{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:25:47Z","timestamp":1760984747767},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2012,11,21]],"date-time":"2012-11-21T00:00:00Z","timestamp":1353456000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol Imaging Biol"],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.1007\/s11307-012-0603-x","type":"journal-article","created":{"date-parts":[[2012,12,11]],"date-time":"2012-12-11T19:26:50Z","timestamp":1355254010000},"page":"307-315","source":"Crossref","is-referenced-by-count":16,"title":["MRI Tracking of Macrophages Labeled with Glucan Particles Entrapping a Water Insoluble Paramagnetic Gd-Based Agent"],"prefix":"10.1007","volume":"15","author":[{"given":"Sara","family":"Figueiredo","sequence":"first","affiliation":[]},{"given":"Juan Carlos","family":"Cutrin","sequence":"additional","affiliation":[]},{"given":"Silvia","family":"Rizzitelli","sequence":"additional","affiliation":[]},{"given":"Elisa","family":"De Luca","sequence":"additional","affiliation":[]},{"given":"Jo\u00e3o Nuno","family":"Moreira","sequence":"additional","affiliation":[]},{"given":"Carlos F. G. C.","family":"Geraldes","sequence":"additional","affiliation":[]},{"given":"Silvio","family":"Aime","sequence":"additional","affiliation":[]},{"given":"Enzo","family":"Terreno","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2012,11,21]]},"reference":[{"key":"603_CR1","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1021\/nl0624263","volume":"7","author":"CW Lu","year":"2007","unstructured":"Lu CW, Hung Y, Hsiao JK et al (2007) Bifunctional magnetic silica nanoparticles for highly efficient human stem cell labeling. Nano Lett 7:149\u2013154","journal-title":"Nano Lett"},{"key":"603_CR2","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1016\/j.neuroimage.2006.04.219","volume":"32","author":"EM Shapiro","year":"2006","unstructured":"Shapiro EM, Gonzalez-Perez O, Manuel Garcia-Verdugo J et al (2006) Magnetic resonance imaging of the migration of neuronal precursors generated in the adult rodent brain. NeuroImage 32:1150\u20131157","journal-title":"NeuroImage"},{"key":"603_CR3","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1182\/blood-2004-02-0655","volume":"104","author":"AS Arbab","year":"2004","unstructured":"Arbab AS, Yocum GT, Kalish H et al (2004) Efficient magnetic cell labeling with protamine sulfate complexed to ferumoxides for cellular MRI. Blood 104:1217\u20131223","journal-title":"Blood"},{"key":"603_CR4","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1002\/mrm.22843","volume":"65","author":"KS Tang","year":"2011","unstructured":"Tang KS, Shapiro EM (2011) Enhanced magnetic cell labeling efficiency using \u2013NH2 coated MPIOs. Magn Reson Med 65:1564\u20131569","journal-title":"Magn Reson Med"},{"key":"603_CR5","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1097\/01.rli.0000246147.44835.4c","volume":"41","author":"FL Giesel","year":"2006","unstructured":"Giesel FL, Stroick M, Griebe M et al (2006) Gadofluorine uptake in stem cells as a new magnetic resonance imaging tracking method: an in vitro and in vivo study. Invest Radiol 41:868\u2013873","journal-title":"Invest Radiol"},{"key":"603_CR6","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1002\/mrm.20072","volume":"51","author":"S Geninatti Crich","year":"2004","unstructured":"Geninatti Crich S, Biancone L, Cantaluppi V et al (2004) Improved route for the visualization of stem cells labeled with a Gd-\/Eu-chelate as dual (MRI and fluorescence) agent. Magn Reson Med 51:938\u2013944","journal-title":"Magn Reson Med"},{"key":"603_CR7","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/nbm.1088","volume":"20","author":"L Biancone","year":"2007","unstructured":"Biancone L, Geninatti Crich S, Cantaluppi V et al (2007) Magnetic resonance imaging of gadolinium-labeled pancreatic islets for experimental transplantation. NMR Biomed 20:40\u201348","journal-title":"NMR Biomed"},{"key":"603_CR8","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1021\/mp2001044","volume":"8","author":"V Menchise","year":"2011","unstructured":"Menchise V, Digilio G, Gianolio E et al (2011) In vivo labeling of B16 melanoma tumor xenograft with a thiol-reactive gadolinium based MRI contrast agent. Mol Pharm 8:1750\u20131756","journal-title":"Mol Pharm"},{"key":"603_CR9","first-page":"3233","volume":"6","author":"A Hedlund","year":"2011","unstructured":"Hedlund A, Ahr\u00e9n M, Gustafsson H et al (2011) Gd2O3 nanoparticles in hematopoietic cells for MRI contrast enhancement. Int J Nanomedicine 6:3233\u20133240","journal-title":"Int J Nanomedicine"},{"key":"603_CR10","doi-asserted-by":"crossref","first-page":"191","DOI":"10.3727\/096368911X593118","volume":"21","author":"J Guenoun","year":"2012","unstructured":"Guenoun J, Koning GA, Doeswijk G et al (2012) Cationic Gd-DTPA liposomes for highly efficient labeling of mesenchymal stem cells and cell tracking with MRI. Cell Transplant 21:191\u2013205","journal-title":"Cell Transplant"},{"key":"603_CR11","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1002\/nbm.1699","volume":"24","author":"EJ Ribot","year":"2011","unstructured":"Ribot EJ, Miraux S, Konsman JP et al (2011) In vivo MR tracking of therapeutic microglia to a human glioma model. NMR Biomed 24:1361\u20131368","journal-title":"NMR Biomed"},{"key":"603_CR12","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/cmmi.389","volume":"5","author":"Y Tachibana","year":"2010","unstructured":"Tachibana Y, Enmi J, Mahara A et al (2010) Design and characterization of a polymeric MRI contrast agent based on PVA for in vivo living-cell tracking. Contrast Media Mol Imaging 5:309\u2013317","journal-title":"Contrast Media Mol Imaging"},{"key":"603_CR13","doi-asserted-by":"crossref","first-page":"9482","DOI":"10.1016\/j.biomaterials.2010.08.034","volume":"31","author":"LA Tran","year":"2010","unstructured":"Tran LA, Krishnamurthy R, Muthupillai R et al (2010) Gadonanotubes as magnetic nanolabels for stem cell detection. Biomaterials 31:9482\u20139491","journal-title":"Biomaterials"},{"key":"603_CR14","doi-asserted-by":"crossref","first-page":"5427","DOI":"10.1016\/j.biomaterials.2010.03.049","volume":"31","author":"CL Tseng","year":"2010","unstructured":"Tseng CL, Shih IL, Stobinski L, Lin FH (2010) Gadolinium hexanedione nanoparticles for stem cell labeling and tracking via magnetic resonance imaging. Biomaterials 31:5427\u20135435","journal-title":"Biomaterials"},{"key":"603_CR15","doi-asserted-by":"crossref","first-page":"5717","DOI":"10.1166\/jnn.2009.1237","volume":"9","author":"J Fizet","year":"2009","unstructured":"Fizet J, Rivi\u00e8re C, Bridot JL et al (2009) Multi-luminescent hybrid gadolinium oxide nanoparticles as potential cell labeling. J Nanosci Nanotechnol 9:5717\u20135725","journal-title":"J Nanosci Nanotechnol"},{"key":"603_CR16","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1002\/mrm.21503","volume":"59","author":"IS Nolte","year":"2008","unstructured":"Nolte IS, Gungor S, Erber R et al (2008) In vitro labeling of glioma cells with gadofluorine M enhances T1 visibility without affecting glioma cell growth or motility. Magn Reson Med 59:1014\u20131020","journal-title":"Magn Reson Med"},{"key":"603_CR17","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.cbpa.2009.10.003","volume":"14","author":"EJ New","year":"2010","unstructured":"New EJ, Parker D, Smith DG, Walton JW (2010) Development of responsive lanthanide probes for cellular applications. Cur Opinion Chem Biol 14:238\u2013246","journal-title":"Cur Opinion Chem Biol"},{"key":"603_CR18","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1002\/nbm.924","volume":"17","author":"JW Bulte","year":"2004","unstructured":"Bulte JW, Kraitchman DL (2004) Iron oxide MR contrast agents for molecular and cellular imaging. NMR Biomed 17:484\u2013499","journal-title":"NMR Biomed"},{"key":"603_CR19","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1038\/nbt1121","volume":"23","author":"ET Ahrens","year":"2005","unstructured":"Ahrens ET, Flores R, Xu H, Morel PA (2005) In vivo imaging platform for tracking immunotherapeutic cells. Nat Biotechnol 23:983\u2013987","journal-title":"Nat Biotechnol"},{"key":"603_CR20","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1007\/s00259-010-1687-7","volume":"38","author":"L Ottobrini","year":"2011","unstructured":"Ottobrini L, Martelli C, Trabattoni DL et al (2011) In vivo imaging of immune cell trafficking in cancer. Eur J Nucl Med Mol Imaging 38:949\u2013968","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"603_CR21","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1038\/nature07774","volume":"458","author":"M Aouadi","year":"2009","unstructured":"Aouadi M, Tesz GJ, Nicoloro SM et al (2009) Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation. Nature 458:1180\u20131184","journal-title":"Nature"},{"key":"603_CR22","doi-asserted-by":"crossref","unstructured":"Soto ER, Caras AC, Kut LC, et al. (2012) Glucan particles for macrophage targeted delivery of nanoparticles. J Drug Deliv (in press)","DOI":"10.1155\/2012\/143524"},{"key":"603_CR23","doi-asserted-by":"crossref","first-page":"681","DOI":"10.3390\/polym2040681","volume":"2","author":"E Soto","year":"2010","unstructured":"Soto E, Kim YS, Lee J et al (2010) Glucan particle encapsulated rifampicin for targeted delivery to macrophages. Polymers 2:681\u2013689","journal-title":"Polymers"},{"key":"603_CR24","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1021\/bc700329p","volume":"19","author":"ER Soto","year":"2008","unstructured":"Soto ER, Ostroff GR (2008) Characterization of multilayered nanoparticles inside yeast cell wall particles for DNA delivery. Bioconjugate Chem 19:840\u2013848","journal-title":"Bioconjugate Chem"},{"key":"603_CR25","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1042\/BJ20110352","volume":"436","author":"GJ Tesz","year":"2011","unstructured":"Tesz GJ, Aouadi M, Prot M et al (2011) Glucan particles for selective delivery of siRNA to phagocytic cells in mice. Biochem J 436:351\u2013362","journal-title":"Biochem J"},{"key":"603_CR26","first-page":"82","volume-title":"Biology and chemistry of beta glucan (volume 1): beta glucans-mechanisms of action","author":"E Soto","year":"2011","unstructured":"Soto E, Ostroff G (2011) Use of beta-1,3-d-glucans for drug delivery applications. In: Vetvicka V, Novak M (eds) Biology and chemistry of beta glucan (volume 1): beta glucans-mechanisms of action. Bentham Press, Oak Park, p 82"},{"key":"603_CR27","doi-asserted-by":"crossref","first-page":"10635","DOI":"10.1039\/c1cc14019a","volume":"47","author":"S Figueiredo","year":"2011","unstructured":"Figueiredo S, Moreira JN, Geraldes CF et al (2011) Yeast cell wall particles: a promising class of nature-inspired microcarriers for multimodal imaging. Chem Commun 47:10635\u201310637","journal-title":"Chem Commun"},{"key":"603_CR28","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/35092620","volume":"413","author":"GD Brown","year":"2001","unstructured":"Brown GD, Gordon S (2001) Immune recognition: a new receptor for \u03b2-glucans. Nature 413:36\u201337","journal-title":"Nature"},{"key":"603_CR29","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1756-8722-2-25","volume":"2","author":"GC Chan","year":"2009","unstructured":"Chan GC, Chan WK, Sze DM (2009) The effects of beta-glucan on human immune and cancer cells. J Hematol Oncol 2:25\u201335","journal-title":"J Hematol Oncol"},{"key":"603_CR30","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1128\/IAI.00086-09","volume":"77","author":"H Huang","year":"2009","unstructured":"Huang H, Ostroff GR, Lee CK et al (2009) Distinct patterns of dendritic cell cytokine release stimulated by fungal beta-glucans and toll-like receptor agonists. Infect Immun 77:1774\u20131781","journal-title":"Infect Immun"},{"key":"603_CR31","doi-asserted-by":"crossref","first-page":"312","DOI":"10.4049\/jimmunol.1200603","volume":"189","author":"H Huang","year":"2012","unstructured":"Huang H, Ostroff GR, Lee CK et al (2012) Relative contributions of Dectin-1 and complement to immune responses to particulate \u03b2-glucans. J Immunol 189:312\u2013317","journal-title":"J Immunol"},{"key":"603_CR32","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/j.carbpol.2011.08.091","volume":"87","author":"H Vu-Quang","year":"2012","unstructured":"Vu-Quang H, Muthiah M, Lee HJ et al (2012) Immune cell-specific delivery of beta-glucan-coated iron oxide nanoparticles for diagnosing liver metastasis by MR imaging. Carbohydr Polym 87:1159\u20131168","journal-title":"Carbohydr Polym"},{"key":"603_CR33","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1007\/BF02668092","volume":"12","author":"PL Anelli","year":"2001","unstructured":"Anelli PL, Lattuada L, Lorusso V et al (2001) Mixed micelles containing lipophilic gadolinium complexes as MRA contrast agents. Magn Reson Mater Phys Biol Med 12:114\u2013120","journal-title":"Magn Reson Mater Phys Biol Med"},{"key":"603_CR34","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1002\/mrm.22586","volume":"65","author":"E Gianolio","year":"2011","unstructured":"Gianolio E, Arena F, Strijkers GJ et al (2011) Photochemical activation of endosomal escape of MRI-Gd-agents in tumor cells. Magn Reson Med 65:212\u2013219","journal-title":"Magn Reson Med"},{"key":"603_CR35","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.jhep.2009.09.008","volume":"51","author":"M Domenicali","year":"2009","unstructured":"Domenicali M, Caraceni P, Giannone F et al (2009) A novel model of CCl4-induced cirrhosis with ascites in the mouse. J Hepatol 51:991\u2013999","journal-title":"J Hepatol"},{"key":"603_CR36","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1136\/jcp.2008.058248","volume":"62","author":"R Ramachandran","year":"2009","unstructured":"Ramachandran R, Kakar S (2009) Histological patterns in drug-induced liver disease. J Clin Pathol 62:481\u2013492","journal-title":"J Clin Pathol"},{"key":"603_CR37","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1515\/bchm3.1986.367.2.681","volume":"367","author":"A Becker","year":"1986","unstructured":"Becker A, Neumeier R, Heidrich C et al (1986) Cell surface glycoproteins of hepatocytes and hepatoma cells identified by monoclonal antibodies. Biol Chem Hoppe-Seyler 367:681\u2013688","journal-title":"Biol Chem Hoppe-Seyler"},{"key":"603_CR38","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1042\/bj20031253","volume":"377","author":"J Rejman","year":"2004","unstructured":"Rejman J, Oberle V, Zuhorn IS, Hoekstra D (2004) Size-dependent internalization of particles via the pathways of clathrin- and caveolae-mediated endocytosis. Biochem J 377:159\u2013169","journal-title":"Biochem J"},{"key":"603_CR39","doi-asserted-by":"crossref","first-page":"3019","DOI":"10.1021\/cr100025t","volume":"110","author":"E Terreno","year":"2010","unstructured":"Terreno E, Delli Castelli D, Viale A, Aime S (2010) Challenges for molecular magnetic resonance imaging. Chem Rev 110:3019\u20133042","journal-title":"Chem Rev"},{"key":"603_CR40","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1002\/mrm.20793","volume":"55","author":"E Terreno","year":"2006","unstructured":"Terreno E, Geninatti Crich S, Belfiore S et al (2006) Effect of the intracellular localization of a Gd-based imaging probe on the relaxation enhancement of water protons. Magn Reson Med 55:491\u2013497","journal-title":"Magn Reson Med"},{"key":"603_CR41","first-page":"e00164","volume":"2","author":"H Huang","year":"2011","unstructured":"Huang H, Ostroff GR, Lee CK et al (2011) Robust stimulation of humoral and cellular immune responses following vaccination with antigen-loaded \u03b2-glucan particles. MBio 2:e00164\u201310","journal-title":"MBio"},{"key":"603_CR42","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1111\/j.1600-0854.2012.01382.x","volume":"13","author":"HS Goodridge","year":"2012","unstructured":"Goodridge HS, Underhill DM, Touret N (2012) Mechanisms of Fc receptor and Dectin-1 activation for phagocytosis. Traffic 13:1062\u20131071","journal-title":"Traffic"},{"key":"603_CR43","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/j.1600-0854.2006.00525.x","volume":"8","author":"B Schneider","year":"2007","unstructured":"Schneider B, Schueller C, Utermoehlen O, Haas A (2007) Lipid microdomain-dependent macropinocytosis determines compartmentation of Afipia felis. Traffic 8:226\u2013240","journal-title":"Traffic"},{"key":"603_CR44","doi-asserted-by":"crossref","unstructured":"Scherbart AM, Langer J, Bushmelev A et al (2011) Contrasting macrophage activation by fine and ultrafine titanium dioxide particles is associated with different uptake mechanisms. Part Fibre Toxicol 8, art.31","DOI":"10.1186\/1743-8977-8-31"},{"key":"603_CR45","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1038\/icb.2011.20","volume":"89","author":"JP Lim","year":"2011","unstructured":"Lim JP, Gleeson PA (2011) Macropinocytosis: an endocytic pathway for internalising large gulps. Immunol Cell Biol 89:836\u2013843","journal-title":"Immunol Cell Biol"},{"key":"603_CR46","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.1021\/bm1007103","volume":"11","author":"LP Fernando","year":"2010","unstructured":"Fernando LP, Kandel PK, Yu J et al (2010) Mechanism of cellular uptake of highly fluorescent conjugated polymer nanoparticles. Biomacromolecules 11:2675\u20132682","journal-title":"Biomacromolecules"},{"key":"603_CR47","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/hep.22950","volume":"50","author":"KR Karlmark","year":"2009","unstructured":"Karlmark KR, Weiskirchen R, Zimmermann HW et al (2009) Hepatic recruitment of the inflammatory Gr1+ monocyte subset upon liver injury promotes hepatic fibrosis. Hepatology 50:261\u2013274","journal-title":"Hepatology"},{"key":"603_CR48","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1124\/jpet.108.137992","volume":"326","author":"T Tajima","year":"2008","unstructured":"Tajima T, Murata T, Aritake K et al (2008) Lipopolysaccharide induces macrophage migration via prostaglandin D(2) and prostaglandin E(2). J Pharmacol Exp Ther 326:493\u2013501","journal-title":"J Pharmacol Exp Ther"},{"key":"603_CR49","doi-asserted-by":"crossref","first-page":"4038","DOI":"10.1182\/blood-2004-03-1140","volume":"104","author":"J Herre","year":"2004","unstructured":"Herre J, Marshall AS, Caron E et al (2004) Dectin-1 uses novel mechanisms for yeast phagocytosis in macrophages. Blood 104:4038\u20134045","journal-title":"Blood"},{"key":"603_CR50","doi-asserted-by":"crossref","first-page":"597","DOI":"10.3390\/medicina43080076","volume":"43","author":"D Akramiene","year":"2007","unstructured":"Akramiene D, Kondrotas A, Didziapetriene J, Kevelaitis E (2007) Effects of \u03b2-glucans on the immune system. Medicina (Kaunas) 43:597\u2013606","journal-title":"Medicina (Kaunas)"},{"key":"603_CR51","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/89863","volume":"7","author":"FO Nestle","year":"2001","unstructured":"Nestle FO, Banchereau J, Hart D (2001) Dendritic cells: on the move from bench to bedside. Nat Med 7:761\u2013765","journal-title":"Nat Med"},{"key":"603_CR52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1365-2249.2003.02161.x","volume":"133","author":"PA Morel","year":"2003","unstructured":"Morel PA, Feili-Hariri M, Coates PT, Thomson AW (2003) Dendritic cells, T cell tolerance and therapy of adverse immune reactions. Clin Exp Immunol 133:1\u201310","journal-title":"Clin Exp Immunol"}],"container-title":["Molecular Imaging and Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11307-012-0603-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11307-012-0603-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11307-012-0603-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,6]],"date-time":"2019-07-06T23:05:31Z","timestamp":1562454331000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11307-012-0603-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,21]]},"references-count":52,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["603"],"URL":"https:\/\/doi.org\/10.1007\/s11307-012-0603-x","relation":{},"ISSN":["1536-1632","1860-2002"],"issn-type":[{"value":"1536-1632","type":"print"},{"value":"1860-2002","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,21]]}}}