H, Lishner M. Co-administration of simvastatin and cytotoxic drugs is advantageous in myeloma cell lines. Anticancer Drugs. 2004;15:79\u201384.","journal-title":"Anticancer Drugs"},{"key":"1347_CR19","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1093\/carcin\/22.8.1111","volume":"22","author":"J Gusman","year":"2001","unstructured":"Gusman J, Malonne H, Atassi G. A reappraisal of the potential chemopreventive and chemotherapeutic properties of resveratrol. Carcinogenesis. 2001;22:1111\u20137.","journal-title":"Carcinogenesis"},{"key":"1347_CR20","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1002\/cmdc.200700121","volume":"2","author":"L Zhang","year":"2007","unstructured":"Zhang L, Radovic\u2010Moreno AF, Alexis F, Gu FX, Basto PA, Bagalkot V, et al. Co\u2010delivery of hydrophobic and hydrophilic drugs from nanoparticle\u2013aptamer bioconjugates. ChemMedChem. 2007;2:1268\u201371.","journal-title":"ChemMedChem"},{"key":"1347_CR21","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.biomaterials.2008.10.062","volume":"30","author":"AL Lee","year":"2009","unstructured":"Lee AL, Wang Y, Cheng HY, Pervaiz S, Yang YY. The co-delivery of paclitaxel and Herceptin using cationic micellar nanoparticles. Biomaterials. 2009;30:919\u201327.","journal-title":"Biomaterials"},{"key":"1347_CR22","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1038\/nrd3600","volume":"10","author":"AT Shaw","year":"2011","unstructured":"Shaw AT, Yasothan U, Kirkpatrick P. Crizotinib. Nat Rev Drug Discov. 2011;10:897\u20138.","journal-title":"Nat Rev Drug Discov"},{"key":"1347_CR23","doi-asserted-by":"crossref","first-page":"4408","DOI":"10.1158\/0008-5472.CAN-06-4443","volume":"67","author":"HY Zou","year":"2007","unstructured":"Zou HY, Li Q, Lee JH, Arango ME, McDonnell SR, Yamazaki S, et al. An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms. Cancer Res. 2007;67:4408\u201317.","journal-title":"Cancer Res"},{"key":"1347_CR24","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1111\/j.1476-5381.2012.01849.x","volume":"166","author":"WJ Zhou","year":"2012","unstructured":"Zhou WJ, Zhang X, Cheng C, Wang F, Wang XK, Liang YJ, et al. Crizotinib (PF-02341066) reverses multidrug resistance in cancer cells by inhibiting the function of P-glycoprotein. Br J Pharmacol. 2012;166:1669\u201383.","journal-title":"Br J Pharmacol"},{"key":"1347_CR25","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1517\/14728214.2013.777426","volume":"18","author":"F Casaluce","year":"2013","unstructured":"Casaluce F, Sgambato A, Maione P, Ciardiello F, Gridelli C. Emerging mitotic inhibitors for non-small cell carcinoma. Expert Opin Emerg Drugs. 2013;18:97\u2013107.","journal-title":"Expert Opin Emerg Drugs"},{"key":"1347_CR26","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s11010-006-9302-8","volume":"296","author":"P Limtrakul","year":"2007","unstructured":"Limtrakul P, Chearwae W, Shukla S, Phisalphong C, Ambudkar SV. Modulation of function of three ABC drug transporters, P-glycoprotein (ABCB1), mitoxantrone resistance protein (ABCG2) and multidrug resistance protein 1 (ABCC1) by tetrahydrocurcumin, a major metabolite of curcumin. Mol Cell Biochem. 2007;296:85\u201395.","journal-title":"Mol Cell Biochem"},{"key":"1347_CR27","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1016\/j.biomaterials.2004.06.024","volume":"26","author":"X Zhang","year":"2005","unstructured":"Zhang X, Li Y, Chen X, Wang X, Xu X, Liang Q, et al. Synthesis and characterization of the paclitaxel\/MPEG-PLA block copolymer conjugate. Biomaterials. 2005;26:2121\u20138.","journal-title":"Biomaterials"},{"key":"1347_CR28","doi-asserted-by":"crossref","first-page":"2778","DOI":"10.1021\/la0629025","volume":"23","author":"F Li","year":"2007","unstructured":"Li F, Li S, El Ghzaoui A, Nouailhas H, Zhuo R. Synthesis and gelation properties of PEG\u2013PLA\u2013PEG triblock copolymers obtained by coupling monohydroxylated PEG\u2013PLA with adipoyl chloride. Langmuir. 2007;23:2778\u201383.","journal-title":"Langmuir"},{"key":"1347_CR29","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.jconrel.2005.09.034","volume":"109","author":"G Gaucher","year":"2005","unstructured":"Gaucher G, Dufresne M-H, Sant VP, Kang N, Maysinger D, Leroux J-C. Block copolymer micelles: preparation, characterization and application in drug delivery. J Control Release. 2005;109:169\u201388.","journal-title":"J Control Release"},{"key":"1347_CR30","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1021\/bm301720g","volume":"14","author":"B Layekand","year":"2013","unstructured":"Layekand B, Singh J. Amino acid grafted chitosan for high performance gene delivery: comparison of amino acid hydrophobicity on vector and polyplex characteristics. Biomacromolecules. 2013;14:485\u201394.","journal-title":"Biomacromolecules"},{"key":"1347_CR31","doi-asserted-by":"crossref","first-page":"e15358","DOI":"10.1371\/journal.pone.0015358","volume":"5","author":"B Akg\u00fcl","year":"2010","unstructured":"Akg\u00fcl B, Lin K-W, Yang H-MO, Chen Y-H, Lu T-H, Chen C-H, et al. Garlic accelerates red blood cell turnover and splenic erythropoietic gene expression in mice: evidence for erythropoietin-independent erythropoiesis. PLoS One. 2010;5:e15358.","journal-title":"PLoS One"},{"key":"1347_CR32","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.forsciint.2008.03.018","volume":"178","author":"C Pistos","year":"2008","unstructured":"Pistos C, Papoutsis I, Dona A, Stefanidou M, Athanaselis S, Maravelias C, et al. Off-line HPLC method combined to LC-MS for the determination of sildenafil and its active metabolite in post-mortem human blood according to confirmation criteria. Forensic Sci Int. 2008;178:192\u20138.","journal-title":"Forensic Sci Int"},{"key":"1347_CR33","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.jconrel.2011.08.007","volume":"156","author":"VM Gaspar","year":"2011","unstructured":"Gaspar VM, Correia IJ, Sousa \u00c2, Silva F, Paquete CM, Queiroz JA, et al. Nanoparticle mediated delivery of pure P53 supercoiled plasmid DNA for gene therapy. J Control Release. 2011;156:212\u201322.","journal-title":"J Control Release"},{"key":"1347_CR34","doi-asserted-by":"crossref","first-page":"10269","DOI":"10.1158\/0008-5472.CAN-06-1500","volume":"66","author":"M Zakikhani","year":"2006","unstructured":"Zakikhani M, Dowling R, Fantus IG, Sonenberg N, Pollak M. Metformin is an AMP kinase\u2013dependent growth inhibitor for breast cancer cells. Cancer Res. 2006;66:10269\u201373.","journal-title":"Cancer Res"},{"key":"1347_CR35","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.nantod.2012.01.002","volume":"7","author":"SC Owen","year":"2012","unstructured":"Owen SC, Chan DP, Shoichet MS. Polymeric micelle stability. Nano Today. 2012;7:53\u201365.","journal-title":"Nano Today"},{"key":"1347_CR36","doi-asserted-by":"crossref","first-page":"8493","DOI":"10.1016\/j.biortech.2010.05.092","volume":"101","author":"K Madhavan Nampoothiri","year":"2010","unstructured":"Madhavan Nampoothiri K, Nair NR, John RP. An overview of the recent developments in polylactide (PLA) research. Bioresour Technol. 2010;101:8493\u2013501.","journal-title":"Bioresour Technol"},{"key":"1347_CR37","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.ijpharm.2006.10.020","volume":"334","author":"G He","year":"2007","unstructured":"He G, Ma LL, Pan J, Venkatraman S. ABA and BAB type triblock copolymers of PEG and PLA: a comparative study of drug release properties and \u201cstealth\u201d particle characteristics. Int J Pharm. 2007;334:48\u201355.","journal-title":"Int J Pharm"},{"key":"1347_CR38","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1517\/14656566.2012.688029","volume":"13","author":"PM Fordeand","year":"2012","unstructured":"Fordeand PM, Rudin CM. Crizotinib in the treatment of non-small-cell lung cancer. Expert Opin Pharmacother. 2012;13:1195\u2013201.","journal-title":"Expert Opin Pharmacother"},{"key":"1347_CR39","doi-asserted-by":"crossref","first-page":"504","DOI":"10.2174\/1389200211314040012","volume":"14","author":"MM Yallapu","year":"2013","unstructured":"Yallapu MM, Ebeling MC, Jaggi M, Chauhan SC. Plasma proteins interaction with curcumin nanoparticles: implications in cancer therapeutics. Curr Drug Metab. 2013;14:504\u201315.","journal-title":"Curr Drug Metab"},{"key":"1347_CR40","doi-asserted-by":"crossref","unstructured":"Pungkham H, Swatdipakdi N, Theerasilp M, Karnkla S, Chittchang M, Ploypradith P, et al. PEG-b-PCL and PEG-b-PLA polymeric micelles as nanocarrieres for lamellarin N delivery. Engineering in Medicine and Biology Society, EMBC, 2011 Annual International Conference of the IEEE2011. 2011;3245\u20138","DOI":"10.1109\/IEMBS.2011.6090882"},{"key":"1347_CR41","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.jconrel.2009.12.020","volume":"143","author":"C Zhan","year":"2010","unstructured":"Zhan C, Gu B, Xie C, Li J, Liu Y, Lu W. Cyclic RGD conjugated poly(ethylene glycol)-co-poly(lactic acid) micelle enhances paclitaxel anti-glioblastoma effect. J Control Release. 2010;143:136\u201342.","journal-title":"J Control Release"},{"key":"1347_CR42","doi-asserted-by":"crossref","first-page":"3735","DOI":"10.1158\/0008-5472.CAN-11-0375","volume":"71","author":"Z Shi","year":"2011","unstructured":"Shi Z, Tiwari AK, Patel AS, Fu L-W, Chen Z-S. Roles of sildenafil in enhancing drug sensitivity in cancer. Cancer Res. 2011;71:3735\u20138.","journal-title":"Cancer Res"},{"key":"1347_CR43","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.jconrel.2004.04.026","volume":"98","author":"A Vila","year":"2004","unstructured":"Vila A, Gill H, McCallion O, Alonso MJ. Transport of PLA-PEG particles across the nasal mucosa: effect of particle size and PEG coating density. J Control Release. 2004;98:231\u201344.","journal-title":"J Control Release"},{"key":"1347_CR44","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.ijpharm.2005.10.010","volume":"307","author":"DE Owens III","year":"2006","unstructured":"Owens III DE, Peppas NA. Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles. Int J Pharm. 2006;307:93\u2013102.","journal-title":"Int J Pharm"},{"key":"1347_CR45","doi-asserted-by":"crossref","first-page":"406","DOI":"10.3109\/02652048.2011.576784","volume":"28","author":"H Asadi","year":"2011","unstructured":"Asadi H, Rostamizadeh K, Salari D, Hamidi M. Preparation of biodegradable nanoparticles of tri-block PLA-PEG-PLA copolymer and determination of factors controlling the particle size using artificial neural network. J Microencapsul. 2011;28:406\u201316.","journal-title":"J Microencapsul"},{"key":"1347_CR46","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0939-6411(00)00143-0","volume":"51","author":"R Gref","year":"2001","unstructured":"Gref R, Quellec P, Sanchez A, Calvo P, Dellacherie E, Alonso MJ. Development and characterization of CyA-loaded poly(lactic acid)\u2013poly(ethylene glycol)PEG micro- and nanoparticles. Comparison with conventional PLA particulate carriers. Eur J Pharm Biopharm. 2001;51:111\u20138.","journal-title":"Eur J Pharm Biopharm"},{"key":"1347_CR47","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1093\/toxsci\/kfs006","volume":"126","author":"W-S Cho","year":"2012","unstructured":"Cho W-S, Duffin R, Thielbeer F, Bradley M, Megson IL, MacNee W, et al. Zeta potential and solubility to toxic ions as mechanisms of lung inflammation caused by metal\/metal oxide nanoparticles. Toxicol Sci. 2012;126:469\u201377.","journal-title":"Toxicol Sci"},{"key":"1347_CR48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev-bioeng-071811-150124","volume":"14","author":"A Albanese","year":"2012","unstructured":"Albanese A, Tang PS, Chan WC. The effect of nanoparticle size, shape, and surface chemistry on biological systems. Annu Rev Biomed Eng. 2012;14:1\u201316.","journal-title":"Annu Rev Biomed Eng"},{"key":"1347_CR49","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jconrel.2005.09.011","volume":"110","author":"P Jie","year":"2005","unstructured":"Jie P, Venkatraman SS, Min F, Freddy BYC, Huat GL. Micelle-like nanoparticles of star-branched PEO\u2013PLA copolymers as chemotherapeutic carrier. J Control Release. 2005;110:20\u201333.","journal-title":"J Control Release"},{"key":"1347_CR50","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jconrel.2009.05.037","volume":"139","author":"H Zhang","year":"2009","unstructured":"Zhang H, Xia H, Wang J, Li Y. High intensity focused ultrasound-responsive release behavior of PLA-b-PEG copolymer micelles. J Control Release. 2009;139:31\u20139.","journal-title":"J Control Release"},{"key":"1347_CR51","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.colsurfb.2011.10.003","volume":"99","author":"E Ayano","year":"2012","unstructured":"Ayano E, Karaki M, Ishihara T, Kanazawa H, Okano T. Poly (N-isopropylacrylamide)\u2013PLA and PLA blend nanoparticles for temperature-controllable drug release and intracellular uptake. Colloids Surf B: Biointerfaces. 2012;99:67\u201373.","journal-title":"Colloids Surf B: Biointerfaces"},{"key":"1347_CR52","doi-asserted-by":"crossref","first-page":"18202","DOI":"10.1073\/pnas.1006965107","volume":"107","author":"A Das","year":"2010","unstructured":"Das A, Durrant D, Mitchell C, Mayton E, Hoke NN, Salloum FN, et al. Sildenafil increases chemotherapeutic efficacy of doxorubicin in prostate cancer and ameliorates cardiac dysfunction. Proc Natl Acad Sci. 2010;107:18202\u20137.","journal-title":"Proc Natl Acad Sci"},{"key":"1347_CR53","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jconrel.2008.10.016","volume":"134","author":"K Hu","year":"2009","unstructured":"Hu K, Li J, Shen Y, Lu W, Gao X, Zhang Q, et al. Lactoferrin-conjugated PEG-PLA nanoparticles with improved brain delivery: in vitro and in vivo evaluations. J Control Release. 2009;134:55\u201361.","journal-title":"J Control Release"},{"key":"1347_CR54","doi-asserted-by":"crossref","first-page":"3507","DOI":"10.1242\/jcs.072900","volume":"123","author":"MQ Gao","year":"2010","unstructured":"Gao MQ, Kim BG, Kang S, Choi YP, Park H, Kang KS, et al. Stromal fibroblasts from the interface zone of human breast carcinomas induce an epithelial-mesenchymal transition-like state in breast cancer cells in vitro. J Cell Sci. 2010;123:3507\u201314.","journal-title":"J Cell Sci"},{"key":"1347_CR55","first-page":"1531","volume":"103","author":"JJ Chen","year":"2012","unstructured":"Chen JJ, Sun YL, Tiwari AK, Xiao ZJ, Sodani K, Yang DH, et al. PDE5 inhibitors, sildenafil and vardenafil, reverse multidrug resistance by inhibiting the efflux function of multidrug resistance protein 7 (ATP-binding Cassette C10) transporter. Cancer Res. 2012;103:1531\u20137.","journal-title":"Cancer Res"},{"key":"1347_CR56","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/sj.cgt.7700751","volume":"11","author":"A Stege","year":"2004","unstructured":"Stege A, Priebsch A, Nieth C, Lage H. Stable and complete overcoming of MDR1\/P-glycoprotein-mediated multidrug resistance in human gastric carcinoma cells by RNA interference. Cancer Gene Ther. 2004;11:699\u2013706.","journal-title":"Cancer Gene Ther"},{"key":"1347_CR57","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1200\/jco.2011.29.15_suppl.2501","volume":"29","author":"D Camidge","year":"2011","unstructured":"Camidge D, Bang Y, Kwak E, Shaw A, Iafrate A, Maki R, et al. Progression-free survival (PFS) from a phase I study of crizotinib (PF-02341066) in patients with ALK-positive non-small cell lung cancer (NSCLC). J Clin Oncol. 2011;29:2501.","journal-title":"J Clin Oncol"}],"container-title":["Pharmaceutical Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11095-014-1347-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11095-014-1347-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11095-014-1347-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T07:54:42Z","timestamp":1565250882000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11095-014-1347-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,13]]},"references-count":57,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["1347"],"URL":"https:\/\/doi.org\/10.1007\/s11095-014-1347-x","relation":{},"ISSN":["0724-8741","1573-904X"],"issn-type":[{"value":"0724-8741","type":"print"},{"value":"1573-904X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,13]]}}}