{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T08:38:52Z","timestamp":1776587932260,"version":"3.51.2"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T00:00:00Z","timestamp":1595894400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T00:00:00Z","timestamp":1595894400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BD\/51994\/2012"],"award-info":[{"award-number":["SFRH\/BD\/51994\/2012"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UID\/NEU\/04539\/2019"],"award-info":[{"award-number":["UID\/NEU\/04539\/2019"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["POCI-01-0145-FEDER-007440"],"award-info":[{"award-number":["POCI-01-0145-FEDER-007440"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDB\/04539\/2020"],"award-info":[{"award-number":["UIDB\/04539\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["UIDP\/04539\/2020"],"award-info":[{"award-number":["UIDP\/04539\/2020"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Med Oncol"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1007\/s12032-020-01394-6","type":"journal-article","created":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T08:13:39Z","timestamp":1595924019000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Acute myeloid leukemia sensitivity to metabolic inhibitors: glycolysis showed to be a better therapeutic target"],"prefix":"10.1007","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0455-4970","authenticated-orcid":false,"given":"Beatriz","family":"Lapa","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1470-4802","authenticated-orcid":false,"given":"Ana Cristina","family":"Gon\u00e7alves","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0755-8077","authenticated-orcid":false,"given":"Joana","family":"Jorge","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2599-6433","authenticated-orcid":false,"given":"Raquel","family":"Alves","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7994-4650","authenticated-orcid":false,"given":"Ana Salom\u00e9","family":"Pires","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4185-7871","authenticated-orcid":false,"given":"Ana Margarida","family":"Abrantes","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3426-6363","authenticated-orcid":false,"given":"Margarida","family":"Coucelo","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4145-854X","authenticated-orcid":false,"given":"Antero","family":"Abrunhosa","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7202-1650","authenticated-orcid":false,"given":"Maria Filomena","family":"Botelho","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8685-3853","authenticated-orcid":false,"given":"Jos\u00e9 Manuel","family":"Nascimento-Costa","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4142-4841","authenticated-orcid":false,"given":"Ana Bela","family":"Sarmento-Ribeiro","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2020,7,28]]},"reference":[{"key":"1394_CR1","doi-asserted-by":"publisher","first-page":"382","DOI":"10.3389\/fphys.2015.00382","volume":"6","author":"P Ghaffari","year":"2015","unstructured":"Ghaffari P, Mardinoglu A, Nielsen J. Cancer metabolism: a modeling perspective. Front. Physiol. 2015;6:382. https:\/\/doi.org\/10.3389\/fphys.2015.00382.","journal-title":"Front. Physiol."},{"issue":"7424","key":"1394_CR2","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1038\/nature11706","volume":"491","author":"A Schulze","year":"2012","unstructured":"Schulze A, Harris AL. How cancer metabolism is tuned for proliferation and vulnerable to disruption. Nature. 2012;491(7424):364\u201373. https:\/\/doi.org\/10.1038\/nature11706.","journal-title":"Nature"},{"issue":"5","key":"1394_CR3","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1038\/nrc3038","volume":"11","author":"WH Koppenol","year":"2011","unstructured":"Koppenol WH, Bounds PL, Dang CV. Otto Warburg's contributions to current concepts of cancer metabolism. Nat Rev Cancer. 2011;11(5):325\u201337. https:\/\/doi.org\/10.1038\/nrc3038.","journal-title":"Nat Rev Cancer"},{"key":"1394_CR4","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1016\/j.redox.2017.04.018","volume":"12","author":"B Kalyanaraman","year":"2017","unstructured":"Kalyanaraman B. Teaching the basics of cancer metabolism: Developing antitumor strategies by exploiting the differences between normal and cancer cell metabolism. Redox Biol. 2017;12:833\u201342. https:\/\/doi.org\/10.1016\/j.redox.2017.04.018.","journal-title":"Redox Biol"},{"issue":"3191","key":"1394_CR5","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1126\/science.123.3191.309","volume":"123","author":"O Warburg","year":"1956","unstructured":"Warburg O. On the origin of cancer cells. Science. 1956;123(3191):309\u201314. https:\/\/doi.org\/10.1126\/science.123.3191.309.","journal-title":"Science"},{"issue":"2","key":"1394_CR6","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/nrc2981","volume":"11","author":"RA Cairns","year":"2011","unstructured":"Cairns RA, Harris IS, Mak TW. Regulation of cancer cell metabolism. Nat Rev Cancer. 2011;11(2):85\u201395. https:\/\/doi.org\/10.1038\/nrc2981.","journal-title":"Nat Rev Cancer"},{"issue":"6","key":"1394_CR7","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.3892\/ol.2012.928","volume":"4","author":"J Zheng","year":"2012","unstructured":"Zheng J. Energy metabolism of cancer: glycolysis versus oxidative phosphorylation (review). Oncol Lett. 2012;4(6):1151\u20137. https:\/\/doi.org\/10.3892\/ol.2012.928.","journal-title":"Oncol Lett"},{"issue":"1","key":"1394_CR8","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.cmet.2015.12.006","volume":"23","author":"NN Pavlova","year":"2016","unstructured":"Pavlova NN, Thompson CB. The emerging hallmarks of cancer metabolism. Cell Metab. 2016;23(1):27\u201347. https:\/\/doi.org\/10.1016\/j.cmet.2015.12.006.","journal-title":"Cell Metab"},{"issue":"24","key":"1394_CR9","doi-asserted-by":"publisher","first-page":"3981","DOI":"10.1007\/s00018-008-8224-x","volume":"65","author":"SJ Yeung","year":"2008","unstructured":"Yeung SJ, Pan J, Lee MH. Roles of p53, MYC and HIF-1 in regulating glycolysis: the seventh hallmark of cancer. Cell Mol Life Sci CMLS. 2008;65(24):3981\u201399. https:\/\/doi.org\/10.1007\/s00018-008-8224-x.","journal-title":"Cell Mol Life Sci CMLS"},{"issue":"4","key":"1394_CR10","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1007\/s11033-015-3858-x","volume":"42","author":"R Courtnay","year":"2015","unstructured":"Courtnay R, Ngo DC, Malik N, Ververis K, Tortorella SM, Karagiannis TC. Cancer metabolism and the Warburg effect: the role of HIF-1 and PI3K. Mol Biol Rep. 2015;42(4):841\u201351. https:\/\/doi.org\/10.1007\/s11033-015-3858-x.","journal-title":"Mol Biol Rep"},{"issue":"8","key":"1394_CR11","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1016\/j.bbabio.2017.02.001","volume":"1858","author":"P Danhier","year":"2017","unstructured":"Danhier P, Banski P, Payen VL, Grasso D, Ippolito L, Sonveaux P, et al. Cancer metabolism in space and time: beyond the Warburg effect. Biochem Biophys Acta. 2017;1858(8):556\u201372. https:\/\/doi.org\/10.1016\/j.bbabio.2017.02.001.","journal-title":"Biochem Biophys Acta"},{"issue":"8","key":"1394_CR12","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1517\/14728222.11.8.1055","volume":"11","author":"H Hagland","year":"2007","unstructured":"Hagland H, Nikolaisen J, Hodneland LI, Gjertsen BT, Bruserud O, Tronstad KJ. Targeting mitochondria in the treatment of human cancer: a coordinated attack against cancer cell energy metabolism and signalling. Expert Opin Ther Targets. 2007;11(8):1055\u201369. https:\/\/doi.org\/10.1517\/14728222.11.8.1055.","journal-title":"Expert Opin Ther Targets"},{"issue":"1","key":"1394_CR13","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.blre.2016.08.005","volume":"31","author":"J Prada-Arismendy","year":"2017","unstructured":"Prada-Arismendy J, Arroyave JC, Rothlisberger S. Molecular biomarkers in acute myeloid leukemia. Blood Rev. 2017;31(1):63\u2013766. https:\/\/doi.org\/10.1016\/j.blre.2016.08.005.","journal-title":"Blood Rev"},{"issue":"6","key":"1394_CR14","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1007\/s12185-013-1407-8","volume":"98","author":"SM Chan","year":"2013","unstructured":"Chan SM, Majeti R. Role of DNMT3A, TET2, and IDH1\/2 mutations in pre-leukemic stem cells in acute myeloid leukemia. Int J Hematol. 2013;98(6):648\u201357. https:\/\/doi.org\/10.1007\/s12185-013-1407-8.","journal-title":"Int J Hematol"},{"key":"1394_CR15","doi-asserted-by":"publisher","first-page":"41","DOI":"10.3389\/fonc.2018.00041","volume":"8","author":"Y Sun","year":"2018","unstructured":"Sun Y, Chen BR, Deshpande A. Epigenetic regulators in the development, maintenance, and therapeutic targeting of acute myeloid leukemia. Front Oncol. 2018;8:41. https:\/\/doi.org\/10.3389\/fonc.2018.00041.","journal-title":"Front Oncol"},{"issue":"8","key":"1394_CR16","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1016\/j.exphem.2015.05.009","volume":"43","author":"A Eriksson","year":"2015","unstructured":"Eriksson A, Lennartsson A, Lehmann S. Epigenetic aberrations in acute myeloid leukemia: early key events during leukemogenesis. Exp Hematol. 2015;43(8):609\u201324. https:\/\/doi.org\/10.1016\/j.exphem.2015.05.009.","journal-title":"Exp Hematol"},{"issue":"11","key":"1394_CR17","doi-asserted-by":"publisher","first-page":"2112","DOI":"10.3109\/10428194.2010.512966","volume":"51","author":"K Suganuma","year":"2010","unstructured":"Suganuma K, Miwa H, Imai N, Shikami M, Gotou M, Goto M, et al. Energy metabolism of leukemia cells: glycolysis versus oxidative phosphorylation. Leuk Lymphoma. 2010;51(11):2112\u20139. https:\/\/doi.org\/10.3109\/10428194.2010.512966.","journal-title":"Leuk Lymphoma"},{"issue":"2","key":"1394_CR18","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1007\/s10637-019-00796-2","volume":"38","author":"J Jorge","year":"2020","unstructured":"Jorge J, Petronilho S, Alves R, Coucelo M, Goncalves AC, Nascimento Costa JM, et al. Apoptosis induction and cell cycle arrest of pladienolide B in erythroleukemia cell lines. Investig New Drugs. 2020;38(2):369\u201377. https:\/\/doi.org\/10.1007\/s10637-019-00796-2.","journal-title":"Investig New Drugs"},{"issue":"3","key":"1394_CR19","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.jceh.2015.05.003","volume":"5","author":"AF Brito","year":"2015","unstructured":"Brito AF, Abrantes AM, Ribeiro M, Oliveira R, Casalta-Lopes J, Goncalves AC, et al. Fluorine-18 fluorodeoxyglucose uptake in hepatocellular carcinoma: correlation with glucose transporters and p53 expression. J Clin Exp Hepatol. 2015;5(3):183\u20139. https:\/\/doi.org\/10.1016\/j.jceh.2015.05.003.","journal-title":"J Clin Exp Hepatol"},{"issue":"5","key":"1394_CR20","doi-asserted-by":"publisher","first-page":"2053","DOI":"10.3892\/or.2013.2299","volume":"29","author":"H Miwa","year":"2013","unstructured":"Miwa H, Shikami M, Goto M, Mizuno S, Takahashi M, Tsunekawa-Imai N, et al. Leukemia cells demonstrate a different metabolic perturbation provoked by 2-deoxyglucose. Oncol Rep. 2013;29(5):2053\u20137. https:\/\/doi.org\/10.3892\/or.2013.2299.","journal-title":"Oncol Rep"},{"issue":"6","key":"1394_CR21","doi-asserted-by":"publisher","first-page":"241","DOI":"10.3109\/07357907.2014.907419","volume":"32","author":"M Goto","year":"2014","unstructured":"Goto M, Miwa H, Shikami M, Tsunekawa-Imai N, Suganuma K, Mizuno S, et al. Importance of glutamine metabolism in leukemia cells by energy production through TCA cycle and by redox homeostasis. Cancer Invest. 2014;32(6):241\u20137. https:\/\/doi.org\/10.3109\/07357907.2014.907419.","journal-title":"Cancer Invest"},{"issue":"1","key":"1394_CR22","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/s00280-013-2193-y","volume":"72","author":"H Liu","year":"2013","unstructured":"Liu H, Kurtoglu M, Cao Y, Xi H, Kumar R, Axten JM, et al. Conversion of 2-deoxyglucose-induced growth inhibition to cell death in normoxic tumor cells. Cancer Chemother Pharmacol. 2013;72(1):251\u201362. https:\/\/doi.org\/10.1007\/s00280-013-2193-y.","journal-title":"Cancer Chemother Pharmacol"},{"issue":"4","key":"1394_CR23","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1007\/s00280-010-1391-0","volume":"67","author":"H Xi","year":"2011","unstructured":"Xi H, Kurtoglu M, Liu H, Wangpaichitr M, You M, Liu X, et al. 2-Deoxy-d-glucose activates autophagy via endoplasmic reticulum stress rather than ATP depletion. Cancer Chemother Pharmacol. 2011;67(4):899\u2013910. https:\/\/doi.org\/10.1007\/s00280-010-1391-0.","journal-title":"Cancer Chemother Pharmacol"},{"issue":"4","key":"1394_CR24","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1093\/abbs\/gms006","volume":"44","author":"W Xiong","year":"2012","unstructured":"Xiong W, Jiao Y, Huang W, Ma M, Yu M, Cui Q, et al. Regulation of the cell cycle via mitochondrial gene expression and energy metabolism in HeLa cells. Acta Biochim Biophys Sin. 2012;44(4):347\u201358. https:\/\/doi.org\/10.1093\/abbs\/gms006.","journal-title":"Acta Biochim Biophys Sin"},{"issue":"11","key":"1394_CR25","doi-asserted-by":"publisher","first-page":"3049","DOI":"10.1158\/1535-7163.MCT-07-0310","volume":"6","author":"M Kurtoglu","year":"2007","unstructured":"Kurtoglu M, Gao N, Shang J, Maher JC, Lehrman MA, Wangpaichitr M, et al. Under normoxia, 2-deoxy-d-glucose elicits cell death in select tumor types not by inhibition of glycolysis but by interfering with N-linked glycosylation. Mol Cancer Ther. 2007;6(11):3049\u201358. https:\/\/doi.org\/10.1158\/1535-7163.MCT-07-0310.","journal-title":"Mol Cancer Ther"},{"issue":"3","key":"1394_CR26","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1038\/sj.leu.2404081","volume":"20","author":"H Quentmeier","year":"2006","unstructured":"Quentmeier H, MacLeod RA, Zaborski M, Drexler HG. JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders. Leukemia. 2006;20(3):471\u20136. https:\/\/doi.org\/10.1038\/sj.leu.2404081.","journal-title":"Leukemia"},{"issue":"11","key":"1394_CR27","doi-asserted-by":"publisher","first-page":"2187","DOI":"10.1038\/leu.2013.102","volume":"27","author":"C Marty","year":"2013","unstructured":"Marty C, Lacout C, Droin N, Le Couedic JP, Ribrag V, Solary E, et al. A role for reactive oxygen species in JAK2 V617F myeloproliferative neoplasm progression. Leukemia. 2013;27(11):2187\u201395. https:\/\/doi.org\/10.1038\/leu.2013.102.","journal-title":"Leukemia"},{"key":"1394_CR28","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/b978-0-12-396521-9.00014-0","volume":"12","author":"M Seo","year":"2014","unstructured":"Seo M, Crochet RB, Lee Y-H. Targeting altered metabolism-emerging cancer therapeutic. Strategies. 2014;12:427\u201348. https:\/\/doi.org\/10.1016\/b978-0-12-396521-9.00014-0.","journal-title":"Strategies"},{"issue":"2","key":"1394_CR29","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.canlet.2014.09.003","volume":"355","author":"D Zhang","year":"2014","unstructured":"Zhang D, Li J, Wang F, Hu J, Wang S, Sun Y. 2-Deoxy-D-glucose targeting of glucose metabolism in cancer cells as a potential therapy. Cancer Lett. 2014;355(2):176\u201383. https:\/\/doi.org\/10.1016\/j.canlet.2014.09.003.","journal-title":"Cancer Lett"},{"issue":"2\u20133","key":"1394_CR30","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.mam.2012.07.001","volume":"34","author":"M Mueckler","year":"2013","unstructured":"Mueckler M, Thorens B. The SLC2 (GLUT) family of membrane transporters. Mol Aspects Med. 2013;34(2\u20133):121\u201338. https:\/\/doi.org\/10.1016\/j.mam.2012.07.001.","journal-title":"Mol Aspects Med"},{"key":"1394_CR31","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/205357","author":"MB Calvo","year":"2010","unstructured":"Calvo MB, Figueroa A, Pulido EG, Campelo RG, Aparicio LA. Potential role of sugar transporters in cancer and their relationship with anticancer therapy. Int J Endocrinol. 2010. https:\/\/doi.org\/10.1155\/2010\/205357.","journal-title":"Int J Endocrinol"},{"key":"1394_CR32","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1016\/B978-008045382-8.00054-X","volume-title":"Comprehensive natural products II","author":"DG Nagle","year":"2010","unstructured":"Nagle DG, Zhou Y-D. Natural products as probes of selected targets in tumor cell biology and hypoxic signaling. In: Liu H-W, Mander L, editors. Comprehensive natural products II. Oxford: Elsevier; 2010. p. 651\u2013683."},{"issue":"53","key":"1394_CR33","doi-asserted-by":"publisher","first-page":"8149","DOI":"10.1038\/sj.onc.1206053","volume":"21","author":"LA Shchepina","year":"2002","unstructured":"Shchepina LA, Pletjushkina OY, Avetisyan AV, Bakeeva LE, Fetisova EK, Izyumov DS, et al. Oligomycin, inhibitor of the F0 part of H+-ATP-synthase, suppresses the TNF-induced apoptosis. Oncogene. 2002;21(53):8149\u201357. https:\/\/doi.org\/10.1038\/sj.onc.1206053.","journal-title":"Oncogene"},{"issue":"9","key":"1394_CR34","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.1016\/S0891-5849(03)00107-2","volume":"34","author":"M Comelli","year":"2003","unstructured":"Comelli M, Di Pancrazio F, Mavelli I. Apoptosis is induced by decline of mitochondrial ATP synthesis in erythroleukemia cells. Free Radic Biol Med. 2003;34(9):1190\u20139. https:\/\/doi.org\/10.1016\/S0891-5849(03)00107-2.","journal-title":"Free Radic Biol Med"},{"issue":"4","key":"1394_CR35","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1016\/j.bbrc.2005.05.061","volume":"332","author":"A Gemin","year":"2005","unstructured":"Gemin A, Sweet S, Preston TJ, Singh G. Regulation of the cell cycle in response to inhibition of mitochondrial generated energy. Biochem Biophys Res Commun. 2005;332(4):1122\u201332. https:\/\/doi.org\/10.1016\/j.bbrc.2005.05.061.","journal-title":"Biochem Biophys Res Commun"},{"issue":"17","key":"1394_CR36","doi-asserted-by":"publisher","first-page":"4561","DOI":"10.1182\/blood-2011-04-348888","volume":"118","author":"PA Ho","year":"2011","unstructured":"Ho PA, Kopecky KJ, Alonzo TA, Gerbing RB, Miller KL, Kuhn J, et al. Prognostic implications of the IDH1 synonymous SNP rs11554137 in pediatric and adult AML: a report from the Children's Oncology Group and SWOG. Blood. 2011;118(17):4561\u20136. https:\/\/doi.org\/10.1182\/blood-2011-04-348888.","journal-title":"Blood"},{"issue":"15","key":"1394_CR37","doi-asserted-by":"publisher","first-page":"4511","DOI":"10.1158\/1078-0432.CCR-16-2628","volume":"23","author":"Q Xu","year":"2017","unstructured":"Xu Q, Li Y, Lv N, Jing Y, Xu Y, Li W, et al. Correlation between isocitrate dehydrogenase gene aberrations and prognosis of patients with acute myeloid leukemia: a systematic review and meta-analysis. Clin Cancer Res. 2017;23(15):4511\u201322. https:\/\/doi.org\/10.1158\/1078-0432.CCR-16-2628.","journal-title":"Clin Cancer Res"},{"key":"1394_CR38","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/2050-7771-2-18","volume":"2","author":"K Willander","year":"2014","unstructured":"Willander K, Falk IJ, Chaireti R, Paul E, Hermansson M, Green H, et al. Mutations in the isocitrate dehydrogenase 2 gene and IDH1 SNP 105C>T have a prognostic value in acute myeloid leukemia. Biomark Res. 2014;2:18. https:\/\/doi.org\/10.1186\/2050-7771-2-18.","journal-title":"Biomark Res"}],"container-title":["Medical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12032-020-01394-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12032-020-01394-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12032-020-01394-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T23:59:30Z","timestamp":1627430370000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12032-020-01394-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,28]]},"references-count":38,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["1394"],"URL":"https:\/\/doi.org\/10.1007\/s12032-020-01394-6","relation":{},"ISSN":["1357-0560","1559-131X"],"issn-type":[{"value":"1357-0560","type":"print"},{"value":"1559-131X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,28]]},"assertion":[{"value":"7 April 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 July 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 July 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no conflicts of interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This research project was approved by the Institutional Review Board of the Medical School of the University of Coimbra (reference: 072-CE-2017).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors declare that they consent to the manuscript publication.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"72"}}