{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T07:43:36Z","timestamp":1740123816455,"version":"3.37.3"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2015,11,9]],"date-time":"2015-11-09T00:00:00Z","timestamp":1447027200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia (PT)","doi-asserted-by":"publisher","award":["SFRH\/BD\/70316\/2010","SFRH\/BD\/66875\/2009"],"award-info":[{"award-number":["SFRH\/BD\/70316\/2010","SFRH\/BD\/66875\/2009"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Transgenic Res"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1007\/s11248-015-9918-0","type":"journal-article","created":{"date-parts":[[2015,11,9]],"date-time":"2015-11-09T12:22:40Z","timestamp":1447071760000},"page":"139-148","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Suppressed glycolytic metabolism in the prostate of transgenic rats overexpressing calcium-binding protein regucalcin underpins reduced cell proliferation"],"prefix":"10.1007","volume":"25","author":[{"given":"C\u00e1tia V.","family":"Vaz","sequence":"first","affiliation":[]},{"given":"Ricardo","family":"Marques","sequence":"additional","affiliation":[]},{"given":"Henrique J.","family":"Cardoso","sequence":"additional","affiliation":[]},{"given":"Cl\u00e1udio J.","family":"Maia","sequence":"additional","affiliation":[]},{"given":"S\u00edlvia","family":"Socorro","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2015,11,9]]},"reference":[{"key":"9918_CR1","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1080\/10715760701361531","volume":"41","author":"O Alqawi","year":"2007","unstructured":"Alqawi O, Wang HP, Espiritu M, Singh G (2007) Chronic hypoxia promotes an aggressive phenotype in rat prostate cancer cells. Free Radic Res 41:788\u2013797","journal-title":"Free Radic Res"},{"key":"9918_CR2","doi-asserted-by":"crossref","first-page":"C1560","DOI":"10.1152\/ajpcell.00506.2009","volume":"298","author":"M Chehtane","year":"2010","unstructured":"Chehtane M, Khaled AR (2010) Interleukin-7 mediates glucose utilization in lymphocytes through transcriptional regulation of the hexokinase II gene. Am J Physiol Cell Physiol 298:C1560\u2013C1571","journal-title":"Am J Physiol Cell Physiol"},{"key":"9918_CR3","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/9780470122822.ch2","volume":"37","author":"J Everse","year":"1973","unstructured":"Everse J, Kaplan NO (1973) Lactate dehydrogenases: structure and function. Adv Enzymol Relat Areas Mol Biol 37:61\u2013133","journal-title":"Adv Enzymol Relat Areas Mol Biol"},{"key":"9918_CR4","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s11306-006-0043-1","volume":"3","author":"CY Lin","year":"2007","unstructured":"Lin CY, Wu H, Tjeerdema RS, Viant MR (2007) Evaluation of metabolite extraction strategies from tissue samples using NMR metabolomics. Metabolomics 3:55\u201367","journal-title":"Metabolomics"},{"key":"9918_CR5","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1002\/jcb.22158","volume":"107","author":"C Maia","year":"2009","unstructured":"Maia C, Santos C, Schmitt F, Socorro S (2009) Regucalcin is under-expressed in human breast and prostate cancers: Effect of sex steroid hormones. J Cell Biochem 107:667\u2013676","journal-title":"J Cell Biochem"},{"key":"9918_CR6","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s00018-013-1323-3","volume":"71","author":"R Marques","year":"2014","unstructured":"Marques R, Maia CJ, Vaz CV, Correia S, Socorro S (2014a) The diverse roles of calcium-binding protein regucalcin in cell biology: from tissue expression and signalling to disease. Cell Mol Life Sci 71:93\u2013111","journal-title":"Cell Mol Life Sci"},{"key":"9918_CR7","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.yexcr.2014.08.007","volume":"330","author":"R Marques","year":"2014","unstructured":"Marques R, Vaz CV, Maia CJ, Gomes M, Gama A, Alves G, Santos CR, Schmitt F, Socorro S (2014b) Histopathological and in vivo evidence of regucalcin as a protective molecule in mammary gland carcinogenesis. Exp Cell Res 330:325\u2013335","journal-title":"Exp Cell Res"},{"key":"9918_CR8","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1038\/emboj.2011.158","volume":"30","author":"CE Massie","year":"2011","unstructured":"Massie CE, Lynch A, Ramos-Montoya A, Boren J, Stark R, Fazli L, Warren A, Scott H, Madhu B, Sharma N, Bon H, Zecchini V, Smith DM, Denicola GM, Mathews N, Osborne M, Hadfield J, Macarthur S, Adryan B, Lyons SK, Brindle KM, Griffiths J, Gleave ME, Rennie PS, Neal DE, Mills IG (2011) The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis. EMBO J 30:2719\u20132733","journal-title":"EMBO J"},{"key":"9918_CR9","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1111\/j.1742-4658.2007.05686.x","volume":"274","author":"R Moreno-S\u00e1nchez","year":"2007","unstructured":"Moreno-S\u00e1nchez R, Rodr\u00edguez-Enr\u00edquez S, Mar\u00edn-Hern\u00e1ndez A, Saavedra E (2007) Energy metabolism in tumor cells. FEBS J 274:1393\u20131418","journal-title":"FEBS J"},{"key":"9918_CR10","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1023\/A:1006844815743","volume":"175","author":"T Murata","year":"1997","unstructured":"Murata T, Shinya N, Yamaguchi M (1997) Expression of calcium-binding protein regucalcin mRNA in the cloned human hepatoma cells (HegG2): stimulation by insulin. Mol Cell Biochem 175:163\u2013168","journal-title":"Mol Cell Biochem"},{"key":"9918_CR11","first-page":"637","volume":"16","author":"T Nakagawa","year":"2005","unstructured":"Nakagawa T, Sawada N, Yamaguchi M (2005) Overexpression of regucalcin suppresses cell proliferation of cloned normal rat kidney proximal tubular epithelial NRK52E cells. Int J Mol Med 16:637\u2013643","journal-title":"Int J Mol Med"},{"key":"9918_CR12","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1002\/jcb.21005","volume":"99","author":"C Nakashima","year":"2006","unstructured":"Nakashima C, Yamaguchi M (2006) Overexpression of regucalcin enhances glucose utilization and lipid production in cloned rat hepatoma H4-II-E cells: involvement of insulin resistance. J Cell Biochem 99:1582\u20131592","journal-title":"J Cell Biochem"},{"key":"9918_CR13","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/jdi.12252","volume":"6","author":"H Okada","year":"2015","unstructured":"Okada H, Senmaru T, Fukui M, Kondo Y, Ishigami A, Maruyama N, Obayashi H, Yamazaki M, Nakamura N, Hasegawa G (2015) Senescence marker protein-30\/gluconolactonase deficiency exacerbates diabetic nephropathy through tubular injury in a mouse model of type 1 diabetes. J Diabetes Investig 6:35\u201343","journal-title":"J Diabetes Investig"},{"key":"9918_CR14","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1093\/nar\/29.9.e45","volume":"29","author":"M Pfaffl","year":"2001","unstructured":"Pfaffl M (2001) A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 29:e45","journal-title":"Nucleic Acids Res"},{"key":"9918_CR15","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/414799a","volume":"414","author":"AR Saltiel","year":"2001","unstructured":"Saltiel AR, Kahn CR (2001) Insulin signalling and the regulation of glucose and lipid metabolism. Nature 414:799\u2013806","journal-title":"Nature"},{"key":"9918_CR16","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1471-2490-5-6","volume":"5","author":"JB Schnier","year":"2005","unstructured":"Schnier JB, Nishi K, Gumerlock PH, Gorin FA, Bradbury EM (2005) Glycogen synthesis correlates with androgen-dependent growth arrest in prostate cancer. BMC Urol 5:6","journal-title":"BMC Urol"},{"key":"9918_CR17","doi-asserted-by":"crossref","first-page":"E242","DOI":"10.1152\/ajpendo.90388.2008","volume":"295","author":"IA Simpson","year":"2008","unstructured":"Simpson IA, Dwyer D, Malide D, Moley KH, Travis A, Vannucci SJ (2008) The facilitative glucose transporter GLUT3: 20\u00a0years of distinction. Am J Physiol Endocrinol Metab 295:E242\u2013E253","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"9918_CR18","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1016\/j.biocel.2012.08.013","volume":"44","author":"CV Vaz","year":"2012","unstructured":"Vaz CV, Alves MG, Marques R, Moreira PI, Oliveira PF, Maia CJ, Socorro S (2012) Androgen-responsive and nonresponsive prostate cancer cells present a distinct glycolytic metabolism profile. Int J Biochem Cell Biol 44:2077\u20132084","journal-title":"Int J Biochem Cell Biol"},{"key":"9918_CR19","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1002\/pros.22835","volume":"74","author":"CV Vaz","year":"2014","unstructured":"Vaz CV, Maia CJ, Marques R, Gomes IM, Correia S, Alves MG, Cavaco JE, Oliveira PF, Socorro S (2014) Regucalcin is an androgen-target gene in the rat prostate modulating cell-cycle and apoptotic pathways. Prostate 74:1189\u20131198","journal-title":"Prostate"},{"key":"9918_CR20","doi-asserted-by":"crossref","unstructured":"Vaz CV, Marques R, Alves MG, Oliveira PF, Cavaco JE, Maia CJ, Socorro S (2015) Androgens enhance the glycolytic metabolism and lactate export in prostate cancer cells by modulating the expression of GLUT1, GLUT3, PFK, LDH and MCT4 genes. J Cancer Res Clin Oncol. doi: 10.1007\/s00432-015-1992-4","DOI":"10.1007\/s00432-015-1992-4"},{"key":"9918_CR21","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1023\/A:1021831621210","volume":"4","author":"JI Wolfsdorf","year":"2003","unstructured":"Wolfsdorf JI, Weinstein DA (2003) Glycogen storage diseases. Rev Endocr Metab Disord 4:95\u2013102","journal-title":"Rev Endocr Metab Disord"},{"key":"9918_CR22","first-page":"371","volume":"15","author":"M Yamaguchi","year":"2005","unstructured":"Yamaguchi M (2005) Role of regucalcin in maintaining cell homeostasis and function (review). Int J Mol Med 15:371\u2013389","journal-title":"Int J Mol Med"},{"key":"9918_CR23","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s11010-010-0443-4","volume":"341","author":"M Yamaguchi","year":"2010","unstructured":"Yamaguchi M (2010) Regucalcin and metabolic disorders: osteoporosis and hyperlipidemia are induced in regucalcin transgenic rats. Mol Cell Biochem 341:119\u2013133","journal-title":"Mol Cell Biochem"},{"key":"9918_CR24","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1007\/s10495-013-0859-x","volume":"18","author":"M Yamaguchi","year":"2013","unstructured":"Yamaguchi M (2013) The anti-apoptotic effect of regucalcin is mediated through multisignaling pathways. Apoptosis 18:1145\u20131153","journal-title":"Apoptosis"},{"key":"9918_CR25","first-page":"1333","volume":"8","author":"M Yamaguchi","year":"2014","unstructured":"Yamaguchi M (2014) Involvement of regucalcin as a suppressor protein in human carcinogenesis: insight into the gene therapy. J Cancer Res Clin Oncol 8:1333\u20131341","journal-title":"J Cancer Res Clin Oncol"},{"key":"9918_CR26","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.metabol.2013.01.023","volume":"62","author":"M Yamaguchi","year":"2013","unstructured":"Yamaguchi M, Murata T (2013) Involvement of regucalcin in lipid metabolism and diabetes. Metabolism 62:1045\u20131051","journal-title":"Metabolism"},{"key":"9918_CR27","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.3892\/ijmm.2015.2164","volume":"35","author":"M Yamaguchi","year":"2015","unstructured":"Yamaguchi M, Murata T (2015) Suppressive effects of exogenous regucalcin on the proliferation of human pancreatic cancer MIA PaCa-2 cells in vitro. Int J Mol Med 35:1773\u20131778","journal-title":"Int J Mol Med"},{"key":"9918_CR28","first-page":"323","volume":"20","author":"M Yamaguchi","year":"2007","unstructured":"Yamaguchi M, Nakagawa T (2007) Change in lipid components in the adipose and liver tissues of regucalcin transgenic rats with increasing age: suppression of leptin and adiponectin gene expression. Int J Mol Med 20:323","journal-title":"Int J Mol Med"},{"key":"9918_CR29","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1248\/cpb.35.2025","volume":"35","author":"M Yamaguchi","year":"1987","unstructured":"Yamaguchi M, Shibano H (1987) Calcium-binding protein isolated from rat liver cytosol reverses activation of pyruvate kinase by Ca2+. Chem Pharm Bull (Tokyo) 35:2025\u20132029","journal-title":"Chem Pharm Bull (Tokyo)"},{"key":"9918_CR30","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1002\/jcb.20335","volume":"94","author":"M Yamaguchi","year":"2005","unstructured":"Yamaguchi M, Uchiyama S (2005) Regucalcin stimulates osteoclast-like cell formation in mouse marrow cultures. J Cell Biochem 94:794\u2013803","journal-title":"J Cell Biochem"},{"key":"9918_CR31","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1248\/cpb.26.1915","volume":"26","author":"M Yamaguchi","year":"1978","unstructured":"Yamaguchi M, Yamamoto T (1978) Purification of calcium binding substance from soluble fraction of normal rat liver. Chem Pharm Bull (Tokyo) 26:1915\u20131918","journal-title":"Chem Pharm Bull (Tokyo)"},{"key":"9918_CR32","doi-asserted-by":"crossref","first-page":"4489","DOI":"10.1248\/cpb.33.4489","volume":"33","author":"M Yamaguchi","year":"1985","unstructured":"Yamaguchi M, Yoshida H (1985) Regulatory effect of calcium-binding protein isolated from rat liver cytosol on activation of fructose 1,6-diphosphatase by Ca2+-calmodulin. Chem Pharm Bull (Tokyo) 33:4489\u20134493","journal-title":"Chem Pharm Bull (Tokyo)"},{"key":"9918_CR33","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1248\/cpb.37.388","volume":"37","author":"M Yamaguchi","year":"1989","unstructured":"Yamaguchi M, Mori S, Suketa Y (1989) Effects of Ca2+ and V5+ on glucose-6-phosphatase activity in rat liver microsomes: the Ca2+ effect is reversed by regucalcin. Chem Pharm Bull (Tokyo) 37:388\u2013390","journal-title":"Chem Pharm Bull (Tokyo)"},{"key":"9918_CR34","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1002\/jcb.10249","volume":"86","author":"M Yamaguchi","year":"2002","unstructured":"Yamaguchi M, Morooka Y, Misawa H, Tsurusaki Y, Nakajima R (2002) Role of endogenous regucalcin in transgenic rats: suppression of kidney cortex cytosolic protein phosphatase activity and enhancement of heart muscle microsomal Ca2+ ATPase activity. J Cell Biochem 86:520\u2013529","journal-title":"J Cell Biochem"},{"key":"9918_CR35","first-page":"647","volume":"14","author":"M Yamaguchi","year":"2004","unstructured":"Yamaguchi M, Igarashi A, Uchiyama S, Sawada N (2004) Hyperlipidemia is induced in regucalcin transgenic rats with increasing age. Int J Mol Med 14:647","journal-title":"Int J Mol Med"}],"container-title":["Transgenic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11248-015-9918-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11248-015-9918-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11248-015-9918-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T09:36:42Z","timestamp":1718185002000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11248-015-9918-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,9]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["9918"],"URL":"https:\/\/doi.org\/10.1007\/s11248-015-9918-0","relation":{},"ISSN":["0962-8819","1573-9368"],"issn-type":[{"type":"print","value":"0962-8819"},{"type":"electronic","value":"1573-9368"}],"subject":[],"published":{"date-parts":[[2015,11,9]]}}}