{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T22:19:50Z","timestamp":1776377990481,"version":"3.51.2"},"reference-count":79,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,8,7]],"date-time":"2014-08-07T00:00:00Z","timestamp":1407369600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Environ Sci Pollut Res"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1007\/s11356-014-3337-2","type":"journal-article","created":{"date-parts":[[2014,8,6]],"date-time":"2014-08-06T02:35:43Z","timestamp":1407292543000},"page":"667-678","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Ecotoxicological effects of salicylic acid in the freshwater fish Salmo trutta fario: antioxidant mechanisms and histological alterations"],"prefix":"10.1007","volume":"22","author":[{"given":"B.","family":"Nunes","sequence":"first","affiliation":[]},{"given":"J. C.","family":"Campos","sequence":"additional","affiliation":[]},{"given":"R.","family":"Gomes","sequence":"additional","affiliation":[]},{"given":"M. R.","family":"Braga","sequence":"additional","affiliation":[]},{"given":"A. S.","family":"Ramos","sequence":"additional","affiliation":[]},{"given":"S. C.","family":"Antunes","sequence":"additional","affiliation":[]},{"given":"A. T.","family":"Correia","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2014,8,7]]},"reference":[{"key":"3337_CR1","first-page":"105","volume":"6","author":"H Aebi","year":"1984","unstructured":"Aebi H (1984) Catalase in vitro. Method Enzymol 6:105\u2013121","journal-title":"Method Enzymol"},{"issue":"3","key":"3337_CR2","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1080\/09593331708616381","volume":"17","author":"BM Alazemi","year":"1996","unstructured":"Alazemi BM, Lewis JW, Andrews EB (1996) Gill damage in the fresh water fish Gnathonemus petersii (Family: Mormyridae) exposed to selected pollutants: an ultrastructural study. Environ Technol 17(3):225\u2013238","journal-title":"Environ Technol"},{"issue":"7\u20138","key":"3337_CR3","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1023\/A:1001935304035","volume":"38","author":"A Antunes","year":"2000","unstructured":"Antunes A, Ferrand N, Alexandrino P (2000) A highly polymorphic plasma protein locus in brown trout (Salmo trutta L.) populations from Portugal. Biochem Genet 38(7\u20138):217\u2013226","journal-title":"Biochem Genet"},{"issue":"8","key":"3337_CR4","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1039\/b926647j","volume":"12","author":"SC Antunes","year":"2010","unstructured":"Antunes SC, Marques SM, Pereira R, Gon\u00e7alves F, Nunes B (2010) Testing procedures for the determination of several biomarkers in different species, for environmental assessment of pollution. J Environ Monitor 12(8):1625\u20131630","journal-title":"J Environ Monitor"},{"issue":"10","key":"3337_CR5","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1517\/17460441.2012.714363","volume":"7","author":"JA Arnott","year":"2012","unstructured":"Arnott JA, Planey SL (2012) The influence of lipophilicity in drug discovery and design. Expert Opin Drug Discov 7(10):863\u2013875","journal-title":"Expert Opin Drug Discov"},{"issue":"13\u201314","key":"3337_CR6","first-page":"1825","volume":"57","author":"JR Arthur","year":"2000","unstructured":"Arthur JR (2000) The glutathione peroxidases. Cell Mol Life Sci 57(13\u201314):1825\u20131835","journal-title":"Cell Mol Life Sci"},{"issue":"2","key":"3337_CR7","first-page":"103","volume":"10","author":"MMN Authman","year":"2013","unstructured":"Authman MMN, Ibrahim SA, El-Kasheif MA, Gaber HS (2013) Heavy metals Ppollution and their effects on gills and liver of the Nile catfish inhabiting El-Rahawy Drain, Egypt. Global Vet 10(2):103\u2013115","journal-title":"Global Vet"},{"issue":"2\u20133","key":"3337_CR8","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.scitotenv.2008.04.028","volume":"402","author":"KK Barnes","year":"2008","unstructured":"Barnes KK, Kolpin DW, Furlong ET, Zaugg SD, Meyer MT, Barber LB (2008) A national reconnaissance of pharmaceuticals and other organic wastewater contaminants in the United States\u2014I) Groundwater. Sci Total Environ 402(2\u20133):192\u2013200","journal-title":"Sci Total Environ"},{"issue":"3","key":"3337_CR9","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1021\/es801845a","volume":"43","author":"MJ Benotti","year":"2009","unstructured":"Benotti MJ, Trenholm RA, Vanderford BJ, Holady JC, Stanford BD, Snyder SA (2009) Pharmaceuticals and endocrine disrupting compounds in U.S. drinking water. Environ Sci Technol 43(3):597\u2013603","journal-title":"Environ Sci Technol"},{"key":"3337_CR10","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1046\/j.1365-2761.1999.00134.x","volume":"22","author":"D Bernet","year":"1999","unstructured":"Bernet D, Schmidt H, Meier W, Burkhardt-Holm P, Wahli T (1999) Histopathology in fish: proposal for a protocol to assess aquatic pollution. J Fish Dis 22:25\u201334","journal-title":"J Fish Dis"},{"key":"3337_CR11","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.toxlet.2007.10.012","volume":"176","author":"J-P Besse","year":"2008","unstructured":"Besse J-P, Garric J (2008) Human pharmaceuticals in surface waters Implementation of a prioritization methodology and application to the French situation. Toxicol Lett 176:104\u2013123","journal-title":"Toxicol Lett"},{"key":"3337_CR12","doi-asserted-by":"crossref","unstructured":"Bradford M (1976). A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein dye binding. Anal Biochem 72:248\u2013254","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"3337_CR13","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S0076-6879(78)52032-6","volume":"52","author":"JA Buege","year":"1978","unstructured":"Buege JA, Aust SD (1978) Microsomal lipid peroxidation. Method Enzymol 52:302\u2013310","journal-title":"Method Enzymol"},{"key":"3337_CR14","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/S0076-6879(85)13062-4","volume":"113","author":"I Carlberg","year":"1985","unstructured":"Carlberg I, Mannervik B (1985) Glutathione reductase. Method Enzymol 113:484\u2013490","journal-title":"Method Enzymol"},{"issue":"1","key":"3337_CR15","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s00128-009-9726-4","volume":"83","author":"J Carrola","year":"2009","unstructured":"Carrola J, Fonta\u00ednhas-Fernandes A, Matos P, Rocha E (2009) Liver histopathology in brown trout (Salmo trutta f. fario) from the Tinhela river, subjected to mine drainage from the abandoned Jales mine (Portugal). B Environ Contam Toxicol 83(1):35\u201341","journal-title":"B Environ Contam Toxicol"},{"issue":"3","key":"3337_CR16","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0378-4274(03)00068-7","volume":"142","author":"M Cleuvers","year":"2003","unstructured":"Cleuvers M (2003) Aquatic ecotoxicity of pharmaceuticals including the assessment of combination effects. Toxicol Lett 142(3):185\u2013194","journal-title":"Toxicol Lett"},{"issue":"3\u20134","key":"3337_CR17","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.aquatox.2011.07.017","volume":"105","author":"V Contardo-Jara","year":"2011","unstructured":"Contardo-Jara V, Lorenza C, Pflugmacher S, N\u00fctzmann G, Kloas W, Wiegand C (2011) Exposure to human pharmaceuticals Carbamazepine, Ibuprofen and Bezafibrate causes molecular effects in Dreissena polymorpha. Aquat Toxicol 105(3\u20134):428\u2013437","journal-title":"Aquat Toxicol"},{"issue":"6","key":"3337_CR18","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1289\/ehp.99107s6907","volume":"107","author":"CG Daughton","year":"1999","unstructured":"Daughton CG, Ternes TA (1999) Pharmaceuticals and personal care products in the environment: agents of subtle changes? Environ Health Perspect 107(6):907\u2013938","journal-title":"Environ Health Perspect"},{"key":"3337_CR19","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1749-6632.1971.tb46905.x","volume":"179","author":"C Davison","year":"1971","unstructured":"Davison C (1971) Salicylate metabolism in man. Ann NY Acad Sci 179:249\u2013268","journal-title":"Ann NY Acad Sci"},{"issue":"3","key":"3337_CR20","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.cbi.2009.11.024","volume":"183","author":"H Doi","year":"2010","unstructured":"Doi H, Horie T (2010) Salicylic acid-induced hepatotoxicity triggered by oxidative stress. Chem-Biol Interact 183(3):363\u2013368","journal-title":"Chem-Biol Interact"},{"issue":"2","key":"3337_CR21","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0009-2797(02)00004-2","volume":"140","author":"H Doi","year":"2002","unstructured":"Doi H, Iwasaki H, Masubuchi Y, Nishigaki R, Horie T (2002) Chemiluminescence associated with the oxidative metabolism of salicylic acid in rat liver microsomes. Chem-Biol Interact 140(2):109\u2013119","journal-title":"Chem-Biol Interact"},{"issue":"1","key":"3337_CR22","doi-asserted-by":"crossref","first-page":"71","DOI":"10.2989\/16085914.2012.666376","volume":"37","author":"RA El-Bassat","year":"2012","unstructured":"El-Bassat RA, Touliabah HE, Harisa GI (2012) Toxicity of four pharmaceuticals from different classes to isolated plankton species. Afr J Aquat Sci 37(1):71\u201380","journal-title":"Afr J Aquat Sci"},{"issue":"2","key":"3337_CR23","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.aquatox.2005.09.009","volume":"76","author":"K Fent","year":"2006","unstructured":"Fent K, Weston AA, Caminada D (2006) Ecotoxicology of human pharmaceuticals. Aquat Toxicol 76(2):122\u2013159","journal-title":"Aquat Toxicol"},{"key":"3337_CR24","first-page":"203","volume-title":"Fish adaptations","author":"MN Fernandes","year":"2003","unstructured":"Fernandes MN, Mazon AF (2003) Environmental pollution and fish gill morphology. In: Val AL, Kapoor BG (eds) Fish adaptations. Science Publishers, Enfield, pp 203\u2013231"},{"key":"3337_CR25","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3354\/dao004043","volume":"4","author":"T Fischer-Scherl","year":"1988","unstructured":"Fischer-Scherl T, Hoffman RW (1988) Gill morphology of native brown trout Salmo trutta m. fario experiencing acute and chronic acidification of a brook in Bavaria, FRG. Dis Aquatic Organ 4:43\u201351","journal-title":"Dis Aquatic Organ"},{"key":"3337_CR26","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S0076-6879(84)05015-1","volume":"105","author":"L Floh\u00e9","year":"1984","unstructured":"Floh\u00e9 L, G\u00fcnzler WA (1984) Assays of glutathione peroxidase. Method Enzymol 105:114\u2013121","journal-title":"Method Enzymol"},{"issue":"2\u20133","key":"3337_CR27","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.scitotenv.2008.02.021","volume":"402","author":"MJ Focazio","year":"2008","unstructured":"Focazio MJ, Kolpin DW, Barnes KK, Furlong ET, Meyer MT, Zaugg SD, Barber LB, Thurman ME (2008) A national reconnaissance for pharmaceutical sand other organic wastewater contaminants in the United States\u2014II. Untreated drinking water sources. Sci Total Environ 402(2\u20133):201\u2013216","journal-title":"Sci Total Environ"},{"key":"3337_CR28","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.ecoenv.2005.04.004","volume":"64","author":"F Gagn\u00e9","year":"2006","unstructured":"Gagn\u00e9 F, Blaise C, Andr\u00e9 C (2006) Occurrence of pharmaceutical products in a municipal effluent and toxicity to rainbow trout (Oncorhynchus mykiss) hepatocytes. Ecotoxicol Environ Safe 64:329\u2013336","journal-title":"Ecotoxicol Environ Safe"},{"issue":"22","key":"3337_CR29","doi-asserted-by":"crossref","first-page":"7130","DOI":"10.1016\/S0021-9258(19)42083-8","volume":"249","author":"WH Habig","year":"1974","unstructured":"Habig WH, Pabst MJ, Jakoby WB (1974) Glutathione-S-transferases\u2014the first enzymatic step in mercapturic acid formation. J Biol Chem 249(22):7130\u20137139","journal-title":"J Biol Chem"},{"issue":"2","key":"3337_CR30","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0045-6535(97)00354-8","volume":"36","author":"B Halling-Sorensen","year":"1998","unstructured":"Halling-Sorensen B, Nors Nielsen S, Lanzky PF, Ingerslev F, Holten Lutzhoft HC, Jorgensen SE (1998) Occurrence, fate and effects of pharmaceutical substances in the environment\u2014a review. Chemosphere 36(2):357\u2013393","journal-title":"Chemosphere"},{"key":"3337_CR31","first-page":"297","volume":"7","author":"WE Hawkins","year":"1984","unstructured":"Hawkins WE, Overstreet RM, Provancha MJ (1984) Effects of space shuttle exhaust plumes on gills of some estuarine fishes: a light and electron microscopic study. Harold W. Manter Lab Parasitol 7:297\u2013309","journal-title":"Manter Lab Parasitol"},{"key":"3337_CR32","doi-asserted-by":"crossref","unstructured":"Hinton DE, Segner H, Au DWT, Kullman SW, Hardman RC (2008) Liver toxicity (Chapter VII). In: DiGiulio RT, Hinton DE (eds) The toxicology of fishes. CRC Press, Boca Raton, Florida, USA","DOI":"10.1201\/9780203647295.ch7"},{"key":"3337_CR33","first-page":"1","volume-title":"Fish physiology","author":"CM Hughes","year":"1984","unstructured":"Hughes CM (1984) General anatomy of the gills. In: Hoar RDJ, Marshal WS (eds) Fish physiology. Academic Press, New York, pp 1\u201372"},{"key":"3337_CR34","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1242\/jeb.64.2.447","volume":"64","author":"GM Hughes","year":"1976","unstructured":"Hughes GM, Perry SF (1976) Morphometric study of trout gills: a light-microscope method suitable for the evaluation of pollutant action. J Exp Biol 64:447\u2013460","journal-title":"J Exp Biol"},{"issue":"3","key":"3337_CR35","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1002\/tox.20015","volume":"19","author":"G Huschek","year":"2004","unstructured":"Huschek G, Hansen PD, Maurer HH, Krengel D, Kayser A (2004) Environmental risk assessment of medicinal products for human use according to European Commission recommendations. Environ Toxicol 19(3):226\u2013240","journal-title":"Environ Toxicol"},{"issue":"11","key":"3337_CR36","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1001\/archderm.136.11.1390","volume":"136","author":"S Imayama","year":"2000","unstructured":"Imayama S, Ueda S, Isoda M (2000) Histologic changes in the skin of hairless mice following peeling with salicylic acid. Arch Dermatol 136(11):1390\u20131395","journal-title":"Arch Dermatol"},{"issue":"1\u20133","key":"3337_CR37","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.scitotenv.2004.12.068","volume":"348","author":"M Isidori","year":"2005","unstructured":"Isidori M, Lavorgna M, Nardelli A, Parrella A, Previtera L, Rubino M (2005) Ecotoxicity of naproxen and its phototransformation products. Sci Total Environ 348(1\u20133):93\u2013101","journal-title":"Sci Total Environ"},{"key":"3337_CR38","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1577\/1548-8659(1983)112<689:AIGEMO>2.0.CO;2","volume":"112","author":"CH Jagoe","year":"1983","unstructured":"Jagoe CH, Haines TA (1983) Alterations in gill epithelial morphology of yearling Sunapee trout exposed to acute acid stress. Trans Am Fish Soc 112:689\u2013695","journal-title":"Trans Am Fish Soc"},{"issue":"1\u20133","key":"3337_CR39","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.scitotenv.2005.06.014","volume":"362","author":"AC Johnson","year":"2006","unstructured":"Johnson AC, Williams RJ, Matthiessen P (2006) The potential steroid hormone contribution of farm animals to freshwaters, the United Kingdom as a case study. Sci Total Environ 362(1\u20133):166\u2013178","journal-title":"Sci Total Environ"},{"issue":"3","key":"3337_CR40","first-page":"275","volume":"33","author":"Y Kim","year":"2007","unstructured":"Kim Y, Choi K, Jung J, Park S, Kim P, Park GJ (2007) Aquatic toxicity of acetaminophen, carbamazepine, cimetidine, diltiazem and six major sulfonamides, and their potential ecological risks in Korea. Environ Int 33(3):275\u2013370","journal-title":"Environ Int"},{"issue":"3","key":"3337_CR41","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.jhazmat.2007.07.008","volume":"148","author":"DGJ Larsson","year":"2007","unstructured":"Larsson DGJ, Pedro C, Paxeus N (2007) Effluent from drug manufactures contains extremely high levels of pharmaceuticals. J Hazard Mater 148(3):751\u2013755","journal-title":"J Hazard Mater"},{"issue":"12","key":"3337_CR42","doi-asserted-by":"crossref","first-page":"3793","DOI":"10.1016\/j.scitotenv.2009.03.009","volume":"407","author":"AY-C Lin","year":"2009","unstructured":"Lin AY-C, Tsai Y-T (2009) Occurrence of pharmaceuticals in Taiwan\u2019s surface waters: impact of waste streams from hospitals and pharmaceutical production facilities. Sci Total Environ 407(12):3793\u20133802","journal-title":"Sci Total Environ"},{"issue":"4","key":"3337_CR43","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1139\/f85-083","volume":"42","author":"J Mallatt","year":"1985","unstructured":"Mallatt J (1985) Fish gill structural changes induced by toxicants and other irritants: a statistical review. Can J Fish Aquat Sci 42(4):630\u2013648","journal-title":"Can J Fish Aquat Sci"},{"issue":"8","key":"3337_CR44","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1016\/j.scitotenv.2011.01.013","volume":"409","author":"S Meland","year":"2011","unstructured":"Meland S, Farmen E, Heier LS, Rosseland BO, Salbu B, Song Y, Tollefsen KE (2011) Hepatic gene expression profile in brown trout (Salmo trutta) exposed to traffic related contaminants. Science Total Environ 409(8):1430\u20131443","journal-title":"Science Total Environ"},{"issue":"11","key":"3337_CR45","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1016\/j.chemosphere.2006.02.003","volume":"64","author":"Z Moldovan","year":"2006","unstructured":"Moldovan Z (2006) Occurrences of pharmaceutical and personal care products as micropollutants in rivers from Romania. Chemosphere 64(11):1808\u20131817","journal-title":"Chemosphere"},{"issue":"11","key":"3337_CR46","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1139\/f85-222","volume":"42","author":"TW Moon","year":"1985","unstructured":"Moon TW, Walsh PJ, Mommsen TP (1985) Fish hepatocytes: a model metabolic system. Can J Fish Aquat Sci 42(11):1772\u20131782","journal-title":"Can J Fish Aquat Sci"},{"issue":"2","key":"3337_CR47","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.ecoenv.2005.07.009","volume":"65","author":"V Nero","year":"2006","unstructured":"Nero V, Farwell A, Lee LEJ, Van Meer T, MacKinnon MD, Dixon DG (2006) The effects of salinity on naphthenic acid toxicity to yellow perch: Gill and liver histopathology. Ecotoxicol Environ Safe 65(2):252\u2013264","journal-title":"Ecotoxicol Environ Safe"},{"issue":"2","key":"3337_CR48","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.ygcen.2012.04.009","volume":"177","author":"F Norambuena","year":"2012","unstructured":"Norambuena F, Mackenzie S, Bell JG, Callol A, Est\u00e9vez A, Duncan N (2012) Prostaglandin (F and E, 2- and 3-series) production and cyclooxygenase (COX-2) gene expression of wild and cultured broodstock of Senegalese sole (Solea senegalensis). Gen Comp Endocrinol 177(2):256\u2013262","journal-title":"Gen Comp Endocrinol"},{"key":"3337_CR49","unstructured":"OECD (1992) OECD Guideline for testing of chemicals: Fish, Short-term Toxicity Test on Embryo and Sac-fry Stages"},{"key":"3337_CR50","first-page":"1302","volume":"2","author":"A Osman","year":"2010","unstructured":"Osman A, Reheem A, AbuelFadl K, Rab A (2010) Enzymatic and histopathologic biomarkers as indicators of aquatic pollution in fishes. Nat Sci 2:1302\u20131311","journal-title":"Nat Sci"},{"issue":"3","key":"3337_CR51","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.ecoenv.2010.09.010","volume":"74","author":"JH Pamplona","year":"2011","unstructured":"Pamplona JH, Oba ET, da Silva TA, Ramos LP, Ramsdorf WA, Cestari MM, Oliveira Ribeiro CA, Zampronio AR, Silva de Assis HC (2011) Subchronic effects of dipyrone on the fish species Rhamdia quelen. Ecotoxicol Environ Safe 74(3):342\u2013349","journal-title":"Ecotoxicol Environ Safe"},{"key":"3337_CR52","volume-title":"Sublethal and chronic effects of pollutants on freshwater fish","author":"V Poleksic","year":"1994","unstructured":"Poleksic V, Mitrovic-Tutundzic V (1994) Fish gills as a monitor of sublethal and chronic effects of pollution. In: M\u00fcller R, Lloyd R (eds) Sublethal and chronic effects of pollutants on freshwater fish. Fishing News Books, Oxford"},{"issue":"4","key":"3337_CR53","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.aquatox.2004.02.001","volume":"67","author":"F Pomati","year":"2004","unstructured":"Pomati F, Netting AG, Calamari D, Neilan BA (2004) Effects of erythromycin, tetraycline and ibuprofen on the growth of Synechocystis sp. and Lemna minor. Aquat Toxicol 67(4):387\u2013396","journal-title":"Aquat Toxicol"},{"key":"3337_CR54","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.chemosphere.2011.03.033","volume":"84","author":"B Quinn","year":"2011","unstructured":"Quinn B, Schmidt W, O\u2019Rourke K, Hernan R (2011) Effects of the pharmaceuticals gemfibrozil and diclofenac on biomarker expression in the zebra mussel (Dreissena polymorpha) and their comparison with standardised toxicity tests. Chemosphere 84:657\u2013663","journal-title":"Chemosphere"},{"issue":"7","key":"3337_CR55","first-page":"32","volume":"3","author":"MI Rendon","year":"2010","unstructured":"Rendon MI, Berson DS, Cohen JL, Roberts WE, Starker I, Wang B (2010) Evidence and considerations in the application of chemical peels in skin disorders and aesthetic resurfacing. J Clin Aesthet Dermatol 3(7):32\u201343","journal-title":"J Clin Aesthet Dermatol"},{"key":"3337_CR56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jmor.1052230103","volume":"223","author":"E Rocha","year":"1995","unstructured":"Rocha E, Monteiro RAF, Pereira CA (1995) Microanatomical organization of the hepatic stroma of the brown trout, Salmo trutta fario (Teleostei, Salmonidae): a qualitative and quantitative approach. J Morphol 223:1\u201311","journal-title":"J Morphol"},{"key":"3337_CR57","doi-asserted-by":"crossref","unstructured":"Rosety-Rodr\u00edguez M, Ordo\u00f1ez FJ, Rosety M, Rosety JM, Ribelles A, Carrasco C (2002) Morpho-histochemical changes in the gills of turbot, Scophthalmus maximus L., induced by sodium dodecyl sulfate. Ecotoxicol Environ Safe 51 (3): 223\u2013228","DOI":"10.1006\/eesa.2001.2148"},{"issue":"1\u20132","key":"3337_CR58","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0021-9673(01)01266-3","volume":"938","author":"F Sacher","year":"2001","unstructured":"Sacher F, Lange FT, Brauch H-J, Blankenhorn I (2001) Pharmaceuticals in groundwaters. Analytical methods and results of a monitoring program in Baden-W\u00fcrttemberg, Germany. J Chromatogr A 938(1\u20132):199\u2013210","journal-title":"J Chromatogr A"},{"key":"3337_CR59","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1007\/s11270-013-1689-8","volume":"224","author":"N SanJuan-Reyes","year":"2013","unstructured":"SanJuan-Reyes N, G\u00f3mez-Oliv\u00e1n LM, Galar-Mart\u00ednez M, Vieyra-Reyes P, Garc\u00eda-Medina S, Islas-Flores H, Neri-Cruz N (2013) Effluent from an NSAID-manufacturing plant in Mexico induces oxidative stress on Cyprinus carpio. Water Air Soil Pollut 224:1689","journal-title":"Water Air Soil Pollut"},{"key":"3337_CR60","unstructured":"Sayed H-A. H.M (2013) Some Morphological Studies on the Respiratory System of Tilapia nilotica (Oreochromus niloticus) and African catfish (Clarias gariepinus). Thesis"},{"issue":"7","key":"3337_CR61","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/j.marpolbul.2011.04.043","volume":"62","author":"W Schmidt","year":"2011","unstructured":"Schmidt W, O\u2019Rourke K, Hernan R, Quinn B (2011) Effects of the pharmaceuticals gemfibrozil and diclofenac on the marine mussel (Mytilus spp.) and their comparison with standardized toxicity tests. Mar Pollut Bull 62(7):1389\u20131395","journal-title":"Mar Pollut Bull"},{"key":"3337_CR62","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-642-76729-6","volume-title":"Enzyme handbook","author":"D Schomburg","year":"1991","unstructured":"Schomburg D, Salzmann M (1991) Enzyme handbook. Springer-Verlag, Berlin"},{"key":"3337_CR63","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.aquatox.2004.03.014","volume":"68","author":"J Schwaiger","year":"2004","unstructured":"Schwaiger J, Ferling H, Mallow U, Wintermayr H, Negele RD (2004) Toxic effects of the non-steroidal anti-inflammatory drug diclofenac: Part I. Histopathological alterations and bioaccumulation in rainbow trout. Aquat Toxicol 68:141\u2013150","journal-title":"Aquat Toxicol"},{"issue":"1\u20133","key":"3337_CR64","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.scitotenv.2004.03.015","volume":"329","author":"PE Stackelberg","year":"2004","unstructured":"Stackelberg PE, Furlong ET, Meyer MT, Zaugg SD, Henderson AK, Reissman DB (2004) Persistence of pharmaceutical compounds and other organic wastewater contaminants in a conventional drinking-water-treatment plant. Sci Total Environ 329(1\u20133):99\u2013113","journal-title":"Sci Total Environ"},{"issue":"2","key":"3337_CR65","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/BF00004528","volume":"10","author":"ED Stevens","year":"1992","unstructured":"Stevens ED (1992) Gill morphometry of the red drum, Sciaenops ocellatus. Fish Physiol Biochem 10(2):169\u2013176","journal-title":"Fish Physiol Biochem"},{"key":"3337_CR66","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0166-445X(83)90053-X","volume":"4","author":"JHM Temmink","year":"1983","unstructured":"Temmink JHM, Bouwmeister PJ, de Jong P, van den Berg JHJ (1983) An ultrastructural study of chromate induced hyperplasia in the gills of rainbow trout (Salmo gairdneri). Aquat Toxicol 4:165\u2013179","journal-title":"Aquat Toxicol"},{"key":"3337_CR67","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1139\/f88-194","volume":"45","author":"J Tietge","year":"1988","unstructured":"Tietge J, Johnson R, Bergman H (1988) Morphometric changes in gill secondary lamellae of brook trout (Salvelinus fontinalis) after long-term exposure to acid and aluminum. Can J Aquat Sci 45:1643\u20131648","journal-title":"Can J Aquat Sci"},{"issue":"2","key":"3337_CR68","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.aquatox.2004.03.015","volume":"68","author":"R Triebskorn","year":"2004","unstructured":"Triebskorn R, Casper H, Heyd A, Eikemper R, K\u00f6hler H-R, Schwaiger J (2004) Toxic effects of the non-steroidal anti-inflammatory drug diclofenac: Part II. Cytological effects in liver, kidney, gills and intestine of rainbow trout (Oncorhynchus mykiss). Aquat Toxicol 68(2):151\u2013166","journal-title":"Aquat Toxicol"},{"key":"3337_CR69","doi-asserted-by":"crossref","first-page":"71","DOI":"10.2174\/157489012799362377","volume":"7","author":"M Ugurlucan","year":"2012","unstructured":"Ugurlucan M, Cag\u00e7ar MI, Turhan FN, Ziyade S, Karatepe Yildiz Y, Zencirci E, Ugurlucan FG, Arslan HA, Korkmaz S, Filizcan U, Cicek S (2012) Aspirin: from a historical perspective. Rec Pat Cardiovasc Drug Disc 7:71\u201376","journal-title":"Rec Pat Cardiovasc Drug Disc"},{"issue":"5","key":"3337_CR70","doi-asserted-by":"crossref","first-page":"R1098","DOI":"10.1152\/ajpregu.00731.2002","volume":"285","author":"RD Anholt van","year":"2003","unstructured":"van Anholt RD, Spanings T, Koven W, Wendelaar BSE (2003) Effects of acetylsalicylic acid treatment on thyroid hormones, prolactins, and the stress response of tilapia (Oreochromis mossambicus). Am J Physiol Regul Integr Comp Physiol 285(5):R1098\u2013106","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"1","key":"3337_CR71","first-page":"3","volume":"20","author":"JR Vane","year":"1998","unstructured":"Vane JR, Botting RM (1998) Mechanism of action of antiinflammatory drugs. Int J Tissue React 20(1):3\u201315","journal-title":"Int J Tissue React"},{"issue":"3","key":"3337_CR72","doi-asserted-by":"crossref","first-page":"131","DOI":"10.17221\/15\/2009-VETMED","volume":"54","author":"J Velisek","year":"2009","unstructured":"Velisek J, Svobodova Z, Piackova V (2009) Effects of acute exposure to bifenthrin on some haematological, biochemical and histopathological parameters of rainbow trout (Oncorhynchus mykiss). Vet Med-Czech 54(3):131\u2013137","journal-title":"Vet Med-Czech"},{"issue":"21","key":"3337_CR73","doi-asserted-by":"crossref","first-page":"13371","DOI":"10.1073\/pnas.222543099","volume":"99","author":"TD Warner","year":"2002","unstructured":"Warner TD, Mitchell JA (2002) Cyclooxygenase-3 (COX-3): filling in the gaps toward COX continuum? Proc Natl Acad Sci J 99(21):13371\u201313373","journal-title":"Proc Natl Acad Sci J"},{"issue":"1\u20133","key":"3337_CR74","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0048-9697(02)00064-5","volume":"295","author":"S Weigel","year":"2002","unstructured":"Weigel S, Kuhlmann J, H\u00fchnerfuss H (2002) Drugs and personal care products as ubiquitous pollutants: occurrence and distribution of clofibric acid, caffeine and DEET in the North Sea. Sci Total Environ 295(1\u20133):131\u2013141","journal-title":"Sci Total Environ"},{"issue":"6","key":"3337_CR75","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1046\/j.1365-294x.2000.00910.x","volume":"9","author":"S Weiss","year":"2000","unstructured":"Weiss S, Antunes A, Schl\u00f6tterer C, Alexandrino P (2000) Mitochondrial haplotype diversity among Portuguese brown trout Salmo trutta L. populations: relevance to the post-Pleistocene recolonization of northern Europe. Mol Ecol 9(6):691\u2013698","journal-title":"Mol Ecol"},{"issue":"6","key":"3337_CR76","first-page":"785","volume":"48","author":"JM Wilson","year":"2009","unstructured":"Wilson JM, Bunte RM, Anthony J, Carty AJ (2009) Evaluation of rapid cooling and tricaine methanesulfonate (MS222) as methods of euthanasia in zebrafish (Danio rerio). J Am Assoc Lab An Sci 48(6):785\u2013789","journal-title":"J Am Assoc Lab An Sci"},{"issue":"2","key":"3337_CR77","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0166-445X(91)90033-6","volume":"19","author":"GW Winston","year":"1991","unstructured":"Winston GW, Di Giulio RT (1991) Prooxidant and antioxidant mechanisms in aquatic organisms. Aquat Toxicol 19(2):137\u2013161","journal-title":"Aquat Toxicol"},{"issue":"1\u20134","key":"3337_CR78","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s10661-010-1822-8","volume":"181","author":"AG Yasser","year":"2011","unstructured":"Yasser AG, Naser MD (2011) Impact of pollutants on fish collected from different parts of Shatt Al-Arab River: a histopathological study. Environ Monitor Assess 181(1\u20134):175\u2013182","journal-title":"Environ Monitor Assess"},{"key":"3337_CR79","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1042\/0264-6021:3400153","volume":"340","author":"J Zou","year":"1999","unstructured":"Zou J, Neumann NF, Holland JW, Belosevic M, Cunningham C, Secombes CJ, Rowley AF (1999) Fish macrophages express a cyclo-oxygenase-2 homologue after activation. Biochem J 340:153\u2013159","journal-title":"Biochem J"}],"container-title":["Environmental Science and Pollution Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-014-3337-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11356-014-3337-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-014-3337-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T18:49:08Z","timestamp":1649875748000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11356-014-3337-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,7]]},"references-count":79,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["3337"],"URL":"https:\/\/doi.org\/10.1007\/s11356-014-3337-2","relation":{},"ISSN":["0944-1344","1614-7499"],"issn-type":[{"value":"0944-1344","type":"print"},{"value":"1614-7499","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,7]]}}}