{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T09:26:48Z","timestamp":1761989208880,"version":"3.37.3"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"18","license":[{"start":{"date-parts":[[2018,4,21]],"date-time":"2018-04-21T00:00:00Z","timestamp":1524268800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Environ Sci Pollut Res"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1007\/s11356-018-1997-z","type":"journal-article","created":{"date-parts":[[2018,4,21]],"date-time":"2018-04-21T19:30:12Z","timestamp":1524339012000},"page":"17915-17919","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Phthalates and type 1 diabetes: is there any link?"],"prefix":"10.1007","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5967-0231","authenticated-orcid":false,"given":"C\u00edntia","family":"Castro-Correia","sequence":"first","affiliation":[]},{"given":"Lu\u00edsa","family":"Correia-S\u00e1","sequence":"additional","affiliation":[]},{"given":"S\u00f3nia","family":"Norberto","sequence":"additional","affiliation":[]},{"given":"Cristina","family":"Delerue-Matos","sequence":"additional","affiliation":[]},{"given":"Valentina","family":"Domingues","sequence":"additional","affiliation":[]},{"given":"Cristina","family":"Costa-Santos","sequence":"additional","affiliation":[]},{"given":"Manuel","family":"Fontoura","sequence":"additional","affiliation":[]},{"given":"Concei\u00e7\u00e3o","family":"Calhau","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2018,4,21]]},"reference":[{"issue":"2","key":"1997_CR1","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1089\/107555302317371479","volume":"8","author":"PF Baillie-Hamilton","year":"2002","unstructured":"Baillie-Hamilton PF (2002) Chemical toxins: a hypothesis to explain the global obesity epidemic. J Altern Complement Med 8(2):185\u2013192","journal-title":"J Altern Complement Med"},{"key":"1997_CR2","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.mrrev.2012.03.001","volume":"751","author":"JC Caldwell","year":"2012","unstructured":"Caldwell JC (2012) DEHP: genotoxicity and potential carcinogenic mechanisms\u2014a review. Mutat Res 751:82\u2013157","journal-title":"Mutat Res"},{"issue":"suppl 6","key":"1997_CR3","doi-asserted-by":"publisher","first-page":"S53","DOI":"10.1038\/ijo.2008.207","volume":"32","author":"C Casals-Casas","year":"2008","unstructured":"Casals-Casas C, Feige JN, Desvergne B (2008) Interference of pollutants with PPARs: endocrine disruption meets metabolism. Int J Obes 32(suppl 6):S53\u2013S61","journal-title":"Int J Obes"},{"issue":"Suppl. 20","key":"1997_CR4","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1111\/pedi.12184","volume":"15","author":"T Danne","year":"2014","unstructured":"Danne T, Bangstad H-J, Deeb L, Jarosz-Chobot P, Mungaie L, Saboo B, Urakami T, Battelino T, Hanas R (2014) Insulin treatment. Pediatr Diabetes 15(Suppl. 20):115\u2013134","journal-title":"Pediatr Diabetes"},{"issue":"1\u20132","key":"1997_CR5","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.mce.2009.02.017","volume":"304","author":"B Desvergne","year":"2009","unstructured":"Desvergne B, Feige JN, Casals-Casas C (2009) PPAR-mediated activity of phthalates: a link to the obesity epidemic? Mol Cell Endocrinol 304(1\u20132):43\u201348","journal-title":"Mol Cell Endocrinol"},{"issue":"10","key":"1997_CR6","first-page":"727","volume":"30","author":"RH Dong","year":"2017","unstructured":"Dong RH, Zhang H, Zhang MR, Chen JS, Wu M, Li SG, Chen B (2017) Association between phthalate exposure and the use of plastic containers in Shanghai. Biomed Environ Sci 30(10):727\u2013736","journal-title":"Biomed Environ Sci"},{"key":"1997_CR7","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.1056\/NEJM198605223142106","volume":"314","author":"GS Eisenbarth","year":"1986","unstructured":"Eisenbarth GS (1986) Type I diabetes mellitus. A chronic autoimmune disease. N Engl JMed 314:1360\u20131368","journal-title":"N Engl JMed"},{"key":"1997_CR8","first-page":"13","volume":"108","author":"EM Faustman","year":"2000","unstructured":"Faustman EM, Silbernagel SM, Fenske RA, Burbacher TM, Ponce RA (2000) Mechanisms underlying Children\u2019s susceptibility to environmental toxicants. Environ Health Perspect 108:13\u201321","journal-title":"Environ Health Perspect"},{"key":"1997_CR9","unstructured":"Fourth Report (2009) Fourth Report on human exposure to environmental chemicals. Atlanta, GA: U.S. Department of Health and human services, Centers for disease control and prevention. https:\/\/www.cdc.gov\/exposurereport\/"},{"key":"1997_CR10","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.taap.2003.10.010","volume":"198","author":"G Ginsberg","year":"2004","unstructured":"Ginsberg G, Hattis D, Sonawane B (2004) Incorporating pharmacokinetic differences between children and adults in assessing children\u2019s risks to environmental toxicants. Toxicol Appl Pharmacol 198:164\u2013183","journal-title":"Toxicol Appl Pharmacol"},{"issue":"7","key":"1997_CR11","doi-asserted-by":"publisher","first-page":"670","DOI":"10.3390\/ijerph13070670","volume":"13","author":"G Ginsberg","year":"2016","unstructured":"Ginsberg G, Ginsberg J, Foos B (2016) Approaches to Children\u2019s exposure assessment: case study with diethylhexylphthalate (DEHP). Int J Environ Res Public Health 13(7):670","journal-title":"Int J Environ Res Public Health"},{"issue":"2","key":"1997_CR12","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1007\/s11154-007-9049-x","volume":"8","author":"F Grun","year":"2007","unstructured":"Grun F, Blumberg B (2007) Perturbed nuclear receptor signaling by environmental obesogens as emerging factors in the obesity crisis. Rev Endocr Metab Disord 8(2):161\u2013171","journal-title":"Rev Endocr Metab Disord"},{"key":"1997_CR13","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/1476-069X-7-27","volume":"7","author":"EE Hatch","year":"2008","unstructured":"Hatch EE, Nelson JW, Qureshi MM, Weinberg J, Moore LL, Singer M, Webster TF (2008) Association of urinary phthalate metabolite concentrations with body mass index and waist circumference: a cross-sectional study of NHANES data, 1999\u20132002. Environ Health 7:27. https:\/\/doi.org\/10.1186\/1476-069X-7-27","journal-title":"Environ Health"},{"key":"1997_CR14","doi-asserted-by":"publisher","first-page":"e71392","DOI":"10.1371\/journal.pone.0071392","volume":"8","author":"JH Kim","year":"2013","unstructured":"Kim JH, Park HY, Bae S, Lim YH, Hong YC (2013) Diethy lhexyl phthalates is associated with insulin resistance via oxidative stress in the elderly: a panel study. PLoS One 8:e71392","journal-title":"PLoS One"},{"issue":"1526","key":"1997_CR15","doi-asserted-by":"publisher","first-page":"2063","DOI":"10.1098\/rstb.2008.0208","volume":"364","author":"HM Koch","year":"2009","unstructured":"Koch HM, Calafat AM (2009) Human body burdens of chemicals used in plastic manufacture. Philos Trans R Soc Lond B Biol Sci 364(1526):2063\u20132078","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"1997_CR16","doi-asserted-by":"publisher","first-page":"E527","DOI":"10.1152\/ajpendo.00233.2011","volume":"301","author":"Y Lin","year":"2011","unstructured":"Lin Y, Wei J, Li Y, Chen J, Zhou Z, Song L, Wei Z, Lv Z, Chen X, Xia W, Xu S (2011) Developmental exposure to di(2-ethylhexyl) phthalate impairs endocrine pancreas and leads to long-term adverse effects on glucose homeostasis in the rat. Am J Physiol Endocrinol Metab 301:E527\u2013E538","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"8","key":"1997_CR17","doi-asserted-by":"publisher","first-page":"2001","DOI":"10.1016\/j.tiv.2015.08.011","volume":"29","author":"AC Louren\u00e7o","year":"2015","unstructured":"Louren\u00e7o AC, Galbiati V, Corti D, Papale A, Martino-Andrade AJ, Corsini E (2015) The plasticizer dibutyl phthalate (DBP) potentiates chemical allergen-induced THP-1 activation. Toxxicol in Vitro 29(8):2001\u20132008","journal-title":"Toxxicol in Vitro"},{"issue":"6865","key":"1997_CR18","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1038\/414792a","volume":"414","author":"D Mathis","year":"2001","unstructured":"Mathis D, Vence L, Benoist C (2001) \u03b2-cell death during progression to diabetes. Nature 414(6865):792\u2013798","journal-title":"Nature"},{"issue":"1","key":"1997_CR19","doi-asserted-by":"publisher","first-page":"507","DOI":"10.3390\/ijerph110100507","volume":"11","author":"MA Moreira","year":"2013","unstructured":"Moreira MA, Andr\u00e9 LC, Cardeal ZL (2013) Analysis of phthalate migration to food simulants in plastic containers during microwave operations. Int J Environ Res Public Health 11(1):507\u2013526","journal-title":"Int J Environ Res Public Health"},{"key":"1997_CR20","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1542\/peds.113.S3.996","volume":"113","author":"J Moya","year":"2004","unstructured":"Moya J, Bearer CF, Etzel RA (2004) Children\u2019s behavior and physiology and how it affects exposure to environmental contaminants. Pediatrics 113:996\u20131006","journal-title":"Pediatrics"},{"issue":"7","key":"1997_CR21","doi-asserted-by":"publisher","first-page":"1838","DOI":"10.2337\/db11-0153","volume":"60","author":"BA Neel","year":"2011","unstructured":"Neel BA, Sargis RM (2011) The paradox of progress: environmental disruption of metabolism and the diabetes epidemic. Diabetes 60(7):1838\u20131848","journal-title":"Diabetes"},{"issue":"2","key":"1997_CR22","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1590\/S0004-27302008000200003","volume":"52","author":"P Pirot","year":"2008","unstructured":"Pirot P, Cardozo AK, Eizirik DL (2008) Mediators and mechanisms of pancreatic beta-cell death in type 1 diabetes. Arq Bras Endocrinol Metabol 52(2):156\u2013165","journal-title":"Arq Bras Endocrinol Metabol"},{"issue":"2","key":"1997_CR23","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.1007\/s11356-013-2020-3","volume":"21","author":"J Santana","year":"2014","unstructured":"Santana J, Giraudi C, Marengo E, Robotti E, Pires S, Nunes I, Gaspar EM (2014) Preliminary toxicological assessment of phthalate esters from drinking water consumed in Portugal. Environ Sci Pollut Res Int 21(2):1380\u20131390","journal-title":"Environ Sci Pollut Res Int"},{"issue":"4","key":"1997_CR24","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1016\/j.ijheh.2017.01.012","volume":"220","author":"G Schwedler","year":"2017","unstructured":"Schwedler G, Seiwert M, Fiddicke U, I\u00dfleb S, H\u00f6lzer J, Nendza J, Wilhelm M, Wittsiepe J, Koch HM, Schindler BK, G\u00f6en T, Hildebrand J, Joas R, Joas A, Casteleyn L, Angerer J, Castano A, Esteban M, Schoeters G, Den Hond E, Sepai O, Exley K, Bloemen L, Knudsen LE, Kolossa-Gehring M (2017) Human biomonitoring pilot study DEMOCOPHES in Germany: Contribution to a harmonized European approach. Int J Hyg Environ Health 220(4):686\u2013696","journal-title":"Int J Hyg Environ Health"},{"key":"1997_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1034\/j.1600-0463.2003.11101031.x","volume":"111","author":"NE Skakkebaek","year":"2003","unstructured":"Skakkebaek NE, Holm M, Hoei-Hansen C, J\u00f8rgensen N, Rajpert-De ME (2003) Association between testicular dysgenesis syndrome (TDS) and testicular neoplasia: evidence from20 adult patients with signs of maldevelopment of the testis. Acta Pathol. Microbiol. Immunol. Scand 111:1\u20139","journal-title":"Acta Pathol. Microbiol. Immunol. Scand"},{"issue":"4","key":"1997_CR26","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1111\/1753-0407.12325","volume":"8","author":"Y Song","year":"2016","unstructured":"Song Y, Chou EL, Baecker A, You NC, Song Y, Sun Q, Liu S (2016) Endocrine-disrupting chemicals, risk of type 2 diabetes, and diabetes-related metabolic traits: a systematic review and meta-analysis. J Diabetes Jul 8(4):516\u2013532","journal-title":"J Diabetes Jul"},{"issue":"6","key":"1997_CR27","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1289\/ehp.9882","volume":"115","author":"RW Stahlhut","year":"2007","unstructured":"Stahlhut RW, van Wijngaarden E, Dye TD, Cook S, Swan SH (2007) Concentrations of urinary phthalate metabolites are associated with increased waist circumference and insulin resistance in adult U.S. males. Environ Health Perspect 115(6):876\u2013882","journal-title":"Environ Health Perspect"},{"issue":"3","key":"1997_CR28","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1111\/jcmm.12409","volume":"19","author":"Y Sun","year":"2015","unstructured":"Sun Y, Lin Q, Huang Q, Shi J, Qiu L, Kang M et al (2015) Di(2-ethylhexyl) phthalate-induced apoptosis in rat INS-1 cells is dependent on activation of endoplasmic reticulum stress and suppression of antioxidant protection. J Cell Mol Med 19(3):581\u2013594","journal-title":"J Cell Mol Med"},{"key":"1997_CR29","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1507\/endocrj.EJ17-0272","volume":"65","author":"D Sun","year":"2017","unstructured":"Sun D, Zhou L, Wang S, Liu T, Zhu J, Jia Y, Xu J, Chen H, Wang Q, Xu F, Zhang Y, Ye L (2017) Effect of Di-(2-ethylhexyl) phthalate on the hypothalamus-pituitary-thyroid axis in adolescent rat. Endocr J 65:261\u2013268. https:\/\/doi.org\/10.1507\/endocrj.EJ17-0272","journal-title":"Endocr J"},{"issue":"6","key":"1997_CR30","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/S0022-2275(20)30468-5","volume":"43","author":"K Tordjman","year":"2002","unstructured":"Tordjman K, Standley KN, Bernal-Mizrachi C, Leone TC, Coleman T, Kelly DP, Semenkovich CF (2002) PPARalpha suppresses insulin secretion and induces UCP2 in insulinoma cells. J Lipid Res 43(6):936\u2013943","journal-title":"J Lipid Res"},{"key":"1997_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2017\/4614379","volume":"2017","author":"Nina Mickelson Weldingh","year":"2017","unstructured":"Weldingh NM, Jorgensen-Kaur L, Becher R, Holme JA, Bodin J, Nygaard UC, Bolling AK (2017) Bisphenol A is more potent than phtalate metabolites in reducing pancreatic beta-cell function. BioMed Res Int:4614379. https:\/\/doi.org\/10.1155\/2017\/4614379","journal-title":"BioMed Research International"},{"key":"1997_CR32","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.ijheh.2006.11.009","volume":"210","author":"M Wittassek","year":"2007","unstructured":"Wittassek M, Heger W, Koch HM, Becker K, Angerer J, Kolossa-Gehring M (2007) Daily intake of di (2-ethylhexyl) phthalate (DEHP) by German children\u2014a comparison of two estimation models based on urinary DEHP metabolite levels. Int J Hyg Environ Health 210:35\u201342","journal-title":"Int J Hyg Environ Health"},{"key":"1997_CR33","unstructured":"World Health Organization (2013) Fact sheet diabetes: global report on diabetes, http:\/\/www.who.int\/diabetes\/global-report\/en\/ . Global Industry Analysts, \u201cBisphenol A\u2014A Global Strategic Business Report\u201d"},{"key":"1997_CR34","doi-asserted-by":"publisher","first-page":"15469","DOI":"10.1038\/s41598-017-15533-z","volume":"7","author":"Y Wu","year":"2017","unstructured":"Wu Y, Li J, Yan B, Zhu Y, Liu X, Chen M, Li D, Lee CC, Yang X, Ma P (2017) Oral exposure to dibutyl phthalate exacerbates chronic lymphocytic thyroiditis through oxidative stress in female Wistar rats. Sci Rep 7:15469. https:\/\/doi.org\/10.1038\/s41598-017-15533-z","journal-title":"Sci Rep"}],"container-title":["Environmental Science and Pollution Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11356-018-1997-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-018-1997-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-018-1997-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,20]],"date-time":"2022-08-20T16:48:18Z","timestamp":1661014098000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11356-018-1997-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,21]]},"references-count":34,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["1997"],"URL":"https:\/\/doi.org\/10.1007\/s11356-018-1997-z","relation":{},"ISSN":["0944-1344","1614-7499"],"issn-type":[{"type":"print","value":"0944-1344"},{"type":"electronic","value":"1614-7499"}],"subject":[],"published":{"date-parts":[[2018,4,21]]},"assertion":[{"value":"29 November 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 April 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 April 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}