{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T21:31:55Z","timestamp":1773696715690,"version":"3.50.1"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"27","license":[{"start":{"date-parts":[[2018,7,13]],"date-time":"2018-07-13T00:00:00Z","timestamp":1531440000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Environ Sci Pollut Res"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1007\/s11356-018-2419-y","type":"journal-article","created":{"date-parts":[[2018,7,13]],"date-time":"2018-07-13T16:33:06Z","timestamp":1531499586000},"page":"26916-26926","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Unraveling molecular targets of bisphenol A and S in the thyroid gland"],"prefix":"10.1007","volume":"25","author":[{"given":"Clemilson","family":"Berto-J\u00fanior","sequence":"first","affiliation":[]},{"given":"Ana Paula","family":"Santos-Silva","sequence":"additional","affiliation":[]},{"given":"Andrea Claudia Freitas","family":"Ferreira","sequence":"additional","affiliation":[]},{"given":"Jones Bernades","family":"Graceli","sequence":"additional","affiliation":[]},{"given":"Denise Pires","family":"de Carvalho","sequence":"additional","affiliation":[]},{"given":"Paula","family":"Soares","sequence":"additional","affiliation":[]},{"given":"Nelilma Correia","family":"Romeiro","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7832-8717","authenticated-orcid":false,"given":"Leandro","family":"Miranda-Alves","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2018,7,13]]},"reference":[{"issue":"10","key":"2419_CR1","doi-asserted-by":"publisher","first-page":"1566","DOI":"10.1038\/ijo.2016.95","volume":"40","author":"S Ahmed","year":"2016","unstructured":"Ahmed S, Atlas E (2016) Bisphenol S- and bisphenol A-induced adipogenesis of murine preadipocytes occurs through direct peroxisome proliferator-activated receptor gamma activation. Int J Obes 40(10):1566\u20131573. \n                    https:\/\/doi.org\/10.1038\/ijo.2016.95","journal-title":"Int J Obes"},{"issue":"7","key":"2419_CR2","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.1038\/bjp.2008.249","volume":"154","author":"TP Barros","year":"2008","unstructured":"Barros TP, Alderton WK, Reynolds HM, Roach AG, Berghmans S (2008) Zebrafish: an emerging technology for in vivo pharmacological assessment to identify potential safety liabilities in early drug discovery. Br J Pharmacol 154(7):1400\u20131413. \n                    https:\/\/doi.org\/10.1038\/bjp.2008.249","journal-title":"Br J Pharmacol"},{"key":"2419_CR3","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/j.reprotox.2009.06.014","volume":"28","author":"M Bondesson","year":"2009","unstructured":"Bondesson M, J\u00f6nsson J, Pongratz I, Olea N, Cravedi JP, Zalko D, H\u00e5kansson H, Halldin K, Di Lorenzo D, Behl C et al (2009) A CASCADE of effects of bisphenol A. Reprod Toxicol 28:563\u2013567. \n                    https:\/\/doi.org\/10.1016\/j.reprotox.2009.06.014","journal-title":"Reprod Toxicol"},{"issue":"12","key":"2419_CR4","doi-asserted-by":"publisher","first-page":"2266","DOI":"10.1093\/hmg\/ddp162","volume":"18","author":"A Carr\u00e9","year":"2009","unstructured":"Carr\u00e9 A, Szinnai G, Castanet M, Sura-Trueba S, Tron E, Broutin-L\u2019Hermite I et al (2009) Five new TTF1\/NKX2.1 mutations in brain-lung-thyroid syndrome: rescue by PAX8 synergism in one case. Hum Mol Genet 18(12):2266\u20132276. \n                    https:\/\/doi.org\/10.1093\/hmg\/ddp162","journal-title":"Hum Mol Genet"},{"issue":"17","key":"2419_CR5","doi-asserted-by":"publisher","first-page":"30051","DOI":"10.1016\/j.mce.2017.01.038","volume":"S0303-7207","author":"DP Carvalho","year":"2017","unstructured":"Carvalho DP, Dupuy C (2017) Thyroid hormone biosynthesis and release. Mol Cell Endocrinol S0303-7207(17):30051\u201330055. \n                    https:\/\/doi.org\/10.1016\/j.mce.2017.01.038","journal-title":"Mol Cell Endocrinol"},{"key":"2419_CR6","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1016\/j.envres.2011.05.014","volume":"111","author":"JL Carwile","year":"2011","unstructured":"Carwile JL, Michels KB (2011) Urinary bisphenol A and obesity: NHANES 2003-2006. Environ Res 111:825\u2013830. \n                    https:\/\/doi.org\/10.1016\/j.envres.2011.05.014","journal-title":"Environ Res"},{"issue":"2","key":"2419_CR7","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1016\/j.bbr.2010.06.001","volume":"214","author":"DL Champagne","year":"2010","unstructured":"Champagne DL, Hoefnagels CC, de Kloet RE, Richardson MK (2010) Translating rodent behavioral repertoire to zebrafish (Danio rerio): relevance for stress research. Behav Brain Res 214(2):332\u2013342","journal-title":"Behav Brain Res"},{"key":"2419_CR8","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.aquatox.2011.10.013","volume":"108","author":"WK Chan","year":"2012","unstructured":"Chan WK, King MC (2012) Disruption of the hypothalamic-pituitary-thyroid axis in zebrafish embryo-larvae following waterborne exposure to BDE-47, TBBPA and BPA. Aquat Toxicol 108:106\u2013111. \n                    https:\/\/doi.org\/10.1016\/j.aquatox.2011.10.013","journal-title":"Aquat Toxicol"},{"issue":"1\u20132","key":"2419_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.mce.2004.06.006","volume":"223","author":"D Christophe","year":"2004","unstructured":"Christophe D (2004) The control of thyroid-specific gene expression: what exactly have we learned as yet? Mol Cell Endocrinol 223(1\u20132):1\u20134","journal-title":"Mol Cell Endocrinol"},{"key":"2419_CR10","doi-asserted-by":"publisher","unstructured":"Codutti L, van Ingen H, Vascotto C, Fogolari F, Corazza A, Tell G, Quadrifoglio F, Viglino P, Boelens R, Esposito G (2008) The solution structure of DNA-free Pax-8 paired box domain accounts for redox regulation of transcriptional activity in the pax protein family. J Biol Chem 283(48):33321\u201333328. \n                    https:\/\/doi.org\/10.1074\/jbc.M805717200","DOI":"10.1074\/jbc.M805717200"},{"issue":"1","key":"2419_CR11","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.fertnstert.2014.11.005","volume":"103","author":"S Eladak","year":"2015","unstructured":"Eladak S, Grisin T, Moison D, Guerguin NJ et al (2015) A new chapter in the bisphenol A story: bisphenol S and bisphenol F are not safe alternatives to this compound. Fertil Steril 103(1):11\u201321. \n                    https:\/\/doi.org\/10.1016\/j.fertnstert.2014.11.005","journal-title":"Fertil Steril"},{"issue":"Pt 1","key":"2419_CR12","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1042\/bj3310037","volume":"331","author":"C Esposito","year":"1998","unstructured":"Esposito C, Miccadei S, Saiardi A, Civitareale D (1998) PAX 8 activates the enhancer of the human thyroperoxidase gene. Biochem J 331(Pt 1):37\u201340","journal-title":"Biochem J"},{"issue":"3","key":"2419_CR13","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1677\/jme.0.0210347","volume":"21","author":"D Fabbro","year":"1998","unstructured":"Fabbro D, Pellizzari L, Mercuri F, Tell G, Damante G (1998) Pax-8 protein levels regulate thyroglobulin gene expression. J Mol Endocrinol 21(3):347\u2013354","journal-title":"J Mol Endocrinol"},{"issue":"3","key":"2419_CR14","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1016\/j.pbb.2011.04.021","volume":"99","author":"DL Gebauer","year":"2011","unstructured":"Gebauer DL, Pagnussat N, Piato AL, Schaefer IC, Bonan CD, Lara DR (2011) Effects of anxiolytics in zebrafish: similarities and differences between benzodiazepines, buspirone and ethanol. Pharmacol Biochem Behav 99(3):480\u2013486","journal-title":"Pharmacol Biochem Behav"},{"issue":"4","key":"2419_CR15","doi-asserted-by":"publisher","first-page":"2609","DOI":"10.3390\/molecules15042609","volume":"15","author":"R Gerlai","year":"2010","unstructured":"Gerlai R (2010) High-throughput behavioral screens: the first step towards finding genes involved in vertebrate brain function using zebrafish. Molecules 15(4):2609\u20132622. \n                    https:\/\/doi.org\/10.3390\/molecules15042609","journal-title":"Molecules"},{"issue":"6","key":"2419_CR16","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1507\/endocrj.44.775","volume":"44","author":"F Kambe","year":"1997","unstructured":"Kambe F, Seo H (1997) Thyroid-specific transcription factors. Endocr J 44(6):775\u2013784","journal-title":"Endocr J"},{"issue":"5","key":"2419_CR17","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.1073\/pnas.1417731112","volume":"112","author":"CD Kinch","year":"2015","unstructured":"Kinch CD, Kingsley I, Joo-Hyun JHRH, Kurrasch DM (2015) Low-dose exposure to bisphenol A and replacement bisphenol S induces precocious hypothalamic neurogenesis in embryonic zebrafish. Proc Natl Acad Sci U S A 112(5):1475\u20131480. \n                    https:\/\/doi.org\/10.1073\/pnas.1417731112","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2419_CR18","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.etap.2016.10.018","volume":"48","author":"B Kwon","year":"2016","unstructured":"Kwon B, Kho Y, Kim PG, Ji K (2016) Thyroid endocrine disruption in male zebrafish following exposure to binary mixture of bisphenol AF and sulfamethoxazole. Environ Toxicol Pharmacol 48:168\u2013174. \n                    https:\/\/doi.org\/10.1016\/j.etap.2016.10.018","journal-title":"Environ Toxicol Pharmacol"},{"key":"2419_CR19","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.tiv.2017.02.004","volume":"40","author":"S Lee","year":"2017","unstructured":"Lee S, Kim C, Youn H, Choi K (2017) Thyroid hormone disrupting potentials of bisphenol A and its analogues\u2014in vitro comparison study employing rat pituitary (GH3) and thyroid follicular (FRTL-5) cells. Toxicol in Vitro 40:297\u2013304. \n                    https:\/\/doi.org\/10.1016\/j.tiv.2017.02.004","journal-title":"Toxicol in Vitro"},{"key":"2419_CR20","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25(4):402\u2013408"},{"issue":"1","key":"2419_CR21","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/ng0598-83","volume":"19","author":"PE Macchia","year":"1998","unstructured":"Macchia PE, Lapi P, Krude H, Pirro MT, Missero C, Chiovato L, Souabni A, Baserga M, Tassi V, Pinchera A, Fenzi G, Gr\u00fcters A, Busslinger M, Lauro RD (1998) PAX8 mutations associated with congenital hypothyroidism caused by thyroid dysgenesis. Nat Genet 19(1):83\u201386","journal-title":"Nat Genet"},{"issue":"5","key":"2419_CR22","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1089\/zeb.2016.1261","volume":"13","author":"K Makarova","year":"2016","unstructured":"Makarova K, Siudem P, Zawada K, Kurkoviak J (2016) Screening of toxic effects of bisphenol A and products of its degradation: zebrafish (Danio rerio) embryo test and molecular docking. Zebrafish 13(5):466\u2013474. \n                    https:\/\/doi.org\/10.1089\/zeb.2016.1261","journal-title":"Zebrafish"},{"key":"2419_CR23","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/978-3-319-01619-1_3","volume":"228","author":"FP Manfo","year":"2014","unstructured":"Manfo FP, Jubendradass R, Nantia EA, Moundipa PF, Mathur PP (2014) Adverse effects of bisphenol A on male reproductive function. Rev Environ Contam Toxicol 228:57\u201382. \n                    https:\/\/doi.org\/10.1007\/978-3-319-01619-1_3","journal-title":"Rev Environ Contam Toxicol"},{"key":"2419_CR24","doi-asserted-by":"publisher","first-page":"e328","DOI":"10.1542\/peds.2011-3374","volume":"130","author":"NN Maserejian","year":"2012","unstructured":"Maserejian NN, Trachtenberg FL, Hauser R, McKinlay S, Shrader P, Tavares M, Bellinger DC (2012) Dental composite restorations and psychosocial function in children. Pediatrics 130:e328\u2013e338. \n                    https:\/\/doi.org\/10.1542\/peds.2011-3374","journal-title":"Pediatrics"},{"issue":"8","key":"2419_CR25","doi-asserted-by":"publisher","first-page":"e43378","DOI":"10.1371\/journal.pone.0043378","volume":"7","author":"D Melzer","year":"2012","unstructured":"Melzer D, Gates P, Osborn NJ, Henley WE, Cipelli R, Young A, Money C, McCormack P, Schofield P, Mosedale D, Grainger D, Galloway TS (2012) Urinary bisphenol A concentration and angiography-defined coronary artery stenosis. PLoSOne 7(8):e43378. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0043378","journal-title":"PLoSOne"},{"issue":"2","key":"2419_CR26","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1016\/j.etap.2014.02.003","volume":"37","author":"J Michalowicz","year":"2014","unstructured":"Michalowicz J (2014) Bisphenol A\u2014sources, toxicity and biotransformation. Environ Toxicol Pharmacol 37(2):738\u2013758. \n                    https:\/\/doi.org\/10.1016\/j.etap.2014.02.003","journal-title":"Environ Toxicol Pharmacol"},{"key":"2419_CR27","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.ecoenv.2012.11.010","volume":"88","author":"AM Molina","year":"2013","unstructured":"Molina AM, Lora AJ, Blanco A, Monterde JG, Ayala N, Moyano R (2013) Endocrine-active compound evaluation: qualitative and quantitative histomorphological assessment of zebrafish gonads after bisphenol-A exposure. Ecotoxicol Environ Saf 88:155\u2013162. \n                    https:\/\/doi.org\/10.1016\/j.ecoenv.2012.11.010","journal-title":"Ecotoxicol Environ Saf"},{"issue":"1\u20132","key":"2419_CR28","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.mce.2010.03.009","volume":"322","author":"L Montanelli","year":"2010","unstructured":"Montanelli L, Tonacchera M (2010) Genetics and phenomics of hypothyroidism and thyroid dys- and agenesis due to PAX8 and TTF1 mutations. Mol Cell Endocrinol 322(1\u20132):64\u201371. \n                    https:\/\/doi.org\/10.1016\/j.mce.2010.03.009","journal-title":"Mol Cell Endocrinol"},{"issue":"11","key":"2419_CR29","doi-asserted-by":"publisher","first-page":"5185","DOI":"10.1210\/jc.2002-020209","volume":"87","author":"K Moriyama","year":"2002","unstructured":"Moriyama K, Tagami T, Akamizu T, Saijo M, Kanamoto N, Hataya Y, Shimatzu A, Kuzuya H, Nakao K (2002) Thyroid hormone action is disrupted by bisphenol A as an antagonist. J Clin Endocrinol Metab 87(11):5185\u20135190","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"2419_CR30","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1530\/EJE-12-0410","volume":"167","author":"S Narumi","year":"2012","unstructured":"Narumi S, Araki S, Hori N, Muroya K, Yamamoto Y, Asakura Y, Adachi M, Hasegawa T (2012) Functional characterization of four novel PAX8 mutations causing congenital hypothyroidism: new evidence for haploinsufficiency as a disease mechanism. Eur J Endocrinol 167(5):625\u2013632. \n                    https:\/\/doi.org\/10.1530\/EJE-12-0410","journal-title":"Eur J Endocrinol"},{"issue":"4","key":"2419_CR31","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1007\/s12038-007-0068-2","volume":"32","author":"SK Panigrahi","year":"2007","unstructured":"Panigrahi SK, Desiraju GR (2007) Strong and week hydrogen bonds in drug-DNA complexes: a statistical analysis. J Biosci 32(4):677\u2013691","journal-title":"J Biosci"},{"issue":"Pt 2","key":"2419_CR32","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1042\/bj3370253","volume":"337","author":"L Pellizzari","year":"1999","unstructured":"Pellizzari L, Tell G, Damante G (1999) Co-operation between the PAI and RED subdomains of Pax-8 in the interaction with the thyroglobulin promoter. Biochem J 337(Pt 2):253\u2013262","journal-title":"Biochem J"},{"key":"2419_CR33","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1289\/ehp.1103634","volume":"120","author":"C Philippat","year":"2012","unstructured":"Philippat C, Mortamais M, Chevrier C, Petit C, Calafat AM, Ye X, Silva MJ, Brambilla C, Pin I, Charles MA, Cordier S, Slama R (2012) Exposure to phthalates and phenols during pregnancy and offspring size at birth. Environ Health Perspect 120:464\u2013470. \n                    https:\/\/doi.org\/10.1289\/ehp.1103634","journal-title":"Environ Health Perspect"},{"issue":"1\u20132","key":"2419_CR34","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.mce.2009.05.011","volume":"312","author":"P Porazzi","year":"2009","unstructured":"Porazzi P, Calebiro D, Benato F, Tiso N, Persani L (2009) Thyroid gland development and function in the zebrafish model. Mol Cell Endocrinol 312(1\u20132):14\u201323. \n                    https:\/\/doi.org\/10.1016\/j.mce.2009.05.011","journal-title":"Mol Cell Endocrinol"},{"issue":"4","key":"2419_CR35","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1530\/EJE-13-1006","volume":"171","author":"HE Ramos","year":"2014","unstructured":"Ramos HE, Carr\u00e9 A, Chevrier L, Sznnai G, Tron E et al (2014) Extreme phenotypic variability of thyroid dysgenesis in six new cases of congenital hypothyroidism due to PAX8 gene loss-of-function mutations. Eur J Endocrinol 171(4):499\u2013507. \n                    https:\/\/doi.org\/10.1530\/EJE-13-1006","journal-title":"Eur J Endocrinol"},{"key":"2419_CR36","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.reprotox.2013.08.008","volume":"42","author":"JR Rochester","year":"2013","unstructured":"Rochester JR (2013) Bisphenol A and human health: a review of the literature. Reprod Toxicol 42:132\u2013155. \n                    https:\/\/doi.org\/10.1016\/j.reprotox.2013.08.008","journal-title":"Reprod Toxicol"},{"issue":"1","key":"2419_CR37","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1093\/toxsci\/kfu030","volume":"139","author":"AK Rosenmai","year":"2014","unstructured":"Rosenmai AK, Dybdahl M, Pedersen M, Alice van Vugt-Lussenburg BM, Wedebye AB, Taxvig C, Vinggaard AM (2014) Are structural analogues to bisphenol a safe alternatives? Toxicol Sci 139(1):35\u201347. \n                    https:\/\/doi.org\/10.1093\/toxsci\/kfu030","journal-title":"Toxicol Sci"},{"key":"2419_CR38","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.jsbmb.2011.08.007","volume":"127","author":"T Schug","year":"2011","unstructured":"Schug T, Janesick A, Blumberg B, Heindel J (2011) Endocrine disrupting chemicals and disease susceptibility. J Steroid Biochem Mol Biol 127:204\u2013211. \n                    https:\/\/doi.org\/10.1016\/j.jsbmb.2011.08.007","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"1","key":"2419_CR39","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1111\/j.1469-185X.2007.00030.x","volume":"83","author":"R Spence","year":"2008","unstructured":"Spence R, Gerlach G, Lawrence C, Smith C (2008) The behaviour and ecology of the zebrafish, Danio rerio. Biol Rev Camb Philos Soc 83(1):13\u201334. \n                    https:\/\/doi.org\/10.1111\/j.1469-185X.2007.00030.x","journal-title":"Biol Rev Camb Philos Soc"},{"issue":"2","key":"2419_CR40","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1182\/blood-2004-12-4653","volume":"106","author":"S Sumanas","year":"2005","unstructured":"Sumanas S, Jorniak T, Lin S (2005) Identification of novel vascular endothelial-specific genes by the microarray analysis of the zebrafish cloche mutants. Blood 106(2):534\u2013541. \n                    https:\/\/doi.org\/10.1182\/blood-2004-12-4653","journal-title":"Blood"},{"issue":"1\u20132","key":"2419_CR41","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.aquatox.2011.04.007","volume":"105","author":"X Terrien","year":"2011","unstructured":"Terrien X, Jean-Baptiste FBA, Demeneix KWS, Patrick P (2011) Generation of fluorescent zebrafish to study endocrine disruption and potential crosstalk between thyroid hormone and corticosteroids. Aquat Toxicol 105(1\u20132):13\u201320. \n                    https:\/\/doi.org\/10.1016\/j.aquatox.2011.04.007","journal-title":"Aquat Toxicol"},{"issue":"3","key":"2419_CR42","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1210\/er.2011-1050","volume":"33","author":"LN Vandenberg","year":"2012","unstructured":"Vandenberg LN, Colborn T, Hayes TB, Heindel JJ, DRJr J, Lee DH, Shioda T, Soto AM, vom Saal FS, Welshons WV, Zoeller RT, Myers JP (2012) Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses. Endocr Rev 33(3):378\u2013455. \n                    https:\/\/doi.org\/10.1210\/er.2011-105033","journal-title":"Endocr Rev"},{"key":"2419_CR43","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/1472-6823-14-69","volume":"22","author":"M Vicenzi","year":"2014","unstructured":"Vicenzi M, Camilot M, Ferrarini E, Teofoli F, Venturi G, Gaudino R, Cavarzere P, De Marco G, Agretti P, Dimida A, Tonacchera M, Boner A, Antoniazzi F (2014) Identification of a novel pax 8 gene sequence variant in four members of the same family: from congenital hypothyroidism with thyroid hypoplasia to mild subclinical hypothyroidism. BMC Endocr Disord 22:14\u201369. \n                    https:\/\/doi.org\/10.1186\/1472-6823-14-69","journal-title":"BMC Endocr Disord"},{"key":"2419_CR44","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1007\/s00204-008-0364-0","volume":"83","author":"M Yang","year":"2009","unstructured":"Yang M, Ryu JH, Jeon R, Kang D, Yoo KY (2009) Effects of bisphenol A on breast cancer and its risk factors. Arch Toxicol 83:281\u2013285. \n                    https:\/\/doi.org\/10.1007\/s00204-008-0364-0","journal-title":"Arch Toxicol"},{"issue":"1","key":"2419_CR45","doi-asserted-by":"publisher","first-page":"12","DOI":"10.15430\/JCP.2015.20.1.12","volume":"20","author":"O Yang","year":"2015","unstructured":"Yang O, Kim HL, Weon JI, Seo YR (2015) Endocrine-disrupting chemicals: review of toxicological mechanisms using molecular pathway analysis. J Cancer Prev 20(1):12\u201324. \n                    https:\/\/doi.org\/10.15430\/JCP.2015.20.1.12","journal-title":"J Cancer Prev"},{"issue":"5","key":"2419_CR46","doi-asserted-by":"publisher","first-page":"e0176927","DOI":"10.1371\/journal.pone.0176927","volume":"12","author":"DH Zhang","year":"2017","unstructured":"Zhang DH, Zhou EX, Yang ZL (2017a) Waterborne exposure to BPS causes thyroid endocrine disruption in zebrafish larvae. PLoS One 12(5):e0176927. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0176927","journal-title":"PLoS One"},{"issue":"17","key":"2419_CR47","doi-asserted-by":"publisher","first-page":"33580","DOI":"10.1016\/j.envpol.2017.11.027","volume":"S0269-7491","author":"YF Zhang","year":"2017","unstructured":"Zhang YF, Xiao-Min R, Yuan-Yuan L, Xiao-Fang Y, Chuan-Hai L, Zhan-Fen Q, Liang-Hong G (2017b) Bisphenol A alternatives bisphenol S and bisphenol F interfere with thyroid hormone signaling pathway in vitro and in vivo. Environ Pollut S0269-7491(17):33580\u201333587. \n                    https:\/\/doi.org\/10.1016\/j.envpol.2017.11.027","journal-title":"Environ Pollut"}],"container-title":["Environmental Science and Pollution Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11356-018-2419-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-018-2419-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11356-018-2419-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,12]],"date-time":"2019-07-12T19:06:02Z","timestamp":1562958362000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11356-018-2419-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,13]]},"references-count":47,"journal-issue":{"issue":"27","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["2419"],"URL":"https:\/\/doi.org\/10.1007\/s11356-018-2419-y","relation":{},"ISSN":["0944-1344","1614-7499"],"issn-type":[{"value":"0944-1344","type":"print"},{"value":"1614-7499","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,13]]},"assertion":[{"value":"4 January 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 May 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 July 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The Ethics Committee for the Use of Animals (CEUA) of the Federal University of Rio de Janeiro approved all the procedures (number 045\/14).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was supported by Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro (PP-SUS-FAPERJ E-26\/110.282\/2014; JCNE-FAPERJ, E-26\/201.520\/2014; APQ1-FAPERJ, E-26\/111.485\/2014), Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior (CAPES\/Ci\u00eancias sem Fronteiras\/Pesquisador Visitante Especial\/88881.062218\/2014-0), and Conselho Nacional de Desenvolvimento Cient\u00edfico (CNPq, PQ- N\u00edvel 2, 305872\/2016-8). Berto-J\u00fanior scholarship and Ana Paula Santos-Silva fellowship were provided by CAPES. This research was also supported by FAPES No. 03\/2017-UNIVERSAL (#179\/2017) and CNPq No. 12\/2017 (#304724\/2017-3). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Financial support"}},{"value":"No competing financial interests exist.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosure statement"}}]}}