{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T04:21:27Z","timestamp":1769919687009,"version":"3.49.0"},"reference-count":62,"publisher":"Springer Science and Business Media LLC","issue":"22","license":[{"start":{"date-parts":[[2015,1,18]],"date-time":"2015-01-18T00:00:00Z","timestamp":1421539200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Environ Sci Pollut Res"],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1007\/s11356-014-4023-0","type":"journal-article","created":{"date-parts":[[2015,1,16]],"date-time":"2015-01-16T23:22:41Z","timestamp":1421450561000},"page":"17375-17385","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Differential gene transcription, biochemical responses, and cytotoxicity assessment in Pacific oyster Crassostrea gigas exposed to ibuprofen"],"prefix":"10.1007","volume":"22","author":[{"given":"Miguel A. S.","family":"Serrano","sequence":"first","affiliation":[]},{"given":"Maria","family":"Gonzalez-Rey","sequence":"additional","affiliation":[]},{"given":"Jac\u00f3 J.","family":"Mattos","sequence":"additional","affiliation":[]},{"given":"Fabr\u00edcio","family":"Flores-Nunes","sequence":"additional","affiliation":[]},{"given":"\u00c1lvaro C. P.","family":"Mello","sequence":"additional","affiliation":[]},{"given":"Fl\u00e1via L.","family":"Zacchi","sequence":"additional","affiliation":[]},{"given":"Clei E.","family":"Piazza","sequence":"additional","affiliation":[]},{"given":"Mar\u00edlia N.","family":"Siebert","sequence":"additional","affiliation":[]},{"given":"R\u00f4mi S.","family":"Piazza","sequence":"additional","affiliation":[]},{"given":"Diana","family":"Alvarez-Mu\u00f1oz","sequence":"additional","affiliation":[]},{"given":"Sara","family":"Rodriguez-Mozaz","sequence":"additional","affiliation":[]},{"given":"Dami\u00e0","family":"Barcel\u00f3","sequence":"additional","affiliation":[]},{"given":"Maria Jo\u00e3o","family":"Bebianno","sequence":"additional","affiliation":[]},{"given":"Carlos H. A. M.","family":"Gomes","sequence":"additional","affiliation":[]},{"given":"Cl\u00e1udio M. R.","family":"Melo","sequence":"additional","affiliation":[]},{"given":"Afonso C. D.","family":"Bainy","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2015,1,18]]},"reference":[{"key":"4023_CR1","first-page":"121","volume-title":"Catalase. In: Methods of enzymatic analysis","author":"H Aebi","year":"1984","unstructured":"Aebi H (1984) Catalase. In: Methods of enzymatic analysis. Academic press, London, pp 121\u2013126"},{"key":"4023_CR2","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.scitotenv.2004.04.062","volume":"333","author":"D Ashton","year":"2004","unstructured":"Ashton D et al (2004) Investigating the environmental transport of human pharmaceuticals to streams in the United Kingdom. Sci Total Environ 333:167\u2013184. doi: 10.1016\/j.scitotenv.2004.04.062","journal-title":"Sci Total Environ"},{"key":"4023_CR3","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.jhazmat.2005.03.012","volume":"122","author":"D Bendz","year":"2005","unstructured":"Bendz D et al (2005) Occurrence and fate of pharmaceutically active compounds in the environment, a case study: H\u00f6je River in Sweden. J Hazard Mater 122:195\u2013204. doi: 10.1016\/j.jhazmat.2005.03.012","journal-title":"J Hazard Mater"},{"key":"4023_CR4","doi-asserted-by":"crossref","first-page":"226","DOI":"10.3109\/03602532.2011.561353","volume":"43","author":"PG Board","year":"2011","unstructured":"Board PG (2011) The omega-class glutathione transferases: structure, function, and genetics. Drug Metab Rev 43:226\u2013235. doi: 10.3109\/03602532.2011.561353","journal-title":"Drug Metab Rev"},{"key":"4023_CR5","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.gene.2003.12.027","volume":"329","author":"I Boutet","year":"2004","unstructured":"Boutet I et al (2004) Response of the Pacific oyster Crassostrea gigas to hydrocarbon contamination under experimental conditions. Gene 329:147\u2013157. doi: 10.1016\/j.gene.2003.12.027","journal-title":"Gene"},{"key":"4023_CR6","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"M Bradford","year":"1976","unstructured":"Bradford M (1976) A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248\u2013254. doi: 10.1016\/0003-2697(76)90527-3","journal-title":"Anal Biochem"},{"key":"4023_CR7","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1897\/05-426R.1","volume":"25","author":"GL Brun","year":"2006","unstructured":"Brun GL et al (2006) Pharmaceutically active compounds in Atlantic Canadian sewage treatment plant effluents and receiving waters, and potential for environmental effects as measured by acute and chronic aquatic toxicity. Environ Toxicol Chem 25:2163\u20132176","journal-title":"Environ Toxicol Chem"},{"key":"4023_CR8","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1146\/annurev.pharmtox.43.100901.140223","volume":"43","author":"EJ Calabrese","year":"2003","unstructured":"Calabrese EJ, Baldwin LA (2003) Hormesis: the dose-response revolution. Annu Rev Pharmacol Toxicol 43:175\u2013197. doi: 10.1146\/annurev.pharmtox.43.100901.140223","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"4023_CR9","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/S0076-6879(85)13062-4","volume":"113","author":"I Carlberg","year":"1985","unstructured":"Carlberg I, Mannervik B (1985) Glutathione reductase. Meth Enzymol 113:484\u2013490. doi: 10.1016\/S0076-6879(85)13062-4","journal-title":"Meth Enzymol"},{"key":"4023_CR10","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.aquatox.2011.07.017","volume":"105","author":"V Contardo-Jara","year":"2011","unstructured":"Contardo-Jara V et al (2011) Exposure to human pharmaceuticals carbamazepine, ibuprofen and bezafibrate causes molecular effects in Dreissena polymorpha. Aquat Toxicol 105:428\u2013437. doi: 10.1016\/j.aquatox.2011.07.017","journal-title":"Aquat Toxicol"},{"key":"4023_CR11","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1289\/ehp.99107s6907","volume":"107","author":"CG Daughton","year":"1999","unstructured":"Daughton CG, Ternes TA (1999) Pharmaceuticals and personal care products in the environment: agents of subtle change? Environ Health Perspect 107:907\u2013938","journal-title":"Environ Health Perspect"},{"key":"4023_CR12","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.aquatox.2010.04.017","volume":"99","author":"H Ericson","year":"2010","unstructured":"Ericson H, Thorsen G, Kumblad L (2010) Physiological effects of diclofenac, ibuprofen and propranolol on Baltic Sea blue mussels. Aquat Toxicol 99:223\u2013231. doi: 10.1016\/j.aquatox.2010.04.017","journal-title":"Aquat Toxicol"},{"key":"4023_CR13","first-page":"262","volume":"142","author":"A Esteves","year":"2006","unstructured":"Esteves A, Ehrlich R (2006) Invertebrate intracellular fatty acid binding proteins. Comp Biochem Physiol C 142:262\u2013274. doi: 10.1016\/j.cbpc.2005.11.006","journal-title":"Comp Biochem Physiol C"},{"key":"4023_CR14","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0021-9673(01)01154-2","volume":"938","author":"ML Farr\u00e9","year":"2001","unstructured":"Farr\u00e9 ML et al (2001) Determination of drugs in surface water and wastewater samples by liquid chromatography-mass spectrometry: methods and preliminary results including toxicity studies with Vibrio fischeri. J Chromatogr A 938:187\u2013197","journal-title":"J Chromatogr A"},{"issue":"2","key":"4023_CR15","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.aquatox.2005.09.009","volume":"76","author":"K Fent","year":"2006","unstructured":"Fent K, Weston AA, Caminada D (2006) Ecotoxicology of human pharmaceuticals. Aquat Toxicol 76(2):122\u2013159. doi: 10.1016\/j.aquatox.2005.09.009","journal-title":"Aquat Toxicol"},{"key":"4023_CR16","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.scitotenv.2012.08.073","volume":"438","author":"L Ferrando-Climent","year":"2012","unstructured":"Ferrando-Climent L et al (2012) Comprehensive study of ibuprofen and its metabolites in activated sludge batch experiments and aquatic environment. Sci Total Environ 438:404\u2013413. doi: 10.1016\/j.scitotenv.2012.08.073","journal-title":"Sci Total Environ"},{"key":"4023_CR17","first-page":"332","volume":"141","author":"F Gagn\u00e9","year":"2005","unstructured":"Gagn\u00e9 F et al (2005) Inflammatory properties of municipal effluents to Elliptio complanata mussels\u2014lack of effects from anti-inflammatory drugs. Comp Biochem Physiol C 141:332\u2013337. doi: 10.1016\/j.cca.2005.06.006","journal-title":"Comp Biochem Physiol C"},{"key":"4023_CR18","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.clpt.2004.04.006","volume":"76","author":"E Garc\u00eda-Mart\u00edn","year":"2004","unstructured":"Garc\u00eda-Mart\u00edn E et al (2004) Interindividual variability in ibuprofen pharmacokinetics is related to interaction of cytochrome P450 2C8 and 2C9 amino acid polymorphisms. Clin Pharmacol Therap 76:119\u2013127. doi: 10.1016\/j.clpt.2004.04.006","journal-title":"Clin Pharmacol Therap"},{"key":"4023_CR19","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1042\/bj3390607","volume":"339","author":"JK Gierse","year":"1999","unstructured":"Gierse JK et al (1999) Kinetic basis for selective inhibition of cyclo-oxygenases. Biochem J 339:607\u2013614","journal-title":"Biochem J"},{"key":"4023_CR20","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/j.chemosphere.2006.07.051","volume":"66","author":"M G\u00f3mez","year":"2007","unstructured":"G\u00f3mez M et al (2007) Pilot survey monitoring pharmaceuticals and related compounds in a sewage treatment plant located on the Mediterranean coast. Chemosphere 66:993\u20131002. doi: 10.1016\/j.chemosphere.2006.07.051","journal-title":"Chemosphere"},{"key":"4023_CR21","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.aquatox.2011.06.015","volume":"105","author":"M Gonzalez-Rey","year":"2011","unstructured":"Gonzalez-Rey M, Bebianno MJ (2011) Non-steroidal anti-inflammatory drug (NSAID) ibuprofen distresses antioxidant defense system in mussel Mytilus galloprovincialis gills. Aquat Toxicol 105:264\u2013269. doi: 10.1016\/j.aquatox.2011.06.015","journal-title":"Aquat Toxicol"},{"key":"4023_CR22","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.etap.2011.12.017","volume":"33","author":"M Gonzalez-Rey","year":"2012","unstructured":"Gonzalez-Rey M, Bebianno MJ (2012) Does non-steroidal antiinflammatory (NSAID) ibuprofen induce antioxidant stress and endocrine disruption in mussel Mytilus galloprovincialis? Environ Toxicol Pharmacol 33:361\u2013371. doi: 10.1016\/j.etap.2011.12.017","journal-title":"Environ Toxicol Pharmacol"},{"key":"4023_CR23","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0006-2952(97)00143-3","volume":"54","author":"MA Hamman","year":"1997","unstructured":"Hamman MA et al (1997) Regioselective and stereoselective metabolism of ibuprofen by human cytochrome P450 2C. Biochem Pharmacol 54:33\u201341. doi: 10.1371\/journal.pone. 0012329","journal-title":"Biochem Pharmacol"},{"key":"4023_CR24","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/047167558X.ch12","volume-title":"Functional metabolism: regulation and adaptation","author":"M Hermes-Lima","year":"2004","unstructured":"Hermes-Lima M (2004) Oxygen in biology and biochemistry: role of free radicals. In: Storey KB (ed) Functional metabolism: regulation and adaptation. Wiley, New Jersey, pp 319\u2013368"},{"key":"4023_CR25","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.talanta.2005.09.037","volume":"69","author":"MD Hernando","year":"2006","unstructured":"Hernando MD et al (2006) Environmental risk assessment of pharmaceutical residues in wastewater effluents, surface waters and sediments. Talanta 69:334\u2013342. doi: 10.1016\/j.talanta.2005.09.037","journal-title":"Talanta"},{"key":"4023_CR26","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1007\/s00216-012-6144-y","volume":"404","author":"B Huerta","year":"2012","unstructured":"Huerta B et al (2012) Pharmaceuticals in biota in the aquatic environment: analytical methods and environmental implications. Anal Bioanal Chem 404:2611\u20132624. doi: 10.1007\/s00216-012-6144-y","journal-title":"Anal Bioanal Chem"},{"key":"4023_CR27","unstructured":"IMS Institute for Healthcare informatics (2011). The global use of medicines: outlook through 2015. pp. 27. http:\/\/www.imshealth.com\/deployedfiles\/ims\/Global\/Content\/Insights\/IMS%20Institute%20for%20Healthcare%20Informatics\/Global_Use_of_Medicines_Report.pdf"},{"key":"4023_CR28","doi-asserted-by":"crossref","first-page":"6183","DOI":"10.1016\/S0021-9258(20)81842-0","volume":"251","author":"JH Keen","year":"1976","unstructured":"Keen JH, Habig WH, Jakoby W (1976) Mechanism for the several activities of the glutathione S-transferase. J Biol Chem 251:6183\u20136188","journal-title":"J Biol Chem"},{"key":"4023_CR29","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.watres.2006.06.034","volume":"41","author":"SD Kim","year":"2007","unstructured":"Kim SD et al (2007) Occurrence and removal of pharmaceuticals and endocrine disruptors in South Korean surface, drinking, and waste waters. Water Res 41:1013\u20131021. doi: 10.1016\/j.watres.2006.06.034","journal-title":"Water Res"},{"key":"4023_CR30","doi-asserted-by":"crossref","first-page":"2354","DOI":"10.1016\/j.jenvman.2009.01.023","volume":"90","author":"K K\u00fcmmerer","year":"2009","unstructured":"K\u00fcmmerer K (2009) The presence of pharmaceuticals in the environment due to human use\u2014present knowledge and future challenges. J Environ Manag 90:2354\u20132366. doi: 10.1016\/j.jenvman.2009.01.023","journal-title":"J Environ Manag"},{"key":"4023_CR31","first-page":"189","volume":"19","author":"TD Leemann","year":"1993","unstructured":"Leemann TD et al (1993) A major role for cytochrome P450TB (CYP2C subfamily) in the actions of non-steroidal antiinflammatory drugs. Drugs Exp Clin Res 19:189\u2013195. doi: 10.1371\/journal.pone.0012329","journal-title":"Drugs Exp Clin Res"},{"key":"4023_CR32","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.aquatox.2014.04.021","volume":"152","author":"KH L\u00fcchmann","year":"2014","unstructured":"L\u00fcchmann KH et al (2014) A light in the darkness: new biotransformation genes, antioxidant parameters and tissue-specific responses in oysters exposed to phenanthrene. Aquat Toxicol 152:324\u2013334. doi: 10.1016\/j.aquatox.2014.04.021","journal-title":"Aquat Toxicol"},{"key":"4023_CR33","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.toxlet.2008.12.005","volume":"185","author":"JC Madden","year":"2009","unstructured":"Madden JC et al (2009) Pharmaceuticals in the environment: good practice in predicting acute ecotoxicological effects. Toxicol Lett 185:85\u2013101. doi: 10.1016\/j.toxlet.2008.12.005","journal-title":"Toxicol Lett"},{"key":"4023_CR34","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.aquatox.2004.07.003","volume":"70","author":"H Manduzio","year":"2004","unstructured":"Manduzio H et al (2004) Seasonal variations in antioxidant defences in blue mussels Mytilus edulis collected from a polluted area: major contributions in gills of an inducible isoform of Cu\/Zn-superoxide dismutase and of glutathione S-transferase. Aquat Toxicol 70:83\u201393. doi: 10.1016\/j.aquatox.2004.07.003","journal-title":"Aquat Toxicol"},{"key":"4023_CR35","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s10530-009-9425-4","volume":"12","author":"A Markert","year":"2010","unstructured":"Markert A et al (2010) Recently established Crassostrea-reefs versus native Mytilus-beds: differences in ecosystem engineering affects the macrofaunal communities (Wadden Sea of Lower Saxony, southern German Bight). Biol Invasions 12:15\u201332. doi: 10.1007\/s10530-009-9425-4","journal-title":"Biol Invasions"},{"key":"4023_CR36","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.marenvres.2012.06.003","volume":"79","author":"V Matozzo","year":"2012","unstructured":"Matozzo V et al (2012) The nonsteroidal anti-inflammatory drug, ibuprofen, affects the immune parameters in the clam Ruditapes philippinarum. Mar Environ Res 79:116\u2013121. doi: 10.1016\/j.marenvres.2012.06.003","journal-title":"Mar Environ Res"},{"key":"4023_CR37","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.marenvres.2008.02.048","volume":"66","author":"ID Medeiros","year":"2008","unstructured":"Medeiros ID et al (2008a) Differential gene expression in oyster exposed to sewage. Mar Environ Res 66:156\u2013157. doi: 10.1016\/j.marenvres.2008.02.048","journal-title":"Mar Environ Res"},{"key":"4023_CR38","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.etap.2008.05.004","volume":"26","author":"ID Medeiros","year":"2008","unstructured":"Medeiros ID et al (2008b) Induced gene expression in oyster Crassostrea gigas exposed to sewage. Environ Toxicol Pharmacol 26:362\u2013365. doi: 10.1016\/j.etap.2008.05.004","journal-title":"Environ Toxicol Pharmacol"},{"key":"4023_CR39","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.aquatox.2012.10.007","volume":"126","author":"M Milan","year":"2013","unstructured":"Milan M et al (2013) Gene transcription and biomarker responses in the clam Ruditapes philippinarum after exposure to ibuprofen. Aquat Toxicol 126:17\u201329. doi: 10.1016\/j.aquatox.2012.10.007","journal-title":"Aquat Toxicol"},{"issue":"3","key":"4023_CR40","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0090-6980(90)90011-J","volume":"40","author":"M Osada","year":"1990","unstructured":"Osada M, Nomura T (1990) The levels of reproductive cycle prostaglandins associated with the reproductive cycle of the scallop, Patinopecten yessoensis. Prostaglandins 40(3):229\u2013239. doi: 10.1016\/0090-6980(90)90011-J","journal-title":"Prostaglandins"},{"key":"4023_CR41","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.tiv.2009.04.014","volume":"23","author":"M Parolini","year":"2009","unstructured":"Parolini M et al (2009) An in vitro biomarker approach for the evaluation of the ecotoxicity of non-steroidal anti-inflammatory drugs (NSAIDs). Toxicol In Vitro 23:935\u2013942. doi: 10.1016\/j.tiv.2009.04.014","journal-title":"Toxicol In Vitro"},{"key":"4023_CR42","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1016\/j.ecoenv.2011.04.025","volume":"74","author":"M Parolini","year":"2011","unstructured":"Parolini M et al (2011) Chronic effects induced by ibuprofen on the freshwater bivalve Dreissena polymorpha. Ecotox Environ Safe 74:1586\u20131594. doi: 10.1016\/j.ecoenv.2011.04.025","journal-title":"Ecotox Environ Safe"},{"key":"4023_CR43","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ecoenv.2007.07.003","volume":"70","author":"N Pounds","year":"2008","unstructured":"Pounds N et al (2008) Acute and chronic effects of ibuprofen in the mollusc Planorbis carinatus (Gastropoda: Planorbidae). Ecotox Environ Safe 70:47\u201352. doi: 10.1016\/j.ecoenv.2007.07.003","journal-title":"Ecotox Environ Safe"},{"key":"4023_CR44","unstructured":"Qiagen (2009a). QIAzol handbook: for efficient lysis of fatty tissues and all other types of tissue before RNA purification"},{"key":"4023_CR45","unstructured":"Qiagen (2009b). QuantiTect\u00ae reverse transcription handbook, pp 31"},{"key":"4023_CR46","unstructured":"Qiagen (2011). QuantiFast\u00ae SYBR\u00ae Green PCR KIT, Quick Start Protocol, pp 3"},{"issue":"2","key":"4023_CR47","doi-asserted-by":"crossref","first-page":"81s","DOI":"10.18433\/J3T886","volume":"11","author":"P Rao","year":"2008","unstructured":"Rao P, Knaus EE (2008) Evolution of nonsteroidal anti-inflammatory cyclooxygenase (COX) inhibition and beyond drugs (NSAIDs). J Pharm Pharmaceut Sci 11(2):81s\u2013110s","journal-title":"J Pharm Pharmaceut Sci"},{"key":"4023_CR48","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0166-445X(94)00064-W","volume":"31","author":"F Regoli","year":"1995","unstructured":"Regoli F, Principato G (1995) Glutathione, glutathione-dependent and antioxidant enzymes in mussel, Mytilus galloprovincialis, exposed to metals under field and laboratory conditions: implications for the use of biochemical biomarkers. Aquat Toxicol 31:143\u2013164. doi: 10.1016\/0166-445X(94)00064-W","journal-title":"Aquat Toxicol"},{"key":"4023_CR49","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/S0141-1136(02)00146-0","volume":"54","author":"F Regoli","year":"2002","unstructured":"Regoli F et al (2002) Oxidative stress in ecotoxicology: from analysis of individual antioxidants to a more integrated approach. Mar Environ Res 54:419\u2013423. doi: 10.1016\/S0141-1136(02)00146","journal-title":"Mar Environ Res"},{"key":"4023_CR50","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.aquatox.2011.06.014","volume":"105","author":"F Regoli","year":"2011","unstructured":"Regoli F et al (2011) Molecular and biochemical biomarkers in environmental biomonitoring: a comparison of biotransformation and antioxidant defense systems in multiple tissues. Aquat Toxicol 105:56\u201366. doi: 10.1016\/j.aquatox.2011.06.014","journal-title":"Aquat Toxicol"},{"issue":"1\u20133","key":"4023_CR51","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jhazmat.2009.10.100","volume":"175","author":"LH Santos","year":"2010","unstructured":"Santos LH et al (2010) Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment. J Hazard Mater 175(1\u20133):45\u201395. doi: 10.1016\/j.jhazmat.2009.10.100","journal-title":"J Hazard Mater"},{"issue":"20","key":"4023_CR52","doi-asserted-by":"crossref","first-page":"392A","DOI":"10.1021\/es040639t","volume":"38","author":"TA Ternes","year":"2004","unstructured":"Ternes TA, Joss A, Siegrist H (2004) Scrutinizing pharmaceuticals and personal care products in wastewater treatment. Environ Sci Technol 38(20):392A\u2013399A. doi: 10.1021\/es040639t","journal-title":"Environ Sci Technol"},{"key":"4023_CR53","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.marenvres.2008.02.010","volume":"66","author":"G Toledo-Silva","year":"2008","unstructured":"Toledo-Silva G et al (2008) Cloning a new cytochrome P450 isoform (CYP356A1) from oyster Crassostrea gigas. Mar Environ Res 66:15\u201318. doi: 10.1016\/j.marenvres.2008.02.010","journal-title":"Mar Environ Res"},{"key":"4023_CR54","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.envint.2010.10.002","volume":"37","author":"AY Tong","year":"2011","unstructured":"Tong AY, Peake PM, Braund R (2011) Disposal practices for unused medications around the world. Environ Int 37:292\u2013298. doi: 10.1016\/j.envint.2010.10.002","journal-title":"Environ Int"},{"key":"4023_CR55","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.ecoenv.2005.03.013","volume":"64","author":"A Valavanidis","year":"2006","unstructured":"Valavanidis A et al (2006) Molecular biomarkers of oxidative stress in aquatic organisms in relation to toxic environmental pollutants. Ecotox Environ Safe 64:178\u2013189. doi: 10.1016\/j.ecoenv.2005.03.013","journal-title":"Ecotox Environ Safe"},{"key":"4023_CR56","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.chroma.2006.03.005","volume":"1116","author":"SS Verenitch","year":"2006","unstructured":"Verenitch SS, Lowe CJ, Mazumder A (2006) Determination of acidic drugs and caffeine in municipal wastewaters and receiving waters by gas chromatography ion trap tandem mass spectrometry. J Chromatogr A 1116:193\u2013203. doi: 10.1016\/j.chroma.2006.03.005","journal-title":"J Chromatogr A"},{"key":"4023_CR57","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.chemosphere.2004.04.015","volume":"56","author":"S Weigel","year":"2004","unstructured":"Weigel S et al (2004) Determination of selected pharmaceuticals and caffeine in sewage and seawater from Troms\u00f8\/Norway with emphasis on ibuprofen and its metabolites. Chemosphere 56:583\u2013592. doi: 10.1016\/j.chemosphere.2004.04.015","journal-title":"Chemosphere"},{"key":"4023_CR58","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0076-6879(81)77046-0","volume":"77","author":"A Wendel","year":"1981","unstructured":"Wendel A (1981) Glutathione peroxidase. Meth Enzymol 77:325\u2013333. doi: 10.1016\/S0076-6879(81)77046-0","journal-title":"Meth Enzymol"},{"key":"4023_CR59","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1086\/BBLv226n3p269","volume":"226","author":"JM Wright","year":"2014","unstructured":"Wright JM et al (2014) Populations of Pacific oysters Crassostrea gigas respond variably to elevated CO2 and predation by Morula marginalba. Biol Bull 226:269\u2013281","journal-title":"Biol Bull"},{"key":"4023_CR60","volume-title":"Biostatistical analysis","author":"JH Zar","year":"1999","unstructured":"Zar JH (1999) Biostatistical analysis. Prentice-Hall, Englewood Cliffs"},{"key":"4023_CR61","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nature11413","volume":"490","author":"G Zhang","year":"2013","unstructured":"Zhang G et al (2013) The oyster genome reveals stress adaptation and complexity of shell formation. Nature 490:49\u201354. doi: 10.1038\/nature11413","journal-title":"Nature"},{"key":"4023_CR62","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jhazmat.2005.03.001","volume":"122","author":"E Zuccato","year":"2005","unstructured":"Zuccato E et al (2005) Identification of the pharmaceuticals for human use contaminating the Italian aquatic environment. J Hazard Mater 122:205\u2013209. doi: 10.1016\/j.jhazmat.2005.03.001","journal-title":"J Hazard Mater"}],"container-title":["Environmental Science and Pollution Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-014-4023-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11356-014-4023-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-014-4023-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,17]],"date-time":"2025-05-17T00:33:51Z","timestamp":1747442031000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11356-014-4023-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,18]]},"references-count":62,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["4023"],"URL":"https:\/\/doi.org\/10.1007\/s11356-014-4023-0","relation":{},"ISSN":["0944-1344","1614-7499"],"issn-type":[{"value":"0944-1344","type":"print"},{"value":"1614-7499","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,18]]}}}