{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T08:42:14Z","timestamp":1771231334880,"version":"3.50.1"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2018,8,31]],"date-time":"2018-08-31T00:00:00Z","timestamp":1535673600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Appl Biochem Biotechnol"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1007\/s12010-018-2868-2","type":"journal-article","created":{"date-parts":[[2018,8,31]],"date-time":"2018-08-31T02:24:33Z","timestamp":1535682273000},"page":"1113-1130","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Biological Activities Evaluation of Enantiopure Isoxazolidine Derivatives: In Vitro, In Vivo and In Silico Studies"],"prefix":"10.1007","volume":"187","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6522-9434","authenticated-orcid":false,"given":"Habib","family":"Mosbah","sequence":"first","affiliation":[]},{"given":"Hassiba","family":"Chahdoura","sequence":"additional","affiliation":[]},{"given":"Asma","family":"Mannai","sequence":"additional","affiliation":[]},{"given":"Mejdi","family":"Snoussi","sequence":"additional","affiliation":[]},{"given":"Ka\u00efss","family":"Aouadi","sequence":"additional","affiliation":[]},{"given":"Rui M. V.","family":"Abreu","sequence":"additional","affiliation":[]},{"given":"Ali","family":"Bouslama","sequence":"additional","affiliation":[]},{"given":"Lotfi","family":"Achour","sequence":"additional","affiliation":[]},{"given":"Boulbaba","family":"Selmi","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2018,8,31]]},"reference":[{"issue":"14","key":"2868_CR1","doi-asserted-by":"publisher","first-page":"5845","DOI":"10.1021\/jm4017625","volume":"57","author":"RD Taylor","year":"2014","unstructured":"Taylor, R. D., MacCoss, M., & Lawson, A. D. G. (2014). Rings in drugs. Journal of Medicinal Chemistry, 57(14), 5845\u20135859.","journal-title":"Journal of Medicinal Chemistry"},{"key":"2868_CR2","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.bioorg.2018.02.024","volume":"78","author":"M Amara","year":"2018","unstructured":"Amara, M., Muhammad, S., Sumera, Z., Muhammad, S. S., Huma, A. B., Aamer, S., Izhar, H., & Jamshed, I. (2018). Synthesis, molecular modelling and biological evaluation of tetrasubstituted thiazoles towards cholinesterase enzymes and cytotoxicity studies. Bioorganic Chemistry, 78, 141\u2013148.","journal-title":"Bioorganic Chemistry"},{"issue":"24","key":"2868_CR3","doi-asserted-by":"publisher","first-page":"15235","DOI":"10.1021\/acs.chemrev.6b00543","volume":"116","author":"M Berthet","year":"2016","unstructured":"Berthet, M., Cheviet, T., Dujardin, G., Parrot, I., & Martinez, J. (2016). Isoxazolidine: A privileged scaffold for organic and medicinal chemistry. Chemical Reviews, 116(24), 15235\u201315283.","journal-title":"Chemical Reviews"},{"key":"2868_CR4","first-page":"3399","volume":"21","author":"K Aouadi","year":"2007","unstructured":"Aouadi, K., Jeanneau, E., Msaddek, M., & Praly, J. P. (2007). New synthetic routes toward enantiopure (2S,3R,4R)-4-hydroxyisoleucine by 1,3-dipolar cycloaddition of a chiral nitrone to C4 alkenes. Synthesis, 21, 3399\u20133405.","journal-title":"Synthesis"},{"issue":"23","key":"2868_CR5","doi-asserted-by":"publisher","first-page":"2817","DOI":"10.1016\/j.tetlet.2012.03.110","volume":"53","author":"K Aouadi","year":"2012","unstructured":"Aouadi, K., Jeanneau, E., Msaddek, M., & Praly, J. P. (2012). 1,3-Dipolar cycloaddition of a chiral nitrone to (E)-1,4-dichloro-2- butene: A new efficient synthesis of (2S,3S,4R)-4-hydroxyisoleucine. Tetrahedron Letters, 53(23), 2817\u20132821.","journal-title":"Tetrahedron Letters"},{"issue":"34","key":"2868_CR6","doi-asserted-by":"publisher","first-page":"11843","DOI":"10.1016\/S0040-4020(97)00757-6","volume":"53","author":"JPG Seerden","year":"1997","unstructured":"Seerden, J. P. G., Boeren, M. M. M., & Scheeren, H. W. (1997). 1,3-dipolar cycloaddition reactions of nitrones with alkyl vinyl ethers catalyzed by chiral oxazaborolidines. Tetrahedron, 53(34), 11843\u201311852.","journal-title":"Tetrahedron"},{"issue":"2","key":"2868_CR7","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/S0040-4020(96)01095-2","volume":"53","author":"M Frederickson","year":"1997","unstructured":"Frederickson, M. (1997). Optically active isoxazolidines via asymmetric cycloaddition reactions of nitrones with alkenes: Applications in organic synthesis. Tetrahedron, 53(2), 403\u2013425.","journal-title":"Tetrahedron"},{"issue":"24","key":"2868_CR8","doi-asserted-by":"publisher","first-page":"2037","DOI":"10.1080\/00397911.2016.1244692","volume":"46","author":"J Brahmi","year":"2016","unstructured":"Brahmi, J., Ghannay, S., Bakari, S., Kadri, A., Aouadi, K., Msaddek, M., & Vidal, S. (2016). Unprecedented stereoselective synthesis of 3- methylisoxazolidine-5-aryl-1,2,4-oxadiazoles via 1,3-dipolar cycloaddition and study of their in vitro antioxidant activity. Synthetic Communications, 46(24), 2037\u20132044.","journal-title":"Synthetic Communications"},{"key":"2868_CR9","doi-asserted-by":"publisher","unstructured":"Ghannay, S., Bakari, S., Msaddek, M., Vidal, S., Kadri, A., & Aouadi, K. (2018). Design, synthesis, molecular properties and in vitro antioxidant and antibacterial potential of novel enantiopure isoxazolidine derivatives. Arabian Journal of Chemistry. https:\/\/doi.org\/10.1016\/j.arabjc.2018.03.013 .","DOI":"10.1016\/j.arabjc.2018.03.013"},{"issue":"11","key":"2868_CR10","doi-asserted-by":"publisher","first-page":"2302","DOI":"10.1016\/j.bmcl.2017.04.044","volume":"27","author":"S Ghannay","year":"2017","unstructured":"Ghannay, S., Bakari, S., Ghabi, A., Kadri, A., Msaddek, M., & Aouadi, K. (2017). Stereoselective synthesis of enantiopure N-substituted pyrrolidin-2,5-dione derivatives by 1,3-dipolar cycloaddition and assessment of their in vitro antioxidant and antibacterial activities. Bioorganic & Medicinal Chemistry Letters, 27(11), 2302\u20132307.","journal-title":"Bioorganic & Medicinal Chemistry Letters"},{"key":"2868_CR11","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1002\/ardp.200390015","volume":"336","author":"KRR Kumar","year":"2003","unstructured":"Kumar, K. R. R., Mallesha, H., & Rangappa, K. S. (2003). Synthesis of novel isoxazolidine derivatives and their antifungal and antibacterial properties. Archiv der Pharmazie -Pharmaceutical and Medicinal Chemistry, 336, 159\u2013164.","journal-title":"Archiv der Pharmazie -Pharmaceutical and Medicinal Chemistry"},{"issue":"5","key":"2868_CR12","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1111\/j.1747-0285.2010.00956.x","volume":"75","author":"B Loh","year":"2010","unstructured":"Loh, B., Vozzolo, L., Mok, B. J., Lee, C. C., Fitzmaurice, R. J., Caddick, S., & Fassati, A. (2010). Inhibition of HIV-1 replication by isoxazolidine and isoxazole sulfonamides. Chemical Biology & Drug Design, 75(5), 461\u2013474.","journal-title":"Chemical Biology & Drug Design"},{"issue":"1","key":"2868_CR13","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.ejmech.2009.09.034","volume":"45","author":"RS Kumar","year":"2010","unstructured":"Kumar, R. S., Perumal, S., Shetty, K. A., Yogeeswari, P., & Sriram, D. (2010). 1,3-dipolar cycloaddition of C-aryl-N-phenylnitrones to (R)-1-(1-phenylethyl)-3-[(E)-arylmethylidene] tetrahydro-4(1H)-pyridinones: Synthesis and antimycobacterial evaluation of enantiomerically pure spiroisoxazolidines. European Journal of Medicinal Chemistry, 45(1), 124\u2013133.","journal-title":"European Journal of Medicinal Chemistry"},{"issue":"1","key":"2868_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/00304948.2012.643193","volume":"44","author":"TB Nguyen","year":"2012","unstructured":"Nguyen, T. B., Martel, A., Gaulon-Nourry, C., Dhal, R., & Dujardin, G. (2012). 1,3-Dipolar cycloadditions of nitrones to heterosubstituted alkenes part 2: Sila-, thia-, phospha- and halosubstituted alkenes. Organic Preparations and Procedures International, 44(1), 1\u201381.","journal-title":"Organic Preparations and Procedures International"},{"issue":"5","key":"2868_CR15","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1080\/00304948.2010.513886","volume":"42","author":"TB Nguyen","year":"2010","unstructured":"Nguyen, T. B., Martel, A., Gaulon, C., Dhal, R., & Dujardin, G. (2010). 1,3-dipolar cycloadditions of nitrones to heterosubstituted alkenes. Part 1: Oxa and aza-substituted alkenes. Organic Preparations and Procedures International, 42(5), 387\u2013431.","journal-title":"Organic Preparations and Procedures International"},{"issue":"9","key":"2868_CR16","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1016\/j.tetasy.2008.04.006","volume":"19","author":"K Aouadi","year":"2008","unstructured":"Aouadi, K., Jeanneau, E., Msaddek, M., & Praly, J. P. (2008). Analogues of insulin secretagogue (2S,3R,4S)-4-hydroxyisoleucine: Synthesis by 1,3-dipolar cycloaddition reactions of chiral nitrones to alkenes. Tetrahedron: Asymmetry, 19(9), 1145\u20131152.","journal-title":"Tetrahedron: Asymmetry"},{"key":"2868_CR17","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.foodchem.2015.01.001","volume":"177","author":"N Condelli","year":"2015","unstructured":"Condelli, N., Caruso, M. C., Galgano, F., Russo, D., Milella, L., & Favati, F. (2015). Prediction of the antioxidant activity of extra virgin oils produced in the Mediterranean area. Food Chemistry, 177, 233\u2013239.","journal-title":"Food Chemistry"},{"issue":"2","key":"2868_CR18","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.brainres.2004.02.036","volume":"1008","author":"NAV Bell\u00e9","year":"2004","unstructured":"Bell\u00e9, N. A. V., Dalmolin, G. D., Fonini, G., Rubim, M. A., & Rocha, J. B. T. (2004). Polyamines reduces lipid peroxidation induced by different pro-oxidant agents. Brain Research, 1008(2), 245\u2013251.","journal-title":"Brain Research"},{"issue":"4","key":"2868_CR19","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/j.fm.2006.04.010","volume":"24","author":"V Vuddhakul","year":"2007","unstructured":"Vuddhakul, V., Bhooponga, P., Hayeebilana, F., & Subhadhirasakulb, S. (2007). Inhibitory activity of Thai condiments on pandemic strain of Vibrio parahaemolyticus. Food Microbiology, 24(4), 413\u2013418.","journal-title":"Food Microbiology"},{"issue":"13","key":"2868_CR20","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1080\/14786410903387688","volume":"24","author":"M Parveen","year":"2010","unstructured":"Parveen, M., Ghalib, R. M., Khanam, Z., Mehdi, S. H., & Ali, M. (2010). A novel antimicrobial agent from the leaves of Peltophorum vogelianum (Benth.). Natural Product Research, 24(13), 1268\u20131273.","journal-title":"Natural Product Research"},{"issue":"8","key":"2868_CR21","doi-asserted-by":"publisher","first-page":"14402","DOI":"10.3390\/molecules200814402","volume":"20","author":"M Snoussi","year":"2015","unstructured":"Snoussi, M., Noumi, E., Trabelsi, N., Flamini, G., Papetti, A., & De Feo, V. (2015). Mentha spicata essential oil: Chimica composition: Antioxidant and antibacterial activities against planktonic and biofilm cultures of Vibrio spp. strains. Molecules, 20(8), 14402\u201314424.","journal-title":"Molecules"},{"issue":"Suppl 2","key":"2868_CR22","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1289\/ehp.98106497","volume":"106","author":"E Walum","year":"1998","unstructured":"Walum, E. (1998). Acute oral toxicity. Environmental Health Perspectives, 106(Suppl 2), 497\u2013503.","journal-title":"Environmental Health Perspectives"},{"issue":"1","key":"2868_CR23","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1007\/s10616-014-9764-6","volume":"68","author":"R Ben Mansour","year":"2016","unstructured":"Ben Mansour, R., Imtinen, B. H. J., Mohammed, B., Bochra, G., N\u00e9srine, E., Hamadi, A., Zeineb, G. G., & Saloua, L. (2016). Phenolic contents and antioxidant activity of ethanolic extract of Capparis spinosa. Cytotechnology, 68(1), 135\u2013142.","journal-title":"Cytotechnology"},{"issue":"3","key":"2868_CR24","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1021\/ac60147a030","volume":"31","author":"GL Miller","year":"1959","unstructured":"Miller, G. L. (1959). Use of dinitrosalicylic acid reagent for determination of reducing sugar. Analytical Chemistry, 31(3), 426\u2013428.","journal-title":"Analytical Chemistry"},{"key":"2868_CR25","doi-asserted-by":"publisher","first-page":"5870","DOI":"10.1016\/j.bmc.2015.06.068","volume":"23","author":"A Zaman","year":"2015","unstructured":"Zaman, A., Muhammad, R., Sung-Yum, S., Mustafeez, M. B., & Najam-us-Sahar, S. Z. (2015). Synthesis, kinetic mechanism and docking studies of vanillin derivatives as inhibitors of mushroom tyrosinase. Bioorganic & Medicinal Chemistry, 23, 5870\u20135880.","journal-title":"Bioorganic & Medicinal Chemistry"},{"key":"2868_CR26","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1002\/jmr.2266","volume":"26","author":"E Yuriev","year":"2013","unstructured":"Yuriev, E., & Ramsland, P. A. (2013). Latest developments in molecular docking: 2010-2011 in review. Journal of Molecular Recognition, 26, 215\u2013239.","journal-title":"Journal of Molecular Recognition"},{"key":"2868_CR27","unstructured":"Morris, G.M., Huey, R., & Olson, A.J. (2008). \"Using AutoDock for ligand-receptor docking.\" Current Protocols in Bioinformatics Chapter 8: Unit 8.14."},{"issue":"3","key":"2868_CR28","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1023\/B:JCAM.0000035186.90683.f2","volume":"18","author":"A Pedretti","year":"2004","unstructured":"Pedretti, A., Villa, L., & Vistoli, G. (2004). VEGA - an open platform to develop chemo-bio-informatics applications, using plug-in architecture and script programming. Journal of Computer-Aided Molecular Design, 18(3), 167\u2013173.","journal-title":"Journal of Computer-Aided Molecular Design"},{"key":"2868_CR29","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","volume":"31","author":"O Trott","year":"2010","unstructured":"Trott, O., & Olson, A. J. (2010). AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. Journal of Computational Chemistry, 31, 455\u2013461.","journal-title":"Journal of Computational Chemistry"},{"key":"2868_CR30","unstructured":"Delano, W. L. (2002). \u201cThe PyMOL molecular graphics system.\u201d from http:\/\/www.pymol.org ."},{"key":"2868_CR31","unstructured":"Altenbach, H.J., Kottenhahn, M., Vogt, A., Matthaus, M., Grundler, A., Hahn, M. (1997). Method of preparing optically active \u03b1-amino acids and \u03b1-amino acid derivatives. Evonik Degussa GmbH, 19533617 A1, and US Patent 6018050, 2000."},{"key":"2868_CR32","first-page":"2670","volume":"43","author":"S Mukherjee","year":"2004","unstructured":"Mukherjee, S., Raunak, Dhawan, A., Poonam, Prasad, A. K., Olsen, C. E., Cholli, A. L., Errington, W., Raj, H. G., Watterson, A. C., & Prmar, V. S. (2004). Synthetic and biological activity evaluation studies on novel isoxazolidines. Indian Journal of Chemistry, 43, 2670\u20132682.","journal-title":"Indian Journal of Chemistry"},{"key":"2868_CR33","first-page":"215","volume":"7","author":"M Mubeen","year":"2015","unstructured":"Mubeen, M., Kini, S. G., & Pai, K. S. R. (2015). Design, synthesis, antioxidant and anticancer activity of novel pyrazole derivatives. Der Pharma Chemica, 7, 215\u2013223.","journal-title":"Der Pharma Chemica"},{"key":"2868_CR34","first-page":"1267","volume":"3","author":"A Kumar","year":"2014","unstructured":"Kumar, A., Fernandes, J., & Kumar, P. (2014). Synthesis and biological evaluation of some novel isoxazolidine derivatives of carbostyril. International Journal of Pharmacy and Pharmaceutical Sciences, 3, 1267\u20131277.","journal-title":"International Journal of Pharmacy and Pharmaceutical Sciences"},{"key":"2868_CR35","first-page":"38","volume":"4","author":"P Mondal","year":"2012","unstructured":"Mondal, P., Jana, S., Balaji, A., Ramakrishna, R., & Kanthal, L. K. (2012). Synthesis of some new isoxazoline derivatives of chalconised indoline 2-one as a potential analgesic, antibacterial and anthelmimtic agents. Pharmaceutical Chemistry, 4, 38\u201341.","journal-title":"Pharmaceutical Chemistry"},{"issue":"11","key":"2868_CR36","doi-asserted-by":"publisher","first-page":"5169","DOI":"10.1016\/j.ejmech.2010.08.031","volume":"45","author":"A Colak","year":"2010","unstructured":"Colak, A., Terzi, U., Col, M., Karaoglu, S. A., Karabocek, S., Kucukdumlu, A., & Ayaz, A. (2010). DNA binding, antioxidant and antimicrobial activities of homo- and heteronuclear copper(II) and nickel(II) complexes with new oxime-type ligands. European Journal of Medicinal Chemistry, 45(11), 5169\u20135175.","journal-title":"European Journal of Medicinal Chemistry"},{"issue":"5","key":"2868_CR37","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1191\/096032701678227730","volume":"20","author":"M Rahman","year":"2001","unstructured":"Rahman, M., Siddiqui, M. K., & Jamil, K. (2001). Effects of vepacide (Azadirachta indica) on asp artate and al anine aminotransferase profiles in a subchronic study with rats. Human & Experimental Toxicology, 20(5), 243\u2013249.","journal-title":"Human & Experimental Toxicology"},{"issue":"1","key":"2868_CR38","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.jep.2003.11.009","volume":"91","author":"J Hilaly El","year":"2004","unstructured":"El Hilaly, J., Israili, Z. H., & Lyoussi, B. (2004). Acute and chronic toxicological studies of Ajuga iva in experimental animals. Journal of Ethnopharmacology, 91(1), 43\u201350.","journal-title":"Journal of Ethnopharmacology"},{"issue":"9457","key":"2868_CR39","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/S0140-6736(05)70238-5","volume":"365","author":"N Lameire","year":"2005","unstructured":"Lameire, N., Van Biesen, W., & Vanholder, R. (2005). Acute renal failure. The Lancet, 365(9457), 417\u2013430.","journal-title":"The Lancet"},{"issue":"7","key":"2868_CR40","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1097\/00001813-200308000-00008","volume":"14","author":"OS Frankfurt","year":"2003","unstructured":"Frankfurt, O. S., & Krishan, A. (2003). Apoptosis-based drug screening and detection of selective toxicity to cancer cells. Anti-Cancer Drugs, 14(7), 555\u2013561.","journal-title":"Anti-Cancer Drugs"},{"key":"2868_CR41","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1007\/s12010-017-2661-7","volume":"185","author":"M Dinesh","year":"2017","unstructured":"Dinesh, M., Deepika, S., HarishKumar, R., Selvaraj, C. I., & Roopan, S. M. (2017). Evaluation of octyl-\u03b2-D-glucopyranoside (OGP) for cytotoxic, hemolytic, thrombolytic, and antibacterial activity. Applied Biochemistry and Biotechnology, 185, 450\u2013463.","journal-title":"Applied Biochemistry and Biotechnology"},{"key":"2868_CR42","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1002\/ardp.19973300306","volume":"330","author":"H Iris Hall","year":"1997","unstructured":"Iris Hall, H., Robert, A. I., Xaioming, Z., Dwayne, L. D., Tyrone, W., Manik, L. D., Elaine, T., & Rosallah, A. M. (1997). Synthesis and cytotoxic action of 3,5-isoxazolidinediones and 2-isoxazolin-5-ones in murine and human tumors. Archiv der Pharmazie, 330, 67\u201373.","journal-title":"Archiv der Pharmazie"},{"key":"2868_CR43","first-page":"301","volume":"11","author":"GP Dorota","year":"2011","unstructured":"Dorota, G. P., Marcin, C., Karolina, K., & Andrzej, E. W. (2011). Design, synthesis and cytotoxicity of a new series of isoxazolidine based nucleoside analogues. Archiv der Pharmazie Chemistry in Life Sciences, 11, 301\u2013310.","journal-title":"Archiv der Pharmazie Chemistry in Life Sciences"},{"issue":"18","key":"2868_CR44","doi-asserted-by":"publisher","first-page":"3131","DOI":"10.3923\/pjbs.2007.3131.3135","volume":"10","author":"RT Dewi","year":"2007","unstructured":"Dewi, R. T., Iskandar, Y. M., Hanafi, M., Kardono, L. B. S., Angelina, M., Dewijanti, I. D., & Banjarnahor, S. D. S. (2007). Inhibitory effect of Koji Aspergillus terreus on \u03b1-glucosidase activity and postprandial hyperglycemia. Pakistan Journal of Biological Sciences, 10(18), 3131\u20133135.","journal-title":"Pakistan Journal of Biological Sciences"},{"key":"2868_CR45","first-page":"465","volume":"17","author":"R Mahsa","year":"2014","unstructured":"Mahsa, R., Samaneh, J., Soheila, M., & Mahmood, R. M. (2014). Evaluation of alpha- amylase inhibition by Urtica dioica and Juglans regia extracts. Iranian Journal of Basic Medical Sciences, 17, 465\u2013469.","journal-title":"Iranian Journal of Basic Medical Sciences"},{"issue":"6","key":"2868_CR46","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1007\/s12010-013-0271-6","volume":"170","author":"CV Montefusco-Pereira","year":"2013","unstructured":"Montefusco-Pereira, C. V., de Carvalho, M. J., de Ara\u00fajo Boleti, A. P., Teixeira, L. S., Matos, H. R., & Lima, E. S. (2013). Antioxidant, anti-inflammatory, and hypoglycemic effects of the leaf extract from Passiflora nitida Kunth. Applied Biochemistry and Biotechnology, 170(6), 1367\u20131378.","journal-title":"Applied Biochemistry and Biotechnology"},{"key":"2868_CR47","doi-asserted-by":"publisher","DOI":"10.1002\/9781118540398","volume-title":"Evaluation of enzyme inhibitors in drug discovery: A guide for medicinal chemists and pharmacologists","author":"RA Copeland","year":"2013","unstructured":"Copeland, R. A. (2013). Evaluation of enzyme inhibitors in drug discovery: A guide for medicinal chemists and pharmacologists (2nd ed.). New Jersey: Wiley (Chapter 3).","edition":"2"},{"issue":"25","key":"2868_CR48","doi-asserted-by":"publisher","first-page":"7700","DOI":"10.1021\/bi0102050","volume":"40","author":"M Qian","year":"2001","unstructured":"Qian, M., Nahoum, V., Bonicel, J., Bischoff, H., Henrissat, B., & Payan, F. (2001). Enzyme-catalyzed condensation reaction in a mammalian alpha-amylase. High-resolution structural analysis of an enzyme-inhibitor complex. Biochemistry, 40(25), 7700\u20137709.","journal-title":"Biochemistry"}],"container-title":["Applied Biochemistry and Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12010-018-2868-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12010-018-2868-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12010-018-2868-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,6]],"date-time":"2025-07-06T18:32:32Z","timestamp":1751826752000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12010-018-2868-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,31]]},"references-count":48,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["2868"],"URL":"https:\/\/doi.org\/10.1007\/s12010-018-2868-2","relation":{},"ISSN":["0273-2289","1559-0291"],"issn-type":[{"value":"0273-2289","type":"print"},{"value":"1559-0291","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,31]]},"assertion":[{"value":"21 June 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 August 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 August 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of Interest"}}]}}