{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T14:13:18Z","timestamp":1776867198722,"version":"3.51.2"},"reference-count":70,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2016,9,20]],"date-time":"2016-09-20T00:00:00Z","timestamp":1474329600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PIC\/IC\/83297\/2007"],"award-info":[{"award-number":["PIC\/IC\/83297\/2007"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["Pest-OE\/SAU\/UI215\/2014"],"award-info":[{"award-number":["Pest-OE\/SAU\/UI215\/2014"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BD\/79259\/2011"],"award-info":[{"award-number":["SFRH\/BD\/79259\/2011"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["CONT_DOUT\/117\/ICBAS-UP\/215\/10824\/2\/2008"],"award-info":[{"award-number":["CONT_DOUT\/117\/ICBAS-UP\/215\/10824\/2\/2008"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP 93683"],"award-info":[{"award-number":["MOP 93683"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP 102472"],"award-info":[{"award-number":["MOP 102472"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Purinergic Signalling"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1007\/s11302-016-9535-2","type":"journal-article","created":{"date-parts":[[2016,9,20]],"date-time":"2016-09-20T04:07:02Z","timestamp":1474344422000},"page":"719-734","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Adenosine A2A receptor and ecto-5\u2032-nucleotidase\/CD73 are upregulated in hippocampal astrocytes of human patients with mesial temporal lobe epilepsy (MTLE)"],"prefix":"10.1007","volume":"12","author":[{"given":"Aurora R.","family":"Barros-Barbosa","sequence":"first","affiliation":[]},{"given":"F\u00e1tima","family":"Ferreirinha","sequence":"additional","affiliation":[]},{"given":"\u00c2ngela","family":"Oliveira","sequence":"additional","affiliation":[]},{"given":"Marina","family":"Mendes","sequence":"additional","affiliation":[]},{"given":"M. Gra\u00e7a","family":"Lobo","sequence":"additional","affiliation":[]},{"given":"Agostinho","family":"Santos","sequence":"additional","affiliation":[]},{"given":"Rui","family":"Rangel","sequence":"additional","affiliation":[]},{"given":"Julie","family":"Pelletier","sequence":"additional","affiliation":[]},{"given":"Jean","family":"S\u00e9vigny","sequence":"additional","affiliation":[]},{"given":"J. Miguel","family":"Cordeiro","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6114-9189","authenticated-orcid":false,"given":"Paulo","family":"Correia-de-S\u00e1","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2016,9,20]]},"reference":[{"key":"9535_CR1","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/s1474-4422(10)70310-0","volume":"10","author":"A Pitk\u00e4nen","year":"2011","unstructured":"Pitk\u00e4nen A, Lukasiuk K (2011) Mechanisms of epileptogenesis and potential treatment targets. Lancet Neurol 10:173\u2013186. doi: 10.1016\/s1474-4422(10)70310-0","journal-title":"Lancet Neurol"},{"key":"9535_CR2","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1002\/jnr.22829","volume":"90","author":"CM O\u2019Dell","year":"2012","unstructured":"O\u2019Dell CM, Das A, Wallace G, Ray SK, Banik NL (2012) Understanding the basic mechanisms underlying seizures in mesial temporal lobe epilepsy and possible therapeutic targets: a review. J Neurosci Res 90:913\u2013924. doi: 10.1002\/jnr.22829","journal-title":"J Neurosci Res"},{"key":"9535_CR3","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1111\/j.1528-1167.2005.43804.x","volume":"46","author":"F Bartolomei","year":"2005","unstructured":"Bartolomei F, Khalil M, Wendling F, Sontheimer A, R\u00e9gis J, Ranjeva JP, Guye M, Chauvel P (2005) Entorhinal cortex involvement in human mesial temporal lobe epilepsy: an electrophysiologic and volumetric study. Epilepsia 46:677\u2013687. doi: 10.1111\/j.1528-1167.2005.43804.x","journal-title":"Epilepsia"},{"key":"9535_CR4","doi-asserted-by":"publisher","unstructured":"Biagini G, D\u2019Antuono M, Benini R, de Guzman P, Longo D, Avoli M (2013) Perirhinal cortex and temporal lobe epilepsy. Front Cell Neurosci 7. doi: 10.3389\/fncel.2013.00130","DOI":"10.3389\/fncel.2013.00130"},{"key":"9535_CR5","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1212\/WNL.51.5.1256","volume":"51","author":"F Semah","year":"1998","unstructured":"Semah F, Picot MC, Adam C, Broglin D, Arzimanoglou A, Bazin B, Cavalcanti D, Baulac M (1998) Is the underlying cause of epilepsy a major prognostic factor for recurrence? Neurology 51:1256\u20131262. doi: 10.1212\/WNL.51.5.1256","journal-title":"Neurology"},{"key":"9535_CR6","doi-asserted-by":"publisher","first-page":"3853","DOI":"10.1113\/jphysiol.2013.253450","volume":"591","author":"MJ Wall","year":"2013","unstructured":"Wall MJ, Dale N (2013) Neuronal transporter and astrocytic ATP exocytosis underlie activity-dependent adenosine release in the hippocampus. J Physiol 591:3853\u20133871. doi: 10.1113\/jphysiol.2013.253450","journal-title":"J Physiol"},{"key":"9535_CR7","doi-asserted-by":"publisher","first-page":"e87481","DOI":"10.1371\/journal.pone.0087481","volume":"9","author":"RE Sims","year":"2014","unstructured":"Sims RE, Dale N (2014) Activity-dependent adenosine release may be linked to activation of Na+-K+ ATPase: an in vitro rat study. PLoS One 9:e87481. doi: 10.1371\/journal.pone.0087481","journal-title":"PLoS One"},{"key":"9535_CR8","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1111\/j.1476-5381.2012.01932.x","volume":"167","author":"A Heinrich","year":"2012","unstructured":"Heinrich A, And\u00f3 RD, T\u00fari G, R\u00f3zsa B, Sperl\u00e1gh B (2012) K+ depolarization evokes ATP, adenosine and glutamate release from glia in rat hippocampus: a microelectrode biosensor study. Br J Pharmacol 167:1003\u20131020. doi: 10.1111\/j.1476-5381.2012.01932.x","journal-title":"Br J Pharmacol"},{"key":"9535_CR9","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.coph.2007.09.002","volume":"8","author":"D Boison","year":"2008","unstructured":"Boison D (2008) Adenosine as a neuromodulator in neurological diseases. Curr Opin Pharmacol 8:2\u20137. doi: 10.1016\/j.coph.2007.09.002","journal-title":"Curr Opin Pharmacol"},{"key":"9535_CR10","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1111\/jnc.12050","volume":"123","author":"JS Valadas","year":"2012","unstructured":"Valadas JS, Batalha VL, Ferreira DG, Gomes R, Coelho JE, Sebasti\u00e3o AM, Di\u00f3genes MJ, Lopes LV (2012) Neuroprotection afforded by adenosine A2A receptor blockade is modulated by corticotrophin-releasing factor (CRF) in glutamate injured cortical neurons. J Neurochem 123:1030\u20131040. doi: 10.1111\/jnc.12050","journal-title":"J Neurochem"},{"key":"9535_CR11","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.1159\/000343328","volume":"30","author":"T Kanno","year":"2012","unstructured":"Kanno T, Nishizaki T (2012) A2a adenosine receptor mediates PKA-dependent glutamate release from synaptic-like vesicles and Ca2+ efflux from an IP3 - and ryanodine-insensitive intracellular calcium store in astrocytes. Cell Physiol Biochem 30:1398\u20131412. doi: 10.1159\/000343328","journal-title":"Cell Physiol Biochem"},{"key":"9535_CR12","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1002\/glia.22290","volume":"60","author":"M Matos","year":"2012","unstructured":"Matos M, Augusto E, Santos-Rodrigues AD, Schwarzschild MA, Chen JF, Cunha RA, Agostinho P (2012) Adenosine A2A receptors modulate glutamate uptake in cultured astrocytes and gliosomes. Glia 60:702\u2013716. doi: 10.1002\/glia.22290","journal-title":"Glia"},{"key":"9535_CR13","doi-asserted-by":"publisher","first-page":"18492","DOI":"10.1523\/JNEUROSCI.1828-13.2013","volume":"33","author":"M Matos","year":"2013","unstructured":"Matos M, Augusto E, Agostinho P, Cunha RA, Chen JF (2013) Antagonistic interaction between adenosine A2A receptors and Na+\/K+-ATPase-a2 controlling glutamate uptake in astrocytes. J Neurosci 33:18492\u201318502. doi: 10.1523\/JNEUROSCI.1828-13.2013","journal-title":"J Neurosci"},{"key":"9535_CR14","doi-asserted-by":"publisher","first-page":"40464","DOI":"10.1074\/jbc.M111.232009","volume":"286","author":"SH Vaz","year":"2011","unstructured":"Vaz SH, Jorgensen TN, Crist\u00f3v\u00e3o-Ferreira S, Duflot S, Ribeiro JA, Gether U, Sebasti\u00e3o AM (2011) Brain-derived neurotrophic factor (BDNF) enhances GABA transport by modulating the trafficking of GABA transporter-1 (GAT-1) from the plasma membrane of rat cortical astrocytes. J Biol Chem 286:40464\u201340476. doi: 10.1074\/jbc.M111.232009","journal-title":"J Biol Chem"},{"key":"9535_CR15","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/S0306-4522(02)00080-5","volume":"112","author":"LV Lopes","year":"2002","unstructured":"Lopes LV, Cunha RA, Kull B, Fredholm BB, Ribeiro JA (2002) Adenosine A2A receptor facilitation of hippocampal synaptic transmission is dependent on tonic A1 receptor inhibition. Neuroscience 112:319\u2013329. doi: 10.1016\/S0306-4522(02)00080-5","journal-title":"Neuroscience"},{"key":"9535_CR16","doi-asserted-by":"publisher","first-page":"2080","DOI":"10.1523\/JNEUROSCI.3574-05.2006","volume":"26","author":"F Ciruela","year":"2006","unstructured":"Ciruela F, Casad\u00f3 V, Rodrigues RJ, Luj\u00e1n R, Burgue\u00f1o J, Canals M, Borycz J, Rebola N, Goldberg SR, Mallol J, Cort\u00e9s A, Canela E, L\u00f3pez-Gim\u00e9nez JF, Milligan G, Lluis C, Cunha RA, Ferr\u00e9 S, Franco R (2006) Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1-A2A receptor heteromers. J Neurosci 26:2080\u20132087. doi: 10.1523\/JNEUROSCI.3574-05.2006","journal-title":"J Neurosci"},{"key":"9535_CR17","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.neuropharm.2008.04.007","volume":"55","author":"M El Yacoubi","year":"2008","unstructured":"El Yacoubi M, Ledent C, Parmentier M, Costentin J, Vaugeois JM (2008) Evidence for the involvement of the adenosine A2A receptor in the lowered susceptibility to pentylenetetrazol-induced seizures produced in mice by long-term treatment with caffeine. Neuropharmacology 55:35\u201340. doi: 10.1016\/j.neuropharm.2008.04.007","journal-title":"Neuropharmacology"},{"key":"9535_CR18","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1007\/s00210-009-0426-8","volume":"380","author":"M El Yacoubi","year":"2009","unstructured":"El Yacoubi M, Ledent C, Parmentier M, Costentin J, Vaugeois JM (2009) Adenosine A2A receptor deficient mice are partially resistant to limbic seizures. Naunyn Schmiedeberg's Arch Pharmacol 380:223\u2013232. doi: 10.1007\/s00210-009-0426-8","journal-title":"Naunyn Schmiedeberg's Arch Pharmacol"},{"key":"9535_CR19","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1038\/nn.3930","volume":"18","author":"AG Orr","year":"2015","unstructured":"Orr AG, Hsiao EC, Wang MM, Ho K, Kim DH, Wang X, Guo W, Kang J, Yu G, Adame A, Devidze N, Dubal DB, Masliah E, Conklin BR, Mucke L (2015) Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory. Nat Neurosci 18:423\u2013434. doi: 10.1038\/nn.3930","journal-title":"Nat Neurosci"},{"key":"9535_CR20","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1007\/s12035-013-8480-0","volume":"48","author":"K Huicong","year":"2013","unstructured":"Huicong K, Zheng X, Furong W, Zhouping T, Feng X, Qi H, Xiaoyan L, Xiaojiang H, Na Z, Ke X, Zheng Z, Suiqiang Z (2013) The imbalanced expression of adenosine receptors in an epilepsy model corrected using targeted mesenchymal stem cell transplantation. Mol Neurobiol 48:921\u2013930. doi: 10.1007\/s12035-013-8480-0","journal-title":"Mol Neurobiol"},{"key":"9535_CR21","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1007\/s11596-012-0046-2","volume":"32","author":"X Li","year":"2012","unstructured":"Li X, Kang H, Liu X, Liu Z, Shu K, Chen X, Zhu S (2012) Effect of adenosine A2A receptor antagonist ZM241385 on amygdala-kindled seizures and progression of amygdala kindling. J Huazhong Univ Sci Technolog Med Sci 32:257\u2013264. doi: 10.1007\/s11596-012-0046-2","journal-title":"J Huazhong Univ Sci Technolog Med Sci"},{"key":"9535_CR22","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.yebeh.2011.07.004","volume":"22","author":"FE Rosim","year":"2011","unstructured":"Rosim FE, Persike DS, Nehlig A, Amorim RP, de Oliveira DM, Fernandes MJ (2011) Differential neuroprotection by A1 receptor activation and A2A receptor inhibition following pilocarpine-induced status epilepticus. Epilepsy Behav 22:207\u2013213. doi: 10.1016\/j.yebeh.2011.07.004","journal-title":"Epilepsy Behav"},{"key":"9535_CR23","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.phrs.2007.04.011","volume":"56","author":"N Hosseinmardi","year":"2007","unstructured":"Hosseinmardi N, Mirnajafi-Zadeh J, Fathollahi Y, Shahabi P (2007) The role of adenosine A1 and A2A receptors of entorhinal cortex on piriform cortex kindled seizures in rats. Pharmacol Res 56:110\u2013117. doi: 10.1016\/j.phrs.2007.04.011","journal-title":"Pharmacol Res"},{"key":"9535_CR24","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.seizure.2010.11.012","volume":"20","author":"M Fukuda","year":"2011","unstructured":"Fukuda M, Suzuki Y, Hino H, Morimoto T, Ishii E (2011) Activation of central adenosine A2A receptors lowers the seizure threshold of hyperthermia-induced seizure in childhood rats. Seizure 20:156\u2013159. doi: 10.1016\/j.seizure.2010.11.012","journal-title":"Seizure"},{"key":"9535_CR25","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.pneurobio.2007.09.002","volume":"83","author":"JF Chen","year":"2007","unstructured":"Chen JF, Sonsalla PK, Pedata F, Melani A, Domenici MR, Popoli P, Geiger J, Lopes LV, de Mendon\u00e7a A (2007) Adenosine A2A receptors and brain injury: broad spectrum of neuroprotection, multifaceted actions and \"fine tuning\" modulation. Prog Neurobiol 83:310\u2013331. doi: 10.1016\/j.pneurobio.2007.09.002","journal-title":"Prog Neurobiol"},{"key":"9535_CR26","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1002\/hipo.22392","volume":"25","author":"DM Rombo","year":"2015","unstructured":"Rombo DM, Newton K, Nissen W, Badurek S, Horn JM, Minichiello L, Jefferys JG, Sebastiao AM, Lamsa KP (2015) Synaptic mechanisms of adenosine A2A receptor-mediated hyperexcitability in the hippocampus. Hippocampus 25:566\u2013580. doi: 10.1002\/hipo.22392","journal-title":"Hippocampus"},{"key":"9535_CR27","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.neuroscience.2005.01.054","volume":"133","author":"N Rebola","year":"2005","unstructured":"Rebola N, Rodrigues RJ, Lopes LV, Richardson PJ, Oliveira CR, Cunha RA (2005) Adenosine A1 and A2A receptors are co-expressed in pyramidal neurons and co-localized in glutamatergic nerve terminals of the rat hippocampus. Neuroscience 133:79\u201383. doi: 10.1016\/j.neuroscience.2005.01.054","journal-title":"Neuroscience"},{"key":"9535_CR28","doi-asserted-by":"publisher","first-page":"148","DOI":"10.3389\/fnins.2015.00148","volume":"9","author":"RJ Rodrigues","year":"2015","unstructured":"Rodrigues RJ, Tom\u00e9 AR, Cunha RA (2015) ATP as a multi-target danger signal in the brain. Front Neurosci 9:148. doi: 10.3389\/fnins.2015.00148","journal-title":"Front Neurosci"},{"key":"9535_CR29","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1016\/j.cell.2011.07.022","volume":"146","author":"A Panatier","year":"2011","unstructured":"Panatier A, Vall\u00e9e J, Haber M, Murai KK, Lacaille JC, Robitaille R (2011) Astrocytes are endogenous regulators of basal transmission at central synapses. Cell 146:785\u2013798. doi: 10.1016\/j.cell.2011.07.022","journal-title":"Cell"},{"key":"9535_CR30","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1007\/s11302-013-9364-5","volume":"9","author":"S Crist\u00f3v\u00e3o-Ferreira","year":"2013","unstructured":"Crist\u00f3v\u00e3o-Ferreira S, Navarro G, Brugarolas M, P\u00e9rez-Capote K, Vaz SH, Fattorini G, Conti F, Lluis C, Ribeiro JA, McCormick PJ, Casad\u00f3 V, Franco R, Sebasti\u00e3o AM (2013) A1R-A2AR heteromers coupled to Gs and Gi\/0 proteins modulate GABA transport into astrocytes. Purinergic Signal 9:433\u2013449. doi: 10.1007\/s11302-013-9364-5","journal-title":"Purinergic Signal"},{"key":"9535_CR31","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1111\/j.1476-5381.1996.tb15979.x","volume":"119","author":"RA Cunha","year":"1996","unstructured":"Cunha RA, Correia-de-S\u00e1 P, Sebasti\u00e3o AM, Ribeiro JA (1996) Preferential activation of excitatory adenosine receptors at rat hippocampal and neuromuscular synapses by adenosine formed from released adenino nucleotides. Br J Pharmacol 119:253\u2013260. doi: 10.1111\/j.1476-5381.1996.tb15979.x","journal-title":"Br J Pharmacol"},{"key":"9535_CR32","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1111\/epi.13044","volume":"56","author":"ML Diamond","year":"2015","unstructured":"Diamond ML, Ritter AC, Jackson EK, Conley YP, Kochanek PM, Boison D, Wagner AK (2015) Genetic variation in the adenosine regulatory cycle is associated with posttraumatic epilepsy development. Epilepsia 56:1198\u20131206. doi: 10.1111\/epi.13044","journal-title":"Epilepsia"},{"key":"9535_CR33","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1111\/epi.13263","volume":"57","author":"AR Barros-Barbosa","year":"2016","unstructured":"Barros-Barbosa AR, Fonseca AL, Guerra-Gomes S, Ferreirinha F, Santos A, Rangel R, Lobo MG, Correia-de-Sa P, Cordeiro JM (2016) Up-regulation of P2X7 receptor-mediated inhibition of GABA uptake by nerve terminals of the human epileptic neocortex. Epilepsia 57:99\u2013110. doi: 10.1111\/epi.13263","journal-title":"Epilepsia"},{"key":"9535_CR34","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1111\/j.1471-4159.2009.06169.x","volume":"110","author":"V Bancila","year":"2009","unstructured":"Bancila V, Cordeiro JM, Bloc A, Dunant Y (2009) Nicotine-induced and depolarisation-induced glutamate release from hippocampus mossy fibre synaptosomes: two distinct mechanisms. J Neurochem 110:570\u2013580. doi: 10.1111\/j.1471-4159.2009.06169.x","journal-title":"J Neurochem"},{"key":"9535_CR35","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.neuroscience.2015.08.026","volume":"306","author":"AR Barros-Barbosa","year":"2015","unstructured":"Barros-Barbosa AR, Lobo MG, Ferreirinha F, Correia-de-S\u00e1 P, Cordeiro JM (2015) P2X7 receptor activation downmodulates Na+-dependent high-affinity GABA and glutamate transport into rat brain cortex synaptosomes. Neuroscience 306:74\u201390. doi: 10.1016\/j.neuroscience.2015.08.026","journal-title":"Neuroscience"},{"key":"9535_CR36","doi-asserted-by":"publisher","first-page":"C723","DOI":"10.1152\/ajpcell.00462.2010","volume":"300","author":"KW Dunn","year":"2011","unstructured":"Dunn KW, Kamocka MM, McDonald JH (2011) A practical guide to evaluating colocalization in biological microscopy. Am J Physiol Cell Physiol 300:C723\u2013C742. doi: 10.1152\/ajpcell.00462.2010","journal-title":"Am J Physiol Cell Physiol"},{"key":"9535_CR37","doi-asserted-by":"publisher","first-page":"e57065","DOI":"10.1371\/journal.pone.0057065","volume":"8","author":"M Cui","year":"2013","unstructured":"Cui M, Bai X, Li T, Chen F, Dong Q, Zhao Y, Liu X (2013) Decreased extracellular adenosine levels lead to loss of hypoxia-induced neuroprotection after repeated episodes of exposure to hypoxia. PLoS One 8:e57065. doi: 10.1371\/journal.pone.0057065","journal-title":"PLoS One"},{"key":"9535_CR38","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/S0026-895X(25)10955-3","volume":"39","author":"C Nanoff","year":"1991","unstructured":"Nanoff C, Jacobson KA, Stiles GL (1991) The A2 adenosine receptor: guanine nucleotide modulation of agonist binding is enhanced by proteolysis. Mol Pharmacol 39:130\u2013135","journal-title":"Mol Pharmacol"},{"key":"9535_CR39","doi-asserted-by":"publisher","first-page":"C254","DOI":"10.1152\/ajpcell.00025.2006","volume":"291","author":"W Yu","year":"2006","unstructured":"Yu W, Zacharia LC, Jackson EK, Apodaca G (2006) Adenosine receptor expression and function in bladder uroepithelium. Am J Physiol Cell Physiol 291:C254\u2013C265. doi: 10.1152\/ajpcell.00025.2006","journal-title":"Am J Physiol Cell Physiol"},{"key":"9535_CR40","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1002\/(SICI)1096-9861(19981116)401:2<163::AID-CNE2>3.0.CO;2-D","volume":"401","author":"DL Rosin","year":"1998","unstructured":"Rosin DL, Robeva A, Woodard RL, Guyenet PG, Linden J (1998) Immunohistochemical localization of adenosine A2A receptors in the rat central nervous system. J Comp Neurol 401:163\u2013186. doi: 10.1002\/(SICI)1096-9861(19981116)401:2<163::AID-CNE2>3.0.CO;2-D","journal-title":"J Comp Neurol"},{"key":"9535_CR41","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1111\/j.1476-5381.2008.00058.x","volume":"156","author":"M Duarte-Ara\u00fajo","year":"2009","unstructured":"Duarte-Ara\u00fajo M, Nascimento C, Tim\u00f3teo MA, Magalh\u00e3es-Cardoso MT, Correia-de-S\u00e1 P (2009) Relative contribution of ecto-ATPase and ecto-ATPDase pathways to the biphasic effect of ATP on acetylcholine release from myenteric motoneurons. Br J Pharmacol 156:519\u2013533. doi: 10.1111\/j.1476-5381.2008.00058.x","journal-title":"Br J Pharmacol"},{"key":"9535_CR42","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/0304-3940(91)90391-6","volume":"130","author":"SN Schiffmann","year":"1991","unstructured":"Schiffmann SN, Libert F, Vassart G, Vanderhaeghen JJ (1991) Distribution of adenosine A2 receptor mRNA in the human brain. Neurosci Lett 130:177\u2013181. doi: 10.1016\/0304-3940(91)90391-6","journal-title":"Neurosci Lett"},{"key":"9535_CR43","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1111\/j.1476-5381.1996.tb15561.x","volume":"118","author":"AK Dixon","year":"1996","unstructured":"Dixon AK, Gubitz AK, Sirinathsinghji DJ, Richardson PJ, Freeman TC (1996) Tissue distribution of adenosine receptor mRNAs in the rat. Br J Pharmacol 118:1461\u20131468. doi: 10.1111\/j.1476-5381.1996.tb15561.x","journal-title":"Br J Pharmacol"},{"key":"9535_CR44","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1111\/j.1460-9568.2009.06897.x","volume":"30","author":"I D\u2019Alimonte","year":"2009","unstructured":"D\u2019Alimonte I, D\u2019Auro M, Citraro R, Biagioni F, Jiang S, Nargi E, Buccella S, Di Iorio P, Giuliani P, Ballerini P, Caciagli F, Russo E, De Sarro G, Ciccarelli R (2009) Altered distribution and function of A2A adenosine receptors in the brain of WAG\/Rij rats with genetic absence epilepsy, before and after appearance of the disease. Eur J Neurosci 30:1023\u20131035. doi: 10.1111\/j.1460-9568.2009.06897.x","journal-title":"Eur J Neurosci"},{"key":"9535_CR45","doi-asserted-by":"publisher","first-page":"11390","DOI":"10.1523\/JNEUROSCI.5817-12.2013","volume":"33","author":"E Augusto","year":"2013","unstructured":"Augusto E, Matos M, S\u00e9vigny J, El-Tayeb A, Bynoe MS, M\u00fcller CE, Cunha RA, Chen JF (2013) Ecto-5\u2032-nucleotidase (CD73)-mediated formation of adenosine is critical for the striatal adenosine A2A receptor functions. J Neurosci 33:11390\u201311399. doi: 10.1523\/JNEUROSCI.5817-12.2013","journal-title":"J Neurosci"},{"key":"9535_CR46","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/S0920-1211(00)00095-4","volume":"39","author":"CD Bonan","year":"2000","unstructured":"Bonan CD, Walz R, Pereira GS, Worm PV, Battastini AM, Cavalheiro EA, Izquierdo I, Sarkis JJ (2000) Changes in synaptosomal ectonucleotidase activities in two rat models of temporal lobe epilepsy. Epilepsy Res 39:229\u2013238. doi: 10.1016\/S0920-1211(00)00095-4","journal-title":"Epilepsy Res"},{"key":"9535_CR47","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1097\/00005072-199905000-00004","volume":"58","author":"AA Lie","year":"1999","unstructured":"Lie AA, Bl\u00fcmcke I, Beck H, Wiestler OD, Elger CE, Schoen SW (1999) 5\u2032-Nucleotidase activity indicates sites of synaptic plasticity and reactive synaptogenesis in the human brain. J Neuropathol Exp Neurol 58:451\u2013458. doi: 10.1097\/00005072-199905000-00004","journal-title":"J Neuropathol Exp Neurol"},{"key":"9535_CR48","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2015.08.046","author":"D Boison","year":"2015","unstructured":"Boison D (2015) Adenosinergic signaling in epilepsy. Neuropharmacology. doi: 10.1016\/j.neuropharm.2015.08.046","journal-title":"Neuropharmacology"},{"key":"9535_CR49","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1016\/j.bcp.2009.08.005","volume":"78","author":"D Boison","year":"2009","unstructured":"Boison D, Stewart KA (2009) Therapeutic epilepsy research: from pharmacological rationale to focal adenosine augmentation. Biochem Pharmacol 78:1428\u20131437. doi: 10.1016\/j.bcp.2009.08.005","journal-title":"Biochem Pharmacol"},{"key":"9535_CR50","volume-title":"Jasper\u2019s basic mechanisms of the epilepsies [internet]","author":"D Boison","year":"2012","unstructured":"Boison D (2012) Adenosine augmentation therapy. In: Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV (eds) Jasper\u2019s basic mechanisms of the epilepsies [internet], 4th edn. National Center for Biotechnology Information (US), Bethesda (MD)","edition":"4th"},{"key":"9535_CR51","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/0006-8993(95)01313-X","volume":"710","author":"M Glass","year":"1996","unstructured":"Glass M, Faull RL, Bullock JY, Jansen K, Mee EW, Walker EB, Synek BJ, Dragunow M (1996) Loss of A1 adenosine receptors in human temporal lobe epilepsy. Brain Res 710:56\u201368. doi: 10.1016\/0006-8993(95)01313-X","journal-title":"Brain Res"},{"key":"9535_CR52","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1111\/jnc.13130","volume":"134","author":"DA L\u00e9on-Navarro","year":"2015","unstructured":"L\u00e9on-Navarro DA, Albasanz JL, Mart\u00edn M (2015) Hyperthermia-induced seizures alter adenosine A1 and A2A receptors and 5\u2032-nucleotidase activity in rat cerebral cortex. J Neurochem 134:395\u2013404. doi: 10.1111\/jnc.13130","journal-title":"J Neurochem"},{"key":"9535_CR53","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1021\/acs.jmedchem.5b00331","volume":"59","author":"J Kardos","year":"2016","unstructured":"Kardos J, Szab\u00f3 Z, H\u00e9ja L (2016) Framing neuro-glia coupling in antiepileptic drug design. J Med Chem 59:777\u2013787. doi: 10.1021\/acs.jmedchem.5b00331","journal-title":"J Med Chem"},{"key":"9535_CR54","doi-asserted-by":"publisher","DOI":"10.1113\/JP271958","author":"C Henneberger","year":"2016","unstructured":"Henneberger C (2016) Does rapid and physiological astrocyte-neuron signalling amplify epileptic activity? J Physiol. doi: 10.1113\/JP271958","journal-title":"J Physiol"},{"key":"9535_CR55","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1016\/j.biopsych.2015.02.026","volume":"78","author":"M Matos","year":"2015","unstructured":"Matos M, Shen HY, Augusto E, Wang Y, Wei CJ, Wang YT, Agostinho P, Boison D, Cunha RA, Chen JF (2015) Deletion of adenosine A2A receptors from astrocytes disrupts glutamate homeostasis leading to psychomotor and cognitive impairment: relevance to schizophrenia. Biol Psychiatry 78:763\u2013774. doi: 10.1016\/j.biopsych.2015.02.026","journal-title":"Biol Psychiatry"},{"key":"9535_CR56","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s12915-016-0247-4","volume":"14","author":"G Navarro","year":"2016","unstructured":"Navarro G, Cordom\u00ed A, Zelman-Femiak M, Brugarolas M, Moreno E, Aguinaga D, Perez-Benito L, Cort\u00e9s A, Casad\u00f3 V, Mallol J, Canela E, Llu\u00eds C, Pardo L, Garc\u00eda-S\u00e1ez AJ, McCormick PJ, Franco R (2016) Quaternary structure of a G-protein-coupled receptor heterotetramer in complex with Gi and Gs. BMC Biol 14:26. doi: 10.1186\/s12915-016-0247-4","journal-title":"BMC Biol"},{"key":"9535_CR57","doi-asserted-by":"publisher","first-page":"3552","DOI":"10.1172\/JCI65636","volume":"123","author":"RL Williams-Karnesky","year":"2013","unstructured":"Williams-Karnesky RL, Sandau US, Lusardi TA, Lytle NK, Farrell JM, Pritchard EM, Kaplan DL, Boison D (2013) Epigenetic changes induced by adenosine augmentation therapy prevent epileptogenesis. J Clin Invest 123:3552\u20133563. doi: 10.1172\/JCI65636","journal-title":"J Clin Invest"},{"key":"9535_CR58","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.tins.2012.11.008","volume":"36","author":"O Devinsky","year":"2013","unstructured":"Devinsky O, Vezzani A, Najjar S, De Lanerolle NC, Rogawski MA (2013) Glia and epilepsy: excitability and inflammation. Trends Neurosci 36:174\u2013184. doi: 10.1016\/j.tins.2012.11.008","journal-title":"Trends Neurosci"},{"key":"9535_CR59","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/nrneurol.2010.178","volume":"7","author":"A Vezzani","year":"2011","unstructured":"Vezzani A, French J, Bartfai T, Baram TZ (2011) The role of inflammation in epilepsy. Nat Rev Neurol 7:31\u201340. doi: 10.1038\/nrneurol.2010.178","journal-title":"Nat Rev Neurol"},{"key":"9535_CR60","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.neures.2009.08.002","volume":"65","author":"RH Ke","year":"2009","unstructured":"Ke RH, Xiong J, Liu Y, Ye ZR (2009) Adenosine A2A receptor induced gliosis via Akt\/NF-kappaB pathway in vitro. Neurosci Res 65:280\u2013285. doi: 10.1016\/j.neures.2009.08.002","journal-title":"Neurosci Res"},{"key":"9535_CR61","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1002\/glia.10243","volume":"42","author":"R Brambilla","year":"2003","unstructured":"Brambilla R, Cottini L, Fumagalli M, Ceruti S, Abbracchio MP (2003) Blockade of A2A adenosine receptors prevents basic fibroblast growth factor-induced reactive astrogliosis in rat striatal primary astrocytes. Glia 42:190\u2013194. doi: 10.1002\/glia.10243","journal-title":"Glia"},{"key":"9535_CR62","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1515\/BC.2003.054","volume":"384","author":"R Napieralski","year":"2003","unstructured":"Napieralski R, Kempkes B, Gutensohn W (2003) Evidence for coordinated induction and repression of ecto-5\u2032-nucleotidase (CD73) and the A2A adenosine receptor in a human B cell line. Biol Chem 384:483\u2013487. doi: 10.1515\/BC.2003.054","journal-title":"Biol Chem"},{"key":"9535_CR63","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1084\/jem.20062512","volume":"204","author":"S Deaglio","year":"2007","unstructured":"Deaglio S, Dwyer KM, Gao W, Friedman D, Usheva A, Erat A, Chen JF, Enjyoji K, Linden J, Oukka M, Kuchroo VK, Strom TB, Robson SC (2007) Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J Exp Med 204:1257\u20131265. doi: 10.1084\/jem.20062512","journal-title":"J Exp Med"},{"key":"9535_CR64","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1124\/mol.105.015818","volume":"69","author":"T Milojevic","year":"2006","unstructured":"Milojevic T, Reiterer V, Stefan E, Korkhov VM, Dorostkar MM, Ducza E, Ogris E, Boehm S, Freissmuth M, Nanoff C (2006) The ubiquitin-specific protease Usp4 regulates the cell surface level of the A2A receptor. Mol Pharmacol 69:1083\u20131094. doi: 10.1124\/mol.105.015818","journal-title":"Mol Pharmacol"},{"key":"9535_CR65","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1111\/j.1471-4159.1987.tb03419.x","volume":"49","author":"H Hagberg","year":"1987","unstructured":"Hagberg H, Andersson P, Lacarewicz J, Jacobson I, Butcher S, Sandberg M (1987) Extracellular adenosine, inosine, hypoxanthine, and xanthine in relation to tissue nucleotides and purines in rat striatum during transient ischemia. J Neurochem 49:227\u2013231. doi: 10.1111\/j.1471-4159.1987.tb03419.x","journal-title":"J Neurochem"},{"key":"9535_CR66","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1007\/s002100100456","volume":"365","author":"G Arslan","year":"2002","unstructured":"Arslan G, Kull B, Fredholm BB (2002) Anoxia redistributes adenosine A2A receptors in PC12 cells and increases receptor-mediated formation of cAMP. Naunyn Schmiedeberg's Arch Pharmacol 365:150\u2013157. doi: 10.1007\/s002100100456","journal-title":"Naunyn Schmiedeberg's Arch Pharmacol"},{"key":"9535_CR67","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1002\/jnr.23770","volume":"94","author":"F Rassendren","year":"2016","unstructured":"Rassendren F, Audinat E (2016) Purinergic signaling in epilepsy. J Neurosci Res 94:781\u2013793. doi: 10.1002\/jnr.23770","journal-title":"J Neurosci Res"},{"key":"9535_CR68","doi-asserted-by":"publisher","first-page":"1616","DOI":"10.1096\/fj.11-196089","volume":"26","author":"T Engel","year":"2012","unstructured":"Engel T, Gomez-Villafuertes R, Tanaka K, Mesuret G, Sanz-Rodriguez A, Garcia-Huerta P, Miras-Portugal MT, Henshall DC, Diaz-Hernandez M (2012) Seizure suppression and neuroprotection by targeting the purinergic P2X7 receptor during status epilepticus in mice. FASEB J 26:1616\u20131628. doi: 10.1096\/fj.11-196089","journal-title":"FASEB J"},{"key":"9535_CR69","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1111\/epi.12257","volume":"54","author":"A Jimenez-Pacheco","year":"2013","unstructured":"Jimenez-Pacheco A, Mesuret G, Sanz-Rodriguez A, Tanaka K, Mooney C, Conroy R, Miras-Portugal MT, Diaz-Hernandez M, Henshall DC, Engel T (2013) Increased neocortical expression of the P2X7 receptor after status epilepticus and anticonvulsant effect of P2X7 receptor antagonist A-438079. Epilepsia 54:1551\u20131561. doi: 10.1111\/epi.12257","journal-title":"Epilepsia"},{"key":"9535_CR70","doi-asserted-by":"publisher","first-page":"17486","DOI":"10.1038\/srep17486","volume":"5","author":"EM Jimenez-Mateos","year":"2015","unstructured":"Jimenez-Mateos EM, Arribas-Blazquez M, Sanz-Rodriguez A, Concannon C, Olivos-Ore LA, Reschke CR, Mooney CM, Mooney C, Lugara E, Morgan J, Langa E, Jimenez-Pacheco A, Silva LF, Mesuret G, Boison D, Miras-Portugal MT, Letavic M, Artalejo AR, Bhattacharya A, Diaz-Hernandez M, Henshall DC, Engel T (2015) microRNA targeting of the P2X7 purinoceptor opposes a contralateral epileptogenic focus in the hippocampus. Sci Rep 5:17486. doi: 10.1038\/srep17486","journal-title":"Sci Rep"}],"container-title":["Purinergic Signalling"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11302-016-9535-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11302-016-9535-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11302-016-9535-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T20:10:11Z","timestamp":1749586211000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11302-016-9535-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,20]]},"references-count":70,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["9535"],"URL":"https:\/\/doi.org\/10.1007\/s11302-016-9535-2","relation":{},"ISSN":["1573-9538","1573-9546"],"issn-type":[{"value":"1573-9538","type":"print"},{"value":"1573-9546","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,20]]}}}