{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T10:45:21Z","timestamp":1772102721166,"version":"3.50.1"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2012,8,2]],"date-time":"2012-08-02T00:00:00Z","timestamp":1343865600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["AGE"],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1007\/s11357-012-9461-3","type":"journal-article","created":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T06:57:47Z","timestamp":1343804267000},"page":"1949-1959","source":"Crossref","is-referenced-by-count":43,"title":["ACE I\/D and ACTN3 R\/X polymorphisms as potential factors in modulating exercise-related phenotypes in older women in response to a muscle power training stimuli"],"prefix":"10.1007","volume":"35","author":[{"given":"Ana","family":"Pereira","sequence":"first","affiliation":[]},{"given":"Aldo M.","family":"Costa","sequence":"additional","affiliation":[]},{"given":"Mikel","family":"Izquierdo","sequence":"additional","affiliation":[]},{"given":"Ant\u00f3nio J.","family":"Silva","sequence":"additional","affiliation":[]},{"given":"Estela","family":"Bastos","sequence":"additional","affiliation":[]},{"given":"M\u00e1rio C.","family":"Marques","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2012,8,2]]},"reference":[{"key":"9461_CR1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1159\/000235696","volume":"54","author":"II Ahmetov","year":"2009","unstructured":"Ahmetov II, Rogozkin VA (2009) Genes, athlete status and training\u2014an overview. Med Sport Sci 54:43\u201371","journal-title":"Med Sport Sci"},{"key":"9461_CR2","first-page":"443","volume":"33","author":"C Bouchard","year":"2001","unstructured":"Bouchard C, Rankinen T (2001) Individual differences in response to regular physical activity. Med Sci Sports Exerc 33:443\u2013452","journal-title":"Med Sci Sports Exerc"},{"key":"9461_CR3","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1055\/s-0030-1247529","volume":"3","author":"N Bustamante-Ara","year":"2010","unstructured":"Bustamante-Ara N, Santiago C, Verde Z, Yvert T, Gomez-Gallego F, Rodriguez-Romo G et al (2010) ACE and ACTN3 genes and muscle phenotypes in nonagenarians. Int J Sports Med 3:221\u2013222","journal-title":"Int J Sports Med"},{"key":"9461_CR4","doi-asserted-by":"crossref","unstructured":"Chanock SJ, Manolio T, Boehnke M, Boerwinkle E, Hunter DJ, Thomas G, Hirschhorn JN, Abecasis G, Altshuler D, Bailey-Wilson JE, Brooks LD, Cardon LR, Daly M, Donnelly P, Fraumeni JF Jr, Freimer NB, Gerhard DS, Gunter C, Guttmacher AE, Guyer MS, Harris EL, Hoh J, Hoover R, Kong CA, Merikangas KR, Morton CC, Palmer LJ, Phimister EG, Rice JP, Roberts J, Rotimi C, Tucker MA, Vogan KJ, Wacholder S, Wijsman EM, Winn DM, Collins FS (2007) Replicating genotype-phenotype associations. Nature 447(7145):655\u2013660","DOI":"10.1038\/447655a"},{"key":"9461_CR5","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1249\/MSS.0b013e318161eab9","volume":"40","author":"DE Charbonneau","year":"2008","unstructured":"Charbonneau DE, Hanson ED, Ludlow AT, Delmonico MJ, Hurley BF, Roth SM (2008) ACE genotype and the muscle hypertrophic and strength responses to strength training. Med Sci Sports Exerc 40:677\u2013683","journal-title":"Med Sci Sports Exerc"},{"key":"9461_CR6","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1152\/japplphysiol.01139.2004","volume":"99","author":"PM Clarkson","year":"2005","unstructured":"Clarkson PM, Devaney JM, Gordish-Dressman H, Thompson PD, Hubal MJ, Urso M et al (2005) ACTN3 genotype is associated with increases in muscle strength in response to resistance training in women. J Appl Physiol 99:154\u2013163","journal-title":"J Appl Physiol"},{"key":"9461_CR7","doi-asserted-by":"crossref","first-page":"737","DOI":"10.2165\/00007256-200737090-00001","volume":"37","author":"VG Coffey","year":"2007","unstructured":"Coffey VG, Hawley JA (2007) The molecular bases of training adaptation. Sports Med 37:737\u2013763","journal-title":"Sports Med"},{"key":"9461_CR8","first-page":"410","volume":"8","author":"AM Costa","year":"2009","unstructured":"Costa AM, Silva AJ, Garrido ND, Louro H, Marinho DA, Marques MC et al (2009) Angiotensin-converting enzyme genotype affects skeletal muscle strength in elite athletes. J Sports Sci Med 8:410\u2013418","journal-title":"J Sports Sci Med"},{"key":"9461_CR9","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1093\/gerona\/63.11.1227","volume":"63","author":"MJ Delmonico","year":"2008","unstructured":"Delmonico MJ, Zmuda JM, Taylor BC, Cauley JA, Harris TB, Manini TM et al (2008) Association of the ACTN3 genotype and physical functioning with age in older adults. J Gerontol A Biol Sci Med Sci 63:1227\u20131234","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"9461_CR10","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1017\/S0958067000020571","volume":"85","author":"J Folland","year":"2000","unstructured":"Folland J, Leach B, Little T, Hawker K, Myerson S, Montgomery H et al (2000) Angiotensin-converting enzyme genotype affects the response of human skeletal muscle to functional overload. Exp Physiol 85:575\u2013579","journal-title":"Exp Physiol"},{"key":"9461_CR11","doi-asserted-by":"crossref","unstructured":"Garatachea N, Lucia A (2011) Genes and the ageing muscle: a review on genetic association studies. Age (Dordr). doi: 10.1007\/s11357-011-9327-0","DOI":"10.1007\/s11357-011-9327-0"},{"key":"9461_CR12","doi-asserted-by":"crossref","unstructured":"Garatachea N, Fiuza-Luces C, Torres-Luque G, Yvert T, Santiago C, Gomez-Gallego F et al (2011) Single and combined influence of ACE and ACTN3 genotypes on muscle phenotypes in octogenarians. Eur J Appl Physiol. doi: 10.1007\/s00421-011-2217-4","DOI":"10.1007\/s00421-011-2217-4"},{"key":"9461_CR13","first-page":"284","volume":"47","author":"V Gineviciene","year":"2011","unstructured":"Gineviciene V, Pranculis A, Jakaitiene A, Milasius K, Kucinskas V (2011) Genetic variation of the human ACE and ACTN3 genes and their association with functional muscle properties in Lithuanian elite athletes. Medicina (Kaunas) 47:284\u2013290","journal-title":"Medicina (Kaunas)"},{"key":"9461_CR14","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1055\/s-2008-1038677","volume":"30","author":"F Gomez-Gallego","year":"2009","unstructured":"Gomez-Gallego F, Santiago C, Gonzalez-Freire M, Muniesa CA, Fernandez Del Valle M, Perez M et al (2009) Endurance performance: genes or gene combinations? Int J Sports Med 30:66\u201372","journal-title":"Int J Sports Med"},{"key":"9461_CR15","doi-asserted-by":"crossref","first-page":"E150","DOI":"10.1152\/ajpendo.2001.280.1.E150","volume":"280","author":"SE Gordon","year":"2001","unstructured":"Gordon SE, Davis BS, Carlson CJ, Booth FW (2001) ANG II is required for optimal overload-induced skeletal muscle hypertrophy. Am J Physiol Endocrinol Metab 280:E150\u2013E159","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"9461_CR16","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1046\/j.1365-201x.1999.00590.x","volume":"167","author":"M Izquierdo","year":"1999","unstructured":"Izquierdo M, Ibanez J, Gorostiaga E, Garrues M, Zuniga A, Anton A et al (1999) Maximal strength and power characteristics in isometric and dynamic actions of the upper and lower extremities in middle-aged and older men. Acta Physiol Scand 167:57\u201368","journal-title":"Acta Physiol Scand"},{"key":"9461_CR17","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1093\/gerona\/glq189","volume":"66","author":"RN Judson","year":"2011","unstructured":"Judson RN, Wackerhage H, Hughes A, Mavroeidi A, Barr RJ, Macdonald HM et al (2011) The functional ACTN3 577X variant increases the risk of falling in older females: results from two large independent cohort studies. J Gerontol A Biol Sci Med Sci 66:130\u2013135","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"9461_CR18","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/bies.200900110","volume":"32","author":"M Lek","year":"2010","unstructured":"Lek M, Quinlan KG, North KN (2010) The evolution of skeletal muscle performance: gene duplication and divergence of human sarcomeric alpha-actinins. Bioessays 32:17\u201325","journal-title":"Bioessays"},{"key":"9461_CR19","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1055\/s-0030-1267229","volume":"32","author":"RM Lima","year":"2010","unstructured":"Lima RM, Leite TK, Pereira RW, Rabelo HT, Roth SM, Oliveira RJ (2010) ACE and ACTN3 genotypes in older women: muscular phenotypes. Int J Sports Med 32:66\u201372","journal-title":"Int J Sports Med"},{"key":"9461_CR20","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1002\/bies.20061","volume":"26","author":"DG MacArthur","year":"2004","unstructured":"MacArthur DG, North KN (2004) A gene for speed? The evolution and function of alpha-actinin-3. Bioessays 26:786\u2013795","journal-title":"Bioessays"},{"key":"9461_CR21","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1123\/japa.17.4.416","volume":"17","author":"AP Marsh","year":"2009","unstructured":"Marsh AP, Miller ME, Rejeski WJ, Hutton SL, Kritchevsky SB (2009) Lower extremity muscle function after strength or power training in older adults. J Aging Phys Act 17:416\u2013443","journal-title":"J Aging Phys Act"},{"key":"9461_CR22","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1113\/expphysiol.2008.043075","volume":"94","author":"T McCauley","year":"2009","unstructured":"McCauley T, Mastana SS, Hossack J, Macdonald M, Folland JP (2009) Human angiotensin-converting enzyme I\/D and alpha-actinin 3 R577X genotypes and muscle functional and contractile properties. Exp Physiol 94:81\u201389","journal-title":"Exp Physiol"},{"key":"9461_CR23","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s00421-009-1340-y","volume":"109","author":"T McCauley","year":"2010","unstructured":"McCauley T, Mastana SS, Folland JP (2010) ACE I\/D and ACTN3 R\/X polymorphisms and muscle function and muscularity of older Caucasian men. Eur J Appl Physiol 109:269\u2013277","journal-title":"Eur J Appl Physiol"},{"key":"9461_CR24","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1093\/hmg\/10.13.1335","volume":"10","author":"MA Mills","year":"2001","unstructured":"Mills MA, Yang N, Weinberger RP, Vander Woude DL, Beggs AH, Easteal S et al (2001) Differential expression of the actin-binding proteins, alpha-actinin-2 and-3, in different species: implications for the evolution of functional redundancy. Hum Mol Genet 10:1335\u20131346","journal-title":"Hum Mol Genet"},{"key":"9461_CR25","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.exger.2011.12.010","volume":"47","author":"A Pereira","year":"2012","unstructured":"Pereira A, Izquierdo M, Silva AJ, Costa AM, Bastos E, Gonzalez-Badillo JJ et al (2012) Effects of high-speed power training on functional capacity and muscle performance in older women. Exp Gerontol 47:250\u2013255","journal-title":"Exp Gerontol"},{"key":"9461_CR26","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1249\/01.mss.0000222835.28273.80","volume":"38","author":"LS Pescatello","year":"2006","unstructured":"Pescatello LS, Kostek KA, Gordish-Dressman H, Thompson PD, Seip RL, Price TB et al (2006) ACE ID genotype and the muscle strength and size response to unilateral resistance training. Med Sci Sports Exerc 38:1074\u20131081","journal-title":"Med Sci Sports Exerc"},{"key":"9461_CR27","doi-asserted-by":"crossref","first-page":"433","DOI":"10.2165\/11588720-000000000-00000","volume":"41","author":"Z Puthucheary","year":"2011","unstructured":"Puthucheary Z, Skipworth JR, Rawal J, Loosemore M, Van Someren K, Montgomery HE (2011a) The ACE gene and human performance: 12\u00a0years on. Sports Med 41:433\u2013448","journal-title":"Sports Med"},{"key":"9461_CR28","doi-asserted-by":"crossref","first-page":"845","DOI":"10.2165\/11593200-000000000-00000","volume":"48","author":"Z Puthucheary","year":"2011","unstructured":"Puthucheary Z, Skipworth JR, Rawal J, Loosemore M, Van Someren K, Montgomery HE (2011b) Genetic influences in sport and physical performance. Sports Med 48:845\u2013859","journal-title":"Sports Med"},{"key":"9461_CR29","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1097\/JES.0b013e31823b5f13","volume":"40","author":"KF Reid","year":"2012","unstructured":"Reid KF, Fielding RA (2012) Skeletal muscle power: a critical determinant of physical functioning in older adults. Exerc Sport Sci Rev 40:4\u201312","journal-title":"Exerc Sport Sci Rev"},{"key":"9461_CR30","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/8760","volume":"22","author":"MJ Rieder","year":"1999","unstructured":"Rieder MJ, Taylor SL, Clark AG, Nickerson DA (1999) Sequence variation in the human angiotensin converting enzyme. Nat Genet 22:59\u201362","journal-title":"Nat Genet"},{"key":"9461_CR31","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1007\/s00421-010-1608-2","volume":"110","author":"G Rodriguez-Romo","year":"2010","unstructured":"Rodriguez-Romo G, Ruiz JR, Santiago C, Fiuza-Luces C, Gonzalez-Freire M, Gomez-Gallego F et al (2010) Does the ACE I\/D polymorphism, alone or in combination with the ACTN3 R577X polymorphism, influence muscle power phenotypes in young, non-athletic adults? Eur J Appl Physiol 110:1099\u20131106","journal-title":"Eur J Appl Physiol"},{"key":"9461_CR32","doi-asserted-by":"crossref","first-page":"3369","DOI":"10.1519\/JSC.0b013e3181f00c7c","volume":"24","author":"SP Sayers","year":"2010","unstructured":"Sayers SP, Gibson K (2010) A comparison of high-speed power training and traditional slow-speed resistance training in older men and women. J Strength Cond Res 24:3369\u20133380","journal-title":"J Strength Cond Res"},{"key":"9461_CR33","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1249\/MSS.0b013e3181ae2bc0","volume":"42","author":"RA Scott","year":"2010","unstructured":"Scott RA, Irving R, Irwin L, Morrison E, Charlton V, Austin K et al (2010) ACTN3 and ACE genotypes in elite Jamaican and US sprinters. Med Sci Sports Exerc 42:107\u2013112","journal-title":"Med Sci Sports Exerc"},{"key":"9461_CR34","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.exger.2010.11.006","volume":"46","author":"JT Seto","year":"2011","unstructured":"Seto JT, Chan S, Turner N, MacArthur DG, Raftery JM, Berman YD et al (2011) The effect of alpha-actinin-3 deficiency on muscle aging. Exp Gerontol 46:292\u2013302","journal-title":"Exp Gerontol"},{"key":"9461_CR35","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1097\/00005768-199805000-00013","volume":"30","author":"MA Thomis","year":"1998","unstructured":"Thomis MA, Beunen GP, Maes HH, Blimkie CJ, Van Leemputte M, Claessens AL et al (1998) Strength training: importance of genetic factors. Med Sci Sports Exerc 30:724\u2013731","journal-title":"Med Sci Sports Exerc"},{"key":"9461_CR36","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1152\/physiolgenomics.00173.2007","volume":"32","author":"B Vincent","year":"2007","unstructured":"Vincent B, De Bock K, Ramaekers M, Van den Eede E, Van Leemputte M, Hespel P et al (2007) ACTN3 (R577X) genotype is associated with fiber type distribution. Physiol Genomics 32:58\u201363","journal-title":"Physiol Genomics"},{"key":"9461_CR37","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/s00421-006-0293-7","volume":"98","author":"H Wagner","year":"2006","unstructured":"Wagner H, Thaller S, Dahse R, Sust M (2006) Biomechanical muscle properties and angiotensin-converting enzyme gene polymorphism: a model-based study. Eur J Appl Physiol 98:507\u2013515","journal-title":"Eur J Appl Physiol"},{"key":"9461_CR38","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1113\/jphysiol.2007.141887","volume":"586","author":"AG Williams","year":"2008","unstructured":"Williams AG, Folland JP (2008) Similarity of polygenic profiles limits the potential for elite human physical performance. J Physiol 586:113\u2013121","journal-title":"J Physiol"},{"key":"9461_CR39","first-page":"944","volume":"37","author":"AG Williams","year":"2005","unstructured":"Williams AG, Day SH, Folland JP, Gohlke P, Dhamrait S, Montgomery HE (2005) Circulating angiotensin converting enzyme activity is correlated with muscle strength. Med Sci Sports Exerc 37:944\u2013948","journal-title":"Med Sci Sports Exerc"},{"key":"9461_CR40","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1007\/s004390100466","volume":"108","author":"D Woods","year":"2001","unstructured":"Woods D, Hickman M, Jamshidi Y, Brull D, Vassiliou V, Jones A et al (2001) Elite swimmers and the D allele of the ACE I\/D polymorphism. Hum Genet 108:230\u2013232","journal-title":"Hum Genet"},{"key":"9461_CR41","doi-asserted-by":"crossref","unstructured":"Yu JG, Furst DO, Thornell LE (2003) The mode of myofibril remodelling in human skeletal muscle affected by DOMS induced by eccentric contractions. Histochem Cell Biol 119:383\u2013393","DOI":"10.1007\/s00418-003-0522-7"},{"key":"9461_CR42","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1034\/j.1399-0004.2003.00029.x","volume":"63","author":"B Zhang","year":"2003","unstructured":"Zhang B, Tanaka H, Shono N, Miura S, Kiyonaga A, Shindo M et al (2003) The I allele of the angiotensin-converting enzyme gene is associated with an increased percentage of slow-twitch type I fibers in human skeletal muscle. Clin Genet 63:139\u2013144","journal-title":"Clin Genet"}],"container-title":["AGE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11357-012-9461-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11357-012-9461-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11357-012-9461-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,12]],"date-time":"2020-07-12T05:14:35Z","timestamp":1594530875000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11357-012-9461-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,2]]},"references-count":42,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["9461"],"URL":"https:\/\/doi.org\/10.1007\/s11357-012-9461-3","relation":{},"ISSN":["0161-9152","1574-4647"],"issn-type":[{"value":"0161-9152","type":"print"},{"value":"1574-4647","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,2]]}}}