{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:00:05Z","timestamp":1762430405450},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2009,11,25]],"date-time":"2009-11-25T00:00:00Z","timestamp":1259107200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Appl Biochem Biotechnol"],"published-print":{"date-parts":[[2010,9]]},"DOI":"10.1007\/s12010-009-8862-y","type":"journal-article","created":{"date-parts":[[2009,11,24]],"date-time":"2009-11-24T07:05:44Z","timestamp":1259046344000},"page":"192-207","source":"Crossref","is-referenced-by-count":11,"title":["Polyol Additives Modulate the In Vitro Stability and Activity of Recombinant Human Phenylalanine Hydroxylase"],"prefix":"10.1007","volume":"162","author":[{"given":"C\u00e1tia","family":"Nascimento","sequence":"first","affiliation":[]},{"given":"Jo\u00e3o","family":"Leandro","sequence":"additional","affiliation":[]},{"given":"Paulo Roque","family":"Lino","sequence":"additional","affiliation":[]},{"given":"Lu\u00eds","family":"Ramos","sequence":"additional","affiliation":[]},{"given":"Ant\u00f3nio Jos\u00e9","family":"Almeida","sequence":"additional","affiliation":[]},{"given":"Isabel Tavares","family":"de Almeida","sequence":"additional","affiliation":[]},{"given":"Paula","family":"Leandro","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2009,11,25]]},"reference":[{"key":"8862_CR1","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1006\/mgme.1999.2880","volume":"67","author":"U Lichter-Konecki","year":"1999","unstructured":"Lichter-Konecki, U., Hipke, C. M., & Konecki, D. S. (1999). Molecular Genetics and Metabolism, 67, 308\u2013316.","journal-title":"Molecular Genetics and Metabolism"},{"key":"8862_CR2","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1073\/pnas.97.3.1242","volume":"97","author":"N Moller","year":"2000","unstructured":"Moller, N., Meek, S., Bigelow, M., Andrews, J., & Nair, K. S. (2000). Proceedings of National Academy of Sciences USA, 97, 1242\u20131246.","journal-title":"Proceedings of National Academy of Sciences USA"},{"key":"8862_CR3","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1002\/humu.20526","volume":"28","author":"CR Scriver","year":"2007","unstructured":"Scriver, C. R. (2007). Human Mutation, 28, 831\u2013845.","journal-title":"Human Mutation"},{"issue":"Suppl 2","key":"8862_CR4","doi-asserted-by":"crossref","first-page":"S109","DOI":"10.1007\/PL00014370","volume":"159","author":"R Surtees","year":"2000","unstructured":"Surtees, R., & Blau, N. (2000). European Journal of Pediatrics, 159(Suppl 2), S109\u2013S113.","journal-title":"European Journal of Pediatrics"},{"key":"8862_CR5","doi-asserted-by":"crossref","unstructured":"(1993). Arch Dis Child, 68, 426\u2013427.","DOI":"10.1136\/adc.68.3.426"},{"key":"8862_CR6","doi-asserted-by":"crossref","unstructured":"(2001). Pediatrics, 108, 972\u2013982.","DOI":"10.1542\/peds.108.4.972"},{"key":"8862_CR7","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1753-4887.1999.tb06925.x","volume":"57","author":"O Freitas de","year":"1999","unstructured":"de Freitas, O., Izumi, C., Lara, M. G., & Greene, L. J. (1999). Nutrition Reviews, 57, 65\u201370.","journal-title":"Nutrition Reviews"},{"key":"8862_CR8","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1542\/peds.112.S4.1537","volume":"112","author":"KF Widaman","year":"2003","unstructured":"Widaman, K. F., & Azen, C. (2003). Pediatrics, 112, 1537\u20131543.","journal-title":"Pediatrics"},{"key":"8862_CR9","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0022-3476(99)70138-1","volume":"135","author":"S Kure","year":"1999","unstructured":"Kure, S., Hou, D. C., Ohura, T., Iwamoto, H., Suzuki, S., Sugiyama, N., et al. (1999). Journal of Pediatrics, 135, 375\u2013378.","journal-title":"Journal of Pediatrics"},{"key":"8862_CR10","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ymgme.2004.03.006","volume":"82","author":"N Blau","year":"2004","unstructured":"Blau, N., & Erlandsen, H. (2004). Molecular Genetics and Metabolism, 82, 101\u2013111.","journal-title":"Molecular Genetics and Metabolism"},{"key":"8862_CR11","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1073\/pnas.96.5.2339","volume":"96","author":"CN Sarkissian","year":"1999","unstructured":"Sarkissian, C. N., Shao, Z., Blain, F., Peevers, R., Su, H., Heft, R., et al. (1999). Proceedings of National Academy of Sciences USA, 96, 2339\u20132344.","journal-title":"Proceedings of National Academy of Sciences USA"},{"key":"8862_CR12","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.ymthe.2005.02.013","volume":"11","author":"A Gamez","year":"2005","unstructured":"Gamez, A., Sarkissian, C. N., Wang, L., Kim, W., Straub, M., Patch, M. G., et al. (2005). Molecular Therapeutic, 11, 986\u2013989.","journal-title":"Molecular Therapeutic"},{"issue":"Suppl 1","key":"8862_CR13","doi-asserted-by":"crossref","first-page":"S22","DOI":"10.1016\/j.ymgme.2005.06.016","volume":"86","author":"CN Sarkissian","year":"2005","unstructured":"Sarkissian, C. N., & Gamez, A. (2005). Molecular Genetics and Metabolism, 86(Suppl 1), S22\u2013S26.","journal-title":"Molecular Genetics and Metabolism"},{"key":"8862_CR14","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1021\/cr980450y","volume":"99","author":"T Flatmark","year":"1999","unstructured":"Flatmark, T., & Stevens, R. C. (1999). Chemical Reviews, 99, 2137\u20132160.","journal-title":"Chemical Reviews"},{"key":"8862_CR15","doi-asserted-by":"crossref","first-page":"7573","DOI":"10.1021\/bi0160720","volume":"41","author":"M Thorolfsson","year":"2002","unstructured":"Thorolfsson, M., Ibarra-Molero, B., Fojan, P., Petersen, S. B., Sanchez-Ruiz, J. M., & Martinez, A. (2002). Biochemistry, 41, 7573\u20137585.","journal-title":"Biochemistry"},{"key":"8862_CR16","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/nrd1695","volume":"4","author":"S Frokjaer","year":"2005","unstructured":"Frokjaer, S., & Otzen, D. E. (2005). Nature Reviews Drug Discovery, 4, 298\u2013306.","journal-title":"Nature Reviews Drug Discovery"},{"key":"8862_CR17","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0378-5173(03)00376-4","volume":"266","author":"DJ Crommelin","year":"2003","unstructured":"Crommelin, D. J., Storm, G., Verrijk, R., de Leede, L., Jiskoot, W., & Hennink, W. E. (2003). International Journal of Pharmaceutics, 266, 3\u201316.","journal-title":"International Journal of Pharmaceutics"},{"key":"8862_CR18","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0378-5173(99)00152-0","volume":"185","author":"W Wang","year":"1999","unstructured":"Wang, W. (1999). International Journal of Pharmaceutics, 185, 129\u2013188.","journal-title":"International Journal of Pharmaceutics"},{"key":"8862_CR19","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ymthe.2003.11.002","volume":"9","author":"A Gamez","year":"2004","unstructured":"Gamez, A., Wang, L., Straub, M., Patch, M. G., & Stevens, R. C. (2004). Molecular Therapeutic, 9, 124\u2013129.","journal-title":"Molecular Therapeutic"},{"key":"8862_CR20","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1021\/bi00324a002","volume":"24","author":"SC Kwok","year":"1985","unstructured":"Kwok, S. C., Ledley, F. D., DiLella, A. G., Robson, K. J., & Woo, S. L. (1985). Biochemistry, 24, 556\u2013561.","journal-title":"Biochemistry"},{"key":"8862_CR21","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1006\/mgme.2000.2970","volume":"69","author":"P Leandro","year":"2000","unstructured":"Leandro, P., Rivera, I., Lechner, M. C., de Almeida, I. T., & Konecki, D. (2000). Molecular Genetics and Metabolism, 69, 204\u2013212.","journal-title":"Molecular Genetics and Metabolism"},{"key":"8862_CR22","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"MM Bradford","year":"1976","unstructured":"Bradford, M. M. (1976). Analytical Biochemistry, 72, 248\u2013254.","journal-title":"Analytical Biochemistry"},{"key":"8862_CR23","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0076-6879(87)42003-X","volume":"142","author":"S Kaufman","year":"1987","unstructured":"Kaufman, S. (1987). Methods in Enzymology, 142, 3\u201317.","journal-title":"Methods in Enzymology"},{"key":"8862_CR24","doi-asserted-by":"crossref","first-page":"33251","DOI":"10.1074\/jbc.274.47.33251","volume":"274","author":"R Kleppe","year":"1999","unstructured":"Kleppe, R., Uhlemann, K., Knappskog, P. M., & Haavik, J. (1999). Journal of Biological Chemistry, 274, 33251\u201333258.","journal-title":"Journal of Biological Chemistry"},{"key":"8862_CR25","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/0076-6879(86)31045-0","volume":"131","author":"CN Pace","year":"1986","unstructured":"Pace, C. N. (1986). Methods in Enzymology, 131, 266\u2013280.","journal-title":"Methods in Enzymology"},{"key":"8862_CR26","doi-asserted-by":"crossref","first-page":"11790","DOI":"10.1021\/bi00037a017","volume":"34","author":"PM Knappskog","year":"1995","unstructured":"Knappskog, P. M., & Haavik, J. (1995). Biochemistry, 34, 11790\u201311799.","journal-title":"Biochemistry"},{"key":"8862_CR27","doi-asserted-by":"crossref","first-page":"3254","DOI":"10.1021\/bi00793a015","volume":"10","author":"SS Lehrer","year":"1971","unstructured":"Lehrer, S. S. (1971). Biochemistry, 10, 3254\u20133263.","journal-title":"Biochemistry"},{"key":"8862_CR28","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1111\/j.1432-1033.1996.0813r.x","volume":"242","author":"PM Knappskog","year":"1996","unstructured":"Knappskog, P. M., Flatmark, T., Aarden, J. M., Haavik, J., & Martinez, A. (1996). European Journal of Biochemistry, 242, 813\u2013821.","journal-title":"European Journal of Biochemistry"},{"key":"8862_CR29","first-page":"77","volume":"67","author":"S Kaufman","year":"1993","unstructured":"Kaufman, S. (1993). Advances in Enzymology and Related Areas of Molecular Biology, 67, 77\u2013264.","journal-title":"Advances in Enzymology and Related Areas of Molecular Biology"},{"key":"8862_CR30","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1042\/bj1390741","volume":"139","author":"SL Woo","year":"1974","unstructured":"Woo, S. L., Gillam, S. S., & Woolf, L. I. (1974). Biochemical Journal, 139, 741\u2013749.","journal-title":"Biochemical Journal"},{"key":"8862_CR31","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1016\/S0021-9258(17)30123-0","volume":"254","author":"N Chang","year":"1979","unstructured":"Chang, N., Kaufman, S., & Milstien, S. (1979). Journal of Biological Chemistry, 254, 2665\u20132668.","journal-title":"Journal of Biological Chemistry"},{"key":"8862_CR32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-5173(00)00423-3","volume":"203","author":"W Wang","year":"2000","unstructured":"Wang, W. (2000). International journal of pharmaceutics, 203, 1\u201360.","journal-title":"International journal of pharmaceutics"},{"key":"8862_CR33","first-page":"1","volume-title":"Formulation, characterization and stability of protein drugs","author":"MF Powell","year":"1996","unstructured":"Powell, M. F. (1996). In R. Pearlman & Y. J. Wang (Eds.), Formulation, characterization and stability of protein drugs (pp. 1\u2013140). New York: Plenum Press."},{"key":"8862_CR34","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.bpc.2005.11.010","volume":"120","author":"IL Shulgin","year":"2006","unstructured":"Shulgin, I. L., & Ruckenstein, E. (2006). Biophysical Chemistry, 120, 188\u2013198.","journal-title":"Biophysical Chemistry"},{"key":"8862_CR35","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1002\/humu.10198","volume":"21","author":"AL Pey","year":"2003","unstructured":"Pey, A. L., Desviat, L. R., Gamez, A., Ugarte, M., & Perez, B. (2003). Human Mutation, 21, 370\u2013378.","journal-title":"Human Mutation"},{"key":"8862_CR36","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1046\/j.1432-1327.2001.01958.x","volume":"268","author":"E Bjorgo","year":"2001","unstructured":"Bjorgo, E., de Carvalho, R. M., & Flatmark, T. (2001). European Journal of Biochemistry, 268, 997\u20131005.","journal-title":"European Journal of Biochemistry"},{"key":"8862_CR37","doi-asserted-by":"crossref","first-page":"11300","DOI":"10.1016\/S0021-9258(19)86484-0","volume":"254","author":"R Shiman","year":"1979","unstructured":"Shiman, R., Gray, D. W., & Pater, A. (1979). Journal of Biological Chemistry, 254, 11300\u201311306.","journal-title":"Journal of Biological Chemistry"},{"key":"8862_CR38","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/S0022-2836(02)00560-0","volume":"320","author":"OA Andersen","year":"2002","unstructured":"Andersen, O. A., Flatmark, T., & Hough, E. (2002). Journal of Molecular Biology, 320, 1095\u20131108.","journal-title":"Journal of Molecular Biology"},{"key":"8862_CR39","doi-asserted-by":"crossref","first-page":"26571","DOI":"10.1074\/jbc.M400879200","volume":"279","author":"AJ Stokka","year":"2004","unstructured":"Stokka, A. J., Carvalho, R. N., Barroso, J. F., & Flatmark, T. (2004). Journal of Biological Chemistry, 279, 26571\u201326580.","journal-title":"Journal of Biological Chemistry"},{"key":"8862_CR40","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0065-3233(08)60656-7","volume":"51","author":"SN Timasheff","year":"1998","unstructured":"Timasheff, S. N. (1998). Advances in Protein Chemistry, 51, 355\u2013432.","journal-title":"Advances in Protein Chemistry"},{"key":"8862_CR41","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1006\/jmbi.2001.4819","volume":"310","author":"DW Bolen","year":"2001","unstructured":"Bolen, D. W., & Baskakov, I. V. (2001). Journal of Molecular Biology, 310, 955\u2013963.","journal-title":"Journal of Molecular Biology"},{"key":"8862_CR42","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0167-4838(96)00010-6","volume":"1295","author":"M Barteri","year":"1996","unstructured":"Barteri, M., Gaudiano, M. C., & Santucci, R. (1996). Biochimica et Biophysica Acta, 1295, 51\u201358.","journal-title":"Biochimica et Biophysica Acta"},{"key":"8862_CR43","first-page":"323","volume":"276","author":"PR Lino","year":"2009","unstructured":"Lino, P. R., Almeida, A. J., de Tavares, A. I., & Leandro, P. (2009). FEBS Journal, 276, 323.","journal-title":"FEBS Journal"}],"container-title":["Applied Biochemistry and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12010-009-8862-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12010-009-8862-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12010-009-8862-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,27]],"date-time":"2023-05-27T17:09:11Z","timestamp":1685207351000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12010-009-8862-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11,25]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,9]]}},"alternative-id":["8862"],"URL":"https:\/\/doi.org\/10.1007\/s12010-009-8862-y","relation":{},"ISSN":["0273-2289","1559-0291"],"issn-type":[{"value":"0273-2289","type":"print"},{"value":"1559-0291","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,11,25]]}}}