{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T06:02:48Z","timestamp":1760853768939},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2014,4,23]],"date-time":"2014-04-23T00:00:00Z","timestamp":1398211200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["AGE"],"published-print":{"date-parts":[[2014,6]]},"DOI":"10.1007\/s11357-014-9654-z","type":"journal-article","created":{"date-parts":[[2014,4,22]],"date-time":"2014-04-22T16:43:50Z","timestamp":1398185030000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Cholesterol metabolism changes under long-term dietary restrictions while the cholesterol homeostasis remains unaffected in the cortex and hippocampus of aging rats"],"prefix":"10.1007","volume":"36","author":[{"given":"Kosara","family":"Smiljanic","sequence":"first","affiliation":[]},{"given":"Tim","family":"Vanmierlo","sequence":"additional","affiliation":[]},{"given":"Aleksandra","family":"Mladenovic Djordjevic","sequence":"additional","affiliation":[]},{"given":"Milka","family":"Perovic","sequence":"additional","affiliation":[]},{"given":"Sanja","family":"Ivkovic","sequence":"additional","affiliation":[]},{"given":"Dieter","family":"L\u00fctjohann","sequence":"additional","affiliation":[]},{"given":"Selma","family":"Kanazir","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2014,4,23]]},"reference":[{"key":"9654_CR1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.expneurol.2008.01.016","volume":"211","author":"MM Adams","year":"2008","unstructured":"Adams MM, Shi L, Linville MC, Forbes ME, Long AB, Bennett C, Newton IG, Carter CS, Sonntag WE, Riddle DR, Brunso-Bechtold JK (2008) Caloric restriction and age affect synaptic proteins in hippocampal CA3 and spatial learning ability. Exp Neurol 211:141\u2013149","journal-title":"Exp Neurol"},{"key":"9654_CR2","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1100\/tsw.2009.46","volume":"9","author":"S Asha Devi","year":"2009","unstructured":"Asha Devi S (2009) Aging brain: prevention of oxidative stress by vitamin E and exercise. Sci World J 9:366\u2013372","journal-title":"Sci World J"},{"key":"9654_CR3","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/S0022-2275(20)31660-6","volume":"42","author":"I Bjorkhem","year":"2001","unstructured":"Bjorkhem I, Starck L, Andersson U, L\u00fctjohann D, von Bahr S, Pikuleva I, Babiker A, Diczfalusy U (2001) Oxysterols in the circulation of patients with the Smith\u2013Lemli\u2013Opitz syndrome: abnormal levels of 24S- and 27-hydroxycholesterol. J Lipid Res 42:366\u2013371","journal-title":"J Lipid Res"},{"key":"9654_CR4","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/nrn1809","volume":"7","author":"SN Burke","year":"2006","unstructured":"Burke SN, Barnes CA (2006) Neural plasticity in the aging brain. Nat Neurosci 7:30\u201340","journal-title":"Nat Neurosci"},{"key":"9654_CR5","doi-asserted-by":"crossref","unstructured":"Camargo N, Brouwers JF, Loos M, Gutmann DH, Smit AB, Verheijen MH (2012) High-fat diet ameliorates neurological deficits caused by defective astrocyte lipid metabolism. FASEB J 6(10):4302\u20134315","DOI":"10.1096\/fj.12-205807"},{"issue":"6","key":"9654_CR6","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1159\/000323481","volume":"57","author":"S Couillard-Despres","year":"2011","unstructured":"Couillard-Despres S, Iglseder B, Aigner L (2011) Neurogenesis, cellular plasticity and cognition: the impact of stem cells in the adult and aging brain\u2014a mini-review. Gerontology 57(6):559\u2013564","journal-title":"Gerontology"},{"key":"9654_CR7","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.arr.2006.05.002","volume":"5","author":"RG Cutler","year":"2006","unstructured":"Cutler RG, Mattson MP (2006) The adversities of aging. Ageing Res Rev 5:221\u2013238","journal-title":"Ageing Res Rev"},{"issue":"3","key":"9654_CR8","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1677\/JOE-08-0242","volume":"198","author":"E Marinis De","year":"2008","unstructured":"De Marinis E, Martini C, Trentalance A, Pallottini V (2008) Sex differences in hepatic regulation of cholesterol homeostasis. J Endocrinol 198(3):635\u2013643","journal-title":"J Endocrinol"},{"issue":"2","key":"9654_CR9","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1097\/00041433-200104000-00003","volume":"12","author":"JM Dietschy","year":"2001","unstructured":"Dietschy JM, Turley SD (2001) Cholesterol metabolism in the brain. Curr Opin Lipidol 12(2):105\u2013112","journal-title":"Curr Opin Lipidol"},{"key":"9654_CR10","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.jsbmb.2010.02.026","volume":"121","author":"K Fon Tacer","year":"2010","unstructured":"Fon Tacer K, Pompon D, Rozman D (2010) Adaptation of cholesterol synthesis to fasting and TNF-alpha: profiling cholesterol intermediates in the liver, brain, and testis. J Steroid Biochem Mol Biol 121:619\u2013625","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"2","key":"9654_CR11","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s12035-008-8040-1","volume":"38","author":"A Font\u00e1n-Lozano","year":"2008","unstructured":"Font\u00e1n-Lozano A, L\u00f3pez-Lluch G, Delgado-Garc\u00eda JM, Navas P, Carri\u00f3n AM (2008) Molecular bases of caloric restriction regulation of neuronal synaptic plasticity. Mol Neurobiol 38(2):167\u2013177","journal-title":"Mol Neurobiol"},{"issue":"6257","key":"9654_CR12","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/343425a0","volume":"343","author":"JL Goldstein","year":"1990","unstructured":"Goldstein JL, Brown MS (1990) Regulation of the mevalonate pathway. Nature 343(6257):425\u2013430","journal-title":"Nature"},{"key":"9654_CR13","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.mcn.2005.02.006","volume":"29","author":"C Goritz","year":"2005","unstructured":"Goritz C, Mauch DH, Frank W, Pfrieger FW (2005) Multiple mechanisms mediate cholesterol-induced synaptogenesis in a CNS neuron. Mol Cell Neurosci 29:190\u2013201","journal-title":"Mol Cell Neurosci"},{"issue":"2","key":"9654_CR14","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.jcis.2008.09.057","volume":"329","author":"K Hac-Wydro","year":"2009","unstructured":"Hac-Wydro K, Wydro P, Dynarowicz-\u0141atka P, Paluch M (2009) Cholesterol and phytosterols effect on sphingomyelin\/phosphatidylcholine model membranes\u2014thermodynamic analysis of the interactions in ternary monolayers. J Colloid Interface Sci 329(2):265\u2013272","journal-title":"J Colloid Interface Sci"},{"key":"9654_CR15","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.nbd.2006.12.019","volume":"26","author":"VK Halagappa","year":"2007","unstructured":"Halagappa VK, Guo Z, Pearson M, Matsuoka Y, Cutler RG, Laferla FM, Mattson MP (2007) Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer\u2019s disease. Neurobiol Dis 26:212\u2013220","journal-title":"Neurobiol Dis"},{"key":"9654_CR16","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.neulet.2006.12.022","volume":"414","author":"K Hayakawa","year":"2007","unstructured":"Hayakawa K, Mishima K, Nozako M, Hazekawa M, Aoyama Y, Ogata A, Harada K, Fujioka M, Abe K, Egashira N, Iwasaki K, Fujiwara M (2007) High-cholesterol feeding aggravates cerebral infarction via decreasing the CB1 receptor. Neurosci Lett 414:183\u2013187","journal-title":"Neurosci Lett"},{"key":"9654_CR17","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.bbalip.2006.03.015","volume":"1761","author":"PJ Jansen","year":"2006","unstructured":"Jansen PJ, Lutjohann D, Abildayeva K, Vanmierlo T, Plosch T, Plat J, von Bergmann K, Groen AK, Ramaekers FC, Kuipers F, Mulder M (2006) Dietary plant sterols accumulate in the brain. Biochim Biophys Acta 1761:445\u2013453","journal-title":"Biochim Biophys Acta"},{"issue":"3","key":"9654_CR18","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1096\/fj.12-211235","volume":"27","author":"M Jansen","year":"2013","unstructured":"Jansen M, Wang W, Greco D, Bellenchi GC, di Porzio U, Brown AJ, Ikonen E (2013) What dictates the accumulation of desmosterol in the developing brain? FASEB J 27(3):865\u2013870","journal-title":"FASEB J"},{"issue":"4","key":"9654_CR19","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1037\/a0014188","volume":"23","author":"S Jessberger","year":"2008","unstructured":"Jessberger S, Gage FH (2008) Stem-cell-associated structural and functional plasticity in the aging hippocampus. Psychol Aging 23(4):684\u2013691","journal-title":"Psychol Aging"},{"key":"9654_CR20","doi-asserted-by":"crossref","first-page":"3579","DOI":"10.1523\/JNEUROSCI.4741-08.2009","volume":"29","author":"JM Karasinska","year":"2009","unstructured":"Karasinska JM, Rinninger F, L\u00fctjohann D, Ruddle P, Franciosi S, Kruit JK, Singaraja RR, Hirsch-Reinshagen V, Fan J, Brunham LR, Bissada N, Ramakrishnan R, Wellington CL, Parks JS, Hayden MR (2009) Specific loss of brain ABCA1 increases brain cholesterol uptake and influences neuronal structure and function. J Neurosci 29:3579\u20133589","journal-title":"J Neurosci"},{"issue":"2","key":"9654_CR21","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.jnutbio.2013.09.015","volume":"25","author":"H Koivisto","year":"2014","unstructured":"Koivisto H, Grimm MO, Rothhaar TL, Berkecz R, L\u00fctjohann D, Giniatullina R, Takalo M, Miettinen PO, Lahtinen HM, Giniatullin R, Penke B, Jan\u00e1ky T, Broersen LM, Hartmann T, Tanila H (2014) Special lipid-based diets alleviate cognitive deficits in the APPswe\/PS1dE9 transgenic mouse model of Alzheimer\u2019s disease independent of brain amyloid deposition. J Nutr Biochem 25(2):157\u2013169","journal-title":"J Nutr Biochem"},{"issue":"1","key":"9654_CR22","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.plipres.2011.11.004","volume":"51","author":"MD Ledesma","year":"2012","unstructured":"Ledesma MD, Martin MG, Dotti CG (2012) Lipid changes in the aged brain: effect on synaptic function and neuronal survival. Prog Lipid Res 51(1):23\u201335","journal-title":"Prog Lipid Res"},{"key":"9654_CR23","doi-asserted-by":"crossref","first-page":"16536","DOI":"10.1074\/jbc.M001811200","volume":"275","author":"J Li-Hawkins","year":"2000","unstructured":"Li-Hawkins J, Lund EG, Turley SD, Russell DW (2000) Disruption of the oxysterol 7alpha-hydroxylase gene in mice. J Biol Chem 275:16536\u201316542","journal-title":"J Biol Chem"},{"key":"9654_CR24","doi-asserted-by":"crossref","first-page":"7238","DOI":"10.1073\/pnas.96.13.7238","volume":"96","author":"EG Lund","year":"1999","unstructured":"Lund EG, Guileyardo JM, Russell DW (1999) cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain. Proc Natl Acad Sci U S A 96:7238\u20137243","journal-title":"Proc Natl Acad Sci U S A"},{"key":"9654_CR25","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1194\/jlr.M200071-JLR200","volume":"43","author":"D Lutjohann","year":"2002","unstructured":"Lutjohann D, Brzezinka A, Barth E, Abramowski D, Staufenbiel M, von Bergmann K, Beyreuther K, Multhaup G, Bayer TA (2002) Profile of cholesterol-related sterols in aged amyloid precursor protein transgenic mouse brain. J Lipid Res 43:1078\u20131085","journal-title":"J Lipid Res"},{"key":"9654_CR26","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/jcb.21158","volume":"101","author":"C Martini","year":"2007","unstructured":"Martini C, Pallottini V, Cavallini G, Donati A, Bergamini E, Trentalance A (2007) Caloric restrictions affect some factors involved in age-related hypercholesterolemia. J Cell Biochem 101:235\u2013243","journal-title":"J Cell Biochem"},{"key":"9654_CR27","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.mad.2008.09.010","volume":"129","author":"C Martini","year":"2008","unstructured":"Martini C, Pallottini V, De Marinis E, Marino M, Cavallini G, Donati A, Straniero S, Trentalance A (2008) Omega-3 as well as caloric restriction prevent the age-related modifications of cholesterol metabolism. Mech Ageing Dev 129:722\u2013727","journal-title":"Mech Ageing Dev"},{"key":"9654_CR28","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1126\/science.294.5545.1354","volume":"294","author":"DH Mauch","year":"2001","unstructured":"Mauch DH, Nagler K, Schumacher S et al (2001) CNS synaptogenesis promoted by glia-derived cholesterol. Science 294:1354\u20131357","journal-title":"Science"},{"key":"9654_CR29","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/0031-9384(93)90243-9","volume":"54","author":"LW Means","year":"1993","unstructured":"Means LW, Higgins JL, Fernandez TJ (1993) Mid-life onset of dietary restriction extends life and prolongs cognitive functioning. Physiol Behav 54:503\u2013508","journal-title":"Physiol Behav"},{"key":"9654_CR30","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.neuint.2009.10.008","volume":"56","author":"A Mladenovic Djordjevic","year":"2010","unstructured":"Mladenovic Djordjevic A, Perovic M, Tesic V, Tanic N, Rakic L, Ruzdijic S, Kanazir S (2010) Long-term dietary restriction modulates the level of presynaptic proteins in the cortex and hippocampus of the aging rat. Neurochem Int 56:250\u2013255","journal-title":"Neurochem Int"},{"key":"9654_CR31","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.brainresrev.2007.03.011","volume":"55","author":"F Mora","year":"2007","unstructured":"Mora F, Segovia G, del Arco A (2007) Aging, plasticity and environmental enrichment: structural changes and neurotransmitter dynamics in several areas of brain. Brain Res Rev 55:78\u201388","journal-title":"Brain Res Rev"},{"key":"9654_CR32","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.mad.2004.11.010","volume":"126","author":"MF Mulas","year":"2005","unstructured":"Mulas MF, Demuro G, Mulas C, Putzolu M, Cavallini G, Donati A, Bergamini E, Dessi S (2005) Dietary restriction counteracts age-related changes in cholesterol metabolism in the rat. Mech Ageing Dev 126:648\u2013654","journal-title":"Mech Ageing Dev"},{"key":"9654_CR33","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1023\/B:BGEN.0000006557.92558.60","volume":"4","author":"V Pallottini","year":"2003","unstructured":"Pallottini V, Marino M, Cavallini G, Bergamini E, Trentalance A (2003) Age-related changes of isoprenoid biosynthesis in rat liver and brain. Biogerontology 4:371\u2013378","journal-title":"Biogerontology"},{"issue":"12","key":"9654_CR34","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1111\/ejn.12249","volume":"37","author":"JH Park","year":"2013","unstructured":"Park JH, Glass Z, Sayed K, Michurina TV, Lazutkin A, Mineyeva O, Velmeshev D, Ward WF, Richardson A, Enikolopov G (2013) Calorie restriction alleviates the age-related decrease in neural progenitor cell division in the aging brain. Eur J Neurosci 37(12):1987\u20131993","journal-title":"Eur J Neurosci"},{"key":"9654_CR35","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1007\/s10522-009-9220-8","volume":"10","author":"M Perovic","year":"2009","unstructured":"Perovic M, Mladenovic Djordjevic A, Smiljanic K, Tanic N, Rakic L, Ruzdijic S, Kanazir S (2009) Expression of cholesterol homeostasis genes in the brain of the male rat is affected by age and dietary restriction. Biogerontology 10:735\u2013745","journal-title":"Biogerontology"},{"key":"9654_CR36","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1093\/ajcn\/6.6.644","volume":"6","author":"DW Peterson","year":"1958","unstructured":"Peterson DW (1958) Plant sterols and tissue cholesterol levels. Am J Clin Nutr 6:644\u2013649","journal-title":"Am J Clin Nutr"},{"key":"9654_CR37","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1002\/bies.10195","volume":"25","author":"F Pfrieger","year":"2002","unstructured":"Pfrieger F (2002) Outsourcing in the brain: do neurons depend on cholesterol delivery by astrocytes. Bioessays 25:72\u201376","journal-title":"Bioessays"},{"key":"9654_CR38","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0005-2736(03)00024-5","volume":"1610","author":"FW Pfrieger","year":"2003","unstructured":"Pfrieger FW (2003) Role of cholesterol in synapse formation and function. Biochim Biophys Acta 1610:271\u2013280","journal-title":"Biochim Biophys Acta"},{"key":"9654_CR39","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.plipres.2011.06.002","volume":"50","author":"FW Pfrieger","year":"2011","unstructured":"Pfrieger FW, Ungerer N (2011) Cholesterol metabolism in neurons and astrocytes. Prog Lipid Res 50:357\u2013371","journal-title":"Prog Lipid Res"},{"key":"9654_CR40","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/sj.ejcn.1601071","volume":"54","author":"J Plat","year":"2000","unstructured":"Plat J, van Onselen EN, van Heugten MM, Mensink RP (2000) Effects on serum lipids, lipoproteins and fat soluble antioxidant concentrations of consumption frequency of margarines and shortenings enriched with plant stanol esters. Eur J Clin Nutr 54:671\u2013677","journal-title":"Eur J Clin Nutr"},{"key":"9654_CR41","doi-asserted-by":"crossref","first-page":"8350","DOI":"10.1073\/pnas.0903541106","volume":"106","author":"K Saito","year":"2009","unstructured":"Saito K, Dubreuil V, Arai Y, Wilsch-Br\u00e4uninger M, Schwudke D, Saher G, Miyata T, Breier G, Thiele C, Shevchenko A, Nave KA, Huttner WB (2009) Ablation of cholesterol biosynthesis in neural stem cells increases their VEGF expression and angiogenesis but causes neuron apoptosis. Proc Natl Acad Sci U S A 106:8350\u20138355","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"9654_CR42","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1194\/jlr.M022376","volume":"53","author":"Y Sato","year":"2012","unstructured":"Sato Y, Suzuki I, Nakamura T, Bernier F, Aoshima K, Oda Y (2012) Identification of a new plasma biomarker of Alzheimer\u2019s disease using metabolomics technology. J Lipid Res 53(3):567\u2013576","journal-title":"J Lipid Res"},{"issue":"1","key":"9654_CR43","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/j.1748-1716.2012.02450.x","volume":"206","author":"M Segatto","year":"2012","unstructured":"Segatto M, Trapani L, Lecis C, Pallottini V (2012) Regulation of cholesterol biosynthetic pathway in different regions of the rat central nervous system. Acta Physiol (Oxf) 206(1):62\u201371","journal-title":"Acta Physiol (Oxf)"},{"key":"9654_CR44","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.brainresbull.2005.11.005","volume":"70","author":"G Segovia","year":"2006","unstructured":"Segovia G, Yag\u00fce AG, Garc\u00eda-Verdugo JM, Mora F (2006) Environmental enrichment promotes neurogenesis and changes the extracellular concentrations of glutamate and GABA in the hippocampus of aged rats. Brain Res Bull 70:8\u201314","journal-title":"Brain Res Bull"},{"issue":"3","key":"9654_CR45","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/S0021-9258(18)96879-1","volume":"241","author":"MD Siperstein","year":"1966","unstructured":"Siperstein MD, Fagan VM (1966) Feedback control of mevalonate synthesis by dietary cholesterol. J Biol Chem 241(3):602\u2013609","journal-title":"J Biol Chem"},{"key":"9654_CR46","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1007\/s11745-013-3836-9","volume":"48","author":"K Smiljanic","year":"2013","unstructured":"Smiljanic K, Vanmierlo T, Mladenovic Djordjevic A, Perovic M, Loncarevic-Vasiljkovic N, Tesic V, Lj R, Ruzdijic S, Lutjohann D, Kanazir S (2013) Aging induces tissue-specific changes in cholesterol metabolism in rat brain and liver. Lipids 48:1069\u20131077","journal-title":"Lipids"},{"issue":"4","key":"9654_CR47","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1111\/j.1471-4159.2011.07351.x","volume":"118","author":"AM Stranahan","year":"2011","unstructured":"Stranahan AM, Cutler RG, Button C, Telljohann R, Mattson MP (2011) Diet-induced elevations in serum cholesterol are associated with alterations in hippocampal lipid metabolism and increased oxidative stress. J Neurochem 118(4):611\u2013615","journal-title":"J Neurochem"},{"issue":"1\u20132","key":"9654_CR48","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.neulet.2006.04.034","volume":"403","author":"KM Thelen","year":"2006","unstructured":"Thelen KM, Falkai P, Bayer TA, Lutjohann D (2006) Cholesterol synthesis rate in human hippocampus declines with aging. Neurosci Lett 403(1\u20132):15\u201319","journal-title":"Neurosci Lett"},{"key":"9654_CR49","doi-asserted-by":"crossref","unstructured":"Trapani L and Pallottini V (2010) Age-related hypercholesterolemia and HMG-CoA reductase dysregulation: sex does matter (a gender perspective). Curr Gerontol Geriatr Res. doi: 10.1155\/2010\/420139","DOI":"10.1155\/2010\/420139"},{"key":"9654_CR50","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1074\/jbc.M509530200","volume":"281","author":"S Vainio","year":"2006","unstructured":"Vainio S, Jansen M, Koivusalo M, R\u00f3g T, Karttunen M, Vattulainen I, Ikonen E (2006) Significance of sterol structural specificity. Desmosterol cannot replace cholesterol in lipid rafts. J Biol Chem 281:348\u2013355","journal-title":"J Biol Chem"},{"issue":"2","key":"9654_CR51","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s11130-011-0219-3","volume":"66","author":"T Vanmierlo","year":"2011","unstructured":"Vanmierlo T, Rutten K, van Vark-van der Zee LC, Friedrichs S, Bloks VW, Blokland A, Ramaekers FC, Sijbrands E, Steinbusch H, Prickaerts J, Kuipers F, L\u00fctjohann D, Mulder M (2011) Cerebral accumulation of dietary derivable plant sterols does not interfere with memory and anxiety related behavior in Abcg5\u2212\/\u2212mice. Plant Foods Hum Nutr 66(2):149\u2013156","journal-title":"Plant Foods Hum Nutr"},{"issue":"4","key":"9654_CR52","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1194\/jlr.M017244","volume":"53","author":"T Vanmierlo","year":"2012","unstructured":"Vanmierlo T, Weing\u00e4rtner O, van der Pol S, Husche C, Kerksiek A, Friedrichs S, Sijbrands E, Steinbusch H, Grimm M, Hartmann T, Laufs U, B\u00f6hm M, de Vries HE, Mulder M, L\u00fctjohann D (2012) Dietary intake of plant sterols stably increases plant sterol levels in the murine brain. J Lipid Res 53(4):726\u2013735","journal-title":"J Lipid Res"},{"key":"9654_CR53","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1126\/science.1090776","volume":"302","author":"A Wechsler","year":"2003","unstructured":"Wechsler A, Brafman A, Shafir M, Heverin M, Gottlieb H, Damari G, Gozlan-Kelner S, Spivak I, Moshkin O, Fridman E, Becker Y, Skaliter R, Einat P, Faerman A, Bj\u00f6rkhem I, Feinstein E (2003) Generation of viable cholesterol-free mice. Science 302:2087","journal-title":"Science"}],"container-title":["AGE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11357-014-9654-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11357-014-9654-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11357-014-9654-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T03:16:37Z","timestamp":1648869397000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11357-014-9654-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,23]]},"references-count":53,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["9654"],"URL":"https:\/\/doi.org\/10.1007\/s11357-014-9654-z","relation":{},"ISSN":["0161-9152","1574-4647"],"issn-type":[{"value":"0161-9152","type":"print"},{"value":"1574-4647","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,23]]},"article-number":"9654"}}