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Adventitious roots were induced from <jats:italic>in vitro<\/jats:italic>-grown plant leaves cultured on MS medium supplemented with 1\u00a0mg\/L IBA. Growth and secondary metabolites accumulation (phenolics, flavonoids, hydroxycinnamic acids) were monitored weekly to determine the optimal harvesting time. Then, the adventitious roots were elicited for 4\u00a0weeks with varying concentrations of yeast extract\u2013YE (50, 100 and 200\u00a0mg\/L) and extracted with ethanol. The extracts were evaluated for their hepatoprotective effects against ethanol-induced hepatotoxicity and analyzed through high-performance liquid chromatography coupled with electrospray ionization mass spectrometry (HPLC\u2013ESI\u2013MS\/MS). Roots of greenhouse-cultivated plants were used to compare the results obtained from <jats:italic>in vitro<\/jats:italic> -grown adventitious roots. IBA supplementation induced 100% adventitious root formation, with maximum biomass and phenolic accumulation after 4\u00a0weeks. Hydroxycinnamic acid levels increased significantly with YE treatment at all the concentrations, particularly in case of chlorogenic acid and di-O-caffeoylquinic acid isomers. The root extracts displayed significant <jats:italic>in vitro<\/jats:italic> hepatoprotective effects, particularly at 50\u00a0mg\/L YE elicitation. Overall, the elicitation of <jats:italic>I. crithmoides<\/jats:italic> liquid root cultures with yeast extract offers a promising, efficient, and cost-effective approach for optimizing the production of valuable caffeoylquinic acids having potential pharmaceutical use.<\/jats:p>","DOI":"10.1007\/s11240-024-02690-z","type":"journal-article","created":{"date-parts":[[2024,1,20]],"date-time":"2024-01-20T15:01:47Z","timestamp":1705762907000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Establishment and elicitation of liquid adventitious root cultures of Inula crithmoides L. for increased caffeoylquinic acids production and hepatoprotective properties"],"prefix":"10.1007","volume":"156","author":[{"given":"Lu\u00edsa","family":"Cust\u00f3dio","sequence":"first","affiliation":[]},{"given":"Zolt\u00e1n","family":"Czi\u00e1ky","sequence":"additional","affiliation":[]},{"given":"Viana","family":"Casta\u00f1eda-Loaiza","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8732-710X","authenticated-orcid":false,"given":"Maria Jo\u00e3o","family":"Rodrigues","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2024,1,20]]},"reference":[{"key":"2690_CR1","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1080\/13102818.2008.10817580","volume":"22","author":"M Aasim","year":"2008","unstructured":"Aasim M, Khawar KM, \u00d6zcan S (2008) In vitro regeneration of red squill Urginea maritima (L.) 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