{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T19:57:01Z","timestamp":1762459021890},"reference-count":86,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2012,9,21]],"date-time":"2012-09-21T00:00:00Z","timestamp":1348185600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Curr Hypertens Rep"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1007\/s11906-012-0310-7","type":"journal-article","created":{"date-parts":[[2012,9,20]],"date-time":"2012-09-20T15:37:41Z","timestamp":1348155461000},"page":"498-509","source":"Crossref","is-referenced-by-count":72,"title":["Circulating miRNAs: Reflecting or Affecting Cardiovascular Disease?"],"prefix":"10.1007","volume":"14","author":[{"given":"Vanessa P. M.","family":"van Empel","sequence":"first","affiliation":[]},{"given":"Leon J.","family":"De Windt","sequence":"additional","affiliation":[]},{"given":"Paula A. da Costa","family":"Martins","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2012,9,21]]},"reference":[{"key":"310_CR1","doi-asserted-by":"crossref","first-page":"13027","DOI":"10.1073\/pnas.0805038105","volume":"105","author":"E Rooij van","year":"2008","unstructured":"van Rooij E, Sutherland LB, Thatcher JE, DiMaio JM, Naseem RH, Marshall WS, Hill JA, Olson EN. Dysregulation of micrornas after myocardial infarction reveals a role of mir-29 in cardiac fibrosis. Proc Natl Acad Sci U S A. 2008;105:13027\u201332.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"310_CR2","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1038\/ncb2126","volume":"12","author":"PA Costa Martins da","year":"2010","unstructured":"da Costa Martins PA, Salic K, Gladka MM, Armand AS, Leptidis S, el Azzouzi H, Hansen A, Coenen-de Roo CJ, Bierhuizen MF, van der Nagel R, van Kuik J, de Weger R, de Bruin A, Condorelli G, Arbones ML, Eschenhagen T, De Windt LJ. Microrna-199b targets the nuclear kinase dyrk1a in an auto-amplification loop promoting calcineurin\/nfat signalling. Nat Cell Biol. 2010;12:1220\u20137.","journal-title":"Nat Cell Biol"},{"key":"310_CR3","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1161\/01.RES.0000257913.42552.23","volume":"100","author":"D Sayed","year":"2007","unstructured":"Sayed D, Hong C, Chen IY, Lypowy J, Abdellatif M. Micrornas play an essential role in the development of cardiac hypertrophy. Circ Res. 2007;100:416\u201324.","journal-title":"Circ Res"},{"key":"310_CR4","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1038\/nature07511","volume":"456","author":"T Thum","year":"2008","unstructured":"Thum T, Gross C, Fiedler J, Fischer T, Kissler S, Bussen M, Galuppo P, Just S, Rottbauer W, Frantz S, Castoldi M, Soutschek J, Koteliansky V, Rosenwald A, Basson MA, Licht JD, Pena JT, Rouhanifard SH, Muckenthaler MU, Tuschl T, Martin GR, Bauersachs J, Engelhardt S. Microrna-21 contributes to myocardial disease by stimulating map kinase signalling in fibroblasts. Nature. 2008;456:980\u20134.","journal-title":"Nature"},{"key":"310_CR5","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1126\/science.1174381","volume":"324","author":"A Bonauer","year":"2009","unstructured":"Bonauer A, Carmona G, Iwasaki M, Mione M, Koyanagi M, Fischer A, Burchfield J, Fox H, Doebele C, Ohtani K, Chavakis E, Potente M, Tjwa M, Urbich C, Zeiher AM, Dimmeler S. Microrna-92a controls angiogenesis and functional recovery of ischemic tissues in mice. Science. 2009;324:1710\u20133.","journal-title":"Science"},{"key":"310_CR6","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1161\/CIRCRESAHA.108.191270","volume":"104","author":"Y Suarez","year":"2009","unstructured":"Suarez Y, Sessa WC. Micrornas as novel regulators of angiogenesis. Circ Res. 2009;104:442\u201354.","journal-title":"Circ Res"},{"key":"310_CR7","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1161\/CIRCULATIONAHA.107.687947","volume":"116","author":"T Thum","year":"2007","unstructured":"Thum T, Galuppo P, Wolf C, Fiedler J, Kneitz S, van Laake LW, Doevendans PA, Mummery CL, Borlak J, Haverich A, Gross C, Engelhardt S, Ertl G, Bauersachs J. Micrornas in the human heart: A clue to fetal gene reprogramming in heart failure. Circulation. 2007;116:258\u201367.","journal-title":"Circulation"},{"key":"310_CR8","doi-asserted-by":"crossref","first-page":"18255","DOI":"10.1073\/pnas.0608791103","volume":"103","author":"E Rooij van","year":"2006","unstructured":"van Rooij E, Sutherland LB, Liu N, Williams AH, McAnally J, Gerard RD, Richardson JA, Olson EN. A signature pattern of stress-responsive micrornas that can evoke cardiac hypertrophy and heart failure. Proc Natl Acad Sci U S A. 2006;103:18255\u201360.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"310_CR9","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1373\/clinchem.2007.097972","volume":"54","author":"SS Chim","year":"2008","unstructured":"Chim SS, Shing TK, Hung EC, Leung TY, Lau TK, Chiu RW, Lo YM. Detection and characterization of placental micrornas in maternal plasma. Clin Chem. 2008;54:482\u201390.","journal-title":"Clin Chem"},{"key":"310_CR10","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1111\/j.1365-2141.2008.07077.x","volume":"141","author":"CH Lawrie","year":"2008","unstructured":"Lawrie CH, Gal S, Dunlop HM, Pushkaran B, Liggins AP, Pulford K, Banham AH, Pezzella F, Boultwood J, Wainscoat JS, Hatton CS, Harris AL. Detection of elevated levels of tumour-associated micrornas in serum of patients with diffuse large b-cell lymphoma. Br J Haematol. 2008;141:672\u20135.","journal-title":"Br J Haematol"},{"key":"310_CR11","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1038\/cr.2008.282","volume":"18","author":"X Chen","year":"2008","unstructured":"Chen X, Ba Y, Ma L, Cai X, Yin Y, Wang K, Guo J, Zhang Y, Chen J, Guo X, Li Q, Li X, Wang W, Wang J, Jiang X, Xiang Y, Xu C, Zheng P, Zhang J, Li R, Zhang H, Shang X, Gong T, Ning G, Zen K, Zhang CY. Characterization of micrornas in serum: A novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res. 2008;18:997\u20131006.","journal-title":"Cell Res."},{"key":"310_CR12","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1093\/clinchem\/48.10.1647","volume":"48","author":"NB Tsui","year":"2002","unstructured":"Tsui NB, Ng EK, Lo YM. Stability of endogenous and added rna in blood specimens, serum, and plasma. Clin Chem. 2002;48:1647\u201353.","journal-title":"Clin Chem"},{"key":"310_CR13","doi-asserted-by":"crossref","first-page":"5003","DOI":"10.1073\/pnas.1019055108","volume":"108","author":"JD Arroyo","year":"2011","unstructured":"\u2022 Arroyo JD, Chevillet JR, Kroh EM, Ruf IK, Pritchard CC, Gibson DF, Mitchell PS, Bennett CF, Pogosova-Agadjanyan EL, Stirewalt DL, Tait JF, Tewari M. Argonaute2 complexes carry a population of circulating micrornas independent of vesicles in human plasma. Proc Natl Acad Sci U S A. 2011;108:5003\u20135008. This study demonstrates that most circulating miRNAs are protein-, mainly Ago2-, bound.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"310_CR14","doi-asserted-by":"crossref","first-page":"e3694","DOI":"10.1371\/journal.pone.0003694","volume":"3","author":"MP Hunter","year":"2008","unstructured":"\u2022 Hunter MP, Ismail N, Zhang X, Aguda BD, Lee EJ, Yu L, Xiao T, Schafer J, Lee ML, Schmittgen TD, Nana-Sinkam SP, Jarjoura D, Marsh CB. Detection of microrna expression in human peripheral blood microvesicles. PLoS One. 2008;3:e3694. This work shows that stable miRNAs are carried by microvesicles in the circulation.","journal-title":"PLoS One"},{"key":"310_CR15","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/ncb1596","volume":"9","author":"H Valadi","year":"2007","unstructured":"\u2022 Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO. Exosome-mediated transfer of mrnas and micrornas is a novel mechanism of genetic exchange between cells. Nat Cell Biol. 2007;9:654\u2013659. This study demonstrates that exosomes contain stable mRNAs and miRNAs in the circulation and can mediate transporte between cells.","journal-title":"Nat Cell Biol."},{"key":"310_CR16","doi-asserted-by":"crossref","first-page":"7248","DOI":"10.1093\/nar\/gkq601","volume":"38","author":"K Wang","year":"2010","unstructured":"Wang K, Zhang S, Weber J, Baxter D, Galas DJ. Export of micrornas and microrna-protective protein by mammalian cells. Nucleic Acids Res. 2010;38:7248\u201359.","journal-title":"Nucleic Acids Res"},{"key":"310_CR17","first-page":"232","volume":"60","author":"E Suleymanoglu","year":"2006","unstructured":"Suleymanoglu E. Phospholipid-nucleic acid recognition: Developing an immobilized liposome chromatography for DNA separation and analysis. PDA J Pharm Sci Technol. 2006;60:232\u20139.","journal-title":"PDA J Pharm Sci Technol"},{"key":"310_CR18","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1093\/nar\/gkl220","volume":"34","author":"T Janas","year":"2006","unstructured":"Janas T, Yarus M. Specific rna binding to ordered phospholipid bilayers. Nucleic Acids Res. 2006;34:2128\u201336.","journal-title":"Nucleic Acids Res"},{"key":"310_CR19","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1007\/BF02993973","volume":"30","author":"Y Manavbasi","year":"2007","unstructured":"Manavbasi Y, Suleymanoglu E. Nucleic acid-phospholipid recognition: Fourier transform infrared spectrometric characterization of ternary phospholipid-inorganic cation-DNA complex and its relevance to chemicopharmaceutical design of nanometric liposome based gene delivery formulations. Arch Pharm Res. 2007;30:1027\u201340.","journal-title":"Arch Pharm Res."},{"key":"310_CR20","doi-asserted-by":"crossref","first-page":"954","DOI":"10.3748\/wjg.v11.i7.954","volume":"11","author":"B Lou","year":"2005","unstructured":"Lou B, Liao XL, Wu MP, Cheng PF, Yin CY, Fei Z. High-density lipoprotein as a potential carrier for delivery of a lipophilic antitumoral drug into hepatoma cells. World J Gastroenterol. 2005;11:954\u20139.","journal-title":"World J Gastroenterol"},{"key":"310_CR21","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/ncb2210","volume":"13","author":"KC Vickers","year":"2011","unstructured":"\u2022 Vickers KC, Palmisano BT, Shoucri BM, Shamburek RD, Remaley AT. Micrornas are transported in plasma and delivered to recipient cells by high-density lipoproteins. Nat Cell Biol. 2011;13:423\u2013433. Here, HLD is identified as a transport system for miRNAs in circulation that enables intracellular communication.","journal-title":"Nat Cell Biol."},{"key":"310_CR22","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1038\/ncb1800","volume":"10","author":"J Skog","year":"2008","unstructured":"Skog J, Wurdinger T, van Rijn S, Meijer DH, Gainche L, Sena-Esteves M, Curry Jr WT, Carter BS, Krichevsky AM, Breakefield XO. Glioblastoma microvesicles transport rna and proteins that promote tumour growth and provide diagnostic biomarkers. Nat Cell Biol. 2008;10:1470\u20136.","journal-title":"Nat Cell Biol."},{"key":"310_CR23","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1161\/CIRCRESAHA.110.226456","volume":"107","author":"SF Mause","year":"2010","unstructured":"Mause SF, Weber C. Microparticles: Protagonists of a novel communication network for intercellular information exchange. Circ Res. 2010;107:1047\u201357.","journal-title":"Circ Res"},{"key":"310_CR24","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1038\/ncb1930","volume":"11","author":"YS Lee","year":"2009","unstructured":"Lee YS, Pressman S, Andress AP, Kim K, White JL, Cassidy JJ, Li X, Lubell K, Lim do H, Cho IS, Nakahara K, Preall JB, Bellare P, Sontheimer EJ, Carthew RW. Silencing by small rnas is linked to endosomal trafficking. Nat Cell Biol. 2009;11:1150\u20136.","journal-title":"Nat Cell Biol."},{"key":"310_CR25","doi-asserted-by":"crossref","first-page":"ra81","DOI":"10.1126\/scisignal.2000610","volume":"2","author":"A Zernecke","year":"2009","unstructured":"\u2022\u2022 Zernecke A, Bidzhekov K, Noels H, Shagdarsuren E, Gan L, Denecke B, Hristov M, Koppel T, Jahantigh MN, Lutgens E, Wang S, Olson EN, Schober A, Weber C. Delivery of microrna-126 by apoptotic bodies induces cxcl12-dependent vascular protection. Sci Signal. 2009;2:81. This study shows that apoptotic bodies generated during atherosclerosis are able to convey paracrine signals to target vascular cells triggering their response. Furthermore, miR-126 was shown to be transported in circulation via apoptotic bodies to recipient cells.","journal-title":"Sci Signal"},{"key":"310_CR26","doi-asserted-by":"crossref","first-page":"e13247","DOI":"10.1371\/journal.pone.0013247","volume":"5","author":"K Ohshima","year":"2010","unstructured":"Ohshima K, Inoue K, Fujiwara A, Hatakeyama K, Kanto K, Watanabe Y, Muramatsu K, Fukuda Y, Ogura S, Yamaguchi K, Mochizuki T. Let-7 microrna family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell line. PLoS One. 2010;5:e13247.","journal-title":"PLoS One"},{"key":"310_CR27","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.molcel.2010.06.010","volume":"39","author":"Y Zhang","year":"2010","unstructured":"Zhang Y, Liu D, Chen X, Li J, Li L, Bian Z, Sun F, Lu J, Yin Y, Cai X, Sun Q, Wang K, Ba Y, Wang Q, Wang D, Yang J, Liu P, Xu T, Yan Q, Zhang J, Zen K, Zhang CY. Secreted monocytic mir-150 enhances targeted endothelial cell migration. Mol Cell. 2010;39:133\u201344.","journal-title":"Mol Cell."},{"key":"310_CR28","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1136\/hrt.2008.151233","volume":"94","author":"JS Alpert","year":"2008","unstructured":"Alpert JS, Thygesen K, Jaffe A, White HD. The universal definition of myocardial infarction: A consensus document: Ischaemic heart disease. Heart. 2008;94:1335\u201341.","journal-title":"Heart"},{"key":"310_CR29","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1161\/01.CIR.102.11.1216","volume":"102","author":"AS Jaffe","year":"2000","unstructured":"Jaffe AS, Ravkilde J, Roberts R, Naslund U, Apple FS, Galvani M, Katus H. It\u2019s time for a change to a troponin standard. Circulation. 2000;102:1216\u201320.","journal-title":"Circulation"},{"key":"310_CR30","first-page":"375","volume":"5","author":"JA Shand","year":"2011","unstructured":"Shand JA, Howe A. Ckmb and troponin i levels post coronary artery bypass surgery show a graded association with mortality. Biomark Med. 2011;5:375.","journal-title":"Biomark Med."},{"key":"310_CR31","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1093\/eurheartj\/ehm161","volume":"28","author":"JP Bassand","year":"2007","unstructured":"Bassand JP, Hamm CW, Ardissino D, Boersma E, Budaj A, Fernandez-Aviles F, Fox KA, Hasdai D, Ohman EM, Wallentin L, Wijns W. Guidelines for the diagnosis and treatment of non-st-segment elevation acute coronary syndromes. Eur Heart J. 2007;28:1598\u2013660.","journal-title":"Eur Heart J."},{"key":"310_CR32","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1016\/S0735-1097(97)00317-3","volume":"30","author":"B Lauer","year":"1997","unstructured":"Lauer B, Niederau C, Kuhl U, Schannwell M, Pauschinger M, Strauer BE, Schultheiss HP. Cardiac troponin t in patients with clinically suspected myocarditis. J Am Coll Cardiol. 1997;30:1354\u20139.","journal-title":"J Am Coll Cardiol"},{"key":"310_CR33","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1093\/eurheartj\/ehq456","volume":"32","author":"S Agewall","year":"2011","unstructured":"Agewall S, Giannitsis E, Jernberg T, Katus H. Troponin elevation in coronary vs. Non-coronary disease. Eur Heart J. 2011;32:404\u201311.","journal-title":"Eur Heart J."},{"key":"310_CR34","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1126\/science.1139089","volume":"316","author":"E Rooij van","year":"2007","unstructured":"van Rooij E, Sutherland LB, Qi X, Richardson JA, Hill J, Olson EN. Control of stress-dependent cardiac growth and gene expression by a microrna. Science. 2007;316:575\u20139.","journal-title":"Science"},{"key":"310_CR35","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1161\/CIRCGENETICS.110.957415","volume":"3","author":"MF Corsten","year":"2010","unstructured":"\u2022\u2022 Corsten MF, Dennert R, Jochems S, Kuznetsova T, Devaux Y, Hofstra L, Wagner DR, Staessen JA, Heymans S, Schroen B. Circulating microrna-208b and microrna-499 reflect myocardial damage in cardiovascular disease. Circ Cardiovasc Genet. 2010;3:499\u2013506. This study shows miR-208b and miR-499 to be the most upregulated miRNAs in circulation in 32 AMI patients. There is a correlation between both miRNA levels and TnT levels in circulation.","journal-title":"Circ Cardiovasc Genet."},{"key":"310_CR36","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.1093\/eurheartj\/ehq167","volume":"31","author":"Y D\u2019Alessandra","year":"2010","unstructured":"\u2022\u2022 D\u2019Alessandra Y, Devanna P, Limana F, Straino S, Di Carlo A, Brambilla PG, Rubino M, Carena MC, Spazzafumo L, De Simone M, Micheli B, Biglioli P, Achilli F, Martelli F, Maggiolini S, Marenzi G, Pompilio G, Capogrossi MC. Circulating micrornas are new and sensitive biomarkers of myocardial infarction. Eur Heart J. 2010;31:2765\u20132773. This work indicates that miR-1, miR-133a, miR-133b and miR-499 are the most abundant circulating miRNAs in 33 STEMI patients. It also shows that circulating miR-208a is increased in a mouse model of MI.","journal-title":"Eur Heart J."},{"key":"310_CR37","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1253\/circj.CJ-10-0457","volume":"75","author":"Y Fukushima","year":"2011","unstructured":"Fukushima Y, Nakanishi M, Nonogi H, Goto Y, Iwai N. Assessment of plasma mirnas in congestive heart failure. Circ J. 2011;75:336\u201340.","journal-title":"Circ J"},{"key":"310_CR38","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1373\/clinchem.2010.144121","volume":"56","author":"T Adachi","year":"2010","unstructured":"Adachi T, Nakanishi M, Otsuka Y, Nishimura K, Hirokawa G, Goto Y, Nonogi H, Iwai N. Plasma microrna 499 as a biomarker of acute myocardial infarction. Clin Chem. 2010;56:1183\u20135.","journal-title":"Clin Chem"},{"key":"310_CR39","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1161\/CIRCRESAHA.109.215566","volume":"107","author":"S Fichtlscherer","year":"2010","unstructured":"Fichtlscherer S, De Rosa S, Fox H, Schwietz T, Fischer A, Liebetrau C, Weber M, Hamm CW, Roxe T, Muller-Ardogan M, Bonauer A, Zeiher AM, Dimmeler S. Circulating micrornas in patients with coronary artery disease. Circ Res. 2010;107:677\u201384.","journal-title":"Circ Res"},{"key":"310_CR40","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1042\/CS20090645","volume":"119","author":"Y Cheng","year":"2010","unstructured":"\u2022\u2022 Cheng Y, Tan N, Yang J, Liu X, Cao X, He P, Dong X, Qin S, Zhang C. A translational study of circulating cell-free microrna-1 in acute myocardial infarction. Clin Sci (Lond). 2010;119:87\u201395. This study shows increased levels of circulating miR-1 in 31 AMI patients, and in a rat model of MI. Furthermore, miR-1 levels correlate with CK-MB levels in AMI patients, with infarct size in the animal model and with the degree of cell damage.","journal-title":"Clin Sci (Lond)."},{"key":"310_CR41","doi-asserted-by":"crossref","first-page":"2772","DOI":"10.1172\/JCI36154","volume":"119","author":"TE Callis","year":"2009","unstructured":"Callis TE, Pandya K, Seok HY, Tang RH, Tatsuguchi M, Huang ZP, Chen JF, Deng Z, Gunn B, Shumate J, Willis MS, Selzman CH, Wang DZ. Microrna-208a is a regulator of cardiac hypertrophy and conduction in mice. J Clin Invest. 2009;119:2772\u201386.","journal-title":"J Clin Invest"},{"key":"310_CR42","doi-asserted-by":"crossref","first-page":"22678","DOI":"10.1016\/S0021-9258(18)54623-8","volume":"266","author":"WR Thompson","year":"1991","unstructured":"Thompson WR, Nadal-Ginard B, Mahdavi V. A myod1-independent muscle-specific enhancer controls the expression of the beta-myosin heavy chain gene in skeletal and cardiac muscle cells. J Biol Chem. 1991;266:22678\u201388.","journal-title":"J Biol Chem"},{"key":"310_CR43","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.bbrc.2009.11.005","volume":"391","author":"J Ai","year":"2010","unstructured":"\u2022\u2022 Ai J, Zhang R, Li Y, Pu J, Lu Y, Jiao J, Li K, Yu B, Li Z, Wang R, Wang L, Li Q, Wang N, Shan H, Yang B. Circulating microrna-1 as a potential novel biomarker for acute myocardial infarction. Biochem Biophys Res Commun. 2010;391:73\u201377. This work shows increased circulating levels of miR-1 in 93 AMI patients, which correlate with QRS widening. Furthermore, this was the first study identifying specific circulating miRNA signatures in CAD patients.","journal-title":"Biochem Biophys Res Commun"},{"key":"310_CR44","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s00395-010-0123-2","volume":"106","author":"B Meder","year":"2011","unstructured":"\u2022\u2022 Meder B, Keller A, Vogel B, Haas J, Sedaghat-Hamedani F, Kayvanpour E, Just S, Borries A, Rudloff J, Leidinger P, Meese E, Katus HA, Rottbauer W. Microrna signatures in total peripheral blood as novel biomarkers for acute myocardial infarction. Basic Res Cardiol. 2011;106:13\u201323. This study suggests a miRNA signature (multimarker) as a novel biomarker of MI.","journal-title":"Basic Res Cardiol."},{"key":"310_CR45","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1159\/000328869","volume":"118","author":"O Gidlof","year":"2011","unstructured":"\u2022\u2022 Gidlof O, Andersson P, van der Pals J, Gotberg M, Erlinge D. Cardiospecific microrna plasma levels correlate with troponin and cardiac function in patients with st elevation myocardial infarction, are selectively dependent on renal elimination, and can be detected in urine samples. Cardiology. 2011;118:217\u2013226. This study shows an increase in circulating miR-1, miR-133a, miR-208b and miR-499 levels in 25 STEMI patients, and in a pig model of MI. Levels of circulating miR-208b correlate with TnT levels in circulation after MI.","journal-title":"Cardiology"},{"key":"310_CR46","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1161\/CIRCRESAHA.110.226357","volume":"107","author":"A Zampetaki","year":"2010","unstructured":"\u2022\u2022 Zampetaki A, Kiechl S, Drozdov I, Willeit P, Mayr U, Prokopi M, Mayr A, Weger S, Oberhollenzer F, Bonora E, Shah A, Willeit J, Mayr M. Plasma microrna profiling reveals loss of endothelial mir-126 and other micrornas in type 2 diabetes. Circ Res. 2010;107:810\u2013817. This study reveals a plasma signature for type 2 diabetes, including decreased levels of circulating miR-126.","journal-title":"Circ Res"},{"key":"310_CR47","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.jacc.2012.03.056","volume":"60","author":"A Zampetaki","year":"2012","unstructured":"Zampetaki A, Willeit P, Tilling L, Drozdov I, Prokopi M, Renard JM, Mayr A, Weger S, Schett G, Shah A, Boulanger CM, Willeit J, Chowienczyk PJ, Kiechl S, Mayr M. Prospective study on circulating micrornas and risk of myocardial infarction. J Am Coll Cardiol. 2012;60:290\u20139.","journal-title":"J Am Coll Cardiol"},{"key":"310_CR48","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1161\/CIRCRESAHA.110.218297","volume":"106","author":"AJ Tijsen","year":"2010","unstructured":"\u2022 Tijsen AJ, Creemers EE, Moerland PD, de Windt LJ, van der Wal AC, Kok WE, Pinto YM. Mir423-5p as a circulating biomarker for heart failure. Circ Res. 2010;106:1035\u20131039. This study identified a specific circulating miRNA signature in patients with HF. MiR-423-5p is one of the strongest elevated miRNAs, strongly correlating with the clinical diagnosis of HF.","journal-title":"Circ Res"},{"key":"310_CR49","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1373\/clinchem.2009.131797","volume":"55","author":"OF Laterza","year":"2009","unstructured":"\u2022 Laterza OF, Lim L, Garrett-Engele PW, Vlasakova K, Muniappa N, Tanaka WK, Johnson JM, Sina JF, Fare TL, Sistare FD, Glaab WE. Plasma micrornas as sensitive and specific biomarkers of tissue injury. Clin Chem. 2009;55:1977\u20131983. This study suggests tissue-specific miRNAs as sensitive biomarkers of tissue injury. Circulating miR-124 levels, a brain-specific miRNA, are increased upon cerebral ischemia.","journal-title":"Clin Chem"},{"key":"310_CR50","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1161\/STROKEAHA.107.500736","volume":"39","author":"K Jeyaseelan","year":"2008","unstructured":"Jeyaseelan K, Lim KY, Armugam A. Microrna expression in the blood and brain of rats subjected to transient focal ischemia by middle cerebral artery occlusion. Stroke. 2008;39:959\u201366.","journal-title":"Stroke"},{"key":"310_CR51","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1152\/physiolgenomics.00211.2009","volume":"42","author":"C Voellenkle","year":"2010","unstructured":"Voellenkle C, van Rooij J, Cappuzzello C, Greco S, Arcelli D, Di Vito L, Melillo G, Rigolini R, Costa E, Crea F, Capogrossi MC, Napolitano M, Martelli F. Microrna signatures in peripheral blood mononuclear cells of chronic heart failure patients. Physiol Genomics. 2010;42:420\u20136.","journal-title":"Physiol Genomics."},{"key":"310_CR52","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1161\/01.STR.30.4.736","volume":"30","author":"WD Rosamond","year":"1999","unstructured":"Rosamond WD, Folsom AR, Chambless LE, Wang CH, McGovern PG, Howard G, Copper LS, Shahar E. Stroke incidence and survival among middle-aged adults: 9-year follow-up of the atherosclerosis risk in communities (aric) cohort. Stroke. 1999;30:736\u201343.","journal-title":"Stroke"},{"key":"310_CR53","doi-asserted-by":"crossref","first-page":"e7689","DOI":"10.1371\/journal.pone.0007689","volume":"4","author":"KS Tan","year":"2009","unstructured":"Tan KS, Armugam A, Sepramaniam S, Lim KY, Setyowati KD, Wang CW, Jeyaseelan K. Expression profile of micrornas in young stroke patients. PLoS One. 2009;4:e7689.","journal-title":"PLoS One"},{"key":"310_CR54","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1373\/clinchem.2009.133801","volume":"56","author":"AK Saenger","year":"2010","unstructured":"Saenger AK, Christenson RH. Stroke biomarkers: Progress and challenges for diagnosis, prognosis, differentiation, and treatment. Clin Chem. 2010;56:21\u201333.","journal-title":"Clin Chem"},{"key":"310_CR55","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s00592-010-0226-0","volume":"48","author":"L Kong","year":"2011","unstructured":"Kong L, Zhu J, Han W, Jiang X, Xu M, Zhao Y, Dong Q, Pang Z, Guan Q, Gao L, Zhao J, Zhao L. Significance of serum micrornas in pre-diabetes and newly diagnosed type 2 diabetes: A clinical study. Acta Diabetol. 2011;48:61\u20139.","journal-title":"Acta Diabetol."},{"key":"310_CR56","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/jcbfm.2009.186","volume":"30","author":"DZ Liu","year":"2010","unstructured":"Liu DZ, Tian Y, Ander BP, Xu H, Stamova BS, Zhan X, Turner RJ, Jickling G, Sharp FR. Brain and blood microrna expression profiling of ischemic stroke, intracerebral hemorrhage, and kainate seizures. J Cereb Blood Flow Metab. 2010;30:92\u2013101.","journal-title":"J Cereb Blood Flow Metab"},{"key":"310_CR57","first-page":"1265","volume":"3","author":"L Zeng","year":"2011","unstructured":"Zeng L, Liu J, Wang Y, Wang L, Weng S, Tang Y, Zheng C, Cheng Q, Chen S, Yang GY. Microrna-210 as a novel blood biomarker in acute cerebral ischemia. Front Biosci (Elite Ed). 2011;3:1265\u201372.","journal-title":"Front Biosci (Elite Ed)."},{"key":"310_CR58","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.pharmthera.2009.10.003","volume":"125","author":"P Fasanaro","year":"2010","unstructured":"Fasanaro P, Greco S, Ivan M, Capogrossi MC, Martelli F. Microrna: Emerging therapeutic targets in acute ischemic diseases. Pharmacol Ther. 2010;125:92\u2013104.","journal-title":"Pharmacol Ther"},{"key":"310_CR59","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1002\/iub.427","volume":"63","author":"C Devlin","year":"2011","unstructured":"Devlin C, Greco S, Martelli F, Ivan M. Mir-210: More than a silent player in hypoxia. IUBMB Life. 2011;63:94\u2013100.","journal-title":"IUBMB Life."},{"key":"310_CR60","doi-asserted-by":"crossref","first-page":"15878","DOI":"10.1074\/jbc.M800731200","volume":"283","author":"P Fasanaro","year":"2008","unstructured":"Fasanaro P, D\u2019Alessandra Y, Di Stefano V, Melchionna R, Romani S, Pompilio G, Capogrossi MC, Martelli F. Microrna-210 modulates endothelial cell response to hypoxia and inhibits the receptor tyrosine kinase ligand ephrin-a3. J Biol Chem. 2008;283:15878\u201383.","journal-title":"J Biol Chem"},{"key":"310_CR61","doi-asserted-by":"crossref","first-page":"147","DOI":"10.4238\/2012.January.27.1","volume":"11","author":"CS Gan","year":"2012","unstructured":"Gan CS, Wang CW, Tan KS. Circulatory microrna-145 expression is increased in cerebral ischemia. Genet Mol Res. 2012;11:147\u201352.","journal-title":"Genet Mol Res"},{"key":"310_CR62","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/nature08195","volume":"460","author":"KR Cordes","year":"2009","unstructured":"Cordes KR, Sheehy NT, White MP, Berry EC, Morton SU, Muth AN, Lee TH, Miano JM, Ivey KN, Srivastava D. Mir-145 and mir-143 regulate smooth muscle cell fate and plasticity. Nature. 2009;460:705\u201310.","journal-title":"Nature"},{"key":"310_CR63","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.yjmcc.2011.07.011","volume":"51","author":"C Widera","year":"2011","unstructured":"\u2022\u2022 Widera C, Gupta SK, Lorenzen JM, Bang C, Bauersachs J, Bethmann K, Kempf T, Wollert KC, Thum T. Diagnostic and prognostic impact of six circulating micrornas in acute coronary syndrome. J Mol Cell Cardiol. 2011;51:872\u2013875. This study shows elevated levels of circulating miR-1, miR-133a and miR-208b in 196 STEMI patients, which correlate with circulating levels of high-sensitive TnT.","journal-title":"J Mol Cell Cardiol"},{"key":"310_CR64","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1161\/ATVBAHA.108.166066","volume":"28","author":"X Long","year":"2008","unstructured":"Long X, Bell RD, Gerthoffer WT, Zlokovic BV, Miano JM. Myocardin is sufficient for a smooth muscle-like contractile phenotype. Arterioscler Thromb Vasc Biol. 2008;28:1505\u201310.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"310_CR65","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nature10146","volume":"473","author":"P Libby","year":"2011","unstructured":"Libby P, Ridker PM, Hansson GK. Progress and challenges in translating the biology of atherosclerosis. Nature. 2011;473:317\u201325.","journal-title":"Nature"},{"key":"310_CR66","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.bbrc.2010.03.075","volume":"394","author":"M Hoekstra","year":"2010","unstructured":"\u2022\u2022 Hoekstra M, van der Lans CA, Halvorsen B, Gullestad L, Kuiper J, Aukrust P, van Berkel TJ, Biessen EA. The peripheral blood mononuclear cell microrna signature of coronary artery disease. Biochem Biophys Res Commun. 2010;394:792\u2013797. This study shows that miRNAs can be used as sensitive biomarkers of CAD. Unstable angina pectoris patients can be discriminated from stable patients based on increased levels of circulating miR-134, miR-198 and miR-370.","journal-title":"Biochem Biophys Res Commun"},{"key":"310_CR67","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1161\/01.RES.0000137877.89448.78","volume":"95","author":"C Urbich","year":"2004","unstructured":"Urbich C, Dimmeler S. Endothelial progenitor cells: Characterization and role in vascular biology. Circ Res. 2004;95:343\u201353.","journal-title":"Circ Res"},{"key":"310_CR68","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.cca.2010.09.029","volume":"412","author":"T Li","year":"2011","unstructured":"\u2022 Li T, Cao H, Zhuang J, Wan J, Guan M, Yu B, Li X, Zhang W. Identification of mir-130a, mir-27b and mir-210 as serum biomarkers for atherosclerosis obliterans. Clin Chim Acta. 2011;412:66\u201370. This is the first study showing decreased levels of miR-181a in monocytes of obese patients and monocytic miRNAs as biomarkers of CAD and the metabolic syndrome.","journal-title":"Clin Chim Acta."},{"key":"310_CR69","doi-asserted-by":"crossref","first-page":"E1213","DOI":"10.1210\/jc.2012-1008","volume":"97","author":"M Hulsmans","year":"2012","unstructured":"Hulsmans M, Sinnaeve P, Van der Schueren B, Mathieu C, Janssens S, Holvoet P. Decreased mir-181a expression in monocytes of obese patients is associated with the occurrence of metabolic syndrome and coronary artery disease. J Clin Endocrinol Metab. 2012;97:E1213\u20138.","journal-title":"J Clin Endocrinol Metab"},{"key":"310_CR70","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1161\/CIRCULATIONAHA.108.792986","volume":"118","author":"DS Frankel","year":"2008","unstructured":"Frankel DS, Meigs JB, Massaro JM, Wilson PW, O\u2019Donnell CJ, D\u2019Agostino RB, Tofler GH. Von willebrand factor, type 2 diabetes mellitus, and risk of cardiovascular disease: The framingham offspring study. Circulation. 2008;118:2533\u20139.","journal-title":"Circulation"},{"key":"310_CR71","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1056\/NEJM199306103282306","volume":"328","author":"DM Nathan","year":"1993","unstructured":"Nathan DM. Long-term complications of diabetes mellitus. N Engl J Med. 1993;328:1676\u201385.","journal-title":"N Engl J Med"},{"key":"310_CR72","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/clpt.2011.93","volume":"90","author":"C Herder","year":"2011","unstructured":"Herder C, Karakas M, Koenig W. Biomarkers for the prediction of type 2 diabetes and cardiovascular disease. Clin Pharmacol Ther. 2011;90:52\u201366.","journal-title":"Clin Pharmacol Ther"},{"key":"310_CR73","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.devcel.2008.07.002","volume":"15","author":"S Wang","year":"2008","unstructured":"Wang S, Aurora AB, Johnson BA, Qi X, McAnally J, Hill JA, Richardson JA, Bassel-Duby R, Olson EN. The endothelial-specific microrna mir-126 governs vascular integrity and angiogenesis. Dev Cell. 2008;15:261\u201371.","journal-title":"Dev Cell."},{"key":"310_CR74","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.yjmcc.2012.04.003","volume":"53","author":"S Meng","year":"2012","unstructured":"Meng S, Cao JT, Zhang B, Zhou Q, Shen CX, Wang CQ. Downregulation of microrna-126 in endothelial progenitor cells from diabetes patients, impairs their functional properties, via target gene spred-1. J Mol Cell Cardiol. 2012;53:64\u201372.","journal-title":"J Mol Cell Cardiol"},{"key":"310_CR75","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1159\/000218169","volume":"23","author":"AK Pandey","year":"2009","unstructured":"Pandey AK, Agarwal P, Kaur K, Datta M. Micrornas in diabetes: Tiny players in big disease. Cell Physiol Biochem. 2009;23:221\u201332.","journal-title":"Cell Physiol Biochem"},{"key":"310_CR76","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1161\/CIRCULATIONAHA.110.952325","volume":"123","author":"A Caporali","year":"2011","unstructured":"\u2022\u2022 Caporali A, Meloni M, Vollenkle C, Bonci D, Sala-Newby GB, Addis R, Spinetti G, Losa S, Masson R, Baker AH, Agami R, le Sage C, Condorelli G, Madeddu P, Martelli F, Emanueli C. Deregulation of microrna-503 contributes to diabetes mellitus-induced impairment of endothelial function and reparative angiogenesis after limb ischemia. Circulation. 2011;123:282\u2013291. This work demonstrates elevated plasma miR-503 levels in diabetic patients. In vitro, miR-503 is released from endothelial cells after exposure to high glucose, as model of hyperglycemia.","journal-title":"Circulation"},{"key":"310_CR77","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1161\/01.CIR.101.3.329","volume":"101","author":"OA Carretero","year":"2000","unstructured":"Carretero OA, Oparil S. Essential hypertension. Part i: Definition and etiology. Circulation. 2000;101:329\u201335.","journal-title":"Circulation"},{"key":"310_CR78","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1161\/CIRCULATIONAHA.110.012237","volume":"124","author":"S Li","year":"2011","unstructured":"Li S, Zhu J, Zhang W, Chen Y, Zhang K, Popescu LM, Ma X, Lau WB, Rong R, Yu X, Wang B, Li Y, Xiao C, Zhang M, Wang S, Yu L, Chen AF, Yang X, Cai J. Signature microrna expression profile of essential hypertension and its novel link to human cytomegalovirus infection. Circulation. 2011;124:175\u201384.","journal-title":"Circulation"},{"key":"310_CR79","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1161\/CIRCRESAHA.109.197517","volume":"105","author":"Y Cheng","year":"2009","unstructured":"Cheng Y, Liu X, Yang J, Lin Y, Xu DZ, Lu Q, Deitch EA, Huo Y, Delphin ES, Zhang C. Microrna-145, a novel smooth muscle cell phenotypic marker and modulator, controls vascular neointimal lesion formation. Circ Res. 2009;105:158\u201366.","journal-title":"Circ Res"},{"key":"310_CR80","doi-asserted-by":"crossref","first-page":"407","DOI":"10.5732\/cjc.010.10522","volume":"30","author":"J Wei","year":"2011","unstructured":"Wei J, Gao W, Zhu CJ, Liu YQ, Mei Z, Cheng T, Shu YQ. Identification of plasma microrna-21 as a biomarker for early detection and chemosensitivity of non-small cell lung cancer. Chin J Cancer. 2011;30:407\u201314.","journal-title":"Chin J Cancer."},{"key":"310_CR81","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jdermsci.2010.12.010","volume":"61","author":"H Kanemaru","year":"2011","unstructured":"Kanemaru H, Fukushima S, Yamashita J, Honda N, Oyama R, Kakimoto A, Masuguchi S, Ishihara T, Inoue Y, Jinnin M, Ihn H. The circulating microrna-221 level in patients with malignant melanoma as a new tumor marker. J Dermatol Sci. 2011;61:187\u201393.","journal-title":"J Dermatol Sci"},{"key":"310_CR82","doi-asserted-by":"crossref","first-page":"4402","DOI":"10.1073\/pnas.0813371106","volume":"106","author":"K Wang","year":"2009","unstructured":"Wang K, Zhang S, Marzolf B, Troisch P, Brightman A, Hu Z, Hood LE, Galas DJ. Circulating micrornas, potential biomarkers for drug-induced liver injury. Proc Natl Acad Sci U S A. 2009;106:4402\u20137.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"310_CR83","doi-asserted-by":"crossref","unstructured":"Qi R, Weiland M, Gao XX, Zhou L, Mi QS. Identification of endogenous normalizers for serum mirnas by microarray profiling: U6 snrna is not a reliable normalizer. Hepatology. 2011;doi: 10.1002\/hep.25558","DOI":"10.1002\/hep.25558"},{"key":"310_CR84","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1200\/JCO.2008.19.4134","volume":"27","author":"D Lebanony","year":"2009","unstructured":"Lebanony D, Benjamin H, Gilad S, Ezagouri M, Dov A, Ashkenazi K, Gefen N, Izraeli S, Rechavi G, Pass H, Nonaka D, Li J, Spector Y, Rosenfeld N, Chajut A, Cohen D, Aharonov R, Mansukhani M. Diagnostic assay based on hsa-mir-205 expression distinguishes squamous from nonsquamous non-small-cell lung carcinoma. J Clin Oncol. 2009;27:2030\u20137.","journal-title":"J Clin Oncol"},{"key":"310_CR85","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1586\/erm.11.10","volume":"11","author":"AE Szafranska-Schwarzbach","year":"2011","unstructured":"Szafranska-Schwarzbach AE, Adai AT, Lee LS, Conwell DL, Andruss BF. Development of a mirna-based diagnostic assay for pancreatic ductal adenocarcinoma. Expert Rev Mol Diagn. 2011;11:249\u201357.","journal-title":"Expert Rev Mol Diagn"},{"key":"310_CR86","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1002\/emmm.201100154","volume":"3","author":"F Bianchi","year":"2011","unstructured":"Bianchi F, Nicassio F, Marzi M, Belloni E, Dallolio V, Bernard L, Pelosi G, Maisonneuve P, Veronesi G, Di Fiore PP. A serum circulating mirna diagnostic test to identify asymptomatic high-risk individuals with early stage lung cancer. EMBO Mol Med. 2011;3:495\u2013503.","journal-title":"EMBO Mol Med."}],"container-title":["Current Hypertension Reports"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11906-012-0310-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11906-012-0310-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11906-012-0310-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T16:07:02Z","timestamp":1714406822000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11906-012-0310-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,21]]},"references-count":86,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["310"],"URL":"https:\/\/doi.org\/10.1007\/s11906-012-0310-7","relation":{},"ISSN":["1522-6417","1534-3111"],"issn-type":[{"value":"1522-6417","type":"print"},{"value":"1534-3111","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,21]]}}}