{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T14:03:44Z","timestamp":1774015424046,"version":"3.50.1"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T00:00:00Z","timestamp":1503446400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Department of Biotechnology, Ministry of Science and Technology (IN)","award":["BT\/IN\/NEW INDIGO\/03\/RS\/2013"],"award-info":[{"award-number":["BT\/IN\/NEW INDIGO\/03\/RS\/2013"]}]},{"name":"Funda\u00e7\u00e3o para a Ci\u00eancia e Tecnologia","award":["PEst-UID\/QUI\/UI0674\/2013"],"award-info":[{"award-number":["PEst-UID\/QUI\/UI0674\/2013"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Metabolomics"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1007\/s11306-017-1251-6","type":"journal-article","created":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T08:42:51Z","timestamp":1503477771000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Investigation of urinary volatomic alterations in head and neck cancer: a non-invasive approach towards diagnosis and prognosis"],"prefix":"10.1007","volume":"13","author":[{"given":"Ravindra","family":"Taware","sequence":"first","affiliation":[]},{"given":"Khushman","family":"Taunk","sequence":"additional","affiliation":[]},{"given":"Jorge A. M.","family":"Pereira","sequence":"additional","affiliation":[]},{"given":"Rahul","family":"Dhakne","sequence":"additional","affiliation":[]},{"given":"Narayanan","family":"Kannan","sequence":"additional","affiliation":[]},{"given":"Dharmesh","family":"Soneji","sequence":"additional","affiliation":[]},{"given":"Jos\u00e9 S.","family":"C\u00e2mara","sequence":"additional","affiliation":[]},{"given":"H. A.","family":"Nagarajaram","sequence":"additional","affiliation":[]},{"given":"Srikanth","family":"Rapole","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2017,8,23]]},"reference":[{"issue":"3","key":"1251_CR1","doi-asserted-by":"crossref","first-page":"34001","DOI":"10.1088\/1752-7155\/8\/3\/034001","volume":"8","author":"A Amann","year":"2014","unstructured":"Amann, A., Costello, B. D. L., Miekisch, W., Schubert, J., Buszewski, B., Pleil, J., et al. (2014). The human volatilome: Volatile organic compounds (VOCs) in exhaled breath, skin emanations, urine, feces and saliva. Journal of Breath Research, 8(3), 34001.","journal-title":"Journal of Breath Research"},{"issue":"9","key":"1251_CR2","doi-asserted-by":"crossref","first-page":"e108750","DOI":"10.1371\/journal.pone.0108750","volume":"9","author":"RP Arasaradnam","year":"2014","unstructured":"Arasaradnam, R. P., McFarlane, M. J., Ryan-Fisher, C., Westenbrink, E., Hodges, P., Thomas, M. G., et al. (2014). Detection of colorectal cancer (CRC) by urinary volatile organic compound analysis. PloS ONE, 9(9), e108750.","journal-title":"PloS ONE"},{"issue":"137289","key":"1251_CR3","first-page":"21","volume":"2012","author":"G Barrera","year":"2012","unstructured":"Barrera, G. (2012). Oxidative stress and lipid peroxidation products in cancer progression and therapy. ISRN Oncology, 2012(137289), 21.","journal-title":"ISRN Oncology"},{"key":"1251_CR4","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/B978-0-12-394446-7.00027-3","volume-title":"Proteomic and metabolomic approaches to biomarker discovery","author":"J Boccard","year":"2013","unstructured":"Boccard, J., & Rudaz, S. (2013). Mass Spectrometry Metabolomic Data Handling for Biomarker Discovery. In H. J. Issaq & T. D. Veenstra (Eds.), Proteomic and metabolomic approaches to biomarker discovery (pp.\u00a0425\u2013445). Boston: Academic Press."},{"issue":"2","key":"1251_CR5","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1046\/j.1471-4159.1998.71020827.x","volume":"71","author":"A Brand","year":"1998","unstructured":"Brand, A., Leibfritz, D., Hamprecht, B., & Dringen, R. (1998). Metabolism of cysteine in astroglial cells: Synthesis of hypotaurine and taurine. Journal of Neurochemistry, 71(2), 827\u2013832.","journal-title":"Journal of Neurochemistry"},{"issue":"4","key":"1251_CR6","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s11306-006-0037-z","volume":"2","author":"DI Broadhurst","year":"2006","unstructured":"Broadhurst, D. I., & &Kell, D. B. (2006).Statistical strategies for avoiding false discoveries in metabolomics and related experiments. Metabolomics, 2(4), 171\u2013196.","journal-title":"Metabolomics"},{"issue":"10","key":"1251_CR7","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1093\/clinchem\/29.10.1834","volume":"29","author":"DG Burke","year":"1983","unstructured":"Burke, D. G., Halpern, B., Malegan, D., McCairns, E., Danks, D., Schlesinger, P., & Wilken, B. (1983). Profiles of urinary volatiles from metabolic disorders characterized by unusual odors. Clinical Chemistry, 29(10), 1834\u20131838.","journal-title":"Clinical Chemistry"},{"issue":"46","key":"1251_CR8","doi-asserted-by":"crossref","first-page":"5874","DOI":"10.3748\/wjg.v16.i46.5874","volume":"16","author":"JL Chen","year":"2010","unstructured":"Chen, J. L., Tang, H. Q., Hu, J. D., Fan, J., Hong, J., & Gu, J. Z. (2010). Metabolomics of gastric cancer metastasis detected by gas chromatography and mass spectrometry. World Journal of Gastroenterology: WJG, 16(46), 5874\u20135880.","journal-title":"World Journal of Gastroenterology: WJG"},{"issue":"9","key":"1251_CR9","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1136\/gut.22.9.763","volume":"22","author":"JH Cummings","year":"1981","unstructured":"Cummings, J. H. (1981). Short chain fatty acids in the human colon. Gut, 22(9), 763\u2013779.","journal-title":"Gut"},{"issue":"2","key":"1251_CR10","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/j.1464-410X.2006.06610.x","volume":"99","author":"MR Downes","year":"2007","unstructured":"Downes, M. R., Byrne, J. C., Pennington, S. R., Dunn, M. J., Fitzpatrick, J. M., & Watson, R. W. G. (2007). Urinary markers for prostate cancer. BJU International, 99(2), 263\u2013268.","journal-title":"BJU International"},{"issue":"5","key":"1251_CR11","doi-asserted-by":"crossref","first-page":"E359","DOI":"10.1002\/ijc.29210","volume":"136","author":"J Ferlay","year":"2014","unstructured":"Ferlay, J., Soerjomataram, I., Dikshit, R., Eser, S., Mathers, C., Rebelo, M., et al. (2014). Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. International Journal of Cancer, 136(5), E359\u2013E386","journal-title":"International Journal of Cancer"},{"issue":"3","key":"1251_CR12","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s11306-007-0070-6","volume":"3","author":"O Fiehn","year":"2007","unstructured":"Fiehn, O., Robertson, D., Griffin, J. L., Van der Werf, M., Nikolau, B., Morrison, N., et al. (2007). The metabolomics standard initiative (MSI). Metabolomics, 3(3), 175\u2013178.","journal-title":"Metabolomics"},{"issue":"2","key":"1251_CR13","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0891-5849(94)90110-4","volume":"17","author":"CM Frank Kneepkens","year":"1994","unstructured":"Frank Kneepkens, C. M., Lepage, G., & Roy, C. C. (1994). The potential of the hydrocarbon breath test as a measure of lipid peroxidation. Free Radical Biology and Medicine, 17(2), 127\u2013160.","journal-title":"Free Radical Biology and Medicine"},{"key":"1251_CR14","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/978-0-387-75681-3_38","volume":"643","author":"D Gossai","year":"2009","unstructured":"Gossai, D., & Lau-Cam, C. A. (2009). The effects of taurine, hypotaurine, and taurine homologs on erythrocyte morphology, membrane fluidity and cytoskeletal spectrin alterations due to diabetes, alcoholism and diabetes-alcoholism in the rat. Advances in Experimental Medicine and Biology, 643, 369\u2013379.","journal-title":"Advances in Experimental Medicine and Biology"},{"issue":"3","key":"1251_CR15","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s11306-007-0077-z","volume":"3","author":"JL Griffin","year":"2007","unstructured":"Griffin, J. L., Nicholls, A. W., Daykin, C. A., Heald, S., Keun, H. C., Schuppe-Koistinen, I., et al. (2007). Standard reporting requirements for biological samples in metabolomics experiments: Mammalian\/in vivo experiments. Metabolomics, 3(3), 179\u2013188.","journal-title":"Metabolomics"},{"issue":"2","key":"1251_CR16","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1021\/tx00020a008","volume":"4","author":"FP Guengerich","year":"1991","unstructured":"Guengerich, F. P., Kim, D. H., & Iwasaki, M. (1991). Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects. Chemical Research in Toxicology, 4(2), 168\u2013179.","journal-title":"Chemical Research in Toxicology"},{"issue":"2","key":"1251_CR17","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.trsl.2015.01.005","volume":"166","author":"L Guo","year":"2015","unstructured":"Guo, L., Wang, C., Chi, C., Wang, X., Liu, S., Zhao, W., et al. (2015). Exhaled breath volatile biomarker analysis for thyroid cancer. Translational Research, 166(2), 188\u2013195.","journal-title":"Translational Research"},{"issue":"5","key":"1251_CR18","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1039\/C3CS60329F","volume":"43","author":"H Haick","year":"2014","unstructured":"Haick, H., Broza, Y. Y., Mochalski, P., Ruzsanyi, V., & Amann, A. (2014). Assessment, origin, and implementation of breath volatile cancer markers. Chemical Society Reviews, 43(5), 1423\u20131449.","journal-title":"Chemical Society Reviews"},{"issue":"11","key":"1251_CR19","doi-asserted-by":"crossref","first-page":"5949","DOI":"10.1021\/cr300174a","volume":"112","author":"M Hakim","year":"2012","unstructured":"Hakim, M., Broza, Y. Y., Barash, O., Peled, N., Phillips, M., Amann, A., & Haick, H. (2012). Volatile organic compounds of lung cancer and possible biochemical pathways. Chemical Reviews, 112(11), 5949\u20135966.","journal-title":"Chemical Reviews"},{"issue":"6","key":"1251_CR20","first-page":"598","volume":"119","author":"B Halliwell","year":"1992","unstructured":"Halliwell, B., Gutteridge, J. M., & Cross, C. E. (1992). Free radicals, antioxidants, and human disease: Where are we now? The Journal of Laboratory and Clinical Medicine, 119(6), 598\u2013620.","journal-title":"The Journal of Laboratory and Clinical Medicine"},{"issue":"1","key":"1251_CR21","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s13073-016-0289-9","volume":"8","author":"S Huang","year":"2016","unstructured":"Huang, S., Chong, N., Lewis, N. E., Jia, W., Xie, G., & Garmire, L. X. (2016). Novel personalized pathway-based metabolomics models reveal key metabolic pathways for breast cancer diagnosis. Genome Medicine, 8(1), 34.","journal-title":"Genome Medicine"},{"issue":"1\u20132","key":"1251_CR22","first-page":"23","volume":"12","author":"E Inal","year":"2004","unstructured":"Inal, E., Lacin, M., Asal, K., Ceylan, A., Koybasioglu, A., Ileri, F., & Uslu, S. S. (2004). The significance of ferritin, lipid-associated sialic acid, CEA, squamous cell carcinoma (SCC) antigen, and CYFRA 21 \u2013 1 levels in SCC of the head and neck. Kulak Burun Bogaz Ihtis Derg, 12(1\u20132), 23\u201330.","journal-title":"Kulak Burun Bogaz Ihtis Derg"},{"key":"1251_CR23","first-page":"53","volume":"945\u2013946","author":"H Liu","year":"2013","unstructured":"Liu, H., Wang, H., Li, C., Wang, L., Pan, Z., & Wang, L. (2013). Investigation of volatile organic metabolites in lung cancer pleural effusions by solid-phase microextraction and gas chromatography\/mass spectrometry. Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences, 945\u2013946, 53\u201359.","journal-title":"Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences"},{"key":"1251_CR24","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1146\/annurev-cellbio-092910-154237","volume":"27","author":"SY Lunt","year":"2011","unstructured":"Lunt, S. Y., & Vander Heiden, M. G. (2011). Aerobic glycolysis: Meeting the metabolic requirements of cell proliferation. Annual Review of Cell and Developmental Biology, 27, 441\u2013464.","journal-title":"Annual Review of Cell and Developmental Biology"},{"issue":"6","key":"1251_CR25","doi-asserted-by":"crossref","first-page":"e205","DOI":"10.1016\/S1470-2045(14)70115-9","volume":"15","author":"MK Mallath","year":"2014","unstructured":"Mallath, M. K., Taylor, D. G., Badwe, R. A., Rath, G. K., Shanta, V., Pramesh, C. S., et al. (2014). The growing burden of cancer in India: Epidemiology and social context. The Lancet Oncology, 15(6), e205\u2013e212.","journal-title":"The Lancet Oncology"},{"issue":"21","key":"1251_CR26","doi-asserted-by":"crossref","first-page":"3956","DOI":"10.4161\/cc.22136","volume":"11","author":"UE Martinez-Outschoorn","year":"2012","unstructured":"Martinez-Outschoorn, U. E., Lin, Z., Whitaker-Menezes, D., Howell, A., Lisanti, M. P., & Sotgia, F. (2012). Ketone bodies and two-compartment tumor metabolism: Stromal ketone production fuels mitochondrial biogenesis in epithelial cancer cells. Cell Cycle, 11(21), 3956\u20133963.","journal-title":"Cell Cycle"},{"issue":"2","key":"1251_CR27","doi-asserted-by":"crossref","first-page":"537","DOI":"10.7314\/APJCP.2014.15.2.537","volume":"15","author":"A Mishra","year":"2014","unstructured":"Mishra, A., & Meherotra, R. (2014). Head and neck cancer: Global burden and regional trends in India. Asian Pacific Journal of Cancer Prevention, 15(2), 537\u2013550.","journal-title":"Asian Pacific Journal of Cancer Prevention"},{"issue":"2","key":"1251_CR28","doi-asserted-by":"crossref","first-page":"364","DOI":"10.2214\/ajr.184.2.01840364","volume":"184","author":"NA Obuchowski","year":"2005","unstructured":"Obuchowski, N. A., Blackmore, C. C., Karlik, S., & Reinhold, C. (2005). Fundamentals of clinical research for radiologists. American Journal of Roentgenology, 184(2), 364\u2013372.","journal-title":"American Journal of Roentgenology"},{"issue":"6","key":"1251_CR29","doi-asserted-by":"crossref","first-page":"e2253","DOI":"10.1038\/cddis.2016.105","volume":"7","author":"E Panieri","year":"2016","unstructured":"Panieri, E., & Santoro, M. (2016). ROS homeostasis and metabolism: A dangerous liason in cancer cells. Cell Death and Disease, 7(6), e2253.","journal-title":"Cell Death and Disease"},{"issue":"9168","key":"1251_CR30","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1016\/S0140-6736(98)07552-7","volume":"353","author":"M Phillips","year":"1999","unstructured":"Phillips, M., Gleeson, K., Hughes, J. M. B., Greenberg, J., Cataneo, R. N., Baker, L., & McVay, W. P. (1999). Volatile organic compounds in breath as markers of lung cancer: A cross-sectional study. Lancet, 353(9168), 1930\u20131933.","journal-title":"Lancet"},{"issue":"5","key":"1251_CR31","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1042\/BST20160094","volume":"44","author":"M Potter","year":"2016","unstructured":"Potter, M., Newport, E., & Morten, K. J. (2016). The Warburg effect: 80 years on. Biochemical Society Transactions, 44(5), 1499\u20131505.","journal-title":"Biochemical Society Transactions"},{"key":"1251_CR32","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/1752-0509-7-141","volume":"7","author":"MP Pradhan","year":"2013","unstructured":"Pradhan, M. P., Desai, A., & Palakal, M. J. (2013).Systems biology approach to stage-wise characterization of epigenetic genes in lung adenocarcinoma. BMC Systems Biology, 7, 141.","journal-title":"BMC Systems Biology"},{"issue":"21","key":"1251_CR33","doi-asserted-by":"crossref","first-page":"4914","DOI":"10.1002\/cncr.25245","volume":"116","author":"TMB Rezende","year":"2010","unstructured":"Rezende, T. M. B., Freire, M. d. S., & Franco, O. L. (2010). Head and neck cancer. Cancer, 116(21), 4914\u20134925.","journal-title":"Cancer"},{"issue":"2","key":"1251_CR34","doi-asserted-by":"crossref","first-page":"79","DOI":"10.4111\/kju.2011.52.2.79","volume":"52","author":"MJ Roberts","year":"2011","unstructured":"Roberts, M. J., Schirra, H. J., Lavin, M. F., & Gardiner, R. A. (2011). Metabolomics: A novel approach to early and noninvasive prostate cancer detection. Korean Journal of Urology, 52(2), 79\u201389.","journal-title":"Korean Journal of Urology"},{"key":"1251_CR35","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/2049-3002-2-13","volume":"2","author":"D Roy","year":"2014","unstructured":"Roy, D., Mondal, S., Wang, C., He, X., Khurana, A., Giri, S., et al. (2014). Loss of HSulf-1 promotes altered lipid metabolism in ovarian cancer. Cancer & Metabolism, 2, 13.","journal-title":"Cancer & Metabolism"},{"issue":"11","key":"1251_CR36","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/nrc.2016.87","volume":"16","author":"ZT Schug","year":"2016","unstructured":"Schug, Z. T., Voorde, J., Vande, & Gottlieb, E. (2016). The metabolic fate of acetate in cancer. Nature Reviews Cancer, 16(11), 708\u2013717.","journal-title":"Nature Reviews Cancer"},{"issue":"1","key":"1251_CR37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/omi.2014.0116","volume":"19","author":"C Shen","year":"2015","unstructured":"Shen, C., Sun, Z., Chen, D., Su, X., Jiang, J., Li, G., et al. (2015). Developing urinary metabolomic signatures as early bladder cancer diagnostic markers. Omics: A Journal of Integrative Biology, 19(1), 1\u201311.","journal-title":"Omics: A Journal of Integrative Biology"},{"issue":"12","key":"1251_CR38","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1038\/bjc.2011.437","volume":"105","author":"CL Silva","year":"2011","unstructured":"Silva, C. L., Passos, M., & &C\u00e2mara, J. S. (2011). Investigation of urinary volatile organic metabolites as potential cancer biomarkers by solid-phase microextraction in combination with gas chromatography-mass spectrometry. British Journal of Cancer, 105(12), 1894\u20131904.","journal-title":"British Journal of Cancer"},{"key":"1251_CR39","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.talanta.2011.12.041","volume":"89","author":"CL Silva","year":"2012","unstructured":"Silva, C. L., Passos, M., & &C\u00e2mara, J. S. (2012). Solid phase microextraction, mass spectrometry and metabolomic approaches for detection of potential urinary cancer biomarkers - A powerful strategy for breast cancer diagnosis. Talanta, 89, 360\u2013368.","journal-title":"Talanta"},{"issue":"1","key":"1251_CR40","first-page":"419","volume":"29","author":"A Sponring","year":"2009","unstructured":"Sponring, A., Filipiak, W., Mikoviny, T., Ager, C., Schubert, J., Miekisch, W., et al. (2009). Release of volatile organic compounds from the lung cancer cell line NCI-H2087 in vitro. Anticancer Research, 29(1), 419\u2013426.","journal-title":"Anticancer Research"},{"key":"1251_CR41","unstructured":"Stewart, B. W., & Wild, C. P. (2014). World Cancer Report 2014. Geneva: World Health Organization."},{"issue":"3","key":"1251_CR42","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1007\/s12253-011-9376-9","volume":"17","author":"L Tam\u00e1s","year":"2011","unstructured":"Tam\u00e1s, L., Szentk\u00fati, G., Eros, M., D\u00e1nos, K., Brauswetter, D., Szende, B., et al. (2011). Differential biomarker expression in head and neck cancer correlates with anatomical localization. Pathology and Oncology Research, 17(3), 721\u2013727.","journal-title":"Pathology and Oncology Research"},{"issue":"5","key":"1251_CR43","first-page":"G625","volume":"263","author":"C Tiruppathi","year":"1992","unstructured":"Tiruppathi, C., Brandsch, M., Miyamoto, Y., Ganapathy, V., & Leibach, F. H. (1992). Constitutive expression of the taurine transporter in a human colon carcinoma cell line. American Journal of Physiology, 263(5), G625\u2013G631.","journal-title":"American Journal of Physiology"},{"key":"1251_CR44","first-page":"9","volume":"17","author":"A Ulanowska","year":"2010","unstructured":"Ulanowska, A., Ligor, T., Michel, M., & Buszewski, B. (2010). Hyphenated and unconventional methods for searching volatile cancer biomarkers. Ecological Chemistry and Engineering S-Chemia I InzynieriaEkologiczna S. 17, 9\u201323","journal-title":"Ecological Chemistry and Engineering S-Chemia I InzynieriaEkologiczna S"},{"issue":"3191","key":"1251_CR45","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1126\/science.123.3191.309","volume":"123","author":"O Warburg","year":"1956","unstructured":"Warburg, O. (1956). On the origin of cancer cells. Science, 123(3191), 309\u2013314.","journal-title":"Science"},{"issue":"6","key":"1251_CR46","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1085\/jgp.8.6.519","volume":"8","author":"O Warburg","year":"1927","unstructured":"Warburg, O., Ding, Y., Sharma, J., Paetz, M. B., Meixensberger, J., Gaunitz, F., et al. (1927). The metabolism of tumors in the body. The Journal of General Physiology, 8(6), 519\u2013530.","journal-title":"The Journal of General Physiology"},{"issue":"1","key":"1251_CR47","doi-asserted-by":"crossref","first-page":"140","DOI":"10.3390\/metabo5010140","volume":"5","author":"AD Wilson","year":"2015","unstructured":"Wilson, A. D. (2015). Advances in electronic-nose technologies for the detection of volatile biomarker metabolites in the human breath. Metabolites, 5(1), 140\u2013163.","journal-title":"Metabolites"},{"issue":"5","key":"1251_CR48","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1093\/aje\/kwt029","volume":"178","author":"A Wyss","year":"2013","unstructured":"Wyss, A., Hashibe, M., Chuang, S. C., Lee, Y. C. A., Zhang, Z. F., Yu, G. P., et al. (2013). Cigarette, cigar, and pipe smoking and the risk of head and neck cancers: Pooled analysis in the international head and neck cancer epidemiology consortium. American Journal of Epidemiology, 178(5), 679\u2013690.","journal-title":"American Journal of Epidemiology"},{"issue":"W1","key":"1251_CR49","doi-asserted-by":"crossref","first-page":"W251","DOI":"10.1093\/nar\/gkv380","volume":"43","author":"J Xia","year":"2015","unstructured":"Xia, J., Sinelnikov, I. V., Han, B., & Wishart, D. S. (2015). MetaboAnalyst 3.0-making metabolomics more meaningful. Nucleic Acids Research, 43(W1), W251\u2013W257.","journal-title":"Nucleic Acids Research"},{"issue":"6","key":"1251_CR50","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/nprot.2011.319","volume":"6","author":"J Xia","year":"2011","unstructured":"Xia, J., & Wishart, D. S. (2011). Web-based inference of biological patterns, functions and pathways from metabolomic data using MetaboAnalyst. Nature Protocols, 6(6), 743\u2013760.","journal-title":"Nature Protocols"},{"key":"1251_CR51","first-page":"2342","volume":"27","author":"J Xia","year":"2011","unstructured":"Xia, J., Wishart, D. S., & Valencia, A. (2011). MetPA: A web-based metabolomics tool for pathway analysis and visualization. Bioinformatics, 27, 2342\u20132344.","journal-title":"Bioinformatics"},{"key":"1251_CR52","first-page":"233","volume":"10","author":"K Yonezawa","year":"2013","unstructured":"Yonezawa, K., Nishiumii, S., Kitamoto-Matsuda, J., Fujita, T., Morimoto, K., Yamashita, D., et al. (2013). Serum and tissue metabolomics of head and neck cancer. Cancer Genomics & Proteomics, 10, 233\u2013238.","journal-title":"Cancer Genomics & Proteomics"}],"container-title":["Metabolomics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11306-017-1251-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11306-017-1251-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11306-017-1251-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T02:46:50Z","timestamp":1602816410000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11306-017-1251-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,23]]},"references-count":52,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["1251"],"URL":"https:\/\/doi.org\/10.1007\/s11306-017-1251-6","relation":{},"ISSN":["1573-3882","1573-3890"],"issn-type":[{"value":"1573-3882","type":"print"},{"value":"1573-3890","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,23]]},"article-number":"111"}}