{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T01:38:32Z","timestamp":1777081112046,"version":"3.51.4"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,7,16]],"date-time":"2016-07-16T00:00:00Z","timestamp":1468627200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Immunol Res"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1007\/s12026-016-8829-3","type":"journal-article","created":{"date-parts":[[2016,7,16]],"date-time":"2016-07-16T08:03:58Z","timestamp":1468656238000},"page":"197-206","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Vitamin D supplementation effects on FoxP3 expression in T cells and FoxP3+\/IL-17A ratio and clinical course in systemic lupus erythematosus patients: a study in a Portuguese cohort"],"prefix":"10.1007","volume":"65","author":[{"given":"Ant\u00f3nio","family":"Marinho","sequence":"first","affiliation":[]},{"given":"Cl\u00e1udia","family":"Carvalho","sequence":"additional","affiliation":[]},{"given":"Daniela","family":"Boleixa","sequence":"additional","affiliation":[]},{"given":"Andreia","family":"Bettencourt","sequence":"additional","affiliation":[]},{"given":"B\u00e1rbara","family":"Leal","sequence":"additional","affiliation":[]},{"given":"Judite","family":"Guimar\u00e3es","sequence":"additional","affiliation":[]},{"given":"Esmeralda","family":"Neves","sequence":"additional","affiliation":[]},{"given":"Jos\u00e9 Carlos","family":"Oliveira","sequence":"additional","affiliation":[]},{"given":"Isabel","family":"Almeida","sequence":"additional","affiliation":[]},{"given":"F\u00e1tima","family":"Farinha","sequence":"additional","affiliation":[]},{"given":"Paulo P.","family":"Costa","sequence":"additional","affiliation":[]},{"given":"Carlos","family":"Vasconcelos","sequence":"additional","affiliation":[]},{"given":"Berta M.","family":"Silva","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2016,7,16]]},"reference":[{"key":"8829_CR1","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1177\/0961203314566636","volume":"24","author":"C Carvalho","year":"2015","unstructured":"Carvalho C, Marinho A, Leal B, Bettencourt A, Boleixa D, Almeida I et al. Association between vitamin D receptor (VDR) gene polymorphisms and systemic lupus erythematosus in Portuguese patients. Lupus. 2015;24:846\u201353.","journal-title":"Lupus"},{"key":"8829_CR2","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1002\/art.37785","volume":"65","author":"BR Lauwerys","year":"2013","unstructured":"Lauwerys BR, Hachulla E, Spertini F, Lazaro E, Jorgensen C, Mariette X, et al. Down-regulation of interferon signature in systemic lupus erythematosus patients by active immunization with interferon alpha-kinoid. Arthritis Rheum. 2013;65:447\u201356.","journal-title":"Arthritis Rheum"},{"key":"8829_CR3","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.1093\/rheumatology\/ket403","volume":"53","author":"BR Lauwerys","year":"2014","unstructured":"Lauwerys BR, Ducreux J, Houssiau FA. Type I interferon blockade in systemic lupus erythematosus: where do we stand? Rheumatology. 2014;53:1369\u201376.","journal-title":"Rheumatology"},{"key":"8829_CR4","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-9371-7","volume-title":"TH17 cells in health and disease","author":"SE Jiang","year":"2011","unstructured":"Jiang SE. TH17 cells in health and disease. 1st ed. New York: Springer; 2011.","edition":"1"},{"key":"8829_CR5","volume-title":"Systemic lupus erythematosus","author":"RG Lahita","year":"2011","unstructured":"Lahita RG, Tsokos GC, Buyon JP, Koike T. Systemic lupus erythematosus. 5th ed. Cambridge: Academic Press, Elsevier Inc; 2011.","edition":"5"},{"key":"8829_CR6","doi-asserted-by":"publisher","first-page":"R49","DOI":"10.1186\/ar4479","volume":"16","author":"M Mandal","year":"2014","unstructured":"Mandal M, Tripathy R, Panda AK, Pattanaik SS, Dakua S, Pradhan AK, et al. Vitamin D levels in Indian systemic lupus erythematosus patients: association with disease activity index and interferon alpha. Arthritis Res Ther. 2014;16:R49.","journal-title":"Arthritis Res Ther"},{"key":"8829_CR7","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1186\/ar3844","volume":"14","author":"SG Guerra","year":"2012","unstructured":"Guerra SG, Vyse TJ, Graham DSC. The genetics of lupus: a functional perspective. Arthritis Res Ther. 2012;14:211.","journal-title":"Arthritis Res Ther"},{"key":"8829_CR8","first-page":"965","volume":"117","author":"V Mocanu","year":"2013","unstructured":"Mocanu V, Oboroceanu T, Zugun-Eloae F. Current status in vitamin D and regulatory T cells\u2014immunological implications. Rev Med Chir Soc Med Nat Iasi. 2013;117:965\u201373.","journal-title":"Rev Med Chir Soc Med Nat Iasi"},{"key":"8829_CR9","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1086\/649840","volume":"201","author":"MM Del Pozo-Balado","year":"2010","unstructured":"Del Pozo-Balado MM, Leal M, Mendez-Lagares G, Pacheco YM. CD4(+)CD25(+\/hi)CD127(lo) phenotype does not accurately identify regulatory T cells in all populations of HIV-infected persons. J Infect Dis. 2010;201:331\u20135.","journal-title":"J Infect Dis"},{"key":"8829_CR10","doi-asserted-by":"publisher","first-page":"e6635","DOI":"10.1371\/journal.pone.0006635","volume":"4","author":"J Smolders","year":"2009","unstructured":"Smolders J, Thewissen M, Peelen E, Menheere P, Tervaert JW, Damoiseaux J, et al. Vitamin D status is positively correlated with regulatory T cell function in patients with multiple sclerosis. PLoS One. 2009;4:e6635.","journal-title":"PLoS One"},{"key":"8829_CR11","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/B978-0-12-387827-4.00005-X","volume":"112","author":"C Daniel","year":"2011","unstructured":"Daniel C, von Boehmer H. Extrathymic generation of regulatory T cells\u2014chances and challenges for prevention of autoimmune disease. Adv Immunol. 2011;112:177\u2013213.","journal-title":"Adv Immunol"},{"key":"8829_CR12","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/j.autrev.2011.09.008","volume":"11","author":"P Sawla","year":"2012","unstructured":"Sawla P, Hossain A, Hahn BH, Singh RP. Regulatory T cells in systemic lupus erythematosus (SLE); role of peptide tolerance. Autoimmun Rev. 2012;11:611\u20134.","journal-title":"Autoimmun Rev"},{"key":"8829_CR13","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1111\/j.1365-2362.2007.01882.x","volume":"37","author":"SC Lin","year":"2007","unstructured":"Lin SC, Chen KH, Lin CH, Kuo CC, Ling QD, Chan CH. The quantitative analysis of peripheral blood FOXP3-expressing T cells in systemic lupus erythematosus and rheumatoid arthritis patients. Eur J Clin Invest. 2007;37:987\u201396.","journal-title":"Eur J Clin Invest"},{"key":"8829_CR14","doi-asserted-by":"publisher","first-page":"1512","DOI":"10.1136\/ard.2005.049924","volume":"65","author":"A Suarez","year":"2006","unstructured":"Suarez A, Lopez P, Gomez J, Gutierrez C. Enrichment of CD4+ CD25 high T cell population in patients with systemic lupus erythematosus treated with glucocorticoids. Ann Rheum Dis. 2006;65:1512\u20137.","journal-title":"Ann Rheum Dis"},{"key":"8829_CR15","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.4049\/jimmunol.182.3.1689","volume":"182","author":"M Bonelli","year":"2009","unstructured":"Bonelli M, Savitskaya A, Steiner CW, Rath E, Smolen JS, Scheinecker C. Phenotypic and functional analysis of CD4+ CD25\u2212 Foxp3+ T cells in patients with systemic lupus erythematosus. J Immunol. 2009;182:1689\u201395.","journal-title":"J Immunol"},{"key":"8829_CR16","doi-asserted-by":"publisher","first-page":"2579","DOI":"10.4049\/jimmunol.178.4.2579","volume":"178","author":"X Valencia","year":"2007","unstructured":"Valencia X, Yarboro C, Illei G, Lipsky PE. Deficient CD4+ CD25 high T regulatory cell function in patients with active systemic lupus erythematosus. J Immunol. 2007;178:2579\u201388.","journal-title":"J Immunol"},{"key":"8829_CR17","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1007\/s00296-011-2077-6","volume":"32","author":"AS Bansal","year":"2012","unstructured":"Bansal AS, Henriquez F, Sumar N, Patel S. T helper cell subsets in arthritis and the benefits of immunomodulation by 1,25(OH)(2) vitamin D. Rheumatol Int. 2012;32:845\u201352.","journal-title":"Rheumatol Int"},{"key":"8829_CR18","doi-asserted-by":"publisher","first-page":"26R","DOI":"10.1203\/PDR.0b013e31819e76c7","volume":"65","author":"EM Eisenstein","year":"2009","unstructured":"Eisenstein EM, Williams CB. The T(reg)\/Th17 cell balance: a new paradigm for autoimmunity. Pediatr Res. 2009;65:26R\u201331R.","journal-title":"Pediatr Res"},{"key":"8829_CR19","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1016\/j.coi.2012.10.004","volume":"24","author":"J Choi","year":"2012","unstructured":"Choi J, Kim ST, Craft J. The pathogenesis of systemic lupus erythematosus\u2014an update. Curr Opin Immunol. 2012;24:651\u20137.","journal-title":"Curr Opin Immunol"},{"key":"8829_CR20","first-page":"709","volume":"11","author":"M Kunz","year":"2013","unstructured":"Kunz M. Lupus erythematosus. Part I: epidemiology, genetics and immunology. JDDG. 2013;11:709\u201319.","journal-title":"JDDG"},{"key":"8829_CR21","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1007\/s10067-014-2530-5","volume":"33","author":"L Schneider","year":"2014","unstructured":"Schneider L, Dos SA, Santos M, da Silva Chakr RM, Monticielo OA. Vitamin D and systemic lupus erythematosus: state of the art. Clin Rheumatol. 2014;33:1033\u20138.","journal-title":"Clin Rheumatol"},{"key":"8829_CR22","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1093\/rheumatology\/ken394","volume":"48","author":"M Cutolo","year":"2009","unstructured":"Cutolo M. Vitamin D and autoimmune rheumatic diseases. Rheumatology. 2009;48:210\u20132.","journal-title":"Rheumatology"},{"key":"8829_CR23","first-page":"3","volume":"34","author":"PH Hart","year":"2013","unstructured":"Hart PH, Gorman S. Exposure to UV wavelengths in sunlight suppresses immunity. To what extent is UV-induced Vitamin D3 the mediator responsible? Clin Biochem Rev. 2013;34:3\u201313.","journal-title":"Clin Biochem Rev"},{"key":"8829_CR24","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1016\/j.jbspin.2010.09.018","volume":"77","author":"X Guillot","year":"2010","unstructured":"Guillot X, Semerano L, Saidenberg-Kermanac\u2019h N, Falgarone G, Boissier MC. Vitamin D and inflammation. Joint Bone Spine Rev Rhum. 2010;77:552\u20137.","journal-title":"Joint Bone Spine Rev Rhum"},{"key":"8829_CR25","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.autrev.2012.07.007","volume":"12","author":"A Antico","year":"2012","unstructured":"Antico A, Tampoia M, Tozzoli R, Bizzaro N. Can supplementation with vitamin D reduce the risk or modify the course of autoimmune diseases? A systematic review of the literature. Autoimmun Rev. 2012;12:127\u201336.","journal-title":"Autoimmun Rev"},{"key":"8829_CR26","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1097\/BOR.0b013e32830a991b","volume":"20","author":"D Kamen","year":"2008","unstructured":"Kamen D, Aranow C. Vitamin D in systemic lupus erythematosus. Curr Opin Rheumatol. 2008;20:532\u20137.","journal-title":"Curr Opin Rheumatol"},{"key":"8829_CR27","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1016\/j.coph.2010.04.001","volume":"10","author":"F Baeke","year":"2010","unstructured":"Baeke F, Takiishi T, Korf H, Gysemans C, Mathieu C. Vitamin D: modulator of the immune system. Curr Opin Pharmacol. 2010;10:482\u201396.","journal-title":"Curr Opin Pharmacol"},{"key":"8829_CR28","doi-asserted-by":"publisher","first-page":"5276","DOI":"10.4049\/jimmunol.1101211","volume":"188","author":"SW Kang","year":"2012","unstructured":"Kang SW, Kim SH, Lee N, Lee WW, Hwang KA, Shin MS, et al. 1,25-Dihyroxyvitamin D3 promotes FOXP3 expression via binding to vitamin D response elements in its conserved noncoding sequence region. J Immunol. 2012;188:5276\u201382.","journal-title":"J Immunol"},{"key":"8829_CR29","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.cyto.2014.11.020","volume":"74","author":"B Astry","year":"2015","unstructured":"Astry B, Venkatesha SH, Moudgil KD. Involvement of the IL-23\/IL-17 axis and the Th17\/Treg balance in the pathogenesis and control of autoimmune arthritis. Cytokine. 2015;74:54\u201361.","journal-title":"Cytokine"},{"key":"8829_CR30","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.1002\/art.1780400928","volume":"40","author":"MC Hochberg","year":"1997","unstructured":"Hochberg MC. Updating the American college of rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1997;40:1725.","journal-title":"Arthritis Rheum"},{"key":"8829_CR31","doi-asserted-by":"publisher","first-page":"2677","DOI":"10.1002\/art.34473","volume":"64","author":"M Petri","year":"2012","unstructured":"Petri M, Orbai AM, Alarcon GS, Gordon C, Merrill JT, Fortin PR, et al. Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus. Arthritis Rheum. 2012;64:2677\u201386.","journal-title":"Arthritis Rheum"},{"key":"8829_CR32","first-page":"288","volume":"29","author":"DD Gladman","year":"2002","unstructured":"Gladman DD, Ibanez D, Urowitz MB. Systemic lupus erythematosus disease activity index 2000. J Rheumatol. 2002;29:288\u201391.","journal-title":"J Rheumatol"},{"key":"8829_CR33","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1002\/art.1780390303","volume":"39","author":"D Gladman","year":"1996","unstructured":"Gladman D, Ginzler E, Goldsmith C, Fortin P, Liang M, Urowitz M, et al. The development and initial validation of the Systemic Lupus International Collaborating Clinics\/American College of Rheumatology damage index for systemic lupus erythematosus. Arthritis Rheum. 1996;39:363\u20139.","journal-title":"Arthritis Rheum"},{"key":"8829_CR34","doi-asserted-by":"publisher","first-page":"953","DOI":"10.7326\/0003-4819-142-12_Part_1-200506210-00004","volume":"142","author":"JP Buyon","year":"2005","unstructured":"Buyon JP, Petri MA, Kim MY, Kalunian KC, Grossman J, Hahn BH, et al. The effect of combined estrogen and progesterone hormone replacement therapy on disease activity in systemic lupus erythematosus: a randomized trial. Ann Intern Med. 2005;142:953\u201362.","journal-title":"Ann Intern Med"},{"key":"8829_CR35","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1191\/096120399680411281","volume":"8","author":"M Petri","year":"1999","unstructured":"Petri M, Buyon J, Kim M. Classification and definition of major flares in SLE clinical trials. Lupus. 1999;8:685\u201391.","journal-title":"Lupus"},{"key":"8829_CR36","doi-asserted-by":"publisher","first-page":"2550","DOI":"10.1056\/NEJMoa051135","volume":"353","author":"M Petri","year":"2005","unstructured":"Petri M, Kim MY, Kalunian KC, Grossman J, Hahn BH, Sammaritano LR, et al. Combined oral contraceptives in women with systemic lupus erythematosus. N Engl J Med. 2005;353:2550\u20138.","journal-title":"N Engl J Med"},{"key":"8829_CR37","doi-asserted-by":"crossref","first-page":"1080S","DOI":"10.1093\/ajcn\/87.4.1080S","volume":"87","author":"MF Holick","year":"2008","unstructured":"Holick MF, Chen TC. Vitamin D deficiency: a worldwide problem with health consequences. Am J Clin Nutr. 2008;87:1080S\u20136S.","journal-title":"Am J Clin Nutr"},{"key":"8829_CR38","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1136\/ard.2007.069831","volume":"66","author":"Y Arnson","year":"2007","unstructured":"Arnson Y, Amital H, Shoenfeld Y. Vitamin D and autoimmunity: new aetiological and therapeutic considerations. Ann Rheum Dis. 2007;66:1137\u201342.","journal-title":"Ann Rheum Dis"},{"key":"8829_CR39","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1056\/NEJMra070553","volume":"357","author":"MF Holick","year":"2007","unstructured":"Holick MF. Vitamin D deficiency. N Engl J Med. 2007;357:266\u201381.","journal-title":"N Engl J Med"},{"issue":"512\u201331","key":"8829_CR40","first-page":"e8","volume":"40","author":"MA Kriegel","year":"2011","unstructured":"Kriegel MA, Manson JE, Costenbader KH. Does vitamin D affect risk of developing autoimmune disease? a systematic review. Semin Arthritis Rheum. 2011;40(512\u201331):e8.","journal-title":"Semin Arthritis Rheum"},{"key":"8829_CR41","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/ncprheum0989","volume":"5","author":"N Shoenfeld","year":"2009","unstructured":"Shoenfeld N, Amital H, Shoenfeld Y. The effect of melanism and vitamin D synthesis on the incidence of autoimmune disease. Nat Clin Pract Rheumatol. 2009;5:99\u2013105.","journal-title":"Nat Clin Pract Rheumatol"},{"key":"8829_CR42","doi-asserted-by":"publisher","first-page":"1807","DOI":"10.1007\/s00198-009-0954-6","volume":"20","author":"A Mithal","year":"2009","unstructured":"Mithal A, Wahl DA, Bonjour JP, Burckhardt P, Dawson-Hughes B, Eisman JA, et al. Global vitamin D status and determinants of hypovitaminosis D. Osteoporos Int. 2009;20:1807\u201320.","journal-title":"Osteoporos Int"},{"key":"8829_CR43","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.jneuroim.2009.05.012","volume":"213","author":"W Royal 3rd","year":"2009","unstructured":"Royal W 3rd, Mia Y, Li H, Naunton K. Peripheral blood regulatory T cell measurements correlate with serum vitamin D levels in patients with multiple sclerosis. J Neuroimmunol. 2009;213:135\u201341.","journal-title":"J Neuroimmunol"},{"key":"8829_CR44","doi-asserted-by":"publisher","first-page":"e9193","DOI":"10.1371\/journal.pone.0009193","volume":"5","author":"I Ben-Zvi","year":"2010","unstructured":"Ben-Zvi I, Aranow C, Mackay M, Stanevsky A, Kamen DL, Marinescu LM, et al. The impact of vitamin D on dendritic cell function in patients with systemic lupus erythematosus. PLoS One. 2010;5:e9193.","journal-title":"PLoS One"},{"key":"8829_CR45","first-page":"22","volume":"7","author":"CS Wahono","year":"2014","unstructured":"Wahono CS, Rusmini H, Soelistyoningsih D, Hakim R, Handono K, Endharti AT, et al. Effects of 1,25(OH)2D3 in immune response regulation of systemic lupus erithematosus (SLE) patient with hypovitamin D. Int J Clin Exp Med. 2014;7:22\u201331.","journal-title":"Int J Clin Exp Med"},{"key":"8829_CR46","doi-asserted-by":"publisher","first-page":"R221","DOI":"10.1186\/ar4060","volume":"14","author":"B Terrier","year":"2012","unstructured":"Terrier B, Derian N, Schoindre Y, Chaara W, Geri G, Zahr N, et al. Restoration of regulatory and effector T cell balance and B cell homeostasis in systemic lupus erythematosus patients through vitamin D supplementation. Arthritis Res Ther. 2012;14:R221.","journal-title":"Arthritis Res Ther"},{"key":"8829_CR47","doi-asserted-by":"publisher","first-page":"8392","DOI":"10.4049\/jimmunol.175.12.8392","volume":"175","author":"M Miyara","year":"2005","unstructured":"Miyara M, Amoura Z, Parizot C, Badoual C, Dorgham K, Trad S, et al. Global natural regulatory T cell depletion in active systemic lupus erythematosus. J Immunol. 2005;175:8392\u2013400.","journal-title":"J Immunol"},{"key":"8829_CR48","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1097\/BOR.0b013e32833c62b0","volume":"22","author":"JC Crispin","year":"2010","unstructured":"Crispin JC, Tsokos GC. Interleukin-17-producing T cells in lupus. Curr Opin Rheumatol. 2010;22:499\u2013503.","journal-title":"Curr Opin Rheumatol"},{"key":"8829_CR49","doi-asserted-by":"publisher","first-page":"R150","DOI":"10.1186\/ar3100","volume":"12","author":"S Dolff","year":"2010","unstructured":"Dolff S, Quandt D, Wilde B, Feldkamp T, Hua F, Cai X, et al. Increased expression of costimulatory markers CD134 and CD80 on interleukin-17 producing T cells in patients with systemic lupus erythematosus. Arthritis Res Ther. 2010;12:R150.","journal-title":"Arthritis Res Ther"},{"key":"8829_CR50","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1084\/jem.20021553","volume":"197","author":"L Bennett","year":"2003","unstructured":"Bennett L, Palucka AK, Arce E, Cantrell V, Borvak J, Banchereau J, et al. Interferon and granulopoiesis signatures in systemic lupus erythematosus blood. J Exp Med. 2003;197:711\u201323.","journal-title":"J Exp Med"},{"key":"8829_CR51","first-page":"187","volume":"26","author":"LL Reimers","year":"2015","unstructured":"Reimers LL, Crew KD, Bradshaw PT, Santella RM, Steck SE, Sirosh I, et al. Vitamin D-related gene polymorphisms, plasma 25-hydroxyvitamin D, and breast cancer risk. CCC. 2015;26:187\u2013203.","journal-title":"CCC"}],"container-title":["Immunologic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12026-016-8829-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12026-016-8829-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12026-016-8829-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12026-016-8829-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T07:51:12Z","timestamp":1718697072000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12026-016-8829-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,16]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["8829"],"URL":"https:\/\/doi.org\/10.1007\/s12026-016-8829-3","relation":{},"ISSN":["0257-277X","1559-0755"],"issn-type":[{"value":"0257-277X","type":"print"},{"value":"1559-0755","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,16]]}}}