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However, their large-scale production and application are restricted by high production costs. Such costs can be reduced using renewable raw materials and facilitated downstream processing. Here, a novel strategy for mannosylerythritol lipid (MEL) production explores the combination of hydrophilic and hydrophobic carbon sources sideways with a novel downstream processing strategy, based on nanofiltration technology. Co-substrate MEL production by <jats:italic>Moesziomyces antarcticus<\/jats:italic> was threefold higher than using D-glucose with low levels of residual lipids. The use of waste frying oil instead of soybean oil (SBO) in co-substrate strategy resulted in similar MEL production. <jats:italic>Moesziomyces antarcticus<\/jats:italic> cultivations, using 3.9\u00a0M of total carbon in substrates, yields 7.3, 18.1, and 20.1\u00a0g\/L of MEL, and 2.1, 10.0, and 5.1\u00a0g\/L of residual lipids, for D-glucose, SBO, and a combination of D-Glucose and SBO, respectively. Such approach makes it possible to reduce the amount of oil used, offset by the equivalent molar increase in D-glucose, improving sustainability and decreasing residual unconsumed oil substrates, facilitating downstream processing. <jats:italic>Moesziomyces<\/jats:italic> spp. also produces lipases that broken down the oil and, thus, residual unconsumed oils are in the form of free fatty-acids or monoacylglycerol, which are smaller molecules than MEL. Therefore, nanofiltration of ethyl acetate extracts from co-substrate-based culture broths allows to improve MEL purity (ratio of MEL per total MEL and residual lipids) from 66 to 93% using 3-diavolumes.<\/jats:p>","DOI":"10.1007\/s12010-023-04317-z","type":"journal-article","created":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T07:02:56Z","timestamp":1677049376000},"page":"6132-6149","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Substrates of Opposite Polarities and Downstream Processing for Efficient Production of the Biosurfactant Mannosylerythritol Lipids from Moesziomyces spp."],"prefix":"10.1007","volume":"195","author":[{"given":"Nuno Torres","family":"Faria","sequence":"first","affiliation":[]},{"given":"Miguel Figueiredo","family":"Nascimento","sequence":"additional","affiliation":[]},{"given":"Fl\u00e1vio Alves","family":"Ferreira","sequence":"additional","affiliation":[]},{"given":"Teresa","family":"Esteves","sequence":"additional","affiliation":[]},{"given":"Marisa Viegas","family":"Santos","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5177-6237","authenticated-orcid":false,"given":"Frederico Castelo","family":"Ferreira","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2023,2,22]]},"reference":[{"key":"4317_CR1","unstructured":"MarketsandMarkets. 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