{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T12:11:47Z","timestamp":1773317507574,"version":"3.50.1"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum Carl Gustav Carus Dresden an der Technischen Universit\u00e4t Dresden"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Metabolomics"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Lipidomics and its branch epilipidomics are rapidly advancing fields that explore the roles of native and modified lipids (e.g., oxidized, nitrated and halogenated lipid species), respectively, in biological systems. Dysregulation of lipid metabolism and signaling contributes to numerous diseases, including cardiovascular, metabolic, neurodegenerative, and inflammatory conditions. However, multiple challenges, including lack of standardization, limited data integration, and poor clinical translation, hinder progress. To address these, the COST Action EpiLipidNET (CA19105) established a pan-European network fostering collaboration across disciplines to accelerate lipid science and its application to health and disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim of review<\/jats:title>\n                    <jats:p>This review outlines the achievements of EpiLipidNET over its four-year duration, highlights key scientific contributions across five thematic working groups, and presents the future direction of its ongoing activities. The aim is to demonstrate how a collaborative, interdisciplinary framework can catalyze innovation in lipidomics and epilipidomics, enhance methodological harmonization, support early-career researchers, and bridge the gap between basic science, clinical translation, industry, stakeholders, and public engagement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key scientific concepts of review<\/jats:title>\n                    <jats:p>EpiLipidNET structured its networking activities around (i) harmonization of analytical workflows, (ii) development of epilipidomics tools and data integration strategies, (iii) translational studies for clinical lipid biomarkers, (iv) investigation of lipid signaling mechanisms, and (v) dissemination and outreach. The network supported over 460 members globally, launched multiple training schools and scientific missions, produced 110+ publications, and fostered new initiatives in endothelial membrane lipidomics, food lipidomics, plant and algae lipids, and redox lipid biology. Its integrative approach sets a foundation for continued progress toward precision medicine and sustainable health interventions through lipid science.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11306-026-02396-7","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T18:11:04Z","timestamp":1773252664000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Outcomes and future activities of the \u2018Pan-European network in Lipidomics and EpiLipidomics \u2013 EpiLipidNET\u2019"],"prefix":"10.1007","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6979-2235","authenticated-orcid":false,"given":"Julia","family":"Kuligowski","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9815-1517","authenticated-orcid":false,"given":"Justine","family":"Bertrand-Michel","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3050-634X","authenticated-orcid":false,"given":"Amaury","family":"Cazenave-Gassiot","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9282-9013","authenticated-orcid":false,"given":"Laura","family":"Goracci","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8060-7675","authenticated-orcid":false,"given":"Pedro","family":"Domingues","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2856-9165","authenticated-orcid":false,"given":"Matej","family":"Ore\u0161i\u010d","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0649-8503","authenticated-orcid":false,"given":"Margret","family":"Thorsteinsdottir","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1094-5641","authenticated-orcid":false,"given":"Florian","family":"Gruber","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7542-0286","authenticated-orcid":false,"given":"Egon L.","family":"Willighagen","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4054-9279","authenticated-orcid":false,"given":"Corinne M.","family":"Spickett","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4300-4891","authenticated-orcid":false,"given":"Tatjana","family":"Ruskovska","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4089-8460","authenticated-orcid":false,"given":"Valerie B.","family":"O\u2019Donnell","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7472-6843","authenticated-orcid":false,"given":"Patricia","family":"Prabutzki","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1387-9777","authenticated-orcid":false,"given":"Snje\u017eana","family":"Petrovi\u0107","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9477-057X","authenticated-orcid":false,"given":"Joanna","family":"Godzien","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9691-8323","authenticated-orcid":false,"given":"Sara","family":"Tortorella","sequence":"additional","affiliation":[]},{"given":"Ana","family":"Reis","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6620-8221","authenticated-orcid":false,"given":"Irundika H. K.","family":"Dias","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9756-9356","authenticated-orcid":false,"given":"Guy","family":"Schleyer","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5357-3601","authenticated-orcid":false,"given":"Ros\u00e1rio","family":"Domingues","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4692-3885","authenticated-orcid":false,"given":"Maria","family":"Fedorova","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2026,3,11]]},"reference":[{"issue":"D1","key":"2396_CR1","doi-asserted-by":"publisher","first-page":"D679","DOI":"10.1093\/nar\/gkad960","volume":"52","author":"A Agrawal","year":"2024","unstructured":"Agrawal, A., Balc\u0131, H., Hanspers, K., Coort, S. L., Martens, M., Slenter, D. N., Ehrhart, F., Digles, D., Waagmeester, A., Wassink, I., Abbassi-Daloii, T., Lopes, E. N., Iyer, A., Acosta, J. M., Willighagen, L. G., Nishida, K., Riutta, A., Basaric, H., Evelo, C. T., Willighagen, E. L., Kutmon, M., & Pico, A. R. (2024). WikiPathways 2024: Next generation pathway database. Nucleic Acids Research, 52(D1), D679\u2013D689. https:\/\/doi.org\/10.1093\/nar\/gkad960","journal-title":"Nucleic Acids Research"},{"key":"2396_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103211","volume":"75","author":"C Berndt","year":"2024","unstructured":"Berndt, C., Alborzinia, H., Amen, V. S., Ayton, S., Barayeu, U., Bartelt, A., Bayir, H., Bebber, C. M., Birsoy, K., B\u00f6ttcher, J. P., Brabletz, S., Brabletz, T., Brown, A. R., Br\u00fcne, B., Bulli, G., Bruneau, A., Chen, Q., DeNicola, G. M., Dick, T. P., \u2026 Conrad, M. (2024). Ferroptosis in health and disease. Redox Biology, 75, Article 103211. https:\/\/doi.org\/10.1016\/j.redox.2024.103211","journal-title":"Redox Biology"},{"key":"2396_CR3","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.freeradbiomed.2025.03.020","volume":"233","author":"D Biagini","year":"2025","unstructured":"Biagini, D., Bertazzo, G., Ghimenti, S., Lenzi, A., Oger, C., Galano, J.-M., Balas, L., Durand, T., Pugliese, N. R., Armenia, S., Masi, S., Di Francesco, F., & Lomonaco, T. (2025). Dried blood spot analysis of long-chain polyunsaturated fatty acids and oxylipins for monitoring heart failure. Free Radical Biology & Medicine, 233, 13\u201323. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2025.03.020","journal-title":"Free Radical Biology & Medicine"},{"issue":"7","key":"2396_CR4","doi-asserted-by":"publisher","first-page":"1372","DOI":"10.1021\/jasms.3c00057","volume":"34","author":"S Bonciarelli","year":"2023","unstructured":"Bonciarelli, S., Neves, B., Domingues, P., Melo, T., Goracci, L., & Domingues, M. R. (2023). Analysis of phosphatidylinositol modifications by reactive nitrogen species using LC-MS: Coming to grips with their nitroxidative susceptibility. Journal of the American Society for Mass Spectrometry, 34(7), 1372\u20131382. https:\/\/doi.org\/10.1021\/jasms.3c00057","journal-title":"Journal of the American Society for Mass Spectrometry"},{"key":"2396_CR5","doi-asserted-by":"publisher","first-page":"143759","DOI":"10.1016\/j.foodchem.2025.143759","volume":"479","author":"F Chang","year":"2025","unstructured":"Chang, F., Rowart, P., Salvatore, S. R., Rom, O., Mascal, M., & Schopfer, F. J. (2025). The emerging significance of Furan fatty acids in Food, Nutrition, and potential therapeutic Use1. Food Chemistry, 479, 143759. https:\/\/doi.org\/10.1016\/j.foodchem.2025.143759","journal-title":"Food Chemistry"},{"issue":"3","key":"2396_CR6","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2025.184412","volume":"1867","author":"I Company-Mar\u00edn","year":"2025","unstructured":"Company-Mar\u00edn, I., Gunner, J., Poyner, D., Simms, J., Pitt, A. R., & Spickett, C. M. (2025). The effect of oxidative stress on the adenosine A2A receptor activity and signalling. Biochimica et Biophysica Acta - Biomembranes, 1867(3), Article 184412. https:\/\/doi.org\/10.1016\/j.bbamem.2025.184412","journal-title":"Biochimica et Biophysica Acta - Biomembranes"},{"issue":"1","key":"2396_CR7","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-33225-9","volume":"13","author":"A Criscuolo","year":"2022","unstructured":"Criscuolo, A., Nepachalovich, P., del Garcia- Rio, D. F., Lange, M., Ni, Z., Baroni, M., Cruciani, G., Goracci, L., Bl\u00fcher, M., & Fedorova, M. (2022). Analytical and computational workflow for in-depth analysis of oxidized complex lipids in blood plasma. Nature Communications, 13(1), Article 6547. https:\/\/doi.org\/10.1038\/s41467-022-33225-9","journal-title":"Nature Communications"},{"issue":"1","key":"2396_CR8","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1021\/acs.analchem.2c04406","volume":"95","author":"T Damiani","year":"2023","unstructured":"Damiani, T., Bonciarelli, S., Thallinger, G. G., Koehler, N., Krettler, C. A., Saliho\u011flu, A. K., Korf, A., Pauling, J. K., Pluskal, T., Ni, Z., & Goracci, L. (2023). Software and computational tools for LC-MS-based epilipidomics: Challenges and solutions. Analytical Chemistry, 95(1), 287\u2013303. https:\/\/doi.org\/10.1021\/acs.analchem.2c04406","journal-title":"Analytical Chemistry"},{"issue":"1","key":"2396_CR9","doi-asserted-by":"publisher","DOI":"10.1038\/s41597-024-03034-4","volume":"11","author":"A Elloumi","year":"2024","unstructured":"Elloumi, A., Mas-Normand, L., Bride, J., Reversat, G., Bultel-Ponc\u00e9, V., Guy, A., Oger, C., Demion, M., Le Guennec, J.-Y., Durand, T., Vigor, C., S\u00e1nchez-Illana, \u00c1., & Galano, J.-M. (2024). From MS\/MS library implementation to molecular networks: Exploring oxylipin diversity with NEO-MSMS. Scientific Data, 11(1), Article 193. https:\/\/doi.org\/10.1038\/s41597-024-03034-4","journal-title":"Scientific Data"},{"issue":"2","key":"2396_CR10","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1097\/MOL.0b013e328082e4d5","volume":"18","author":"AZ Fernandis","year":"2007","unstructured":"Fernandis, A. Z., & Wenk, M. R. (2007). Membrane lipids as signaling molecules. Current Opinion in Lipidology, 18(2), 121\u2013128. https:\/\/doi.org\/10.1097\/MOL.0b013e328082e4d5","journal-title":"Current Opinion in Lipidology"},{"issue":"5","key":"2396_CR11","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1021\/jasms.1c00370","volume":"33","author":"HB Ferreira","year":"2022","unstructured":"Ferreira, H. B., Barros, C., Melo, T., Paiva, A., & Domingues, M. R. (2022). Looking in depth at oxidized cholesteryl esters by LC\u2013MS\/MS: Reporting specific fragmentation fingerprints and isomer discrimination. Journal of the American Society for Mass Spectrometry, 33(5), 793\u2013802. https:\/\/doi.org\/10.1021\/jasms.1c00370","journal-title":"Journal of the American Society for Mass Spectrometry"},{"issue":"5","key":"2396_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2025.159621","volume":"1870","author":"IMS Guerra","year":"2025","unstructured":"Guerra, I. M. S., Rocha, H., Moreira, S., Gaspar, A., Ferreira, A. C., Santos, H., Rodrigues, E., Castro-Chaves, P., Melo, T., Goracci, L., Domingues, P., Moreira, A. S. P., & Domingues, M. R. (2025). Lipidome plasticity in medium- and long-chain fatty acid oxidation disorders: Insights from dried blood spot lipidomics. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1870(5), Article 159621. https:\/\/doi.org\/10.1016\/j.bbalip.2025.159621","journal-title":"Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids"},{"issue":"1","key":"2396_CR13","doi-asserted-by":"publisher","first-page":"100484","DOI":"10.1016\/j.jlr.2023.100484","volume":"65","author":"AA Hajeyah","year":"2024","unstructured":"Hajeyah, A. A., Protty, M. B., Paul, D., Costa, D., Omidvar, N., Morgan, B., Iwasaki, Y., McGill, B., Jenkins, P. V., Yousef, Z., Allen-Redpath, K., Soyama, S., Choudhury, A., Mitra, R., Yaqoob, P., Morrissey, J. H., Collins, P. W., & O\u2019Donnell, V. B. (2024). Phosphatidylthreonine is a procoagulant lipid detected in human blood and elevated in coronary artery disease. Journal of Lipid Research, 65(1), 100484. https:\/\/doi.org\/10.1016\/j.jlr.2023.100484","journal-title":"Journal of Lipid Research"},{"key":"2396_CR14","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1016\/j.freeradbiomed.2024.09.018","volume":"224","author":"M Halasz","year":"2024","unstructured":"Halasz, M., \u0141uczaj, W., Jarocka-Karpowicz, I., Stasiewicz, A., Soldo, A. M., Soldo, I., Pajtak, A., Sen\u010dar, M., Grgi\u0107, T., Kolak, T., \u017darkovi\u0107, N., Skrzydlewska, E., & Jaganjac, M. (2024). Relationship between systemic biomarker of lipid peroxidation 4-hydroxynonenal and lipidomic profile of morbidly obese patients undergoing bariatric surgery. Free Radical Biology and Medicine, 224, 564\u2013573. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2024.09.018","journal-title":"Free Radical Biology and Medicine"},{"issue":"1","key":"2396_CR15","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-025-00803-6","volume":"20","author":"S He","year":"2025","unstructured":"He, S., Xu, Z., & Han, X. (2025). Lipidome disruption in Alzheimer\u2019s disease brain: Detection, pathological mechanisms, and therapeutic implications. Molecular Neurodegeneration, 20(1), Article 11. https:\/\/doi.org\/10.1186\/s13024-025-00803-6","journal-title":"Molecular Neurodegeneration"},{"issue":"3","key":"2396_CR16","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1093\/eurheartj\/ehz387","volume":"41","author":"M Hilvo","year":"2020","unstructured":"Hilvo, M., Meikle, P. J., Pedersen, E. R., Tell, G. S., Dhar, I., Brenner, H., Sch\u00f6ttker, B., L\u00e4\u00e4peri, M., Kauhanen, D., Koistinen, K. M., Jylh\u00e4, A., Huynh, K., Mellett, N. A., Tonkin, A. M., Sullivan, D. R., Simes, J., Nestel, P., Koenig, W., Rothenbacher, D., \u2026 Laaksonen, R. (2020). Development and validation of a ceramide- and phospholipid-based cardiovascular risk estimation score for coronary artery disease patients. European Heart Journal, 41(3), 371\u2013380. https:\/\/doi.org\/10.1093\/eurheartj\/ehz387","journal-title":"European Heart Journal"},{"key":"2396_CR17","unstructured":"IPHYS-Bioinformatics\/Burn_your_fat (2025). https:\/\/github.com\/IPHYS-Bioinformatics\/Burn_your_fat (accessed 2025-08-27)."},{"issue":"1","key":"2396_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jlr.2024.100704","volume":"66","author":"P Jokesch","year":"2025","unstructured":"Jokesch, P., Holzer, L., Jantscher, L., Guttzeit, S., \u00dcbelhart, R., Oskolkova, O., Bochkov, V., & Gesslbauer, B. (2025b). Identification of plasma proteins binding oxidized phospholipids using pull-down proteomics and OxLDL masking assay\u2021. Journal of Lipid Research, 66(1), Article 100704. https:\/\/doi.org\/10.1016\/j.jlr.2024.100704","journal-title":"Journal of Lipid Research"},{"issue":"2","key":"2396_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jlr.2025.100742","volume":"66","author":"P Jokesch","year":"2025","unstructured":"Jokesch, P., Oskolkova, O., Fedorova, M., Gesslbauer, B., & Bochkov, V. (2025). Contribution of individual phospholipase A2 enzymes to the cleavage of oxidized phospholipids in human blood plasma. Journal of Lipid Research, 66(2), Article 100742. https:\/\/doi.org\/10.1016\/j.jlr.2025.100742","journal-title":"Journal of Lipid Research"},{"key":"2396_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2024.101290","volume":"96","author":"J Jouhet","year":"2024","unstructured":"Jouhet, J., Alves, E., Boutt\u00e9, Y., Darnet, S., Domergue, F., Durand, T., Fischer, P., Fouillen, L., Grube, M., Joub\u00e8s, J., Kalnenieks, U., Kargul, J. M., Khozin-Goldberg, I., Leblanc, C., Letsiou, S., Lupette, J., Markov, G. V., Medina, I., Melo, T., \u2026 Domingues, R. (2024). Plant and algal lipidomes: Analysis, composition, and their societal significance. Progress in Lipid Research, 96, Article 101290. https:\/\/doi.org\/10.1016\/j.plipres.2024.101290","journal-title":"Progress in Lipid Research"},{"key":"2396_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.arres.2024.100111","volume":"13","author":"B Kose","year":"2024","unstructured":"Kose, B., Erkanl\u0131, S., Ko\u00e7ak, A., Guzel, C., Luider, T., Dias, I. H. K., & Baykal, A. T. (2024). Exploring oxysterols and protein carbonylation in cervicovaginal secretions as biomarkers for cervical cancer development. Advances in Redox Research, 13, Article 100111. https:\/\/doi.org\/10.1016\/j.arres.2024.100111","journal-title":"Advances in Redox Research"},{"issue":"6","key":"2396_CR22","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1093\/eurjpc\/zwab112","volume":"29","author":"A Leiherer","year":"2022","unstructured":"Leiherer, A., M\u00fcndlein, A., Laaksonen, R., L\u00e4\u00e4peri, M., Jylh\u00e4, A., Fraunberger, P., & Drexel, H. (2022). Comparison of recent ceramide-based coronary risk prediction scores in cardiovascular disease patients. European Journal of Preventive Cardiology, 29(6), 947\u2013956. https:\/\/doi.org\/10.1093\/eurjpc\/zwab112","journal-title":"European Journal of Preventive Cardiology"},{"issue":"11","key":"2396_CR23","doi-asserted-by":"publisher","first-page":"100671","DOI":"10.1016\/j.jlr.2024.100671","volume":"65","author":"S Mart\u00ednez","year":"2024","unstructured":"Mart\u00ednez, S., Fern\u00e1ndez-Garc\u00eda, M., Londo\u00f1o-Osorio, S., Barbas, C., & Gradillas, A. (2024). Highly reliable LC-MS lipidomics database for efficient human plasma profiling based on NIST SRM 19501. Journal of Lipid Research, 65(11), 100671. https:\/\/doi.org\/10.1016\/j.jlr.2024.100671","journal-title":"Journal of Lipid Research"},{"key":"2396_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2025.117081","volume":"266","author":"S Mart\u00ednez","year":"2025","unstructured":"Mart\u00ednez, S., Gradillas, A., Cermakova, H., Witting, M., & Barbas, C. (2025). Determining carbon-carbon double bond position of unsaturated glycerophospholipids in human plasma NIST\u00ae SRM\u00ae 1950 by electron impact excitation of ions from organics-tandem mass spectrometry (EIEIO-MS\/MS). Journal of Pharmaceutical and Biomedical Analysis, 266, Article 117081. https:\/\/doi.org\/10.1016\/j.jpba.2025.117081","journal-title":"Journal of Pharmaceutical and Biomedical Analysis"},{"issue":"12","key":"2396_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jlr.2024.100676","volume":"65","author":"MA Mateo-Mar\u00edn","year":"2024","unstructured":"Mateo-Mar\u00edn, M. A., & Alves-Bezerra, M. (2024). Targeting acetyl-CoA carboxylases for the treatment of MASLD. Journal of Lipid Research, 65(12), Article 100676. https:\/\/doi.org\/10.1016\/j.jlr.2024.100676","journal-title":"Journal of Lipid Research"},{"key":"2396_CR26","doi-asserted-by":"publisher","DOI":"10.3389\/feduc.2024.1485234","author":"D Milonaityt\u0117","year":"2024","unstructured":"Milonaityt\u0117, D., & Kuda, O. (2024). Burn your fat\u2014a unique DIY board game about triacylglycerol breakdown. Frontiers in Education. https:\/\/doi.org\/10.3389\/feduc.2024.1485234","journal-title":"Frontiers in Education"},{"issue":"1","key":"2396_CR27","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1111\/cod.14804","volume":"93","author":"AI Moore","year":"2025","unstructured":"Moore, A. I., Moreira, A. S. P., Conde, T., Melo, T., Domingues, P., O\u2019Boyle, N. M., & Domingues, M. R. (2025a). Terpene hydroperoxides as lipid peroxidation inducers: Biomimetic and HaCaT cell studies in allergic contact dermatitis. Contact Dermatitis, 93(1), 16\u201330. https:\/\/doi.org\/10.1111\/cod.14804","journal-title":"Contact Dermatitis"},{"issue":"3","key":"2396_CR28","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1111\/cod.14711","volume":"92","author":"AI Moore","year":"2025","unstructured":"Moore, A. I., Moreira, A. S. P., Guerra, I. M. S., Goracci, L., Domingues, P., Melo, T., Domingues, M. R., & O\u2019Boyle, N. M. (2025b). A lipidomic approach towards identifying the effects of fragrance hydroperoxides on keratinocytes. Contact Dermatitis, 92(3), 176\u2013186. https:\/\/doi.org\/10.1111\/cod.14711","journal-title":"Contact Dermatitis"},{"key":"2396_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2022.101176","volume":"87","author":"B Neves","year":"2022","unstructured":"Neves, B., P\u00e9rez-Sala, D., Ferreira, H. B., Guerra, I. M. S., Moreira, A. S. P., Domingues, P., Domingues, M. R., & Melo, T. (2022). Understanding the nitrolipidome: From chemistry to mass spectrometry and biological significance of modified complex lipids. Progress in Lipid Research, 87, Article 101176. https:\/\/doi.org\/10.1016\/j.plipres.2022.101176","journal-title":"Progress in Lipid Research"},{"key":"2396_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2025.118368","volume":"191","author":"AH Nguyen","year":"2025","unstructured":"Nguyen, A. H., Beyene, H. B., Mocciaro, G., Hahnefeld, L., Lamichhane, S., Fabritius, M., Avela, H., Wang, Y., Dickens, A. M., Gurke, R., Yang, B., Griffiths, W. J., Hy\u00f6tyl\u00e4inen, T., Meikle, P. J., & Ore\u0161i\u010d, M. (2025). Intra- and inter-individual variation of the human lipidome. TrAC - Trends in Analytical Chemistry, 191, Article 118368. https:\/\/doi.org\/10.1016\/j.trac.2025.118368","journal-title":"TrAC - Trends in Analytical Chemistry"},{"issue":"2","key":"2396_CR31","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1038\/s41592-022-01710-0","volume":"20","author":"Z Ni","year":"2023","unstructured":"Ni, Z., W\u00f6lk, M., Jukes, G., Mendivelso Espinosa, K., Ahrends, R., Aimo, L., Alvarez-Jarreta, J., Andrews, S., Andrews, R., Bridge, A., Clair, G. C., Conroy, M. J., Fahy, E., Gaud, C., Goracci, L., Hartler, J., Hoffmann, N., Kopczyinki, D., Korf, A., Lopez-Clavijo, A. F., Malik, A., Ackerman, J. M., Molenaar, M. R., O\u2019Donovan, C., Pluskal, T., Shevchenko, A., Slenter, D., Siuzdak, G., Kutmon, M., Tsugawa, H., Willighagen, E. L., Xia, J., O\u2019Donnell, V. B., & Fedorova, M. (2023). Guiding the choice of informatics software and tools for lipidomics research applications. Nature Methods, 20(2), 193\u2013204. https:\/\/doi.org\/10.1038\/s41592-022-01710-0","journal-title":"Nature Methods"},{"issue":"7","key":"2396_CR32","doi-asserted-by":"publisher","first-page":"2670","DOI":"10.1172\/JCI97944","volume":"128","author":"VB O\u2019Donnell","year":"2018","unstructured":"O\u2019Donnell, V. B., Rossjohn, J., & Wakelam, M. J. O. (2018). Phospholipid signaling in innate immune cells. Journal of Clinical Investigation, 128(7), 2670\u20132679. https:\/\/doi.org\/10.1172\/JCI97944","journal-title":"Journal of Clinical Investigation"},{"key":"2396_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2024.101276","volume":"95","author":"K Parchem","year":"2024","unstructured":"Parchem, K., Letsiou, S., Petan, T., Oskolkova, O., Medina, I., Kuda, O., O\u2019Donnell, V. B., Nicolaou, A., Fedorova, M., Bochkov, V., & Gladine, C. (2024). Oxylipin profiling for clinical research: Current status and future perspectives. Progress in Lipid Research, 95, Article 101276. https:\/\/doi.org\/10.1016\/j.plipres.2024.101276","journal-title":"Progress in Lipid Research"},{"issue":"7","key":"2396_CR34","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a041417","volume":"16","author":"S Penkov","year":"2024","unstructured":"Penkov, S., & Fedorova, M. (2024). Membrane epilipidome-lipid modifications, their dynamics, and functional significance. Cold Spring Harbor Perspectives in Biology, 16(7), Article a041417. https:\/\/doi.org\/10.1101\/cshperspect.a041417","journal-title":"Cold Spring Harbor Perspectives in Biology"},{"issue":"20","key":"2396_CR35","doi-asserted-by":"publisher","DOI":"10.3390\/nu16203466","volume":"16","author":"S Petrovic","year":"2024","unstructured":"Petrovic, S., Mouskeftara, T., Paunovic, M., Deda, O., Vucic, V., Milosevic, M., & Gika, H. (2024). Unveiling lipidomic alterations in metabolic syndrome: A study of plasma, liver, and adipose tissues in a dietary-induced rat model. Nutrients, 16(20), Article 3466. https:\/\/doi.org\/10.3390\/nu16203466","journal-title":"Nutrients"},{"issue":"2","key":"2396_CR36","doi-asserted-by":"publisher","DOI":"10.1016\/j.jlr.2024.100739","volume":"66","author":"N Puig","year":"2025","unstructured":"Puig, N., Camps-Renom, P., Hermansson, M., Aguilera-Sim\u00f3n, A., Mar\u00edn, R., Bautista, O., Rotllan, N., Blanco-Sanroman, N., Domine, M. C., \u00d6\u00f6rni, K., S\u00e1nchez-Quesada, J. L., & Benitez, S. (2025). Alterations in LDL and HDL after an ischemic stroke associated with carotid atherosclerosis are reversed after 1 year\u2021. Journal of Lipid Research, 66(2), Article 100739. https:\/\/doi.org\/10.1016\/j.jlr.2024.100739","journal-title":"Journal of Lipid Research"},{"issue":"4","key":"2396_CR37","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1042\/EBC20230090","volume":"68","author":"A Reis","year":"2024","unstructured":"Reis, A., & Dias, H. K. (2024). Oxysterol sulfates in fluids, cells and tissues: How much do we know about their clinical significance, biological relevance and biophysical implications? Essays in Biochemistry, 68(4), 401\u2013410. https:\/\/doi.org\/10.1042\/EBC20230090","journal-title":"Essays in Biochemistry"},{"issue":"887","key":"2396_CR38","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.adw1245","volume":"18","author":"NH Schebb","year":"2025","unstructured":"Schebb, N. H., Kampschulte, N., Hagn, G., Plitzko, K., Meckelmann, S. W., Ghosh, S., Joshi, R., Kuligowski, J., Vuckovic, D., Botana, M. T., S\u00e1nchez-Illana, \u00c1., Zandkarimi, F., Das, A., Yang, J., Schmidt, L., Checa, A., Roche, H. M., Armando, A. M., Edin, M. L., \u2026 O\u2019Donnell, V. B. (2025). Technical recommendations for analyzing oxylipins by liquid chromatography-mass spectrometry. Science Signaling, 18(887), Article eadw1245. https:\/\/doi.org\/10.1126\/scisignal.adw1245","journal-title":"Science Signaling"},{"key":"2396_CR39","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1016\/j.freeradbiomed.2025.07.016","volume":"238","author":"CM Spickett","year":"2025","unstructured":"Spickett, C. M., Domingues, M. R., & Fedorova, M. (2025a). EpiLipidNET virtual special issue on analysis and biological importance of lipids and modified lipids. Free Radical Biology and Medicine, 238, 669\u2013672. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2025.07.016","journal-title":"Free Radical Biology and Medicine"},{"key":"2396_CR40","doi-asserted-by":"publisher","unstructured":"Spickett, C., Ruskovska, T., Tortorella, S., Domingues, M. R., Bartoszek, A., & Vvedenskaya, O. (2025b). Lipodrome: A Board Game as an Educational Tool to Improve Understanding of Lipids.\u00a0https:\/\/doi.org\/10.17632\/f6hk39ztkd.1","DOI":"10.17632\/f6hk39ztkd.1"},{"issue":"1","key":"2396_CR41","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1161\/ATVBAHA.121.316847","volume":"42","author":"SH Tan","year":"2022","unstructured":"Tan, S. H., Koh, H. W. L., Chua, J. Y., Burla, B., Ong, C. C., Teo, L. S. L., Yang, X., Benke, P. I., Choi, H., Torta, F., Richards, A. M., Wenk, M. R., & Chan, M. Y. (2022). Variability of the plasma lipidome and subclinical coronary atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology, 42(1), 100\u2013112. https:\/\/doi.org\/10.1161\/ATVBAHA.121.316847","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"issue":"12","key":"2396_CR42","doi-asserted-by":"publisher","DOI":"10.1016\/j.jlr.2024.100688","volume":"65","author":"I Ten-Dom\u00e9nech","year":"2024","unstructured":"Ten-Dom\u00e9nech, I., Moreno-Gim\u00e9nez, A., Campos-Berga, L., de Zapata Miguel, C., L\u00f3pez-Nogueroles, M., Parra-Llorca, A., Quint\u00e1s, G., Garc\u00eda-Blanco, A., Gormaz, M., & Kuligowski, J. (2024). Impact of maternal health and stress on steroid hormone profiles in human milk: Implications for infant development\u2021. Journal of Lipid Research, 65(12), Article 100688. https:\/\/doi.org\/10.1016\/j.jlr.2024.100688","journal-title":"Journal of Lipid Research"},{"issue":"6","key":"2396_CR43","doi-asserted-by":"publisher","first-page":"4302","DOI":"10.1111\/1541-4337.13225","volume":"22","author":"Z Tietel","year":"2023","unstructured":"Tietel, Z., Hammann, S., Meckelmann, S. W., Ziv, C., Pauling, J. K., W\u00f6lk, M., W\u00fcrf, V., Alves, E., Neves, B., & Domingues, M. R. (2023). An overview of food lipids toward food lipidomics. Comprehensive Reviews in Food Science and Food Safety, 22(6), 4302\u20134354. https:\/\/doi.org\/10.1111\/1541-4337.13225","journal-title":"Comprehensive Reviews in Food Science and Food Safety"},{"key":"2396_CR44","doi-asserted-by":"publisher","unstructured":"Tortorella, S., Ruskovska, T., Spickett, C., Vvedenskaya, O., Bartoszek, A., & Domingues, M. R. (2025). Know Your Fats! A Card Memory Game as an Educational Tool to Improve Understanding of Lipids. https:\/\/doi.org\/10.17632\/42twmxm275.1","DOI":"10.17632\/42twmxm275.1"},{"key":"2396_CR45","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2025.101341","volume":"99","author":"MI Tsap","year":"2025","unstructured":"Tsap, M. I., & Shcherbata, H. R. (2025). The balancing act between lipid droplets and lysosomes for membrane functionality in age-related neurodegeneration and inflammation. Progress in Lipid Research, 99, Article 101341. https:\/\/doi.org\/10.1016\/j.plipres.2025.101341","journal-title":"Progress in Lipid Research"},{"issue":"7","key":"2396_CR46","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2024.184335","volume":"1866","author":"PAMM Varandas","year":"2024","unstructured":"Varandas, P. A. M. M., Belinha, R., Cobb, A. J. A., Prates Ramalho, J. P., Segundo, M. A., Loura, L. M. S., & Silva, E. M. P. (2024). Flow-based bioconjugation of coumarin phosphatidylethanolamine probes: Optimised synthesis and membrane molecular dynamics studies. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1866(7), Article 184335. https:\/\/doi.org\/10.1016\/j.bbamem.2024.184335","journal-title":"Biochimica et Biophysica Acta (BBA) - Biomembranes"},{"issue":"12","key":"2396_CR47","doi-asserted-by":"publisher","first-page":"2146","DOI":"10.1007\/s00125-022-05741-2","volume":"65","author":"J Wang","year":"2022","unstructured":"Wang, J., Liu, J.-J., Gurung, R. L., Liu, S., Lee, J., M, Y., Ang, K., Shao, Y. M., Tang, J.-S., Benke, P. I., Torta, F., Wenk, M. R., Tavintharan, S., Tang, W. E., Sum, C. F., & Lim, S. C. (2022). Clinical variable-based cluster analysis identifies novel subgroups with a distinct genetic signature, lipidomic pattern and cardio-renal risks in Asian patients with recent-onset type 2 diabetes. Diabetologia, 65(12), 2146\u20132156. https:\/\/doi.org\/10.1007\/s00125-022-05741-2","journal-title":"Diabetologia"},{"issue":"1","key":"2396_CR48","doi-asserted-by":"publisher","DOI":"10.1007\/s11306-023-02075-x","volume":"20","author":"M Witting","year":"2024","unstructured":"Witting, M., Malik, A., Leach, A., Bridge, A., Aimo, L., Conroy, M. J., O\u2019Donnell, V. B., Hoffmann, N., Kopczynski, D., Giacomoni, F., Paulhe, N., Gassiot, A. C., Poupin, N., Jourdan, F., & Bertrand-Michel, J. (2024). Challenges and perspectives for naming lipids in the context of lipidomics. Metabolomics, 20(1), Article 15. https:\/\/doi.org\/10.1007\/s11306-023-02075-x","journal-title":"Metabolomics"},{"key":"2396_CR49","doi-asserted-by":"publisher","DOI":"10.1016\/j.trac.2019.04.012","volume":"120","author":"D Wolrab","year":"2019","unstructured":"Wolrab, D., Jir\u00e1sko, R., Chocholou\u0161kov\u00e1, M., Peterka, O., & Hol\u010dapek, M. (2019). Oncolipidomics: Mass spectrometric quantitation of lipids in cancer research. TrAC - Trends in Analytical Chemistry, 120, Article 115480. https:\/\/doi.org\/10.1016\/j.trac.2019.04.012","journal-title":"TrAC - Trends in Analytical Chemistry"},{"issue":"1","key":"2396_CR50","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27765-9","volume":"13","author":"D Wolrab","year":"2022","unstructured":"Wolrab, D., Jir\u00e1sko, R., C\u00edfkov\u00e1, E., H\u00f6ring, M., Mei, D., Chocholou\u0161kov\u00e1, M., Peterka, O., Idkowiak, J., Hrn\u010diarov\u00e1, T., Kucha\u0159, L., Ahrends, R., Brumarov\u00e1, R., Friedeck\u00fd, D., Vivo-Truyols, G., \u0160krha, P., \u0160krha, J., Ku\u010dera, R., Melichar, B., Liebisch, G., \u2026 Hol\u010dapek, M. (2022). Lipidomic profiling of human serum enables detection of pancreatic cancer. Nature Communications, 13(1), Article 124. https:\/\/doi.org\/10.1038\/s41467-021-27765-9","journal-title":"Nature Communications"},{"issue":"11","key":"2396_CR51","doi-asserted-by":"publisher","first-page":"2691","DOI":"10.1253\/circj.CJ-18-0052","volume":"82","author":"K Yamamoto","year":"2018","unstructured":"Yamamoto, K., & Ando, J. (2018). Emerging role of plasma membranes in vascular endothelial mechanosensing. Circulation Journal\u202f: Official Journal of the Japanese Circulation Society, 82(11), 2691\u20132698. https:\/\/doi.org\/10.1253\/circj.CJ-18-0052","journal-title":"Circulation Journal : Official Journal of the Japanese Circulation Society"},{"key":"2396_CR52","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2024.141223","volume":"463","author":"A Zartmann","year":"2025","unstructured":"Zartmann, A., Galano, J.-M., & Hammann, S. (2025). Analysis of glycerol bound \u03c9-oxo-fatty acids as \u03c9-dioxane-FAME-derivatives. Food Chemistry, 463, Article 141223. https:\/\/doi.org\/10.1016\/j.foodchem.2024.141223","journal-title":"Food Chemistry"},{"issue":"5","key":"2396_CR53","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2025.189416","volume":"1880","author":"D Zhao","year":"2025","unstructured":"Zhao, D., Wu, L., & Li, Y. (2025). Targeting lipid metabolism to enhance cancer immunotherapy. Biochimica et Biophysica Acta. Reviews on Cancer, 1880(5), Article 189416. https:\/\/doi.org\/10.1016\/j.bbcan.2025.189416","journal-title":"Biochimica et Biophysica Acta. Reviews on Cancer"}],"container-title":["Metabolomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11306-026-02396-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11306-026-02396-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11306-026-02396-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T18:11:08Z","timestamp":1773252668000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11306-026-02396-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,11]]},"references-count":53,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,4]]}},"alternative-id":["2396"],"URL":"https:\/\/doi.org\/10.1007\/s11306-026-02396-7","relation":{},"ISSN":["1573-3890"],"issn-type":[{"value":"1573-3890","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,11]]},"assertion":[{"value":"13 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 March 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"42"}}