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In view of the limited supply of fish oil (FO) as a feed ingredient, the study of the capacity to biosynthesize long\u2010chain polyunsaturated fatty acids (LC\u2010PUFA) from alternative dietary oil sources is important. We analyzed changes in fatty acid (FA) desaturase 2 (<jats:italic>fads2<\/jats:italic>) and FA elongase 5 (<jats:italic>elovl5<\/jats:italic>) mRNA levels in livers and brains in response to FO replacement with a blend of vegetable oils (VO) and selenium (Se) supplementation. Fish were fed for 60 days with either a diet containing FO or a diet including VO, each supplemented or not with organic Se. Results showed that <jats:italic>fads2<\/jats:italic> and <jats:italic>elovl5<\/jats:italic> transcription was higher in liver when fish were fed VO diets. The brain mRNA levels of both genes were not affected by the dietary replacement of FO by VO. FA composition in the liver and skeletal muscle was altered by FO replacement, particularly by decreasing eicosapentaenoic acid and docosahexaenoic acid contents. The \u03b1\u2010linolenic, linoleic, and arachidonic acid contents increased in both liver and brain of fish fed VO diets. The effect of Se supplementation on lipid metabolism was evident only in fish fed FO, showing a decrease in the transcription of hepatic <jats:italic>fads2<\/jats:italic>. Results indicate that the total replacement of FO by VO in diets modulates the expression of genes involved in LC\u2010PUFA biosynthesis in meagre, affecting the FA profile of the fish flesh.<\/jats:p>","DOI":"10.1007\/s11745-016-4157-6","type":"journal-article","created":{"date-parts":[[2016,5,12]],"date-time":"2016-05-12T02:22:35Z","timestamp":1463019755000},"page":"729-741","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Dietary Oil Source and Selenium Supplementation Modulate <i>Fads2<\/i> and <i>Elovl5<\/i> Transcriptional Levels in Liver and Brain of Meagre (<i>Argyrosomus regius<\/i>)"],"prefix":"10.1002","volume":"51","author":[{"given":"Francisca","family":"Silva\u2010Brito","sequence":"first","affiliation":[{"name":"CIIMAR \u2013 Centro Interdisciplinar de Investiga\u00e7\u00e3o Marinha e Ambiental University of Porto Rua dos Bragas n.289 Porto 4050\u2010123 Portugal"},{"name":"ICBAS \u2013 Instituto de Ci\u00eancias Biom\u00e9dicas de Abel Salazar University of Porto Porto Portugal"}]},{"given":"Leonardo J.","family":"Magnoni","sequence":"additional","affiliation":[{"name":"CIIMAR \u2013 Centro Interdisciplinar de Investiga\u00e7\u00e3o Marinha e Ambiental University of Porto Rua dos Bragas n.289 Porto 4050\u2010123 Portugal"},{"name":"IIB\u2010INTECH \u2013 Instituto de Investigaciones Biotecnol\u00f3gicas\u2010Instituto Tecnol\u00f3gico de Chascom\u00fas (CONICET) Chascom\u00fas Argentina"}]},{"given":"Sthelio Braga","family":"Fonseca","sequence":"additional","affiliation":[{"name":"UFPB \u2013 Universidade Federal da Para\u00edba Para\u00edba Brazil"},{"name":"CCTA \u2013 Centro de Ciencias e Tecnologia Agroalimentar UFCG \u2013 Universidade Federal de Campina Grande Para\u00edba Brazil"}]},{"given":"Maria Jo\u00e3o","family":"Peixoto","sequence":"additional","affiliation":[{"name":"CIIMAR \u2013 Centro Interdisciplinar de Investiga\u00e7\u00e3o Marinha e Ambiental University of Porto Rua dos Bragas n.289 Porto 4050\u2010123 Portugal"},{"name":"ICBAS \u2013 Instituto de Ci\u00eancias Biom\u00e9dicas de Abel Salazar University of Porto Porto Portugal"}]},{"given":"L. Filipe C.","family":"Castro","sequence":"additional","affiliation":[{"name":"CIIMAR \u2013 Centro Interdisciplinar de Investiga\u00e7\u00e3o Marinha e Ambiental University of Porto Rua dos Bragas n.289 Porto 4050\u2010123 Portugal"},{"name":"FCUP \u2013 Faculty of Sciences University of Porto Porto Portugal"}]},{"given":"Isabel","family":"Cunha","sequence":"additional","affiliation":[{"name":"CIIMAR \u2013 Centro Interdisciplinar de Investiga\u00e7\u00e3o Marinha e Ambiental University of Porto Rua dos Bragas n.289 Porto 4050\u2010123 Portugal"}]},{"given":"Rodrigo Ot\u00e1vio","family":"de Almeida Oz\u00f3rio","sequence":"additional","affiliation":[{"name":"CIIMAR \u2013 Centro Interdisciplinar de Investiga\u00e7\u00e3o Marinha e Ambiental University of Porto Rua dos Bragas n.289 Porto 4050\u2010123 Portugal"},{"name":"ICBAS \u2013 Instituto de Ci\u00eancias Biom\u00e9dicas de Abel Salazar University of Porto Porto Portugal"}]},{"given":"Fernando 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