{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T20:48:07Z","timestamp":1773089287162,"version":"3.50.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,4,4]],"date-time":"2020-04-04T00:00:00Z","timestamp":1585958400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,4,4]],"date-time":"2020-04-04T00:00:00Z","timestamp":1585958400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Intern Emerg Med"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1007\/s11739-020-02318-y","type":"journal-article","created":{"date-parts":[[2020,4,4]],"date-time":"2020-04-04T06:02:45Z","timestamp":1585980165000},"page":"101-108","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Outcomes of reperfusion therapy for acute ischaemic stroke in patients aged 90 years or older: a retrospective study"],"prefix":"10.1007","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3711-8788","authenticated-orcid":false,"given":"Clara","family":"Gomes","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0867-2576","authenticated-orcid":false,"given":"Vanessa","family":"Barcelos","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1813-2744","authenticated-orcid":false,"given":"Ver\u00f3nica","family":"Guiomar","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7863-1991","authenticated-orcid":false,"given":"Mariana","family":"Pintalh\u00e3o","sequence":"additional","affiliation":[]},{"given":"Jorge","family":"Almeida","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4208-7370","authenticated-orcid":false,"given":"Lu\u00edsa","family":"Fonseca","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2020,4,4]]},"reference":[{"key":"2318_CR1","unstructured":"United Nations Department of Economic and Social Affairs, Population Division (2019) World Population projections 2019. Available at https:\/\/population.un.org\/wpp\/Publications\/Files\/WPP2019_Highlights.pdf. Accessed 26 June 2019"},{"key":"2318_CR2","doi-asserted-by":"publisher","first-page":"1773","DOI":"10.1016\/S0140-6736(05)67702-1","volume":"366","author":"PM Rothwell","year":"2005","unstructured":"Rothwell PM, Coull AJ, Silver LE, Fairhead JF, Giles MF, Lovelock CE et al (2005) Population-based study of event-rate, incidence, case fatality, and mortality for all acute vascular events in all arterial territories (Oxford Vascular Study). Lancet 366:1773\u20131783","journal-title":"Lancet"},{"key":"2318_CR3","unstructured":"Kammersgaard LP, J\u00f8rgensen HS, Reith J, Nakayama H, Pedersen PM, Olsen TS; Copenhagen Stroke Study (2004) Short- and long-term prognosis for very old stroke patients. The Copenhagen Stroke Study. Age Ageing 33(2):149\u2013154"},{"key":"2318_CR4","doi-asserted-by":"crossref","unstructured":"The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group (1995) Tissue plasminogen activator for acute ischemic stroke. N Engl J Med 333:1581\u20131587","DOI":"10.1056\/NEJM199512143332401"},{"key":"2318_CR5","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1056\/NEJMoa0804656","volume":"359","author":"W Hacke","year":"2008","unstructured":"Hacke W, Kaste M, Bluhmki E, Brozman M, D\u00e1valos A, Guidetti D et al (2008) Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med 359:1317\u20131329","journal-title":"N Engl J Med"},{"key":"2318_CR6","doi-asserted-by":"crossref","unstructured":"Goyal M, Menon BK, Van Zwam WH et al. HERMES Collaborators (2016) Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomized trials. Lancet 387:1723\u20131731","DOI":"10.1016\/S0140-6736(16)00163-X"},{"key":"2318_CR7","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1016\/j.jstrokecerebrovasdis.2016.03.007","volume":"25","author":"PM Pego","year":"2016","unstructured":"Pego PM, Nunes AP, Ferreira P, Sousa C, Amaral-Silva A (2016) Thrombolysis in patients aged over 80 years is equally effective and safe. J Stroke Cerebrovasc Dis 25:1532\u20131538","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"2318_CR8","doi-asserted-by":"publisher","first-page":"1795","DOI":"10.1212\/01.wnl.0000183702.04080.27","volume":"65","author":"ST Engelter","year":"2005","unstructured":"Engelter ST, Reichhart M, Sekoranja L, Georgiadis D, Baumann A, Weder B et al (2005) Thrombolysis in stroke patients aged 80 years and older: Swiss survey of IV thrombolysis. Neurology 65:1795\u20131798","journal-title":"Neurology"},{"key":"2318_CR9","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/j.jstrokecerebrovasdis.2008.03.003","volume":"17","author":"S Pundik","year":"2008","unstructured":"Pundik S, McWilliams-Dunnigan L, Blackham KL, Kirchner HL, Sundararajan S, Sunshine JL et al (2008) Older age does not increase risk of hemorrhagic complications after intravenous and\/or intra-arterial thrombolysis for acute stroke. J Stroke Cerebrovasc Dis 17:266\u2013272","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"2318_CR10","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1159\/000351192","volume":"70","author":"M Balestrino","year":"2013","unstructured":"Balestrino M, Carlino V, Bruno C, Finocchi C, Mancardi GL, Del Sette M, Gandolfo C (2013) Safe and effective outcome of intravenous thrombolysis for acute ischemic stroke in patients aged 90 years or older. Eur Neurol 70:84\u201387","journal-title":"Eur Neurol"},{"key":"2318_CR11","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1007\/s11739-014-1095-2","volume":"9","author":"M Balestrino","year":"2014","unstructured":"Balestrino M, Strada L, Bruno C, Finocchi C, Gandolfo C (2014) Safety and efficacy even after 90 years of age should prompt removal of upper age limits in systemic thrombolysis for stroke. Intern Emerg Med 9:819\u2013820","journal-title":"Intern Emerg Med"},{"key":"2318_CR12","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.jstrokecerebrovasdis.2017.08.031","volume":"27","author":"R Behrouz","year":"2018","unstructured":"Behrouz R, Masju\u00e1n VJ, Vera R, Willey JZ, Zedet M, Moulin S et al (2018) Outcomes of nonagenarians with acute ischemic stroke treated with intravenous thrombolytics. J Stroke Cerebrovasc Dis 27:246\u2013256","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"2318_CR13","doi-asserted-by":"publisher","first-page":"1967","DOI":"10.1161\/STROKEAHA.110.601252","volume":"42","author":"H Sarikaya","year":"2011","unstructured":"Sarikaya H, Arnold M, Engelter ST, Lyrer PA, Michel P, Odier C et al (2011) Intravenous thrombolysis in nonagenarians with ischemic stroke. Stroke 42:1967\u20131970","journal-title":"Stroke"},{"key":"2318_CR14","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1186\/s12877-016-0331-1","volume":"16","author":"S Sagnier","year":"2016","unstructured":"Sagnier S, Galli P, Poli M, Debruxelles S, Renou P, Olindo S, Rouanet F, Sibon I (2016) The impact of intravenous thrombolysis on outcome of patients with acute ischemic stroke after 90 years old. BMC Geriatr 16:156","journal-title":"BMC Geriatr"},{"key":"2318_CR15","doi-asserted-by":"publisher","first-page":"2347","DOI":"10.1161\/STROKEAHA.116.012241","volume":"47","author":"R Arora","year":"2016","unstructured":"Arora R, Salamon E, Katz JM, Cox M, Saver JL, Bhatt DL et al (2016) Use and outcomes of intravenous thrombolysis for acute ischemic stroke in patients \u226590 years of age. Stroke 47:2347\u20132354","journal-title":"Stroke"},{"key":"2318_CR16","doi-asserted-by":"crossref","unstructured":"Drouard-De Rousiers E, Lucas L, Richard S, et al; on behalf of the ETIS (Endovascular Treatment in Ischemic Stroke) Investigators Group (2019) Impact of reperfusion for nonagenarians treated by mechanical thrombectomy. Stroke. doi: 10.1161\/STROKEAHA.119.026448.","DOI":"10.1161\/STROKEAHA.119.026448"},{"key":"2318_CR17","doi-asserted-by":"publisher","first-page":"299","DOI":"10.3174\/ajnr.A4976","volume":"38","author":"M M\u00f6hlenbruch","year":"2017","unstructured":"M\u00f6hlenbruch M, Pfaff J, Sch\u00f6nenberger S, Nagel S, B\u00f6sel J, Herweh C et al (2017) Endovascular stroke treatment of nonagenarians. Am J Neuroradiol 38:299\u2013303","journal-title":"Am J Neuroradiol"},{"key":"2318_CR18","unstructured":"Khan MA, Baird GL, Miller D, Patel A, Tsekhan S, Yaghi S et al (2016) Endovascular treatment of acute ischemic stroke in nonagenarians compared with younger patients in a multicenter cohort. J NeuroIntervent Surg 0:1\u20136"},{"key":"2318_CR19","doi-asserted-by":"crossref","unstructured":"Meyer L, Alexandrou M, Leischner H, Flottmann F, Deb-Chatterji M, Abdullayev N et al (2019) Mechanical thrombectomy in nonagenarians with acute ischemic stroke. J NeuroIntervent Surg 0:1\u20135","DOI":"10.1136\/neurintsurg-2019-014785"},{"issue":"1","key":"2318_CR20","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1161\/01.STR.24.1.35","volume":"24","author":"HP Adam Jr","year":"1993","unstructured":"Adam HP Jr, Bendixen BH, Kappelle LJ, Biller J, Love BB, Gordon DL, Marsh EE (1993) Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke 24(1):35\u201341","journal-title":"Stroke"},{"key":"2318_CR21","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1001\/jama.1995.03530130023023","volume":"274","author":"W Hacke","year":"1995","unstructured":"Hacke W, Kaste M, Fieschi C, Toni D, Lesaffre E, von Kummer R et al (1995) Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke. The European Cooperative Acute Stroke Study (ECASS). JAMA 274:1017\u20131025","journal-title":"JAMA"},{"issue":"4","key":"2318_CR22","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/S0025-6196(11)60542-9","volume":"84","author":"FJ Mateen","year":"2009","unstructured":"Mateen FJ, Nasser M, Spencer BR, Freeman WD, Shuaib A, Demaerschalk BM, Wijdicks EFM (2009) Outcomes of intravenous tissue plasminogen activator for acute ischemic stroke in patients aged 90 years or older. Mayo Clin Proc 84(4):334\u2013338","journal-title":"Mayo Clin Proc"},{"key":"2318_CR23","doi-asserted-by":"publisher","first-page":"2034","DOI":"10.1212\/WNL.0000000000003321","volume":"87","author":"FO Otite","year":"2016","unstructured":"Otite FO, Khandelwal P, Chaturvedi S et al (2016) Increasing atrial fibrillation prevalence in acute ischemic stroke and TIA. Neurology 87:2034\u20132042","journal-title":"Neurology"},{"issue":"9834","key":"2318_CR24","doi-asserted-by":"publisher","first-page":"2352","DOI":"10.1016\/S0140-6736(12)60768-5","volume":"379","author":"P Sandercock","year":"2012","unstructured":"Sandercock P, Wardlaw JM, Lindley RI, Dennis M, Cohen G, Murray G et al (2012) The benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic stroke (the third international stroke trial [IST-3]): a randomized controlled trial. Lancet 379(9834):2352\u20132363","journal-title":"Lancet"},{"key":"2318_CR25","doi-asserted-by":"publisher","first-page":"2284","DOI":"10.1161\/STROKEAHA.106.478156","volume":"38","author":"C Sellars","year":"2007","unstructured":"Sellars C, Bowie L, Bagg J, Sweeney MP, Miller H, Tilston J, Langhorne P, Stott DJ (2007) Risk factors for chest infection in acute stroke: a prospective cohort study. Stroke 38:2284\u20132291","journal-title":"Stroke"},{"issue":"4","key":"2318_CR26","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1212\/01.WNL.0000046586.38284.60","volume":"60","author":"IL Katzan","year":"2003","unstructured":"Katzan IL, Cebul RD, Husak SH, Dawson NV, Baker DW (2003) The effect of pneumonia on mortality among patients hospitalized for acute stroke. Neurology 60(4):620\u2013625","journal-title":"Neurology"},{"issue":"12","key":"2318_CR27","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1111\/j.1468-1331.2008.02310.x","volume":"15","author":"KS Hong","year":"2008","unstructured":"Hong KS, Kang DW, Koo JS, Yu KH, Han MK, Cho YJ, Park JM, Bae HJ, Lee BC (2008) Impact of neurological and medical complications on 3-month outcomes in acute ischaemic stroke. Eur J Neurol 15(12):1324\u20131331","journal-title":"Eur J Neurol"},{"key":"2318_CR28","unstructured":"Finlayson O, Kapral M, Hall R, Sallani E, Selchen D, Saposnik G; Canadian Stroke Network (2011) Stroke Outcome Research Canada (SORCan) Working Group. Risk factors, inpatient care and outcomes of pneumonia after ischemic stroke. Neurology 77(14):1338\u20131345"},{"issue":"2","key":"2318_CR29","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1161\/STROKEAHA.107.489294","volume":"39","author":"B Indredavik","year":"2008","unstructured":"Indredavik B, Rohweder G, Naalsund E, Lydersen S (2008) Medical complications in a comprehensive stroke unit and an early supported discharge service. Stroke 39(2):414\u2013420","journal-title":"Stroke"},{"key":"2318_CR30","doi-asserted-by":"crossref","unstructured":"Heuschmann PU, Kolominsky-Rabas PL, Misselwitz B, et al; for the German Stroke Registers Study Group (2004) Predictors of in-hospital mortality and attributable risks of death after ischemic stroke. Arch Intern Med 164:1761\u20131768","DOI":"10.1001\/archinte.164.16.1761"}],"container-title":["Internal and Emergency Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11739-020-02318-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11739-020-02318-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11739-020-02318-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,3]],"date-time":"2021-04-03T23:45:01Z","timestamp":1617493501000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11739-020-02318-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,4]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["2318"],"URL":"https:\/\/doi.org\/10.1007\/s11739-020-02318-y","relation":{},"ISSN":["1828-0447","1970-9366"],"issn-type":[{"value":"1828-0447","type":"print"},{"value":"1970-9366","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,4]]},"assertion":[{"value":"26 December 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 March 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 April 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The author(s) declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Data collection and analysis was approved by the local ethics committee.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statement of human and animal rights"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}