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To evaluate the rate of weight loss and comorbidity remission failure 10 years or more after RYGB surgery.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Materials and methods<\/jats:title>\n                <jats:p>Retrospective observational cohort study. Patients submitted to RYGB for obesity treatment at a single centre with 10 years or more after surgery underwent a clinical reassessment.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Among the subjects invited for clinical revaluation (<jats:italic>n<\/jats:italic> = 585), only those who performed RYGB and attended the hospital visit were included in the study (<jats:italic>n<\/jats:italic> = 281). The pre-operative mean body mass index (BMI) was 44.4 \u00b1 6.1 kg\/m<jats:sup>2<\/jats:sup>. Mean post-operative time was 12.2 \u00b1 1.1 years. After surgery, mean BMI was significantly lower 33.4 \u00b1 5.8 kg\/m<jats:sup>2<\/jats:sup> (<jats:italic>p<\/jats:italic> &lt; 0.0001), 29.5% with a BMI &lt; 30 kg\/m<jats:sup>2<\/jats:sup>. Mean Total Weight Lost (%TWL) was 24.3 \u00b1 11.4%, reaching a %TWL \u2265 20% in 70.1% with a mean %TWL of 30.0 \u00b1 7.0%. Co-morbidities remission rate was 54.2% for type 2 diabetes, 34.1% for hypertension, 52.4% for hyperlipidemia and 50% for obstructive sleep apnea. Early complications rate was 13.2% and revision surgery occurred in 2.8% of patients. Four patients died of RYGB complications within the first 90 days after surgery.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>RYGB has a high rate of long-term successful weight loss and obesity-associated comorbidity improvement. Weight loss failure requiring revision surgery occurs in a small proportion of patients. Our data confirms the long-term effectiveness of RYGB as primary bariatric intervention.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Graphical abstract<\/jats:title>\n                \n              <\/jats:sec>","DOI":"10.1007\/s11695-021-05458-y","type":"journal-article","created":{"date-parts":[[2021,5,22]],"date-time":"2021-05-22T08:02:47Z","timestamp":1621670567000},"page":"3623-3629","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["How Sustained is Roux-en-Y Gastric Bypass Long-term Efficacy?"],"prefix":"10.1007","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8094-7197","authenticated-orcid":false,"given":"Marta","family":"Guimar\u00e3es","sequence":"first","affiliation":[]},{"given":"Catarina","family":"Os\u00f3rio","sequence":"additional","affiliation":[]},{"given":"Diogo","family":"Silva","sequence":"additional","affiliation":[]},{"given":"Rui F.","family":"Almeida","sequence":"additional","affiliation":[]},{"given":"Ant\u00f3nio","family":"Reis","sequence":"additional","affiliation":[]},{"given":"Samuel","family":"Cardoso","sequence":"additional","affiliation":[]},{"given":"Sofia S.","family":"Pereira","sequence":"additional","affiliation":[]},{"given":"Mariana P.","family":"Monteiro","sequence":"additional","affiliation":[]},{"given":"M\u00e1rio","family":"Nora","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2021,5,22]]},"reference":[{"issue":"11","key":"5458_CR1","doi-asserted-by":"publisher","first-page":"1844","DOI":"10.1161\/CIRCRESAHA.116.307591","volume":"118","author":"BM Wolfe","year":"2016","unstructured":"Wolfe BM, Kvach E, Eckel RH. 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